№ 10(MPHAPP) (2025) THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”

Статьи

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  REACTION OF 4,6-DIAMINO-2-MERCAPTOPYRIMIDINE WITH ALKYL HALIDE Pyrimidine derivatives are among the most important compounds in medicinal chemistry and pharmaceutics [1], possessing a wide range of biological activities, including antidiabetic [2], anti inflammatory [3], anticancer [4], antibacterial [5], antihypertensive, as well as antifungal and antitubercular properties

  G Salieva , S Otajonov , A Karimov , M Turlibekov , T Kholiqov

  319

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  SPECTROPHOTOMETRIC DETERMINATION OF TRACE AMOUNTS OF SILVER(I) IONS USING H-RESORCINOL A new organic reagent, H-resorcinol, was employed as a highly sensitive, selective, and rapid-acting reagent for the determination of silver (I) ions. The interaction of silver (I) with H resorcinol occurs through the formation of a stable coordination bond. At pH = 10, an ammonia buffer solution was used as a background electrolyte, resulting in the formation of a 1:1 (silver:H-resorcinol) molar ratio complex. This approach is of particular importance, as the reliable and selective determination of trace silver ions holds significant analytical value in environmental monitoring, pharmaceutical analysis, and industrial quality control, where the accurate detection of even very low concentrations of silver is essential.

  F Tojiboyeva , K Chulpanov , Z Smanova

  320-321

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  HIRSHFELD SURFACE ANALYSIS OF THE CRYSTAL STRUCTURE OF THE COMPLEX COMPOUND OF Cu (II) NITRATE BASED ON THE 2,5-DI (METHYLTHIO) -1,3,4-THIADIAZOLE LIGAND Currently, the Hirshfeld surface analysis method is widely used to identify intermolecular interactions in the crystal structure of compounds and to study their impact on the stability of the crystal lattice. The theoretical data obtained through this method are yielding good results in studying the practical properties of crystals. Therefore, investigating the structure of this complex using this method is one of the urgent scientific issues of the research.

  G Uzakbergenova , D Dauletbaeva , B Torambetov , Sh Kadirova

  322-323

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  IN VITRO CULTIVATION OF RED-SOIL ASTRAGALUS (ASTRAGALUS TERRAE RUBRAE BUTKOV) The flora of Uzbekistan is rich and diverse, containing numerous rare and endemic plant species. Among them, Red-soil Astragalus (Astragalus terrae rubrae Butkov) is a unique endemic species listed in the “Red Book of Uzbekistan.” This plant is distinguished by its high content of bioactive compounds such as flavonoids, saponins, polysaccharides, and organic acids. These components exhibit cardioprotective, immunostimulatory, and anti-inflammatory activities, making the species a valuable resource for pharmaceutical applications. However, the progressive reduction of its natural populations highlights the necessity of employing in vitro biotechnological approaches for its conservation and large-scale propagation

  N Khoshimova , X Ubaydullayeva

  324

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  HIRSHFELD SURFACE ANALYSIS OF THE COMPLEX FORMED BY Cu (II) NITRATE WITH 1-ETHYL-2- (ETHYLTHIO) -1H-BENZO[d]IMIDAZOLE Hirschfeld surface analysis is a method that enables a more analytical study of intermolecular interactions. This analytical technique allows for the investigation and visualization of the size, shape, quality, and quantity of intermolecular contact surfaces in molecular crystals.

  G Kurbanbaeva , D Raxmonova

  325-326

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  LICORICE ROOT (GLYCYRRHIZA GLABRA L.) AS A MEDICINAL PLANT FROM SOUTHERN KAZAKHSTAN Licorice (Glycyrrhiza spp.) is a genus of perennial legumes whose roots are widely used in traditional medicine as an expectorant, anti-inflammatory, and antiviral agent. In Kazakhstan, licorice is found in the steppes and along moist river floodplains, especially in the southern regions (Turkestan, Zhambyl, and Almaty regions). In recent years, there has been intensive harvesting of wild-growing stocks, which puts the species at risk in some areas. Objective: To characterize the phytochemical profile of licorice roots collected in the southern regions of Kazakhstan and to assess the potential of licorice for the phytomelioration of saline soils.

  B Murzabaev

  327

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  SYNTHESIS OF MEDICINES BASED ON THE COORDINATION COMPOUND OF Zn(II) WITH GLUTARIC AND NICOTINIC ACIDS Chronic deficiency of the trace element zinc is known to lead to immunodeficiency. Zinc is an effective immunostimulant. Zinc is present in all internal organs, tissues, fluids, and almost 100% of the body's enzymatic systems. Zinc acts as a "secondary mediator" of immune cells and significantly shortens the duration of inflammation. When a person catches a cold, a large amount of zinc is consumed in the first few hours, and the need for it increases 6-8 times. Zinc has anti-inflammatory, antioxidant, and antibacterial properties. Zinc reduces susceptibility to acute lower respiratory tract infections. Zinc ions stimulate the production of endogenous α- and γ-interferons, which also exert antiviral activity, including against COVID-19.

  A Gazieva, M Fathullaeva

  328-329

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  SYNTHESIS OF POLYMERIC NITROGEN DONATIONS BASED ON INULIN DERIVATIVES Nitric oxide (NO) donors are widely used in the treatment of cardiovascular diseases, pulmonary hypertension, and are also actively studied in the treatment of neurodegenerative pathologies. Such drugs as Nitroglycerin, Molsidomine and Nicorandil are capable of releasing nitric oxide. In the context of the growing number of chronic diseases and an aging population, there is a growing need for effective and safe means regulating the bioavailability of NO. In addition, the improvement of synthesis methods makes it possible to obtain nitrogen donors with a given structure that ensures controlled release of NO under physiological conditions of the body. For these reasons, the development of new methods for the synthesis of nitrogen donors with controlled release and high biocompatibility is becoming a particularly interesting task.

  F Abduhomidova , A Khusenov , G Rakhmanberdiev , K Ibragimova

  330-331

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  OBTAINING A HERBAL COMPOSITION WITH HEPATOPROTECTIVE PROPERTIES AND DETERMINING THE QUALITY INDICATORS IN ITS COMPOSITION The search for herbal remedies that increase the liver’s resistance to the harmful effects of toxins and stimulate detoxification processes is relevant .

  A Serikbaeva

  332

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  SYNTHESIS OF POLYMER BASES BASED ON INULIN In recent decades, researchers have paid special attention to natural polymers as a basis for creating biocompatible materials that are widely used in medicine, pharmaceuticals, food and cosmetics industries. One of these promising polysaccharides is inulin, a plant heteropolysaccharide consisting mainly of fructose residues. Inulin has a number of valuable properties: it is non-toxic, resistant to human digestive enzymes and can be chemically modified, which makes it attractive for obtaining new functional materials. Due to its bioavailability and ability to structural modification, inulin opens up wide opportunities for creating materials with adjustable properties. For example, various polymer bases with specified physicochemical and biological properties can be created on the basis of inulin. In turn, polymer bases can find application as drug carriers, as well as as components of hydrogel systems and composite materials.

  O Abdullaev , A Khusenov , G Rakhmanberdiev, K Ibragimova

  333

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  FENUGREEK - A NEW PROMISING MEDICINAL PLANT OF UZBEKISTAN In recent years, great attention has been paid to the development of medicinal plants in the country at the state level. In this regard, a number of resolutions and decrees of the President of the Republic of Uzbekistan, in particular, the Decree No. PF-139 dated May 20, 2022 "On measures to create an added value chain through the effective use of the raw material base of medicinal plants, support for processing", stipulates that all districts of the Republic should specialize in the cultivation of anise, saffron, lovage, lavender, stevia, chamomile, marigold, lovage, yarrow, yarrow, yarrow, yarrow, peppermint and other medicinal plants, and in this regard, from 2022 to 2026, new medicinal plant plantations will be established on an area of 36,000 hectares.In 2017, the Decree of the President of the Republic of Uzbekistan PF-5032 "On the establishment of the free economic zones "Nukus-Farm", "Zomin-Farm", "Kosonsoy-Farm", "Syrdaryo-Farm", "Boysun Farm", "Bostonliq-Farm", "Parkent-Farm" also provided for the establishment of the cultivation of medicinal plants in these territories. In order to ensure the implementation of this DecreeNova Pharm JV has acquired the Boysun-farm land plot for the cultivation of various medicinal plants, in particular turmeric and fenugreek plants imported from India, which are used as raw materials for Ayurvedic medicines.

  X Abdumajidov , U Usmanov , N Abdurakhmonova

  334-335

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  SYNTHESIS AND CHARACTERIZATION OF HYDROXYAPATITE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS In this study, the synthesis of hydroxyapatite (HA) is reported. Currently, in addition to the traditional (oral and injection) methods of drug delivery to the body, delivery using some chemical means (micelles, liposomes, etc.) is more preferred by researchers. When using these tools, the advantages of such substances are that they can reduce the cytotoxicity of chemotherapeutic agents, reduce the amount of administered drugs, target delivery, and other features. In our studies, the nanopolymers used for drug delivery encountered some barriers in crossing the cornea of the skin. When HA nanoparticles were used they provided mechanical strength due to their crystalline structure. A hydrothermal synthesis method was used to synthesize HA nanoparticles.

  J Abdusalamov, M Suyundikov, Sh Azizov, M Sharipov, A Turayev

  336-337

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  MORPHOLOGICAL STRUCTURE OF THE TRIPOLIUM PLANT GROWING WILD IN OUR REPUBLIC The Tripolium plant (especially species such as Tripolium vulgare and Tripolium pannonicum) grows wild in Uzbekistan, but their morphological and chemical characteristics have not been sufficiently studied. For the Pharmacopoeia of the Republic of Uzbekistan, the scientific study of new medicinal plants and the development of quality standards serve as an important source for the production of medicinal preparations.

  Z Abduxamidova , M Matazimov

  338-339

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  ISOLATION OF THE METABOLITES FROM ASTRAGALUS ALOPECIAS AND DETERMINATION OF THEIR CHEMICAL STRUCTURE Currently, the drugs used in medicine are mainly synthetic drugs, their therapeutic effect is effective and fast, but they have some harmful effects. Therefore, a lot of work is being done in the world to create drugs from relatively harmless plant raw materials. In Uzbekistan, providing our people with harmless, high-quality, affordable drugs remains one of the important tasks of our state policy.

  A Akhmedov , N Mamadalieva

  340-341

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  SYNTHESIS OF SUPERCHARGED CHITOSAN DERIVATIVES Modern polymer chemistry is actively evolving toward the development of functionalized biopolymers with tailored physicochemical and biomedical properties. Chitosan, a derivative of chitin, is a polymer containing reactive amino groups, which makes it a promising raw material for the design of novel biologically active macromolecular systems. One of the key requirements for chitosan derivatives is their solubility under neutral or mildly alkaline conditions. However, the limited solubility of native chitosan significantly restricts its practical applications. Therefore, the development of highly charged chitosan derivatives remains a relevant and promising research direction. In this context, the introduction of cationic groups into the chitosan backbone can enhance not only its solubility at neutral or slightly alkaline pH values but also its inherent biological activity.

  O Akhmedov , J Abdurakhmanov , Sh Shomurotov , A Turaev

  342-343

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  HANDELIA TRICHOPHYLLA POLYSACCHARIDES Handelia trichophylla is a perennial herbaceous plant of the Asteraceae family, widespread in Central Asia. The plant contains a rich complex of biologically active substances: essential oils, sesquiterpene lactones, flavonoids, polysaccharides, tannins, amino acids, choline, carotenoids, ascorbic acid, organic acids, and sugars. Studying the carbohydrate complex of this species is of interest for the search for new sources of natural polysaccharides with potential biological activity.

  Sh Ashirbaeva, F Kodiralieva, R Rakhmanberdyeva

  344-345

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  DETERMINATION OF THE COMPOSITION OF SOLUBLE VITAMINS IN RAW MATERIALS OF TAGETES PATULA L. USING THE HPLC METHOD In folk medicine, infusions and decoctions obtained from the inflorescences of Tagetes patula L. are widely used. The richness of the plant's composition with biological substances gives it anti-inflammatory, antibacterial, antioxidant, diuretic, sedative, and gastroprotective properties. Soluble vitamins were studied for a deeper study of the chemical composition of the raw material of the plant Tagetes patula L. for the introduction of preparations made from it into medical practice.

  N Akramova, G Ismoilova

  346-347

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  PHYTOCHEMICAL STUDY OF PEROVSKIA SCROPHULARIIFOLIA A decoction of the above-ground part of Perovskia scrophulariifolia Bunge (family Lamiacaeae) is used in folk medicine for scabies in humans and animals, as well as for healing sunburn and skin diseases. Dried flowers of the plant are brewed and consumed as tea to relieve gastrointestinal diseases and abdominal pain. In some countries of the Asian region, P. scrophulariifоlia is used to remove intestinal parasites from the body. The above-ground part of P. scrophulariifolia contains essential oil, abietane diterpenoids, flavonoid diosmetin, phenylpropanoids, anthocyanins, nitrogenous compounds, eugenol glycosides, benzyl alcohol, salidroside and terpenoids. The chemical composition of the roots of P.scrophulariifolia has not been studied.

  S Atqiyaeva , B Okhundedaev , E Botirov , S Sasmakov

  348-349

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  SYNTHESIS OF GALACTOMANNAN DIALDEHYDE DERIVATIVES AND INVESTIGATION OF THEIR PHYSICAL AND CHEMICAL PROPERTIES Galactomannan is a polysaccharide mainly composed of D-mannose and D-galactose, linked by α-1,4 and -1,6 glycosidic bonds. These connections define the structure of the polysaccharide and influence its physicochemical properties. The structure can vary, with different branching from galactose residues affecting its overall characteristics. Dialdehyde derivatives of galactomannan are novel compounds formed through oxidation or chemical modification. These derivatives enhance the polymer's rigidity, solubility, and mechanical strength. They can also react with primary amino groups, forming imino (azomethine) bonds and Schiff bases, which are significant in various applications. This study explores the production of low molecular weight galactomannan dialdehyde derivatives, their reaction conditions, and their physicochemical properties.

  D Amonova , A Boydedaev , M Karimov , M Kalonova , B Muhitdinov , A Turaev , Y Huang , H Wang

  350-351

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  PHYTOCHEMICAL STUDY OF QUINCE FRUITS Quince (Cydonia oblonga) is a valuable source of vitamins, micro- and macroelements, as well as phenolic compounds and flavonoids. The biologically active substances of quince exhibit antioxidant, anti-inflammatory, and tonic effects, making it a promising object of phytochemical research. Studying the chemical composition of quince fruits is relevant for substantiating their application in medicine, dietology, and the food industry.

  Azhibay A, U Umirzakova , B Torlanova

  352

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  ANALYSIS OF FLAVONOID COMPOSITION OF ALLIUM MOTOR BY HPLC In recent years, the isolation of bioactive compounds from natural sources and the evaluation of their pharmaceutical potential have become important directions of scientific research. In particular, plants of the genus Allium have long been used in traditional medicine. Their chemical composition has been shown to include flavonoids, phenolic acids, vitamins, and other biologically active compounds. In this context, a comprehensive chemical analysis of Allium motor and the assessment of its pharmaceutical and bioactive properties represent a relevant task.

  S Yuldoshev

  353

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  COMPARATIVE ANALYSIS OF EXTRACTION METHODS FOR STANDARDIZING GREEN WORMWOOD HERB Green wormwood herb (Artemisia viridis Willd.) is of considerable interest in pharmaceutical practice due to its pronounced biological properties: anti-inflammatory, antiseptic, and choleretic. One of the key stages of standardization is the selection of the optimal extraction method that ensures a high yield of biologically active substances while maintaining their stability. In this regard, the study and comparative evaluation of various extraction methods is a relevant task. This study provides a comparative assessment of the effectiveness of various methods for extracting flavonoids from green wormwood herb collected in the highlands of Kyrgyzstan. The study included ultrasonic extraction and Sokslet extraction. Quantitative determination of the total flavonoid content in green wormwood herb was performed on a Shimadzu spectrophotometer at a wavelength of 410 nm. Using quercetin as a standard, in accordance with the methodology recommended by GF RF XV.

  B Kairova , A Muratalieva , N Rud

  354

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  THE STUDY OF NUMERICAL PARAMETERS OF WALNUT LEAVES (JUGLANS REGIA L.), GROWING IN THE NUT AND FRUIT FORESTS OF KYRGYZSTAN In the official medicine of the CIS countries, a large amount of medicinal plant raw materials is widely used, which is regulated by regulatory documentation on quality. The flora of Kyrgyzstan includes 4,100 species of higher plants, of which more than 200 species are medicinal plants. Walnut (Juglans regia L.), which grows in the unique natural conditions of the Arslanbob forest area of Kyrgyzstan, is a promising source of medicinal plant raw materials. Walnut leaves are widely used in folk medicine due to their antiseptic, anti-inflammatory and restorative properties. The relevance of studying walnut as a medicinal plant raw material is due to its wide application in folk medicine and its high potential for use in official pharmacotherapy. The unique natural growing conditions, rich chemical composition and pronounced medicinal properties make walnut leaves a promising object for scientific research. However, there is no pharmacopoeia article for this raw material. In this regard, an important area is the study of numerical indicators of raw materials, which will become the basis for the development of regulatory documentation.

  A Berdalieva , N Rud , D Zhakypova , A Muratalieva

  355

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  PHARMACOGNOSTIC STUDY OF DENTAL COLLECTION OF MEDICINAL PLANTS monophytopreparations, consisting of a single medicinal plant, demonstrate lower efficacy compared to herbal mixtures that combine several components. This treatment approach, with its broader spectrum of action, allows physicians to offer patients a more comprehensive therapeutic effect.

  G Rakhmanova , K Orynbasarova , A Rybakova , S Mamyrova , U Kemelbekov

  356-357

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  РАЗРАБОТКА МЕТОДИКИ АНАЛИЗА НЕКОТОРЫХ ПСИХОТРОПНЫХ ВЕЩЕСТВ МЕТОДОМ ТСХ Исследование лекарственных препаратов, содержащих психотропные вещества, целесообразно проводить с помощью простого, доступного и экспрессного метода - тонкослойной хроматографии (ТСХ). Преимущества метода - быстрота разделения, высокая разрешающая способность, чувствительность и простота подготовки сорбента, являются основными причинами широкого использования его при экспертном исследовании многих лекарственных препаратов и сложных лекарственных смесей. Метод ТСХ имеет значительные преимущества перед химическими методами, особенно при анализе многокомпонентных лекарственных смесей он позволяет разделять и идентифицировать отдельные составные части, а также близкие по химической структуре и свойствам вещества.

  Абдуллаева М.У. , Олимов Н.К, Сидаметова З.Э, Шерматова М.И

  358-359

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