No. 10(MPHAPP) (2025) THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”

Articles

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  INHIBITORY EFFECT OF LUTEOLIN ON FSH-INDUCED 17β -ESTRADIOL BIOSYNTHESIS In women of reproductive age, estrogen is a C18 steroid with diverse physiological roles, primarily produced by the granulosa cells of the ovaries through endocrine signaling. Its functions include promoting the development of secondary sexual traits, controlling gonadotropin release to trigger ovulation, preparing tissues for progesterone activity, preserving bone density, regulating lipoprotein metabolism, preventing urogenital atrophy, modulating insulin sensitivity, and supporting cognitive health. In healthy premenopausal women, 17β-estradiol (E2) is the predominant circulating estrogen, synthesized in the ovaries. This synthesis occurs through the aromatization of androstenedione into estrone (E1), which is subsequently converted into 17β-estradiol. During normal menstrual cycles, 17β-estradiol functions as a systemic hormone, exerting regulatory actions on distant target tissues.

  Azimova B.J

  436-437

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  EFFECT OF LUTEOLIN ON OVARIAN MORPHOLOGY IN MICE WITH POLYCYSTIC OVARY SYNDROME (PCOS) Polycystic ovary syndrome (PCOS) is a complex and multifactorial reproductive, endocrine and metabolic disorder with diverse clinical manifestations, covering a wide spectrum of symptoms from reproductive dysfunction to metabolic disturbances, which poses significant challenges to patients’ quality of life and health. The etiology of PCOS remains unclear and involves a complex interaction of genetics, environment and endocrine system. This makes prevention, early diagnosis and effective treatment particularly challenging. Current treatment strategies for PCOS are primarily aimed at symptomatic treatment rather than at curing the disease itself. Although existing medications such as oral contraceptives and insulin sensitizers can alleviate symptoms to some extent, their long-term use may be associated with a number of side effects such as lipid metabolism disorders and increased insulin resistance, and some patients may have a suboptimal response to therapy. Luteolin can regulate aromatase expression through the MKK3/6-p38 MAPK-CREB pathway. This study reveals a potential role for TPL2 as a novel target in estrogen biosynthesis, providing new insights for the treatment of PCOS.

  Azimova B.J.

  438-439

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  PROSPECTS FOR THE USE OF APIGENIN IN BREAST CANCER THERAPY Breast cancer (BC) continues to represent one of the most pressing health challenges of modern oncology, ranking as the leading cause of cancer-related morbidity and mortality among women globally. According to recent international epidemiological projections, by the year 2040 the overall incidence of BC is expected to rise by more than 40%, thereby placing an even greater burden on healthcare systems and highlighting the urgent necessity for novel and more effective therapeutic strategies.

  Azimova D.F, Azimova B.J.

  440-441

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  EFFECT OF THE M-10 DRUG ON ARTERIAL PRESSURE IN WHITE RATS Today, cardiovascular diseases are one of the most pressing problems in the global healthcare system and are one of the leading causes of death worldwide. According to the World Health Organization, more than 17 million people die annually from cardiovascular diseases. Therefore, the search for new biologically active substances and the assessment of their impact on the cardiovascular system are of great scientific and practical importance.

  Bakirova Sh.Z.

  442

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  CAPPARIS SPINOSA L. ANTI-HYPOXIA ACTIVITY OF POLYSACCHARIDE ASSEMBLAGES FROM THE ROOT PART OF THE PLANT Hypoxia is one of the leading factors in the pathogenesis of cardiovascular and neurological diseases, ranking first among other pathological conditions in the body in terms of prevalence and death. Most often, the state of hypoxia is observed together in various pathological conditions that occur mainly in diseases of the cardiovascular system, respiratory system, as well as in some infectious diseases and acute poisoning.ypoxia is one of the leading factors in the pathogenesis of cardiovascular and neurological diseases, ranking first among other pathological conditions in the body in terms of prevalence and death.

  Bekmurzayeva Nurjamal Bakhtiyarovna, Azamatov Azizbek Azamat oglu, Botirov Ruzali Anvarovich

  443-444

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  THE EFFECT OF BACTERIAL ENDOTOXINS ON THE LEVEL OF ALANINE AMINOTRANSFERASE AND ASPARTATE AMINOTRANSFERASE IN THE BLOOD Bacterial endotoxins, also known as polysaccharides (LPS), are known to be the main component of the outer membrane of gram-negative bacteria. Bacterial endotoxins are present in the bloodstream throughout life and participate in the regulation of immune system activity at all levels. Lipopolysaccharides enable the adaptation of the immune and other vital body systems to constantly changing external and internal environmental conditions. However, excessive bacterial endotoxins entering the bloodstream can cause the development of endotoxin aggression and endotoxin shock, or acute multiple organ failure syndrome. It has been shown that damage to liver parenchymal cells begins with membrane disruption resulting from lipopolysaccharide activation of the arachidonic acid cascade . It has also been shown that 3 hours after intravenous administration of bacterial endotoxins, the number of lysosomes within parenchymal cells localized around the bile ducts increases

  Ergasheva M.Zh, Elmurodov L.K

  445

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  STUDY OF THE SPECIFIC ACTIVITY OF A BIOACTIVE SUPPLEMENT FOR THE PREVENTION OF CONSTIPATION According to the World Health Organization (WHO) and other medical research data, 10–20% of the global population suffers from chronic constipation. This issue is especially prevalent among women, the elderly, pregnant women, and individuals with sedentary lifestyles. Constipation not only causes discomfort but can also lead to hemorrhoids, anal fissures, intestinal dysfunction, and chronic toxicosis.Long-term use of many synthetic laxatives can result in intestinal habituation (tolerance), dysbiosis, and disruption of the water-electrolyte balance. Therefore, there is a growing demand for natural, safe, and effective alternatives.The global laxative market exceeded $10 billion USD in 2024, and continues to grow annually. In the bioactive supplements segment, constipation-relief products stand out as a distinct and growing category

  Nufuzakhon Adilova, Malika Foziljonova, Abdusattor Tojiboyev

  446

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  EVALUATION OF THE STATE OF THE CARDIOVASCULAR SYSTEM OF RABBITS UNDER INFLUENCE OF FREE AND BOUND FORM OF THE CYTOSTATIC AGENT DOXORUBICIN Targeted drugs, which significantly reduce the toxic effects of cytostatic drugs, are widely used in clinical practice for the treatment of cancer. The Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan has developed a polysaccharide-conjugated form of doxorubicin (DOX), PGA-DOX, which has promising medical implications.

  Usmonov Sh.T, Tagayaliyeva N.A, Baratov K.R, Yakubova R.A, Rakhmonova G.G, Mukhitdinov B.I, Kalanova M.A, Turaev A.S

  447-448

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  ANALYSIS OF GENE EXPRESSION PROFILE CHANGES FOLLOWING THERAPY WITH 4-[(3-ETHOXY-3-OXOPROPANOYL) AMINO] BENZOIC ACID IN EXPERIMENTAL CHRONIC HEART FAILURE Topicality. Chronic heart failure (CHF) is associated with systemic oxidative stress and significant impairment of cellular metabolism, contributing to damage to target organs, particularly the kidneys. Current therapeutic approaches have limited efficacy in correcting these metabolic disorders. Succinate dehydrogenase (SDH) inhibitors, such as 4-[(3-ethoxy-3-oxopropanoyl) amino] benzoic acid (etmaben), are considered potential agents for metabolic therapy; however, their molecular mechanisms of action in established CHF remain poorly understood.

  Grishina A.Yu

  449

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  STUDYING THE CAUSES OF FIBROADENOMA DISEASE IN YOUNG GIRLS IN UZBEKISTAN In recent years, breast diseases, in particular various tumors, have had a significant impact on women's health worldwide. Currently, fibroadenoma (breast cancer) is a benign tumor that is common in young women and girls. Since the widespread prevalence of fibroadenoma in young girls is associated with reproductive health, the psychological state of women, and future motherhood opportunities, an in-depth study of the topic is one of the current issues. Based on the results of epidemiological observations conducted in Uzbekistan, approximately 7-9% of young girls aged 18 25 have been diagnosed with fibroadenoma. Objectives of the study: To conduct a metrological analysis of the causes of fibroadenoma in young girls, to identify hormonal and hereditary factors, and to study the factors influencing it

  Yusupbekov A.A., Ikromova G.N., Malikova L.N, Umarova Z.A

  450

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  RESEARCH ON THE PHARMACOLOGICAL ACTIVITY OF ISATIS TINCTORIA SEED OIL I. tinctoria seed oil contains a number of bioactive components, including alkaloids, flavonoids, and phenolic compounds, which may have anti-inflammatory, antioxidant, antimicrobial, and antiviral effects. Studies of the pharmacological activity of the oil may provide new data for its use as a natural remedy for various diseases, such as respiratory tract infections, skin inflammations, wounds and burns.

  Khakimjanova Sh.O, Tillaeva G.U

  451-452

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  STUDY OF THE ANTIPYRETIC ACTION OF DRY EXTRACT RHEUM TATARICUM L. Herbal preparations are multicomponent, have different mechanisms of action and do not have side effects on the body. Based on this, we studied the pharmacological activity of the dry extract of Rheum Tataricum L. on experimental models .

  Z. A. Khakimova , Z. T. Fayzieva

  453-454

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  EXCRETION OF THE MICROLEMENT MANGANESE Manganese (Mn) is an essential nutrient for cellular activity, acting as a cofactor for enzymes such as arginase and glutamine synthetase. These metalloproteins enable manganese to play a key role in various bodily functions, including development, digestion, reproduction, antioxidant protection, energy production, immune response, and regulation of nerve activity.

  Khayrullaev D, Tulyaganov B.S, Tulyaganov R.T

  455-456

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  THE IMPORTANCE OF TREATING STOMACH AND DUODENAL ULCER DISEASE IN PHYTOTHERAPY AND ITS ANALYSIS THROUGH THE EXAMPLE OF MEDICINAL PLANTS In modern medicine, one of the most pressing challenges is the increasing prevalence of gastrointestinal disorders, particularly gastric and duodenal ulcers. The primary etiological factor of these conditions is the bacterium Helicobacter pylori, which damages the protective mucosal barrier of the gastrointestinal tract, disrupts gastric acidity, and initiates inflammatory processes. Peptic ulcer disease is considered one of the most widespread internal pathologies, requiring a comprehensive therapeutic approach. The main objectives of treatment are pain relief, ulcer healing, prevention of complications, and reduction of recurrence, making this condition a highly relevant issue in contemporary healthcare.

  Sultonova R.X., Ko‘lboyeva.F.D

  457-458

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  THE THERAPEUTIC EFFECTIVENESS IN EXPERIMENTAL GASTRIC ULCERS ACID SODIUM SALT WITH SALLITSILAT INDUKSION GLITSERRIZIN ANALYSIS OF MONOAMMONIY Current period, gastric and o‘n two fingers of the intestine wounds (peptic ulcer disease) health storage system important clinical and social problems one as distinguished is. The world healthyliqni storage organization data according, this pathology of the population, 10-20 % up to that part of the cover will. Though modern in pharmacology wide ko‘lamli medicinal drugs available are, despite them each always also of the patient's individual needs for a complete answer you give can't. For this reason, natural source and less nojoiz‘ya effect have that substances, the therapeutic capabilities of a deep study topical is.

  T. B. Mustanov

  459-460

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  EVALUATION OF HYPOLIPIDEMIC ACTIVITY OF FLAVONOIDS FROM CROCUS SATIVUS It is currently established that lipid metabolism disorders are a leading risk factor for the development of cardiovascular diseases -vascular diseases, mainly due to the significant influence of cholesterol on the development of atherosclerosis, diabetes mellitus, obesity, and, accordingly, the risk of developing ischemic stroke. Therefore, the search for new active agents capable of exerting a pharmacocorrective effect on impaired lipid metabolism remains a highly relevant task. As part of the ongoing search for new non-toxic and effective herbal remedies for the treatment of cardiovascular disease and ischemic stroke, encouraging results were obtained when considering a drug with the tentative name “Saflavin” (dry powder of the aqueous fraction of the ethanol extract of secondary metabolites of Crocus sativus L. stamens).

  Narbutaeva D.A., Tursunkhodjaeva F.M, Makhmudova Sh.R

  461-462

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  EVALUATION OF HYPOLIPIDEMIC ACTIVITY OF FLAVONOIDS FROM CROCUS SATIVUS It is currently established that lipid metabolism disorders are a leading risk factor for the development of cardiovascular diseases -vascular diseases, mainly due to the significant influence of cholesterol on the development of atherosclerosis, diabetes mellitus, obesity, and, accordingly, the risk of developing ischemic stroke. Therefore, the search for new active agents capable of exerting a pharmacocorrective effect on impaired lipid metabolism remains a highly relevant task. As part of the ongoing search for new non-toxic and effective herbal remedies for the treatment of cardiovascular disease and ischemic stroke, encouraging results were obtained when considering a drug with the tentative name “Saflavin” (dry powder of the aqueous fraction of the ethanol extract of secondary metabolites of Crocus sativus L. stamens).

  Narbutaeva D.A, Tursunkhodjaeva F.M, Makhmudova Sh.R

  461-462

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  STUDY OF THE ANTIPROLIFERATIVE ACTIVITY OF A DRY EXTRACT PREPARED FROM THE AERIAL PART OF THE LOCAL LOPHANTHUS ANISATUS BENTH Inflammation is a complex complex reaction of the body as a whole, has a protective-adaptive nature and is formed in the process of evolution, expressed mainly by local tissue changes - alteration, exudation, caused by impaired local circulation, emigration and proliferation of leukocytes. In folk medicine, anise lofant is used for inflammatory processes of the respiratory organs, bronchitis, to improve the immune system, for gastritis, hepatitis, gastrointestinal disorders, as a strengthening and anti-aging agent.

  Normurotova M. M, Sultanova R. H

  463

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  COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF EMHPS AND ITS METABOLITE EMSP ON RESPIRATORY PARAMETERS, MOTOR ACTIVITY AND GENE EXPRESSION OF MITOCHONDRIAL COMPLEXES IN MICE UNDER CONDITIONS OF INTERMITTENT HYPOXIA Intermittent hypoxia (IH) is a pathological factor that provokes oxidative stress, which can initiate a cascade of pathological conditions, mitochondrial dysfunction, inflammation, endothelial dysfunction and metabolic disorders. In this regard, the study of active antioxidants is relevant. In this work, we studied the antihypoxic properties of the metabolite of ethylmethylhydroxypyridine succinate (EMHPS) - ethylmethylsulfapyridine (EMSP) on the IH model in mice. In previous studies, EMSP exhibited antihypoxic and antioxidant properties [1-3].

  Plisko G.A, Ivkin D.Yu

  464

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  METHOD FOR EXPERIMENTAL STUDY OF THE ACUTE TOXICITY OF PLANT COLLECTIONS Currently, the problems of preserving and strengthening human health are becoming increasingly urgent on a global scale. In particular, the side effects of synthetic chemical drugs, allergic reactions, and negative consequences resulting from long-term use increase the need for natural medicines. From this point of view, the importance of medicines prepared on the basis of medicinal plants in our lives is increasing. Medicinal plants have been used in folk medicine since ancient times and have natural, environmentally friendly properties that have a mild effect on the human body. The modern pharmaceutical industry also pays great attention to the production of effective medicines from the components of medicinal herbs. Therefore, conducting scientific research on the study of medicinal plants, the possibilities of their proper collection, processing, and use as a medicinal product is a pressing issue. The choice of this topic, on the one hand, contributes to the formation of a healthy lifestyle, and on the other hand, serves the preservation and development of our national traditional medicine

  Qodirova, O.K, Sultanova, R.X

  465

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  EXPERIMENTAL ANIMAL MODELS USED IN LIVER DISEASES Liver diseases are among the leading causes of mortality worldwide. Animal models play a crucial role in the preclinical stage for the development and evaluation of hepatoprotective drugs. Liver disorders such as hepatitis, steatosis, fibrosis, and cirrhosis pose significant social and economic challenges globally. According to the World Health

  Kuranboyeva M.G

  466-467

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  STUDY OF THE ALLERGIC AND CUMULATIVE EFFECTS OF A HERBAL TEA MADE FROM A CICHORIUM INTYBUS PLANT One of the priority tasks in the field of pharmaceuticals is to provide the population of our republic with effective and safe medicinal products and biologically active supplements (BAS) derived from local plants.

  R.D. Ramazanova, Z.T. Fayziyeva

  468-469

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  ИЗУЧЕНИЕ ЭФФЕКТА ИНТРАНАЗАЛЬНОГО ВВЕДЕНИЯ ИНСУЛИНА И ИНСУЛИНОПОДОБНОГО ПЕПТИДА НА КОГНИТИВНЫЕ ПАРАМЕТРЫ ЖИВОТНЫХ нарушения обменных процессов инсулина и системы передачи сигналов инсулина в центральной нервной системе могут способствовать развитию различных заболеваний головного мозга, следствием большинства из которых являются когнитивные расстройства. Своевременная диагностика и адекватная патогенетическая терапия неврологических осложнений сахарного диабета имеют крайне важное значение в комплексном ведении пациентов с данным заболеванием

  Т Саатов , Г Артыкбаева , Т Ишанходжаев , М Мустафакулов

  470-471

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  STUDYING THE ANTI-INFLAMMATORY PROPERTIES OF SALVIA OFFICINALIS Inflammation is one of the body's defense mechanisms that develops as a response to infection, injury, or other adverse effects. At the same time, chronic inflammatory processes are considered an important pathogenetic factor in the development of atherosclerosis, diabetes mellitus, arthritis, and even oncological diseases. In recent decades, scientific research has shown great interest in natural bioactive substances, particularly extracts from medicinal plants, as potential sources of anti-inflammatory agents.

  Shodmonova S.A, Sultonova R.X

  472-473

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  DETERMINATION OF ANTIMICROBIAL ACTIVITY OF DRY RASPBERRY LEAVES The medicinal properties of plants are determined by their active substances, based on which or by synthesizing which the pharmaceutical industry produces effective medicinal herbal preparations. Therefore, the search for alternative medicinal herbal preparations with a wide spectrum of antimicrobial activity is very relevant.

  Shakirova D.N, Nuralieva H.O, Khabibullaeva Sh.M

  474-475

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