364
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
VALERIANA OFFICINALIS L.
–
MAIN RAW MATERIAL FOR PRODUCING
DRUGS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
Akhmadjonov K.K.
Azamatov A.A.
Ergasheva M.J.
State Institution "The center for pharmaceutical products safety" under the Ministry of Health
of the Republic of Uzbekistan
e-mail: dr.k17111998@gmail.com, tel.: +998 95 980-98-18
https://doi.org/10.5281/zenodo.17337736
Relevance.
The use of valerian has a long history in folk medicine. It was mentioned in written
sources as early as the 2nd century as a sleep aid and sedative. Valerian preparations were
recommended by Galen for insomnia, and in the 16th century, they were used to treat nervousness,
palpitations, and headaches. Beginning in the mid-20th century, valerian tincture began to be used
for stressful situations.
Purpose of the study.
The purpose of our research is
study of the medical use of the main raw
materials of valerian in medicinal practice, namely for the relief of pain in the heart and the treatment
of cardiovascular diseases .
Materials and Methods.
For the study, we used the following primary sources: Avicenna's
textbook "The Canon of Medicine," methodological manuals and a textbook on herbal medicine, an
atlas of medicinal plants of Uzbekistan, a textbook on clinical pharmacology, and articles on the
anatomical and morphological structure of valerian, its distribution, and the collection of medicinal
plant materials. Additional information was obtained from internet resources, online encyclopedias,
and electronic libraries.
Results.
Valerian officinalis, a perennial herbaceous plant, reaches a height of 1-1.5 meters. It
grows in the Caucasus, Europe, the Far East, and Siberia, and is also cultivated in Central Asia.
Valerian's medicinal raw material is the roots and rhizomes, harvested in early spring (when the leaves
are unfurling) or late fall (when the leaves are drying). After cleaning, washing, and drying, the raw
material is ready for use. Valerian root and rhizome contain essential oil, isovaleric acid, and other
chemical compounds. Valerian's action is based on the complex of these organic substances. Its
effects are diverse. For example, it has a calming and anti-anginal effect on the central nervous
system. It also stimulates cardiac activity, relieves smooth muscle spasms (has an antispasmodic
effect), stimulates bile secretion from the liver, and enhances gastric secretion. The sedative effect of
valerian is associated with decreased CNS excitability and enhanced inhibition. It also has an
inhibitory effect on the reticular formation. As a result, valerian helps improve sleep and reduce
stimulant-induced palpitations. It also dilates blood vessels and has a significant hypotensive effect.
Herbal remedies made from the roots of this plant, as well as galenic preparations, are recommended
for the treatment of nervous disorders, agitation, insanity, and mood disorders such as neuroses,
nervous exhaustion, autonomic neuropathy, and others, as well as for the treatment of insomnia and
migraines. Valerian is particularly useful in the treatment of cardiovascular neurosis, angina, and high
blood pressure. Preparations based on valerian have an antagonist effect against brucine and reduce
the stimulating effects of caffeine.
Conclusions.
The results presented in the review confirm the value and availability of valerian
as a medicinal plant material for use in various phytotherapeutic formulations for the correction of a
variety of pathological conditions and the treatment of numerous ailments.
