No. 10(MPHAPP) (2025) THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”

Articles

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  STUDYING ESSENTIAL OIL TECHNOLOGY BASED ON LOCAL PLANT RAW MATERIALS Rose oil, ointments, creams, and sprays based on it are currently widely used in cosmetology and dermatology. Ibn Sina noted that the Damask rose (nasrin) is useful for cooling nerves, helping with ringing and noise in the ears, and toothache. And in Bulgaria, a medicinal product called rozanol has been developed; its active ingredient is rose oil, which has antispasmodic, choleretic, and bactericidal properties.

  D.A. Ergasheva, F.A. Pulatova, M.A. Oloviddinova

  398

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  DETERMINATION OF BIOACTIVE SUBSTANCES IN OIL EXTRACT Vitamin E is a group of important natural compounds, the basis of which is tocopherols and tocotrienols. Tocopherols are used as antioxidants, the most powerful antioxidant is δ-tocopherols. They have a strong neuroprotective, antioxidant effect, and also reduce the risk of cancer. In addition, they have an antihypoxant effect, reducing the need for oxygen in cells. It protects cells from damage by free radicals, thereby slowing down the aging process. All compounds in this group are fat-soluble.

  Mirzalieva G, Pulatova F.A

  399-400

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  MIXED-LIGAND COMPLEX OF COBALT WITH GLUTARIC ACID AND NICOTINAMIDE (CoGANA) MOLECULAR DOCKING ANALYSIS Glutaric acid (pentanedioic acid) is an aliphatic organic compound used as a raw material in the synthesis of anticancer drugs and antibiotics, pharmaceutical and chemical products, as well as a model compound for understanding metabolic disorders and hereditary enzyme deficiencies. Cobalt, being a component of vitamin B12, forms complexes, and its deficiency leads to anemia. Therefore, the synthesis of a complex compound involving glutaric acid, nicotinamide, and cobalt, followed by an analysis of its physicochemical and pharmacokinetic properties, is an important research task.

  G’oyibnazarova M.A, Pulatova G.U, Fatxullayeva M. , Jumabaev F.R.

  401-402

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  THE ROLE OF SAFFRON EXTRACT IN THE REGULATION OF THIOL STATUS INULIN OBTAINED FROM SEVERAL PLANTS ENDEMIC TO KAZAKHSTAN Inulin is a polysaccharide extracted from the vegetative mass and roots of plants (chicory, elecampane, dandelion, etc.) and used as a dietary supplement, improving the nutritional properties of foods, as a sweetener for patients with 2nd type diabetes, and as a valuable prebiotic for the human microbiome. The polysaccharide is found in high concentrations in plant tubers and roots, where it serves as a storage function. Research by several scientists has shown that inulin is also synthesized in large quantities in the rhizomes of certain rubber-bearing plants.

  Turasheva S.K. , Yernazarova G.I, Abzhami Z.N, Alnurova A.A

  403-404

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  BIOLOGICAL CHARACTERISTICS AND MORPHOLOGICAL FEATURES OF GREENHOUSE GRAPES The development of viticulture in protected soil conditions requires the study of the biological and morphological characteristics of various varieties. These studies make it possible to evaluate the anatomical structure of the shoots and the morphological characteristics of the varieties, which is important for the breeding, introduction and adaptation of grapes in Kazakhstan

  Ubaidulla A.M, Alpamysova G.B.

  405

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  MORPHOLOGICAL AND ANATOMICAL FEATURES OF AGRIMONIA ASIATICA JUZ. AND AGRIMONIA PILOSA LDB Representatives of the genus Agrimonia L. are valuable medicinal plants widely used in traditional medicine. However, the morphological and anatomical characteristics of its various species have not been sufficiently studied, which complicates species diagnostics and the rational use of raw materials.

  Yessenova T.M, Alpamysova G.B

  406

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  SYNTHESIS OF NEW BIOACTIVE COMPOUNDS BASED ON ORGANIC CHEMISTRY AND THEIR PROSPECTS FOR APPLICATION IN PHARMACEUTICALS Introduction to Bioactive Compounds and Organic Chemistry The intersection of bioactive compounds and organic chemistry serves as a cornerstone in the advancement of pharmaceutical applications, offering a comprehensive understanding of how natural and synthetic substances can interact within biological systems. Bioactive compounds, which are pivotal in developing therapeutic agents, possess the ability to bring about significant biochemical changes. Organic chemistry, with its focus on the structure, properties, and reactions of carbon-containing compounds, provides the necessary framework for synthesizing new bioactive agents. Recent developments in natural products chemistry, particularly techniques like high-resolution screening and miniaturization of assays, are revolutionizing how these compounds are identified and tested for efficacy. These innovations facilitate the discovery of novel drugs while improving the efficiency of bioassay-guided fractionation processes, thereby enhancing productivity in pharmaceutical research. As the field progresses, the synergy between organic chemistry and bioactive compounds will remain integral to meeting healthcare challenges and fostering drug development.

  Zaripova.R.Sh, Yakubov.Sh.U

  407-408

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  STUDY OF THE ACTIVITY OF α-AMYLASE ENZYME IN WHEAT (TRITICUM) GRAINS GROWING IN UZBEKISTAN Wheat (Triticum) is one of the oldest and most widely cultivated cereal crops in the world. It was domesticated from wild grains and has played a major role in the history of human agriculture. Wheat is mainly used in the production of bread, pasta, sweets, and other food products. Wheat (Triticum aestivum), widely grown in Uzbekistan, is not only a major food source, but also a natural storehouse of valuable biologically active substances. Enzymes contained in the grain, in particular α-amylase, play a key role in the hydrolysis of starch and are one of the important factors determining the nutritional value of wheat. Changes in the activity of this enzyme directly affect the quality of flour products, baking technology, as well as the production of dietary and biologically active additives. Therefore, the study of α-amylase activity in wheat grains grown in Uzbekistan, the identification of its differences by variety, and its application in practice are of urgent scientific and practical importance for the pharmaceutical, food, and biologically active additive production sectors.

  Zaynutdinova G.F, Normakhamatov N.S

  409

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  ТЕРМОДИНАМИКА ВЗАИМОДЕЙСТВИЯ В СИСТЕМЕ НАТРИЙКАРБОКСИМЕТИЛЦЕЛЛЮЛОЗЫ-ПОВИДОН-ЙОДА Карбоксиметилцеллюлоза натрия (NаКМЦ) занимает особое место благодаря хорошей растворимости в воде, полиэлектролитным свойствам, способности вступать в интерполимерные реакции, образовывать фазовые сетки с ионными и ионно координационными связями. Представляет собой нетоксичное и инертное биологическое вещество, что позволяет использовать его в медицине и фармацевтике. По химическому составу повидон-йод поливинилпирролидоном. представляет Широко собой сложную комбинацию йода с используемых вспомогательных веществ в фармацевтической промышленности. Повидон-йод дезинфицирует раны, помогает заживлению ран и предотвращает развитие инфекций. Его также используют с целью антисептической п

  Н Зокирова , С Хазраткулова

  410-411

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  COORDINATION COMPOUND OF VO (II) WITH GLUTARIC ACID AND NICOTINAMIDE To maintain the stability of the internal environment of living organisms, it is extremely important to maintain physiological levels of trace elements. This fact can be explained by the fact that some trace elements are contained in the body in the form of complex coordination compounds with organic ligands, which are more biologically active and less toxic than compounds of inorganic origin. Vanadium is present in the body in very small amounts, but it is known to be involved in the regulation of carbohydrate and lipid metabolism, promotes better oxygenation of haemoglobin, has an insulin-like effect, namely, it promotes the absorption of glucose by cells, and is thought to have an antitumour effect. Nicotinamide participates in redox reactions, plays a role in blood formation, and exhibits antioxidant properties. Glutaric acid participates in energy metabolism and increases the intensity of enzymatic processes

  Shamsutdinova М, Fatkhullayeva М

  412-413

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  CULTIVATION OF HYPERICUM PERFORATUM L. PLANT AND STUDY OF ITS BIOMORPHOLOGICAL PROPERTIES The one of the promising medicinal plant that is widely used in folk medicine is the St John’s wort (Hypericum perforatum L.). Unlike what is already in circulation, research on the distribution of medicinal plants, their bioecological characteristics, growing technology, and their reserve is promise for the pharmaceutical sector. The preparations which contain vitamins, essential oils, caratinoids and alkaloids were recovered from the St John’s wort plant have a twisting, antiseptic and wound tissue fast-graduating effect. In medicine, it is used in the treatment of gastrointestinal (colitis, diarrhea), oral diseases (gingivitis and stomatitis) and Burns of II and III degrees, as well as for rinsing the mouth. Taking into account the above information, the possibilities of planting and caring for the St John’s wort were considered in the irrigated regions of the Republic

  Dusmuratova F.M, Yulchieva M.T

  414

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  DETERMINATION OF BIOLOGICALLY ACTIVE SUBSTANCES AND MICROBIOLOGICAL PURITY IN THE NEW CHOLESTERIC COLLECTION Philogenetic agents, normalizing bile flow, are effectively used in the treatment of liver and gallbladder pathologies. For the treatment and elimination of bile stasis, along with preparations of synthetic origin, medicinal plants with a pronounced choleretic effect are often used. Immortelle flower phytopreparations enhance the liver's functional capacity, thereby increasing bile secretion, leading to an increase in the amount of cholates in bile and a decrease in bile viscosity; corn stalks are effective for gallbladder and urinary tract infections, as well as liver diseases and jaundice.

  H.K. Olimov, A.A. Ismoilov

  415-416

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  DETERMINATION OF ALLAPININ CONTENT BY NON-AQUEOUS ACID-BASE TITRATION AND METHOD VALIDATION Allapinin is an antiarrhythmic drug that blocks sodium channels in the heart due to the presence of lappaconitine. As an antiarrhythmic drug belonging to the diterpene alkaloid group, assessing the quality parameters of Allapinin, studying its properties, and comparatively evaluating quality control methods are essential. Another important task is to assess the validation parameters of the quantitative determination method of Allapinin

  Mirzabdullayeva N.Sh., Ubaydullayev Q.A

  417

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  DETERMINATION OF THE AMOUNT OF OXIDOLIC ACIDS CONTAINED IN THE "SAFROBOS" COLLECTION Cholear agents based on medicinal plants are in high demand in clinical practice, as their effect is milder and longer-lasting compared to synthetic drugs. In order to increase the choleretic properties of plant-derived medicines and treat concomitant diseases, various plant-based preparations are used.

  Olimov H.K, Mirrakhimova T.A

  418-419

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  INFLUENCE OF FACTORS ON THE ADSORPTION ACTIVITY OF SORBENTS In case of drug poisoning, one of the first remedies is the introduction of enterosorbents into the human body. Studies show that enterosorbents may have different ability to bind toxins. Therefore, it was necessary to study the influence of factors such as the pH of the medium, temperature and time on the adsorption activity.

  Osinovskaya K.V, Malakhova A.Yu, Arseniev N.A.

  420

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  QUANTITATIVE DETERMINATION OF ASCORBIC ACID IN A DIETARY SUPPLEMENT VITAMINNI BY HPLC METHOD Gummy dietary supplements in the form of jelly bears represent a modern and convenient dosage form of vitamin-mineral complexes. One of the most demanded components of such supplements is ascorbic acid (vitamin C), which possesses pronounced antioxidant properties and is involved in numerous metabolic processes of the human body. To control the quality of such dietary supplements, it is necessary to use highly accurate analytical methods, among which the most sensitive is the high-performance liquid chromatography (HPLC) method.

  Tleubaeva N.J, Khamdamov M.M

  421-422

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  PHYTOCHEMICAL POTENTIAL AND DIAGNOSTIC FEATURES OF ARTHROPHYTUM LONGIBRACTEATUM KOROVIN Arthrophytum longibracteatum Korovin is a rare species of the family Chenopodiaceae Less., growing in the arid ecosystems of Kazakhstan. This plant remains poorly studied in terms of pharmacognostic aspects, which highlights the necessity of its comprehensive investigation as a potential source of biologically active compounds

  Nurmanbek A.E

  423

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  LIPIDS OF THE AERIAL PARTS OF ARTEMISIA ANNUA L. Lipids of medicinal plants are of interest as a source of biologically active compounds. Artemisia annua L. (annual wormwood) is known for its antimalarial and anti inflammatory properties, but the lipid composition of its aboveground parts has not been sufficiently studied.

  Normakhamatov N.S, A.A. Turaboev, Ch.T.Toshtemirova, F.A.Kodiralieva , A.A.Siddikova

  424-425

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  LIPID COMPOSITION OF THE AERIAL PARTS OF SAGE (SALVIA SP.) Plants of the genus Salvia are rich in biologically active compounds. Studying the lipid complex of the above-ground parts of sage is important for assessing its potential as a source of functionally valuable polyunsaturated fatty acids and related components.

  Normakhamatov N.S, A.A. Turaboev, Ch.T.Toshtemirova, F.A.Kodiralieva, A.A.Siddikova

  426

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  MAHALLIY O’SIMLIK XOMASHYOLARI ASOSIDA OLINGAN O’T HAYDOVCHI YIG’MA TARKIBIDAGI SUVDA ERIYDIGAN VITAMINLARNI O’RGANISHGA DOIR vitaminlar tanada yetarli bo‘lmasa, moddalar almashinuvi (metabolizm) buzilishiga, jismoniy va aqliy faoliyatning susayishiga, hamda tez charchashga olib keladi. Shuningdek, vitamin yetishmovchiligi immun tizimini zaiflashtirib, organizmni kasallik keltiruvchi omillarga nisbatan himoyasiz holatga keltiradi. Natijada turli kasalliklarga, xususan, surunkali va patologik holatlarga moyillik ortadi. Vitaminlar organizmdagi ko‘plab metabolik jarayonlarda ishtirok etgani sababli, ularni kasalliklarning oldini olish va davolashda qo‘llash muhimdir. Ular boshqa davo vositalarining samaradorligini oshirish, ularning ta’sirini kuchaytirish yoki to‘ldirishda ham muhim rol o‘yna

  X Umarxonov , M Mullajonova

  427-428

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  STUDY OF THE WOUND HEALING EFFECT OF NITRO-CONTAINING DERIVATIVES OF CARBOXYMETHYLINULIN Wound healing is a complex process of physiological reactions aimed at restoring the integrity of the skin and tissues. Disruptions in wound healing processes can lead to chronic inflammation, infection, and the formation of difficult-to-treat defects. In this regard, special attention is paid to the development of effective and biocompatible wound healing agents with minimal side effects and promoting accelerated restoration of damaged tissues. It is known that some nitric oxide donors promote accelerated wound healing by stimulating angiogenesis through dilation of blood vessels. In addition, the use of nitric oxide donors also promotes activation of cell proliferation and enhanced collagen synthesis, which plays a key role in restoring skin structure

  Abduhomidova F.O, Ibragimova K.S, Khusenov A.Sh, Rakhmanberdiev G

  430

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  STUDY OF ACUTE TOXICITY OF THE SAMPLE "SILICON POWER NANOSILICON" BASED ON SILICON NANOPARTICLES In recent years, despite significant advances in the field of creating synthetic drugs, many of which, unfortunately, are characterized by the presence of side effects and have contraindications to application, substances of natural origin remain one of the promising sources for obtaining new, highly effective drugs for the prevention and complex therapy of destructive lesions of the stomach and intestines.

  Makhmudova D.M, Tulyaganov R.T, Usmanov U.Kh, Abdurakhmanova N.A

  431-432

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  “PROVIZORSKIY" GEPATOPROTEKTOR BALZAMINI O’TKIR ZAHARLILIGINI O`RGANISH O`simlik tarkibli ko`p komponentli preparat bo`lib,turli davolash mexanizmiga ega organizm uchun nojo`ya ta`sir ko`rsatmaydi.Shundan kelib ciqqan holda,”Provizorskiy” gepatoprotektor balzamini farmakologik xususiyati ekspremental modellarda o`rganildi.

  G Alimdjanova, Z Fayziyeva

  433

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  PHARMACOECONOMIC EVALUATION OF SCREENING AND DIAGNOSIS OF TYPE 2 DIABETES MELLITUS IN OUTPATIENT AND INPATIENT SETTINGS IN KAZAKHSTAN In recent years, there has been a rapid increase in the global prevalence of diabetes mellitus, which has reached the level of a non-communicable epidemic [1]. According to the International Diabetes Federation (IDF), the number of people with diabetes increased from 151 million in 2000 to 425 million in 2017 [2]. According to the National Diabetes Registry of Kazakhstan, as of January 1, 2017, 293,171 patients were registered, including 17,231 patients with type 1 diabetes and 275,736 patients with type 2 diabetes. The annual increase in the number of diabetic patients in Kazakhstan is 8–10%, along with a rising frequency of severe complications. All these factors demonstrate the high relevance of the problem for the country’s healthcare system.

  Alseitov A.M, Nurmaganbetova M.O

  434

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  DETERMINATION OF FLAVONOIDS IN MEDICINAL PLANT EXTRACT (POLYGONUM AVICULARE L) Polygonum aviculare L., also known as knotweed or bird's-foot buckwheat, belongs to the buckwheat family (Polygonaceae). This widespread, seemingly inconspicuous plant grows along roadsides, in yards, and in wastelands. The phytochemical composition of Polygonum aviculare includes tannins, resins, traces of essential oil, vitamins C and K, and provitamin A. Its leaves contain significant amounts of ascorbic acid in reduced form (405–450 mg%) and reversibly oxidized form (253–300 mg%). In addition, the flavonol glycoside avicularin (C₂₀H₁₈O₁₁) has been identified; upon hydrolysis, quercetin and arabinose are formed. Oxymethylanthraquinones have been found in the plant's roots. The plant exhibits anti-inflammatory, hemostatic, diuretic, antioxidant, and restorative properties. It is used for gastrointestinal and urinary tract disorders, bleeding, and in the complex treatment and rehabilitation of cancer patients.

  Aman A.E, Kasimbekova M.D, Ospanova G.S

  435

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