№ 10(MPHAPP) (2025) THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”

Maqolalar

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  PROSPECTS FOR THE DEVELOPMENT OF PHYTOPREPARATIONS BASED ON STELLARIA MEDIA (L.) VILL Chickweed (Stellaria media (L.) Vill.) is a widely distributed medicinal plant containing flavonoids (apigenin and kaempferol glycosides), phenolic acids, and saponins, exhibiting antioxidant, anti-inflammatory, and antimicrobial activity. The plant is used in traditional medicine for inflammatory diseases and metabolic disorders, which confirms the prospects for the development of phytopreparations.

  Zh Seitova , M Ashirov , K Zhakipbekov

  513

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  REVIEW OF CURRENT DATA ON GOLDEN HARE’S EAR (BUPLEURUM AUREI FISCH.) AND PROSPECTS FOR ITS USE IN PHARMACEUTICAL PRACTICE Medicinal plants are a valuable source of biologically active substances (BAS). Among them, a promising object is golden hare’s ear (Bupleurum aurei Fisch.), traditionally used in the treatment of liver and gastrointestinal diseases. Modern studies confirm its rich chemical composition and pharmacological potential.

  M Ashirov , B Toizhanov

  514

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  PROSPECTS FOR THE PHARMACEUTICAL APPLICATION OF TRIBULUS TERRESTRIS L In the pharmaceutical industry, the demand for natural, low-toxicity, and effective phytopreparations is increasing. This interest is associated with the fact that plant-derived substances, compared to synthetic drugs, are generally safer and more accessible. For many centuries, the practice of traditional medicine has demonstrated the positive effects of medicinal plants in the treatment and prevention of various diseases

  R Bazarbayeva , M Koilybaeva

  515

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  HYALURONAN/CHITOSAN HYDROGELS FOR LOCAL DELIVERY OF DOXORUBICIN Cancer is a leading cause of death worldwide, and conventional treatments like chemotherapy often cause significant systemic toxicity. Targeted drug delivery systems are therefore essential. Hydrogels, with high fluid retention and balanced structure, provide an ideal platform for local, controlled delivery. This study focuses on hyaluronan–chitosan hydrogels for localized doxorubicin delivery. Hyaluronan, a natural polysaccharide, offers biocompatibility and degradability, while chitosan enables high drug loading and promotes cell adhesion. Together, they encapsulate doxorubicin for controlled release at the target site. The inclusion of sodium alginate and polyvinyl alcohol optimizes hydrogel structure and properties, aiming to increase local drug concentration, reduce side effects, and improve treatment outcomes. The study investigates hydrogel preparation, characterization, and performance, highlighting their potential in enhancing cancer therapy and advancing innovative drug delivery strategies

  A Boydedaev , D Amonova , M Karimov , M Kalonova , B Muhitdinov, A Turaev, Y Huang , H Wang

  516-517

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  ANTIPROLIFERATIVE ACTIVITY OF AQUEOUS-ETHANOL EXTRACTS OF LENZITES BETULINUS AND TRAMETES VERSICOLOR AGAINST BREAST CARCINOMA CELLS Malignant tumors remain one of the leading causes of mortality worldwide, with breast carcinoma ranking first in incidence among women. Despite the development of modern therapeutic approaches, drug resistance and pronounced side effects of cytostatic drugs necessitate the search for new selective agents with antiproliferative activity. A promising direction is the study of biologically active compounds from natural sources, among which polypore fungi are of particular interest due to their richness in polysaccharides and triterpenoids with pronounced immunostimulatory and cytotoxic properties. In particular, the relatively unexplored yet widely distributed species Lenzites betulinus and Trametes versicolor are potential sources of new anticancer agents.

  H Harbatsevich , T Doroshenko , A Portyanko , N Bobrova , I Severin

  518

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  INVESTIGATION OF THE CYTOTOXICITY OF NEW AMIODARONE DERIVATIVES IN NORMAL HEPATOCYTE CULTURE Arrhythmias remain a pressing challenge in modern cardiology because of their high prevalence and the serious threat they pose to patient survival. Current antiarrhythmic drugs, although effective, are often associated with side effects involving the central nervous system, the gastrointestinal tract, and other organ systems

  Z Khashimova , M Salakhutdinova , K Kakhorova , V Uzbekov , Yu Oshchepkova , Sh Salikhov

  519

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  STUDY OF THE COMBINED ACTIVITY OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE AND TETRAMETHYLENEDIAMINETETRAMINE AGAINST CLINICAL ISOLATES The widespread availability and use of antibacterial and antiseptic agents have led to the emergence of antimicrobial resistance among many strains of pathogenic and conditionally pathogenic microorganisms. Antibiotic resistance poses a particular challenge in the treatment of nosocomial infections in hospital settings, especially in intensive care units (ICUs). Addressing the pharmacotherapy of nosocomial infections in ICUs remains one of the most pressing issues in modern medicine. To tackle this problem, novel antimicrobial agents as well as their combined activity are being investigated. Synergistic interactions between antimicrobials can facilitate therapy and enhance efficacy at lower doses, thereby reducing adverse and toxic effects on the human body

  D Kurlovich, R Kravchenko

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  REPURPOSING 20-HYDROXYECDYSONE FOR CANCER THERAPY: COMPUTATIONAL EVIDENCE FOR AQUAPORIN-5 INHIBITION Aquaporin-5 (AQP5) is a membrane channel protein whose abnormal overexpression has been linked to tumor growth, migration, and metastasis in cancers such as breast, lung, and gastric carcinoma. These oncogenic roles make AQP5 an attractive therapeutic target. Natural compounds like 20-Hydroxyecdysone (ecdysterone), known for diverse biological activities, warrant investigation as potential modulators of AQP5 in cancer.

  M Makhamov , D Abduvokhidov , J Razzokov , A Sharipov

  521

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  DETERMINATION OF THE ACTIVITY LEVEL OF THE GALACTOSIDASE ENZYME ISOLATED FROM CHICKPEAS According to the Decree of the President of the Republic of Uzbekistan No. PF 4947 dated February 7, 2017 "On the Strategy of Actions for the Further Development of the Republic of Uzbekistan", general goals are set, such as developing agriculture, ensuring food security, and increasing export potential. Within the framework of this strategy, measures are being implemented to expand and support the cultivation of legumes, including peas.

  Khurriyat Po’latova

  522

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  STUDY OF ANTIMICROBIAL ACTIVITY OF COSMETIC EMULSION “EMULZARMAJ” In modern cosmetology, interest in the use of herbal remedies with not only caring but also therapeutic and prophylactic properties is growing. Juniperus seravschanica Kom. belongs to the cypress family (Cupressaceae). This evergreen coniferous plant is endemic to the mountainous regions of Central Asia, particularly Uzbekistan, Tajikistan, and Kyrgyzstan. It plays an important role in the region's ecosystems and is valuable both in folk medicine and in modern pharmacology and cosmetology. Juniperus seravschanica Kom. is an endemic species of Central Asia, known for its high content of essential oils, flavonoids, terpenoids, and phenolic compounds. These biologically active substances exhibit pronounced antibacterial, anti-inflammatory, and fungicidal properties.

  D Tayirova , Kh Tukhtaev

  523

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  UNDER X-RAY IRRADIATION It has been shown that the effect of X-ray irradiation at 2 Gy and 4 Gy leads to suppression of the activity of the studied enzymes in various brain structures. Moreover, it was found that pre-administration of saffron extract in many cases prevents significant suppression of the studied enzymes by irradiation, and on the contrary, this antioxidant promotes an increase in their activity in brain structures. Objective: To study the effect of saffron (Crocus sativus L.) stigma extract on the dynamics of changes in the content of different types of surface-exposed SH-groups, structurally masked protein SH-groups, and glutathione under X-ray irradiation at doses of 2 and 4 Gy in different brain regions.

  I Rzayeva, M Valieva , N Aliyev , S Musayeva , S Yagubova , S Atakishizade

  524

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  ASTAXANTHIN AS AN INNOVATIVE ANTIOXIDANT: CREATION AND STUDY OF SERUM WITH HAEMATOCOCCUS PLUVIALIS EXTRACT Interest in natural antioxidants is growing in cosmetology. Astaxanthin from the microalgae Haematococcus pluvialis is more active than many known antioxidants and can protect the skin from photoaging and oxidative stress. Research into the development of stable and safe formulas is needed to incorporate it into cosmetics

  Yesimkhan Zh, U Alimova

  525

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  STUDY OF THE SEDATIVE EFFECT OF A DRY EXTRACT BASED ON LOCAL MEDICINAL PEONY (PAEÓNIA OFFICINÁLIS L.) In order to create medicinal preparations based on local plant raw materials and introduce them into medical practice, it is necessary to study the specific activity of the developed medicinal preparations. A dry extract with a calming effect was obtained from local raw materials using the polyextraction method. roots and rhizomes of the medicinal peony ( Paeonia officinalis L.).

  G Sadikova , G Ismoilova , Z Zuparova

  527

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  THE ROLE OF PHARMACEUTICALS IN THE PREVENTION AND TREATMENT OF DISEASES OF THE FEMALE REPRODUCTIVE SYSTEM Modern pharmacological drugs play a key role in the prevention and treatment of diseases of the female reproductive system, such as menstrual cycle disorders, endometriosis, polycystic ovary syndrome (PCOS), infertility, and osteoporosis. The assessment of the effectiveness and safety of drugs aimed at hormonal therapy, the use of drugs to improve fertility, as well as drugs that regulate metabolism and immune reactions, is an important aspect of modern pharmacotherapy in gynecology.

  Sh Ziyayeva , S Erkenova

  528-529

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  ФИТОХИМИЧЕСКИЙ АНАЛИЗ SCABIOSA OCHROLEUCA L Скабиоза золотистая (Scabiosa ochroleuca L.) - перспективное лекарственное растение, применяемое в народной медицине при заболеваниях ЖКТ, опорно двигательной системы, инфекциях и как ранозаживляющее средство. В её надземной части обнаружены флавоноиды (лютеолин, кверцетин), фенольные соединения, иридоиды, дубильные вещества, сапонины и органические кислоты, обладающие различными фармакологическими эффектами.

  Ағабек Д, М Касимбекова , Б Торланова

  530-531

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  ВЛИЯНИЕ АНТИБИОТИКОВ НА МИКРОБИОЛОГИЧЕСКИЕ ПОКАЗАТЕЛИ ЙОГУРТА Антибиотикорезистентность является одной из наиболее острых проблем современной медицины и пищевой безопасности. Остаточные количества антибиотиков могут попадать в молочную продукцию при применении препаратов для лечения животных. Это не только способствует формированию устойчивых штаммов микроорганизмов, но и изменяет микробиологический состав кисломолочных продуктов, снижая их пищевую и пробиотическую ценность. Йогурт содержит живые молочнокислые бактерии, которые выполняют важные функции: улучшают пищеварение, подавляют развитие патогенной микрофлоры, стимулируют иммунитет. Однако антибиотики способны подавлять не только патогенные, но и полезные микроорганизмы. В этой связи актуальным является исследование действия различных антибиотиков на микрофлору йогурта.

  Жунисбек А, М Нармуратова , С Турашева

  532-533

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  EFFECT OF POLYPHENOLS ISOLATED FROM EUPHORBIA FRANCHETII (B.FEDTSCH) ON LPO PROCESSES IN MITOCHONDRIA The production of free radicals in various tissues and cells of the body through many endogenous and exogenous pathways causes oxidative stress, which leads to the development of various diseases in humans. Therefore, the study of the antioxidant properties of biologically active substances isolated from plants is of great importance. It is known that epidemiologically, fruits and vegetables rich in antioxidants in the diet prevent the development of many diseases associated with oxidative stress. Recent studies have shown that mitochondria play an important role in apoptotic and necrotic cell death. As a result of mitochondrial dysfunction, the number of mitochondria in tissues decreases, deep ultrastructural anomalies of organelles develop, mitochondrial biogenesis is disrupted, the activity of enzyme complexes of the respiratory chain changes, and ATP synthesis is inhibited. At the same time, mitochondrial dysfunction can lead to calcium homeostasis disruption, excessive production of reactive oxygen species, as well as the transition of the megapore to an open conformation, a decrease in the expression of the antiapoptotic protein Bcl-2, the release of cytochrome c, the activation of proapoptotic caspase-3 and the DNA repair enzyme poly (-ADP ribose) polymerase. From the above, it can be seen that a specific mitochondrial dysfunction is observed in the process of lipid peroxidation (LPO) that develops during oxidative stress

  D Isamuhamedova , N Ergashev , R Rakhimov

  534-535

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  FDP PLYUS VA L-KARNITIN BIOLOGIK AKTIV QO‘SHIMCHASINI LABORATOR HAYVONLARNING JISMONIY MEXNAT FAOLLIGIGA TA’SIRINI O‘RGANISH Jahon miqyosida sport yutuqlarining doimiy o'sishi sport sohasida ishlaydigan tadqiqotchilarni sportchilar tanasini jismoniy faoliyatga moslashtirish chegaralarini kengaytiradigan samarali vositalar va usullarni izlashga majbur qilmoqda. Ular orasida dori-darmonlar eng keng qo'llanilishini o‘z o‘rnini topdi, ular asosli foydalanish bilan mashg'ulot yuklaridan keyin tiklanish jarayonlarini sezilarli darajada tezlashtirishga, tananing o'quv jarayonini idrok etishni yaxshilashga va tananing jismoniy faoliyatga moslashishining tarkibiy asoslarini rivojlantirishga yordam beradi. Shunday qilib, sport farmakologiyasi sohasida yangi dori-darmonlarni ishlab chiqish, ilmiy yondashuv va ruxsat etilgan farmakologik preparatlarni qo'llash algoritmidan foydalanish sportchilarning jismoniy ko'rsatkichlarini tiklaydigan va oshiradigan moslashish va energiya ta'minotining asosiy mexanizmlariga maqsadli ta'sir ko'rsatishga imkon beradi.

  Qudratov A.X., Qosimov A.Sh.

  536-537

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  EFFECT OF HYPOGLYCEMIC PLANT COLLECTION EXTRACT ON SOME INDICATORS OF CARBOHYDRATE METABOLISM IN CONDITIONS OF ESPERIMENTAL DIABETES Abu Ali Hussein ibn Abdallah ibn Sina (16 August 980 - 18 June 1037) created works not only on medicine but also on the history of theology, philosophy, astronomy and religion. A number of sources record more than 450 works by Ibn Sina, and only 242 Gypsies have reached us. Ibn Sina's Works list more than 100 herbal products in the treatment of diabetes mellitus. One of the most commonly used plants in diabetes is white mulberry (Morus alba) plant raw materials and large zubturum (Plantago major) leaves. Ibn Sina cited that raw materials of these tumors are high in effectiveness in diabetes mellitus not only when applied separately, but also in the form of folding

  G Malikova

  538-539

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  SCIENTIFIC JUSTIFICATION FOR THE USE OF BUCKWHEAT IN THE COMPOSITION OF PHYTOSUPPOSITORIES FOR THE TREATMENT OF HEMORRHOIDS Hemorrhoids are among the most common diseases of the rectum and anal canal. According to the World Health Organization, 10–15% of the adult population suffers from various forms of hemorrhoids, and among patients over 50 years old, this figure reaches 50–70%. The disease significantly reduces quality of life, being accompanied by pain, inflammation, itching, bleeding, and impaired normal functioning. In my work, I aimed to find a safer and more effective remedy. I chose phytosuppositories, since plant-based raw materials combine availability, low toxicity, and a complex therapeutic effect. Buckwheat, due to its rutin and flavonoid content, strengthens blood vessels and reduces inflammation. In combination with calendula, plantain, oak bark, and sea buckthorn oil, I obtained a preparation with pronounced wound-healing and anti-inflammatory effects.

  S Onlasbek

  540

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  IMMUNOSUPPRESSANTS IN MODERN PHARMACOLOGY: MECHANISMS OF ACTION AND CLINICAL APPLICATION The immune system is a complex network of cells and mediators designed to protect the body from pathogens. However, in some cases (organ transplantation, autoimmune and allergic diseases) this protective reaction becomes excessive or directed against one's own tissues, which requires pharmacological correction. Immunosuppressants are a heterogeneous group of drugs that specifically inhibit the immune response. Their introduction revolutionized transplantology and significantly improved the prognosis for many autoimmune pathologies. However, their use is associated with serious side effects, primarily with an increased risk of infections and cancer, which dictates the need to search for new, more selective targets and drugs.

  Sh Ismatova, R Sultanova

  541

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  THE STUDY OF THE EFFECT OF MEDICINAL PLANTS ON BLOOD PRESSURE According to the literature, arterial hypertension is one of the most widespread diseases today. Alongside pharmaceutical drugs, traditional remedies and medicinal plants are widely used because they are natural, affordable, and have fewer side effects. Therefore, the use of medicinal plants in treatment is of great importance.

  A Rajapov

  542

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  MODERN APPROACHES TO THE USE OF BETA-BLOCKERS IN CLINICAL PHARMACOLOGY Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide and in the Republic of Kazakhstan. According to the World Health Organization (WHO), more than 17.9 million people die from CVDs every year (WHO, 2021). In Kazakhstan, the prevalence of arterial hypertension among the adult population exceeds 25%, which makes its control particularly relevant (Ministry of Health of the Republic of Kazakhstan, 2022).

  Sh Molaikhanov , D Rustamkhanov , M Shakirov

  543-544

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  STUDY OF ACUTE TOXICITY OF "PHYTOBRONCHIS" Inflammatory processes underlie the development of most diseases, be it pathology of the respiratory tract, gastrointestinal tract, joints or skin. Modern medicine has a wide range of anti-inflammatory drugs, but their prolonged use is often accompanied by side effects and complications. In this regard, there is a growing interest in the use of natural remedies, in particular herbal preparations with anti-inflammatory activity. Medicinal plants contain flavonoids, essential oils, tannins and other biologically active components that have a mild but pronounced antiinflammatory effect.

  D Zayniddinova , R Sultanova , N Shiltsova

  545

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  GARLIC WITHOUT ODOR: NEW OPPORTUNITIES FOR IMMUNE ENHANCEMENT Garlic is one of the most extensively studied natural immunomodulators with antibacterial, antiviral, and antioxidant activity. Its use is limited by the presence of a characteristic unpleasant odor associated with sulfur-containing compounds. To reduce the odor, we used cherry, as it is rich in polyphenols, organic acids, and antioxidants, which are able to neutralize volatile garlic compounds while preserving its beneficial properties. This makes the topic relevant for both pharmaceuticals and the food industry

  A Shynkozhaeva , U Umirzakova , B Torlanova

  546

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