No. 10(MPHAPP) (2025) THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”

Articles

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  PHYSIOLOGICAL-BIOCHEMICAL AND MEDICINAL PROPERTIES OF LEMON In this article, I will provide you with information about citrus fruits that we all love to eat, which are widely distributed worldwide and rich in vitamins beneficial for our body. To discuss the nutritional and therapeutic-prophylactic properties of lemons, a lot of information about its chemical composition has been collected in the literature.

  Khudayarova S.I

  277

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  SYNTHESIS OF IMATINIB ESSINATE AND ITS INCLUSION COMPLEXES INHIBITING CANCER CELL PROLIFERATION Cancer is one of the fastest-growing diseases and ranks second worldwide after cardiovascular diseases in terms of mortality.

  Tuymurodova R.A, Islomov B.R, Saidov R.R

  278

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  ASSESSMENT OF MICROBIOLOGICAL PURITY OF CLARY SAGE LEAVES (SALVIA SACLAREA L.) Salvia L. (sage) is one of the largest genera of the Lamiaceae family. Plants of this genus have long been used in folk and traditional medicine in various countries to relieve pain, protect against oxidative stress, free radical damage, angiogenesis, inflammation, as well as bacterial and viral infections.

  Eshnazarova N.H, Pulatova D.K, Urmanova F.F.

  279-280

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  UZUM BARGIDAN QURUQ EKSTRAKTNI OLISH, TARKIBIDAGI TEMIR MIQDORINI ANIQLASH So’nggi yillarda yosh bolalarda, ayniqsa xomilador ayollarda, organizmda temir moddasi yetishmasligi natijasida kamqonlik kasalligi ko’payib bormoqda. Bu kasalliklarda xozirgi kunda temir (II) tuzlari qo’shilgan xar xil nomlardagi dori vositalari mavjud bo’lib, bemorlar tomonidan qabul qilinib kelinmoqda.

  A.K.Saidvaliev, M.M.Mirzaeva

  281-282

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  STORAGE REQUIREMENTS AND SHELF LIFE OF THE DIURETIC HERBAL PREPARATION ‘ALERVA’ Herbal preparations are medicinal products based on plant components such as herbs, flowers, roots, and fruits. They possess various therapeutic and restorative properties and are often used as preventive remedies.

  B. J. Khasanova , N. K. Olimov, M. U. Abdullaeva, Z. E. Sidametova

  283

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  РАЗРАБОТКА МЕТОДА ВЭЖХ ПРИ АНАЛИЗЕ ПРЕПАРАТА «РЕГИДРЕЙД ЦИНК» Создание высокоэффективных многокомпонентных лекарств является одной из основных практических задач современной фармации, поэтому важна проблема контроля, связанная с точной оценкой качественного и количественного состава препаратов.

  Г Холтураева , Х Ганиева , К Убайдуллаев

  284-285

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  STUDY OF THE VITAMIN COMPOSITION OF HIPPOPHAE RHAMNOIDES Sea buckthorn (Hippophaë rhamnóides) is a valuable source of biologically active substances. While the fruit is well-studied, the leaves remain less well-researched, although they contain a complex of vitamins and antioxidants. Determination of their vitamin composition is important for use in the pharmaceutical and food industries, as well as for the prevention of hypovitaminosis.

  K. V. Raimova, N. G. Abdullajanova, R. R. Makhmudov, R. N. Rakhimov

  286-287

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  ARSLONQUYRUQ O‘SIMLIK YER USTKI QISMI XOMASHYOSIDAN SUV YORDAMIDA QURUQ EKSTRAKT OLISH Biofaol dorivor moddalarni o‘simliklardan ajratib olish , biofaol bo‘lgan moddalarni xar tomonlama kimyoviy , fizik-kimyoviy tahlil usullarini ishlab chiqish va dori vositasini yaratish , uni standartlash, sifatini belgilash davr talabi bo‘lib qoldi. Dori vositalarini tahlil qilib, samaradorligini fizik-kimyoviy usullar yordamida tadqiqot usullaridan foydalangan xolda sifatini belgilash talab etilmoqda.

  U Anarmetova , A Saidvaliyev

  288-289

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  YANTOQ O’SIMLIGIDAN QURUQ ESTRAKT OLISH VA UNING TAHLILI Oʻzbekiston hududlarida keng tarqalib oʻsadigan yantoq (верблюжья колючка) oʻsimligini hom ashyosidan suv yordamida quruq ekstrakt olish. Tadqiqot maqsadi: Ishni maqsadi Toshkent viloyati, Bo‘stonliq rayonida o‘stirilgan yantoq (Alhagi pseudalhagi - Верблюжья колючка) oʻsimligining er ustki qismidan suv yordamida quruq ekstrakt olib yig’indini foiz miqdorini aniqlash

  Azlarova N.X, Saidvaliev A.K.

  290-291

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  “САФРОБОЗ” ЙИҒМАСИ ТАРКИБИДАГИ ОКСИДОЛЧИН КИСЛОТАЛАР ЙИҒИНДИСИНИНГ МИҚДОРИНИ АНИҚЛАШ Доривор ўсимликлар асосида олинган сафро хайдовчи воситаларга клиник амалиётида талаб катта, негаки уларни таъсири синтетик дори воситаларга нисбатан юмшоқроқ ва таъсири давомийлироқ. Ўсиликлардан олинадиган дори воситаларини сафро хайдовчи хусусиятини ошириш ва ёндош касалликларни даволаш мақсадида ҳар–ҳил ўсимликлардан турли йиғмалар фойдаланилади.

  Х. Олимов , Т Миррахимова

  292-293

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  ОПРЕДЕЛЕНИЕ БИОЛОГИЧЕСКИ АКТИВНЫХ ВЕЩЕСТВ И МИКРОБИОЛОГИЧЕСКОЙ ЧИСТОТЫ В НОВОМ ЖЕЛЧЕГОННОМ СБОРЕ Желчегонные средства, нормализуя отток желчи эффективно используются при лечении патологии печени и желчного пузыря

  Х Олимов , А Исмoилов

  294-295

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  TAGETES PATULA L. XOMASHYOSI TARKIBIDAGI ERUVCHAN VITAMINLARNI YUSSX USULIDA ANIQLASH Xalq tabobatida Tagetes patula L. o‘simligining to‘pgullaridan olinadigan damlamalar va qaynatmalardan keng foydalanadi. O‘simlik tarkibining biologik moddalar bilan boyliligi unga yallig‘lanishga qarshi, antibakterial, antioksidant, peshob haydovchi, tinchlantiruvchi, gastroprotektor xususiyatlar beradi. Tagetes patula L. o‘simligidan tayyorlangan preparatlarni tibbiyot amaliyotiga joriy etish uchun ushbu o‘simlig xomashyosining kimyoviy tarkibini yanada chuqurroq o‘rganish maqsadida eruvchan vitaminlar tadqiq etildi.

  N Akramova, G Ismoilova

  296-297

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  QUANTITATIVE DETERMINATION OF L-ARGININE HYDROCHLORIDE IN THE DRUG "ESCILAR" BY THE TITRATION METHOD High drug quality is one of the most important criteria for producing a highly effective and safe medication. In modern medicine, medications containing amino acids are widely used for the diagnosis, treatment, and prevention of many diseases. Compared to more complex methods, titration offers a good price-performance ratio, being a more accessible method of quantitative analysis. This method allows for the determination of substance content with high accuracy, down to hundredths of a milligram. Compared to more complex methods, titration offers a good price-performance ratio, being a more accessible method of quantitative analysis. Therefore, the use of titration remains relevant and in demand today.

  Ulugbekov S.S, Tashpulatova A.D

  298

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  ФУРАДРАЗОЛ ДОРИ ВОСИТАСИНИ ЮССХ УСУЛИДА ТАҲЛИЛИ Юқори самарали кўп компонентли дори воситаларини ишлаб чиқиш замонавий фармациянинг асосий амалий вазифаларидан бирига кириб, уларнинг сифат ва миқдорий таркибини аниқ учун муқобил таҳлил усулларини ишлаб чиқиш муҳим аҳамиятга эга. Турли ҳил табиатдаги моддаларни ўз ичига олган кўп компонентли дори моддаларни таҳлил қилиш одатда маълум қийинчиликлар билан боғлиқ

  Н Юнусхожиева, Р Хусаинова

  299-300

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  DETERMINATION OF THE CRYSTAL STRUCTURE OF THE SUBSTANCE "VIAREN" In pharmaceutical technology, most substances used in the development of solid dosage forms have a powdery nature. During the technological processing of such active substances, their physicochemical and technological properties are taken into account. According to biopharmaceutical theory, the quality indicators and bioavailability of finished dosage forms largely depend on the physicochemical and technological parameters of the medicinal substances, primarily on the crystalline modifications of the particles.

  Khujimov A.Kh, Olimov N.K, Usubbaeva Sh.M

  301-302

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  BIOECOLOGICAL PROPERTIES OF AKMELLA OLERACEAE (L.) R.K.JANSEN UNDER INTRODUCTION CONDITIONS For the treatment and timely prevention of diseases, medicinal plants containing bioactive substances are used to obtain pure preparations. Akmella oleraceae is one of the medicinal plants containing bioactive substances. Akmella oleraceae (L.) R.K.Jansen is an annual herb belonging to the Asteraceae family.

  Yulchiyeva M.T, Dusmuratova F.M

  303-304

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  QUALITY CONTROL AND STANDARDIZATION OF BIOACTIVE COMPOUNDS IN THE DRY EXTRACT 'EXTRADENT' Herbal preparations remain an important direction in pharmaceutical science due to their wide pharmacological effects and relatively low toxicity. 'Extradent' is a dry extract consisting of Calendula officinalis, Urtica dioica, Capsella bursa-pastoris, and Polygonum hydropiper. These plants are known to contain flavonoids, carotenoids, tannins, amino acids, and mineral elements that contribute to the therapeutic properties of the preparation.

  Yuldasheva Sh.S, Akhmadjonova D.A

  305

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  DETERMINATION OF STABILITY OF THE COMBINED HEPATOPROTECTIVE DRUG “HEPATON” Stability is one of the key criteria of the quality of medicinal products, determining their effectiveness, safety, and shelf life. It is especially critical to take this parameter into account in the development and production of infusion solutions, since they are administered directly into the systemic bloodstream, bypassing the protective barriers of the body. This means that any changes in the composition or properties of such solutions can immediately affect the patient’s condition. In this regard, infusion preparations must have a high degree of physicochemical stability and strictly comply with a number of parameters close to physiological ones: osmolarity, pH level, transparency, viscosity, and sterility.

  Zhuraeva M.A, Aglokhodjayeva Sh.M, Tashpulatova A.D

  306-307

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  O’ZBEKISTONDA YETISHTIRILGAN DORIXONA UKROPI (FOENICULUM VULGARE MILL.) MEVASI BIOLOGIK FAOL MODDALARI TAHLILI Dorixona ukropi (Foeniculum vulgare Mill.) soyabonguldoshlar oilasiga mansub o’simlik bo’lib, O’zbekiston Respublikasi ko’pgina viloyatlarida yetishtiriladi. Mevasi efir moyiga boy bo’lib, farmatsevtikada keng qo’llaniladi. Adabiyotlar manbaalarini o’rganish natijasi shuni ko’rsatdiki, ushbu o’simlik mevasi biologik faol moddalari O’zbekistonda kam o’rganilgan.

  U Umarov , A Xursandov

  308-309

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  STUDYING THE ELEMENT COMPOSITION OF DRY EXTRACT FROM TRIBULUS TERRESTRIS L. Microelements are essential for living organisms, and numerous studies have shown that minerals play a major role in human life. This is because without them, vital processes cannot proceed properly. They also ensure the formation of the chemical structure of all human tissues, including muscle tissue. It is known that plant macro- and microelements are better absorbed by the human body. Unlike organic compounds in the human body, they are not synthesized, but are obtained only through food. Therefore, a systematic study of the mineral composition of medicinal plants and preparations obtained from them is of great importance in pharmacy. Tribulus terrestris is a promising plant with sufficient reserves and is widely distributed in Uzbekistan. It is being studied for the purpose of obtaining medicines and biologically active additives. In the process of analysis, it is important to study the elemental composition of the dry extract obtained for the purpose of developing a medicine.

  G.Q. Umarova, Kh.M. Komilov

  310-311

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  SPECTROSCOPIC ANALYSIS OF 2-METHYLTHIOBENZOXAZOLE AND THEIR COMPLEX COMPOUNDS WITH 3D-METALS Derivatives of oxazole and 2-aminothiobenzoxazole are recognized as substances of medical importance. It is known that oxazole derivatives are substances with various pharmacological effects. For example, it is used as a remedy against cancer, microbes, inflammation, herbicide, antibacterial, antiviral, antihistamine, antioxidant, estrogen receptor inhibitor, and hepatitis C virus. Compounds of 2-aminothiobenzoxazole also have luminescent properties.

  Sadullaeva S.A

  312-313

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  LOCAL UNDER THE CIRCUMSTANCES CULTIVATED SPANISH LAVENDER (LAVANDULA STOIC L.) OF PHARMACOGNOSTIC FEATURES AND STANDARDIZATION CRITERIA Last in years Uzbekistan In the Republic medicinal plants cultivation, reproduction work and them pharmaceutical to practice current to grow issues state on a scale current direction as confession Our Republic Presidential Decree No. PQ-4901 of November 26, 2020 “On measures to expand the scope of scientific research on the cultivation and processing of medicinal plants, and the development of their seed production” in the decision new, promising medicinal plants scientific basically study, their raw material standardization and pharmacopoeia requirements suitable quality standards working exit task This is fixed. plant our country in the flora natural accordingly wide not distributed and pharmacognostic features enough unexplored because of it scientific in terms of research to do, morphological, anatomical and physicochemical indicators determination and medicinal raw material as standardization criteria working exit pharmaceutical working release, local medicinal drugs assortment in expansion current importance profession will reach.

  Madaminova M.S., Matazimov M.T

  314-315

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  DEVELOPMENT AND STANDARDIZATION OF SYNBIOTICS WITH LACTOBACTERIUM PLANTARUM SUBSTANCE AND OLIGOSACCHARIDES According to the definition by the World Health Organization (WHO), probiotics are viable microorganisms that, when administered in adequate amounts, confer a health benefit on the host. In 2013, the International Scientific Association for Probiotics and Prebiotics refined this definition, stating that the term «probiotic» may only be applied to preparations that meet the following requirements: accurate information on the microorganisms present, including their strains, is provided; a sufficient number of viable bacteria is maintained until the end of the shelf life; and studies confirming the safety and efficacy of the introduced strains are available. Thus, fermented food products and fecal transplants that do not specify species and strain composition are not considered probiotics. Experimental studies and numerous clinical observations have shown that different probiotic strains are necessary for the correction of intestinal symptoms.

  Kalmakhanova L.M, Dzhumagaziyeva A.B

  316

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  MACROSCOPIC EXAMINATION OF THE COMMON SELF-HEAL (PRUNELLA VULGARIS L.) Common self-heal (Prunella vulgaris L.) is a promising medicinal plant used in folk medicine as an anti-inflammatory, antihistamine, antibacterial, and antifungal agent. In light of the growing interest in herbal preparations, the study of morphological characteristics of the above ground parts of this species growing in the Republic of Uzbekistan is of particular importance.

  Nurullaeva D.Kh, Farmanova N.T, Khalilullaev M.U

  317

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  DETERMINATION OF COMMODITY INDICATORS (FINENESS AND IMPURITIES) OF NEPETA DENSIFLORA HERB The primary source for the search of new medicinal plants is the arsenal of traditional medicine. Various species of the genus Nepeta (family Lamiaceae) are used in folk medicine to strengthen and stabilize the immune system, enhance the overall tone of the body, and reduce the impact of adverse environmental factors on human health.

  Kuandyk A.T, Orynbasarova K.K

  318

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