№ 10(MPHAPP) (2025) THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”

Maqolalar

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  РОЛЬ БИОЛОГИЧЕСКИ АКТИВНЫХ ДОБАВОК К ПИЩЕ В ЖИЗНЕДНЯТЕЛЬНОСТИ ЧЕЛОВЕКА Биологически активные добавки (БАД) – это вещества, активирующие реакции саморегуляции организма, восстанавливающие естественный динамический баланс и открывающие путь к исцелению. В США их употребляет 80% населения, а в Европе - более 50%. БАД – это натуральные или аналогичные биологически активные вещества, предназначенные для непосредственного приема внутрь в форме порошка, таблеток, капсул, сиропов, экстрактов, настоек, концентратов и т.п.

  М Абдуллаева, Н Олимов , З Сидаметова , Ш Таджиева

  360-361

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  B GURUH VITAMINLARI SAQLAGAN DORI VOSITALARI TAHLILINING MUQOBIL USULLARINI ISHLAB CHIQISH VA VALIDATSIYALASH So‘nggi yillarda biologik faol qo‘shimchalar va vitamin-mineral komplekslarga bo‘lgan talab ortib bormoqda. Aholining turmush tarzi, ekologik omillar hamda ovqatlanishdagi nomutanosibliklar organizmda vitaminlar, xususan, B guruhi vitaminlari yetishmovchiligi xavfini oshirmoqda. Vitamin B2 (riboflavin), B3 (nikotinamid) va B6 (piridoksin) moddalar almashinuvi, asab tizimi faoliyati va immun tizimni mustahkamlashda muhim ahamiyatga ega. Shu bois, “Компливит актив” kabi biologik faol moddalar saqlagan kompleks preparatlardagi vitaminlar miqdorini aniq belgilash ularning sifatini nazorat qilish, xavfsizligi va samaradorligini ta’minlashda dolzarbdir. Farmakopeya talablari va xalqaro standartlarga muvofiq holda miqdoriy tahlil metodlarini ishlab chiqish va amalda qo‘llash zamonaviy farmatsevtik tahlilning muhim vazifalaridan biri hisoblanadi.

  Sobirjonov D.B, Shamsiev Sh.Sh

  362

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  STUDY OF THE BIOLOGICAL ACTIVITY OF THE COMPLEX COMPOUND [Cu (Tsk)2](Glu)2 USING THE PASS ONLINE PROGRAM A powerful set of methods for predicting the biological activity of chemical compounds on a computer is methods based on Bayesian probability. The Pass software package is a program capable of predicting the biological activity spectra of chemical compounds known to date. The Pass program (online) is based on the study of the biological activity of substances depending on their structure. This program contains known Pa and Pi values for the substance, these values represent the theoretical probability. That is, Pa is pharmacologically active, Pi is pharmacologically inactive. If Pa >0.71, such a molecule is considered active. The online pass program works on the principle of structural biological activity. In this case, the value of Pa determines the pharmacological activity of the substance against a certain disease, and the value of Pi determines the low pharmacological activity against this disease.

  O Umirzakova , G Nuraliyeva

  363

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  VALERIANA OFFICINALIS L. – MAIN RAW MATERIAL FOR PRODUCING DRUGS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES The use of valerian has a long history in folk medicine. It was mentioned in written sources as early as the 2nd century as a sleep aid and sedative. Valerian preparations were recommended by Galen for insomnia, and in the 16th century, they were used to treat nervousness, palpitations, and headaches. Beginning in the mid-20th century, valerian tincture began to be used for stressful situations.

  K Akhmadjonov , A Azamatov , M Ergasheva

  364

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  PROSPECTS FOR THE USE OF ESSENTIAL OIL FROM FILIPENDULOUS YARROW RAW MATERIALS Filipendulous yarrow (Achillea filipendulina Lam.) is a perennial herbaceous plant widely distributed in Central and Southwest Asia. Plants of the Achillea genus have traditionally been used in folk and modern medicine due to their high content of biologically active compounds. Of particular interest is the essential oil of A. filipendulina, which exhibits antibacterial, antimicrobial, antioxidant, and anti-inflammatory effects. Despite the widespread use of the Achillea genus, the essential oil of A. filipendulina remains insufficiently studied, which determines the relevance of its investigation.

  A Akhan , T Bekezhanova , A Karaubaeva , K Zhaparkulova , E Zhaiymbaeva

  365-366

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  DEVELOPMENT OF BIODEGRADABLE BANDAGES FROM PINUS SYLVESTRIS BARK: PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL ACTIVITY Modern medicine has an urgent need for environmentally friendly, biocompatible, and effective wound dressing materials. The bark of Scots pine (Pinus sylvestris) is a promising renewable source of biologically active compounds with proven antimicrobial and wound-healing properties, which determines the relevance of its study.

  I Chapaksin , B Chapaksina , A Seytenova

  367

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  ОПРЕДЕЛЕНИЕ КОЛИЧЕСТВО ОБЩЕГО БЕЛКА В БАДЕ « » Преимущество биологически активных добавок на основе фитопрепаратов заключается в том, что они зачастую имеют комплексный состав и действуют сразу в нескольких фармакологически активных направлениях: гепатопротекторном, антиоксидантном, желчегонном, противовоспалительном и иммуномодулирующем. Среди них следует отметить биологически активную добавку «…» которые состоит из экстрактов лекарственных растений и, благодаря их синергетическому эффекту, обладает высокой эффективностью в улучшении функции печени.

  И Иминова , Р Хусаинова, М Иминова

  368-369

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  “GEPA-LAYK” QURUQ EKSTRAKTI TARKIBIDAGI FLAVONOIDLAR MIQDORINI ANIQLASH Bugungi kunda jigar kasalliklari dunyo miqyosida eng keng tarqalgan surunkali kasalliklardan biri hisoblanadi. O‘tkir va surunkali gepatitlar, toksik gepatozlar, alkogolli jigar zararlanishlari, steatoz va sirroz kabi holatlar nafaqat rivojlanayotgan, balki rivojlangan davlatlar sog‘liqni saqlash tizimi oldida turgan dolzarb muammolardan biri bo‘lib qolmoqda. Mahalliy xom ashyo asosida jigar kasalliklariga qarshi dori vositasini olish uchun izlanishlar olib borildi.

  Iminova I.M, Sodiqova G.A

  370-371

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  DETERMINATION OF ANTIOXIDANT PROPERTIES OF FACTORY-GROWN CHICKEN EGGSHELLS Today, bone diseases are increasing due to calcium deficiency, and to prevent and eliminate this condition, eggshells are a natural source rich in calcium. They are not only a source of calcium, but also play an important role in the absorption of D3, which is obtained with solar energy, into the body.

  X Fayziyev , Akmal Islomov , M Mustafakulov

  372-373

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  PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL ACTIVITY OF TAMARIX RAMOSISSIMA: A REVIEW Tamarix ramosissima is a shrub plant widely distributed in arid regions. In recent years, its chemical composition and pharmacological properties have been investigated, which opens prospects for the development of new phytopreparations. Phytochemical analysis confirms the presence of flavonoids, phenolic compounds, terpenoids, alkaloids and saponins in the plant, which determines its biological activity.

  A Daulbaev , K Kozhanova , G Kadyrbaeva , N Rakhymbaev

  374-375

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  ʼPEROVSKIA KUDRJASCHEVII – A PROMISING SOURCE OF BIOLOGICALLY ACTIVE TERPENOIDS Perovskia kudrjaschevii Gorschk. & Pjataeva (family Lamiacaeae) is a medicinal, essential oil, dye and honey plant. It is found in Uzbekistan, Tajikistan and Kyrgyzstan. The chemical composition of the components of Perovskia kudrjaschevii has not been previously studied.

  G Ikromova , E Botirov

  376

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  CREATION OF NEW MEDICINAL PRODUCTS In recent years, the development of new, more effective drugs has become a pressing issue due to the increasing level of drug resistance. According to the World Health Organization, more than 700,000 patients die each year from antibiotic-resistant infections. Therefore, the creation of new chemical classes of drugs with a broad spectrum of action and low toxicity is one of the main priorities of the pharmaceutical industry.

  Y Imamova , M Egamberdiyeva

  377

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  PHENOLIC COMPOUNDS OF PLANTS BELONGING TO THE GENUS ATRAPHAХIS At present, the isolation of biologically active substances from plants, the comprehensive study of their chemical structure and properties, as well as the investigation of their biological and pharmacological characteristics, is one of the urgent tasks. Phenolic compounds, which are widespread in the plant kingdom, represent a large class of natural compounds. Phenolic compounds participate in various processes occurring in the human body and exhibit antioxidant properties; moreover, as antiradical agents, they slow down radical mechanism-based reactions that take place in the organism under the influence of external physico-chemical factors.

  U Yulchiyeva, Sh Abdullayev , N Abdulladjonova

  378-379

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  ANALYSIS OF MOLECULAR INTERACTIONS OF THE ENERGY STRUCTURE OF LIPOIC ACID Lipoic acid (LA) is a sulfur-containing organic compound with powerful antioxidant properties, neutralizing free radicals and reducing oxidative stress. This helps prevent diseases such as skin aging, neurodegenerative disorders, cancer, and cardiovascular diseases. Lipoic acid also activates liver enzymes, which helps in detoxification, removal of toxins and heavy metals, and maintaining liver health. Due to the improvement of the body's metabolism, LA is used in medicine as a drug for the treatment of diabetes and cancer. Its antioxidant activity also helps protect cells from damage caused by oxidative stress, slowing down the aging process, improving tissue regeneration, and maintaining cellular health at the molecular level. Lipoic acid, therefore, becomes not only an important element in the therapeutic approach, but also a promising means for the prevention of many diseases associated with metabolic disorders and aging of the body

  F Jumabaev , M Abdulloeva , A Sharipov

  380

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  SYNTHESIS OF ENTEROADSORBENT-INTRODUCING Fe AND Al POLYHYDROXYCATION BETWEEN MONTMORILLONITE LAYERS Efficiency: enterosorbents are substances with a high specific surface area, capable of adsorbing molecules, ions and various particles. They are used in medicine for various purposes, they have antimicrobial and detoxifying properties, for example, the ability to bind to heavy metals and toxins, and they are used in the performance of some complex tasks, such as poisoning models (food poisoning, diarrhea, allergies). Therefore, the synthesis of adsorbents and catalyst carriers, which are absolutely harmless to human health and economically inexpensive, with high adsorption properties, is considered urgent today.

  F Jurayeva, H Alikulova , G Boltayeva

  381-382

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  SYNTHESIS, STRUCTURE, AND INVESTIGATION OF A COMPLEX COMPOUND BASED ON THE BENZIMIDAZOLE DERIVATIVE OF Co (II) Currently, benzimidazole and its derivatives are the main raw materials for the development of important therapeutic agents in medicine and pharmaceuticals. For example, benzimidazole and its derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, and neurotropic, psychoactive, and analgesic properties. The synthesis of drugs with high pharmaceutical properties and the creation of new generations of drugs using new benzimidazole derivatives is currently one of the most important areas of the modern pharmaceutical industry.

  F Khujaeva , SH Allamurodova, SH Daminova

  383-384

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  PROPAGATION OF THE TIEN SHAN SPRUCE BY SEEDS In the context of climate change and urbanization, the introduction and cultivation of ornamental and ecologically significant tree species is of particular importance. The Tien Shan spruce is a valuable species of coniferous plants that is highly decorative and resistant. The study of its seed propagation in the Turkestan region is of practical and scientific significance

  Y Kozhamuratov , G Alpamysova

  385

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  STUDY OF BIOLOGICALLY ACTIVE COMPONENTS OF PEROVSKIA BOTSCHANTZEVII The growing need for medicinal products prepared on the basis of plant raw materials is explained by their high content of biologically active compounds, good efficiency, safety, and a wide range of therapeutic action. Perovskia botschantzevii Kovalevsk. & Koczk (family Lamiacaeae) is a medicinal, essential oil, dye and honey plant growing on rocky slopes, pebbles, in the river valleys of Kyrgyzstan, Uzbekistan, Tajikistan, and Afghanistan.

  S Mullabaeva, F Egamova , M Negmatova, D Siddikov , E Botirov

  386

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  MULTISCALE THEORETICAL INVESTIGATION OF HEAVY METAL AND ORGANIC POLLUTANT SORPTION ON FUNCTIONALIZED CELLULOSE DERIVATIVES Water contamination by heavy metals (Pb²⁺, Cd²⁺, Ni²⁺), metalloid ions (As(III), As(V), Cr(VI)), and persistent organic pollutants (phenolic derivatives, pharmaceutical residues, dyes) remains a major environmental concern worldwide. Conventional water treatment methods are often insufficient to achieve both high efficiency and selectivity. In this context, biopolymeric sorbents based on modified cellulose offer significant advantages due to their biocompatibility, availability, and ease of functionalization. Dialdehyde cellulose grafted with thiosemicarbazide (DAC@TCH) and its thiol-functionalized derivative (DAC@TCH–SH) are particularly promising candidates for the selective binding of toxic metal ions and organic pollutants.

  I Nurgaliev , M Marasulov , A Abilkasimov

  387-388

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  DEVELOPMENT OF NEW PHARMACEUTICAL PRODUCTS BASED ON THE PLANT OBJECT ELAEAGNUS ANGUSTIFOLIA L. The increase in chronic diseases, multi-organ pathology, and complications from long-term use of synthetic drugs necessitates the search for alternative sources of medicines with minimal side effects. In this context, interest in herbal medicines with comprehensive effects and good tolerability is growing. Elaeagnus angustifolia (narrow-leaved oleaster) has traditionally been used in folk medicine as an analgesic and anti-inflammatory agent. Modern studies confirm the presence of bioactive compounds (BACs) in this plant, which can serve as the basis for the development of effective and safe pharmaceutical products, exhibiting antioxidant, analgesic, and antibacterial activities.

  Nurgali Rakhymbaev

  389

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  MAIN GROUPS OF BIOLOGICALLY ACTIVE SUBSTANCES OF CHICKWEED (STELLARIA MEDIA L.) AND THEIR PHARMACOLOGICAL SIGNIFICANCE Chickweed (Stellaria media L.) is a widespread annual plant in the Caryophyllaceae family, possessing a rich chemical composition. Interest in this species stems from the presence of various biologically active substances, which determine its pharmacological activity and potential for use in herbal medicine. However, despite this, there are no medications based on chickweed (Stellaria media L.). Studying its properties would expand the pharmaceutical market.

  B Saipiyeva , G Sayakova

  390

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  ALKYNYLATION REACTIONS OF SOME HETEROATOMIC ALDEHYDES IN THE PARTICIPATION OF PHENYLACETYLENE In our country, the synthesis of new types of chemicals that have found their place in the world market, the creation of methods for obtaining import-substituting compounds intended for export, and their use in the pharmaceutical, chemical, energy, and construction sectors are urgent tasks, and scientific research is being conducted in this area and certain results are being achieved.

  M Saliyeva , O Ziyadullayev

  391-392

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  DETERMINATION OF OPTICAL PROPERTIES OF COLORANTS IN SOME CONFECTIONERY PRODUCTS The aim of the experiment was a qualitative and quantitative analysis of the dyes contained in selected colored confectionery products. The resulting confectionery products consisted of red, yellow, blue, and black dyes, as well as natural beetroot dye. Each product was dry-weighed on a precision analytical balance and ground into powder. The optical properties of the powder were preliminarily analyzed using an X.Rite.eye one pro instrument. The results are presented in the table.

  O Taniyev

  393

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  MACRO- AND MICROELEMENTS IN THE AERIAL PARTS OF ATRAPHAXIS PYRIFOLIA In our research, the main objective was defined as the study of the chemical components of Atraphaxis pyrifolia, a plant belonging to the Polygonaceae family. In June 2025, we initiated the qualitative and quantitative analysis of macro- and microelements in the aerial parts of Atraphaxis pyrifolia, collected in the mountainous areas of Parkent District, Tashkent Region, as part of the study of its chemical components. The analysis of the chemical composition of the studied plant provides an opportunity to draw more precise conclusions about this species.

  A Yulchiyeva, Sh Abdullayev, N Abdullajonova

  394-395

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  PRODUCTION OF DRY POWDER COMPOSITES BASED ON SODIUM AND CALCIUM STEARATE One of the main tasks of the world industry is to provide the construction industry with new, high-quality products. The processing of metals, which perform an important function in the construction industry, is of great importance, that is, their production in various sizes. Therefore, it is necessary to process metals and prepare wires of various sizes from them, to study in more detail the composition of these wires and various physical and mechanical processes occurring on their surfaces, to search for opportunities for the widespread use of dry welding components used in the drawing and processing of metals. Therefore, it is important to develop effective methods for obtaining dry welding components and welding electrodes used in the drawing of metal wires based on local raw materials.

  R Ermatov , G Doliyev, R Zaripova

  396-397

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