No. 1 (2016)

The urgency and relevance of the theme of dissertation. Investigating the dialects as one of the source of inner growth of every national language, clarifying the historical peculiarities which were gathered in an ancient wealth, also identifying current evolution of linguistic occurrence is one of the actual problem in the world linguistics.
In Independence years as a result of conducting consistent targeted reforms in different spheres of society have been increased the attention to the developing of forgetten cultural values, actually to the national language. As a result, «...Reinforcement the role and place of state language in our life, implemented tremendous works on the way of changing it to the national value. During the independent years enlarging the usage of uzbek language in practice, researches targeted in scientific bases, being published new dictionaries, manuals, scientific and public books which arc dedicated to the specific features of our language arc making the contribution to develop the mentality of the society»1. And in its turn, investigating current progress sources, clarifying linguistic nature is one of the actual problem of professional - lexical units a vivid expression of our ancient traditions and values, national mentality, and their naming principles.
Investigated the relation of cognitive activity with onomosiologic process, dialectal peculiarities of Turkic languages, also linguistic corporeal of word and concept, the history of the nation and specific lexis of the infiltration of ethnic-cultural life by foreign and Uzbek linguists. Dialectal lexics and their professional- lexical units, which is the structural part of our spiritual heritage and values, keeping the samples of our nations material and spiritual cultures is one of the source of Uzbek national culture, progress of mentality of society. Gathering language elements kept in regional population, collecting and analyzing them is one of the importance in presenting historical progress of the language. Therefore, after the Independence a great attention is being given to ancient nation’s dialects, studying their specific features rather than to written monuments in different language layers of Uzbek literary language. And it puts into the agenda the necessity of implementing as monographic research the onomasiologic principles in forming professional lexical units. In this purpose the increased research’s theme is important to inform the world linguists and expose the linguistic laws which makes the process be running, clarifying the onomosiologic principles of professional lexic units in Khorezm dialects.
This doctoral thesis serves in certain degree to the implementation activities of the new edition of the law on «Official state language» of the republic of Uzbekistan on December 21 in 1995, the first president of the Republic of Uzbekistan on May 13 in 2016 passed the Presidential Order-4797 on «Establishing Tashkent state Uzbek language and literature university» and other normative-juridical documents concerning to this field.
The aim of research work. The research aims to identify onomastic principles and tendencies of professional lexis in Khorezm region, as well as eventual techniques in object and subject relations existing in this process.
Scientific novelty of the research work includes the following:
it asserts the historical-genetic analyze of sectional lexis in our language and confirms them as a special onomastic system;
during the conceptual progress of onomastic units of professional lexis, the categorization stage of the sign, in some cases the second concept or repeated concept matter can be observed;
structural reconstructing of section lexical units and functional analysis of them arc closely connected with the substrate level problem of the vocabulary composition;
not the derivational progressions in the origin of the onomastic units, but the renaming case, in particular, the functional changes mostly occur;
in categorizing the linguistic nature of professional words mainly, their diachronic peculiarities arc considered with dialectological features linguistic materials should be taken into consideration;
in the development of section lexical units, in particular, in identifying their motives the lingua cultural potential is considered as key factor rather than spiritual-psychological state of the subject.
SUMMARY
1. Regional professional lexical units reflect common Turkish linguistic peculiarities as well as linguacultural features peculiar to speakers of the certain language in the area.
2. Vocational lexical units compared to other systems of the dialects’ lexical units out of the variation in consumption, such as the emergence of new units step by step processes related to social factors such as the globalization and economic development.
3. By analysis of onomasiology and stratigraphy of professional lexical units we can define the developing chronology line. In this case written sources are great of great importance.
4. Because of the regional professional vocabulary of the units formed during the long centuries of development, it is natural that they have formed units which belong to different lexical classes. Lexical layer due to the development of the lexis in literature and other dialects as well as many other words belong to Turkic classes. It is also one of the factors which determine that our ancestors developed on in material and cultural sphere, having their own way of thinking and lifestyle.
5. The reconstruction of linguistic structure of regional professional vocabulary shows that some derivational units went out of Turkish languages sphere and can be met in some languages of Altay family.
б.Опе of the areal peculiarities of genetic research of Oasis’s professional vocabulary is the words in Khorezm dialect arc common to the language systems belonging to the Iranian group. The general vocabulary of the names in the Iranian language; the words existing in Iranian languages, but the content is different; Khoresmian dialect words can be explained on the basis of thematic groups.
7.Typological comparison of the lexical units related to ancient Khorazmian language using Iranian language grammar and dictionaries, as well as, present day carrying out dialectology analysis of dialect materials may clarify the matter of substrate units also.
8. Professional lexical units reflect the cultural development of mankind, at first they were named by the name of the raw materials, which they made of and the name of it also became the subject names. In further stage of human civilization, by adding the suffixes of possessiveness new names arc formed.
9. Linguistic study of the professional lexis related to the names also reflects the intellectual development of humanity. Because they arc connected with the process of knowledge as a product of cognitive activity. In particular, the professional method of selection of lexical units according to the functional nature, level of a clear definition of the functions of their human maturity, as well as public attitudes and rituals arc associated with the seasons in the nature of extralinguistics. The next stage of the development of humanity reflected them in comparison, contrast, likeness with something like the development of the level of the symbolic names.
10. The linguistic analysis of professional lexical units shows that the singling principle as a product of a certain period, which social formations were formed and different genders, gender and social classes have an important role in the society. At the same time, they also have their own internal development stages. Developed by a region or spreading to other regions of the items in the comprehensive development of the society, socio-political and economic relations between the nations, the perception has been established. Therefore, the method mentioned above has been formed later than normal.
11. While observing the methods of selection of motifs of professional lexical units, they arc aware of common features of their professional areas. Throughout the long-term development of our language lexical units of industry appeared in the process by the principles of universal onomasiology and perfection.

The topicality and relevance of the dissertation topics. Highly effective reversible inhibitors of the acetylcholinesterase (AChE) arc widely used in the world for alleviation of poisoning by organophosphorus pesticides and in the treatment of ilnesses such as Alzheimer's disease, myasthenia gravis, glaucoma, paralysis, and paresis. Therefore, the development of highly effective reversible inhibitors of AChE for the use in therapy of different pathologies of the central nervous system, a search among these preparations with antidotal action, chemical modification of the phannacon, as well as the creation of low-dose dose, watersoluble drugs with a wide range of therapeutic index by using the complexing agents arc an important issue today.
With the acquisition independence of Uzbekistan, organization of scientific-research works on creation of the low-dose, effective pharmaceuticals from local herbs for treatment of a number of diseases, and conduction of enhanced measures to provide the population with quality drugs at a high level medicine has led to a definite successes
At present, on the basis of glycyrrhizic acid (GA) by molecular encapsulation, complexes of the poorly soluble pharmakons were obtained, where the desired effect was achieved ath very small amounts of the pharmakons. This method is considered as the most effective way to reduce the side effects of many drug; on the basis of GA and its derivatives, the drugs against acquired immunodeficiency syndrome, skin and stomach cancers, as well as antiinflammatory water-soluble drugs with low doses and a wide of the therapeutic index arc created and put into practice. The research in this area is an urgent task of the bioorganic chemistry and medicine.
The present doctoral dissertation is, to some extent, an accomplishment of the tasks set in the Resolution 416 of the Cabinet of Ministers dated 14 July 2016 «On the procedures to support domestic manufacturers of medicinal drugs and medical devices» and other legislative documents related to the above mentioned activities.
The aim of the study is to develop drugs with a wide therapeutic mcdiccinal action on the basis of nitrogcn-containing organophosphorus reversible inhibitors of AChE possessing an antidote effect and anti-inflammatory drugs based on certain derivatives of glycyrrhizic acid.
The scientific novelty of the research is as follows:
based on alkaloids and some nitrogcn-containing heterocyclic compounds (piperidine, morpholine, hcxamcthylcncimine, anabasine, lupinine, cpilupinina), complex esters and salts of the methyl-, mcthylthion- and phcnyl-phosphonic acid complementary to the active surface of AChE have been synthesized; 
defined the appearance of the diastercomcric anisochronism effect in the NMR spectra of the mctylthiophosphonic acid derivatives with two or more asymmetric centers have been demonstrated;
effective reversible inhibitors of AChE was found.
the research showed the structure-activity relationships;
supramolccular complexes of GA salts with effective reversible AChE inhibitors - alkaloids Dcoxypcganinc hydrochloride (DOP HC) and galantamine in different proportions have been synthesized;
it shows that MASGA and DOP GA (2:1) has high cholinesterase active and less toxicity;
the gel formation of the aqueous solution of the obtained supramolccular complexes of GA and its salts was studied and the critical micelle concentration were determined; presumed mechanism of the process was proposed;
the intcrfcron-inducing activity of the created supramolccular complexes has beed studied; on the basis of the most effective comples, an anti-inflammatory drug, GLAS, has been created.
CONCLUSIONS
1. A series of ethers of O-alkylmcthylphosphonic, O-alkylmcthylthiophosphonic acids on the basis of N-P-hydroxycthyl- and N-P-hydroxypropylmorpholine, piperidine, anabasine, hcxamcthylcncimine, lupininc and cpilupine were synthesized. In the presence in the molecule of the O-alkylmcthylphosphonatc of two and more asymmetric centers, in the PMR spectra, the effect of a diastereoisomeric anisochronicity in the form of duplication of the proton signals of a methyl group directly bound to the phosphorus atom is observed and these properties helps to determine the structure of these kind substanses.
2. For hydrochlorides of O-alkylmcthylphosphonatcs, O-alkylmcthylthion-phosphonates and O-alkylphcnylphosphonatcs, the anticholinesterase activity towards the acetylcholinesterase of human blood erythrocytes and Bu-cholinesterasc of the horse blood serum is studied. All the studied compounds arc reversible inhibitors of the acetylcholinesterase and Bu-cholinesterase; the comparison of Kj values of the mcthylphosphonates and mcthylthiophosphonatcs of lupinine, cpilupine and N-P-hydroxyethylpipcpyridine showed that the replacement of the fragment of P=O by P=S leads to a sharp increase in the anticholinesterase activity for both AChE and BuChE (thionic effect), this is important on creation of new and effective inhibitors of AchcE.
3. O-alkyl-O-[N-(P-oxyethylpipcridinc)] - and O-alkyl-O-[N-(P-oxypropyl-hcxamcthyleniminyl)]mcthylthionic phosphonates arc the strong competitive reversible inhibitors of AChE and BuChE showing a high specificity for the acetylcholinesterase. It is established that O-alkyl-O-[N-(P-oxyethylpipcridinc)]-mcthylthionic phosphonates exhibit a profound preventive effect for the toxic action of armin. In the future it will provide for the creation of drugs arc effective antidotal properties based mcthyltionphosphonatcs.
4. Supramolccular complexes of salts of GA with hydrochlorides of dcsoxydcpcganinc, galantamine and prednisolone arc obtained; their structures arc studied by the methods of UV- and IR-spectroscopy. It is shown that the MGA: deoxydepeganine hydrochloride complex (2:1) surpasses the dcsoxydcpcganinc hydrochloride in its anticholinesterase activity by 85.3 times, and it is 8,3 times less toxic. For the immunosuppressive action, the complex of prednisolone with MGA (Gliprcd), at the doses of 2.5 and 5.0 mg/kg upon peroral administration, surpasses the effect of prednisolone alone given at the dose of 10 mg/kg. This was the basis for drug development of Dcoxypcganinc and Gliprcda.
5. For the first time, the supramolccular complexes of GA salts with SK, AA, PSK and BSK were obtained. Physicochemical constants of the complexes were determined, and their structures were studied by the methods of UV- and IR-spcctroscopies. Based on the results of spectral methods (UV and IR), the formation of new MGA complexes due to hydrophobic interactions and hydrogen bonds between host and guest molecules has been confirmed. This is important in the confirmation structures newly acquired complexes based on the GA.
6. In order to reveal the nature of the forces influencing the process of structuring of water molecules and the viscosity, the hydrodynamics of MASGA-1 (75% purity) and MASGA-2 (97% purity) solutions (at a concentration of 0,2% and below) was studied in control and in the presence of various agents, such as urea (destroying the intcrmolecular hydrogen bonds), xylose (affecting hydrophobic interactions) and KC1 (an electrolyte); as a result, it was found that the process of structuring in solutions may occur not only due to hydrogen bonds, but also via strong hydrophobic interactions. It will help to explain the formation of complexes.
7. As a result of pharmacological studies, it was established that the obtained new complex of MASGA:AA (GLAS) exhibits the interfcron-inducing, profound anti-exudative, anti-inflammatory and wound healing properties and, at the same time, it docs not exert toxic effects on an organism; the therapeutic index (LD5(/ED50) for the GLAS is higher than that for MASGA and AA alone by 4 and 52 times, respectively, whereas the toxicity is 6 times lower than toxicity of AA alone; it is shown, for the first time, that at the doses of 10 and 25 mg/kg, the proliferative effect of this complex exceeds that for AA alone twice. This was the basis for creation of the anti-inflammatory drug on the basis of the complex.
8. The temporary pharmaceutical article for GLAS substance and its dosage form (tablets) has been devised, the project of the technology of preparing the dosage form in the form of tablets (0,05 g) has been developed and the experimental batch of tablets has been prepared. Clinical trials were successfully conducted in three clinical institutions of Tashkent; the reports of the tests were submitted to GDQCMME and to the Ministry of Healthcare of the Republic of Uzbekistan for obtaining the permission for production. According to the Decision of the Presidium of Pharmacological Committee of the Ministry of Healthcare of Republic of Uzbekistan, the medicine has been approved for use in medical practice.

Topicality and relevance of the theme of the dissertation. One of the major problems in the cultivation of cotton today among the cotton cultivating countries in the world is susceptibility of cotton with phytopathogens, which cause considerable damage to agriculture. Development of effective technologies for acceleration of the breeding process through the use of a marker associated biochemical, molecular and genetic techniques which enable to cultivate new varieties with a sign of resistance to pathogens, as well as improving the overall non-specific resistance of cotton to adverse biotic and abiotic factors by inducing natural defense mechanisms arc ones of environmentally friendly methods for cotton protection.
After the independence, increase in the cotton profitability and application of the modem scientific achievements - molecular biology, biotechnology and bioorganic chemistry in cotton farming led the certain results. It is important to note the identification of the role of various biochemical systems in regulation of protective reactions, advancing the ecologically sound methods (marker associated test systems and others) and the means (application of agro drugs based on natural biologically active compounds) which stabilize the cotton productivity.
To date, the biochemical principles of plant immunity, improvement in cotton resistance to the phytopathogens through biologically active compounds arc the crucial tasks of the modem biology in the world. Evaluation of cotton enzyme system involved in the protective reaction upon infection of plants by fungal pathogens, detection of molecular structures, development of enzyme immunoassay method, determination of induced resistance mechanisms, activation of the plant genetic protective potential, development of methods to increase the resistance of plants using the glycyrrhizin acid drugs arc the crucial tasks.
This dissertation research to some extent serves to carry out the tasks provided in Law of the Republic of Uzbekistan «On protection of agricultural plants against pests, diseases and weeds» (2000), Resolution of the Cabinet of Ministers of the Republic of Uzbekistan Nol48 dated 29.03.2004 «On measures of improving the structure and increasing the efficiency of plant protection service, «Roadmap for realized activities programs on modernization and development of agriculture for 2016-2020» dated 07.02.2016 approved by the Cabinet of Ministers, as well as in other legal documents adopted in this area.
The aims of the research arc to detect biochemical mechanisms of cotton protective responses, to develop the test systems for evaluation of the resistance of breeding material to phytopathogen and to increase the resistance of the cotton to biotic factor of the environment through Glycyrrhizic acid based drugs.
Scientific novelty of the research is as follows:
it is proven that mechanisms of primary protective reaction of the resistant and susceptible cotton when exposed to the V. dahlias, F.oxysporum with participation of the anionic peroxidase, polyphenol oxidase, phenylalanine ammonia-lyase which creates local zone of oxidative stress and production of active forms of oxygen at the entry spots of the phytopathogen. It is proven that the major role of the salicylic acid is acting as signaling molecule for the formation of systematic induces cotton resistance;
for the first time the test system for evaluation of cotton resistance to the fungal diseases was created, which enabled to forecast the cotton resistance level based on enzyme linked immunoassay;
the radically new concept is developed for application of natural drugs on cultivation of cotton, as inducers of unspecific resistance, based on DAG-1 and DAG-2 drugs in enhancement of resistance to biotic and abiotic environmental factors;
the major role of salicylic acid is identified in DAG-1, which regulates the cotton resistance to phytopathogen;
the prolonged and growth stimulating effect of the drugs is identified in preseeding treatment of cotton seeds in concentration of 10’7 M, comparable with the natural phytohormones, which enables to decrease the application ratio of chemical fertilizers and increase in cotton productivity.
CONCLUSIONS
1. The features of cotton response reaction were studied with actively involved peroxidase immune enzymes, polyphenol oxidase, and fenilallanin ammonia-lyase in cotton V. dahliae pathogenesis. It was found that the initial stage of cotton protective response to contamination by fungi is the generation of reactive oxygen species, coupled with the activation of anionic peroxidase. Obtained results open possibilities for creation of effective agents and technologies for managing the disease-resistance mechanisms on molecular level.
2. The marker enzymes, which determines the development of defense responses in cotton, are the anionic peroxidases associated with cell wall and exhibits the specificity for fungal chitin. Two homogeneous anionic chitin-specific cotton peroxidases arc identified with isopoints pl ~ 3,5 and ~ pl 3,9 and molecular weight of 93,5 kDa and 85 kDa. Km and their substrate specificity were determined, which arc important in development of the effective method for resistance assessment of the cotton to wilt.
3. Obtained polyclonal antibodies to cotton homogeneous chitin-specific peroxidase pl ~ 3,9. Specificity and sensitivity of the polyclonal antibodies was determined and the antibody conjugate was extracted with alkaline phosphatase. The conditions for enzyme immunoassay were optimized, which serve to improve the methods of rapid selection of cotton resistant forms.
4. For the first time in cotton breeding, more than 200 samples of elite cotton varieties, species, cultures and lines were tested for the resistance to wilt based on the developed test systems. Whereby the obtained data showed the identity of the field tests. This in turn enables to create new cotton species based on scientific validation, and saves the time and sources for the field tests
5. The inducing action of DAG-1 (supramolccular complex glycyrrhizin and salicylic acid) and DAG-2 (monoammonium salt of glycyrrhizic acid) was proved on the activity of cotton phytoimmunity enzymes. The effective drug concentrations of 10-7 M that stimulates the system of cotton resistant to pathogens was determined, which reveals the prospects to use the compounds of non-biocidal origin, and which is important in agricultural practice.
6. Low concentrations of DAG-1 and DAG-2 drugs affect the balance of plant hormones - IAA, ABA and SA in cotton seedlings. It was revealed that the drugs affect the increase in SA content, contributing to the cotton preadaptation to biotic stress factors and reduce in strength of its damaging effect. Obtained data in the future will serve for creation and improvement of new age drugs with immunomodulatory properties.
7. It is proved that the SA enhances the activity of anionic peroxidase, indicating the involvement of enzyme in the protective actions; it stimulates the activity of phenylalanine ammonia-lyase, synthesizing new SA molecules. It is conclusively established that the SA contained in DAG-1 is responsible for the increased activity of cotton immune enzymes.
8. Pretreatment of cottonseeds with DAG-1 and DAG-2 drugs has the highly prolonged effect (up to 30 days) on the activity of phytoimmunity enzymes -peroxidase, polyphenol oxidase, phenylalanine ammonia-lyase in the field, which causes the protective induced property of glycyrrhizinates. Obtained data will serve as the basis for development of new concept to apply the drugs of natural origin as the inducers of non-specific resistance.
9. Pretreatment of the cotton using the DAG-1 and DAG-2 drugs has the growth stimulating effect, positive effect on economic valuable characters of cotton, reduces the susceptibility of the susceptible and moderate resistant cotton varieties to wilt, and also contributes to widening the complex measures for crop protection against environmental adverse impact.

The urgency and relevance of the theme of dissertation. The world practice of a multiparty system reflects the specific features and interests of certain social groups and strata, so the creation and export of it is a threat to peace and stability. Today occur in the practice of multi-party system integration and differentiation processes, strengthening of inter-party competition turned into an objective system and the need for continuous learning activities of political parties. Due to the fact that the multi-party system is the perfection of the political and social phenomenon, relevant research has inherent features of philosophical appropriateness.
In the years of independence, in our country ‘Uzbek model’ of democratic political system was formed, which is according to national and universal values, the transition from one-party system to a multiparty system. The multi-party system in our country is becoming the guarantor of social justice and the rule of law, political stability, and to ensure continuity of power in a democratic manner, the further development of civil society by creating a sphere of political pluralism, diversity of opinions and views, debate, healthy competition.
In democratic countries of the world, the procedure for elections to the representative bodies of state power on the basis of multi-party system has been established. In this connection, the study of problems of strengthening a healthy competition between parties, the deepening of cooperation of political parties with public authorities and governments, civil society, in particular non-profit organizations, further improve the political and legal culture of citizens, empowerment of political parties in elections is one of the most urgent issues of philosophical science. The continuity of the process of democratization and modernization of the political system of Uzbekistan requires continuous improvement ideas and ideologies of political parties, a consensual resolution of inter-party contradictions and conflicts, deep analysis of the interests and needs of the electorate, as well as their scientific research permit.
This dissertation research, in a certain extent, works as the implementation of the defined tasks in the Constitution of the Republic of Uzbekistan, in the Constitutional Law of the Republic of Uzbekistan ‘On strengthening of the role of political parties in the renewal and further democratization of state governance and modernization of the state’, in the Law ‘On political parties’, ‘On the financing of political parties’, the Resolution of the Cabinet of Ministers № 86 of March 16, 2005 ‘On approval of provisions on the public funding of charter activities of political parties’, as well as other legal acts related to this activity.
The purpose of the research is to reveal the philosophical characteristics of the national model of a multiparty system in Uzbekistan, the philosophical generalization of tendencies of development of multi-party practice, and study the proposals and recommendations on improving the methodological foundations of a multiparty system.
The scientific novelty of the research is follows:
standards aimed at improving the practice of further expansion of the powers of political parties in elections to the representative bodies of state power have been worked out;
the expediency of use in multi-party systems of countries in the world the philosophy of the work in accordance with the law, morality and spirituality inherent in the national model of a multiparty system in Uzbekistan is proven;
philosophically justified proposals on the recognition of the faction of a political party as the subject of parliamentary control have been developed;
servicing of philosophy for healthy competition between the factions of political parties to harmonize the interests of factions and deputy groups in the process of adoption of laws, the implementation of parliamentary control over the enforcement of laws has been justified.
CONCLUSION
As a result of research the following conclusions have been made:
1. The genesis of a multiparty system in Uzbekistan, the socio-political actions of the Uzbek people on the formation of the national state, is based on the pursuit of harmonization of the political system and the people's interests, to ensure social stability, the construction of an ideal society and the ideal state.
2. The multi-party system in Uzbekistan has its own evolution, covering the period from unreasonable actions of the people to his association for political purposes, i.e., getting independence, making a free and prosperous homeland. This means that the multi-party system has not been brought in from outside, but it has been emerged on a national basis, on the basis of objective laws.
3. The essence of the ‘Uzbek model’ of a multiparty system is the implementation of activities on the basis of the law, in the framework morality and spirituality, maintaining a balance between the social groups in society, to ensure stability.
4. Democratic governance in Uzbekistan, as a form of management, fully corresponding to the spiritual and moral criteria of international democratic standards and values, provides competition and the development of political parties in a peaceful and healthy environment.
5. The basis of healthy competition between ideological factions of political parties is lawmaking. In this regard, it is appropriate vesting factions of the Legislative Chamber of Oliy Majlis according to the right of legislative initiative.
Political parties must co-work together to the enforcement of existing laws. At the same time, the role of political parties is increasing as entities that provides public monitoring and assisting in the resolution of social problems, increasing the authority of the party society, in a multi-party system to further enhance the quality of legislation in the process of creating healthy competition between political parties from the submission of draft laws prior to their adoption.
6. Enhancing the role and place of the party groups in the local councils of the national model of a multiparty system in Uzbekistan and determining its prospects will enable the resolution of the existing socio-political and economic problems in the country.
7. Strengthening the role of political parties in the process of renewal and democratization of state governance and modernization of the country has a positive effect on the increase in political activity, awareness and political culture of the citizens.
8. Implementation of the political parties as an institution of civil society of public control over an affair of state executive bodies will be an obstacle to abuse and corruption in the government, will ensure the rights and freedoms of the individual, will help to achieve compliance with the interests of the individual, society and the state.
9. In order to further enhance the activity, that is enforcing the interest of the party groups expedient empowerment of political parties that have won the largest number of seats or more political parties that have received an equal number of seats in the elections to the councils of people's deputies of the regions and Tashkent city the right to recommend to the Prime Minister for the position of candidates hokim and granting specific for the formation of the party groups in the district and municipal councils of people's deputies of the number of deputies, political parties who obtain the highest number of scats or more political parties that have received an equal number of seats in the elections to the councils of people's deputies of districts and towns the right to recommend candidates the positions hokims districts (cities) by the hokims respective regions and Tashkent city.
The introduction of this provision in practice will enhance the feasibility of political parties, public control over an affair of local authorities.
10. In Uzbekistan the political parties arc registered in the Ministry of Justice. Proceeding from the principle of separation of powers is expedient registration of political parties is not the executive branch, as an independent entity, i.e., the Central Election Commission.

Actuality and demand of dissertation theme. Every year 10% of metals are destructed in result of corrosion rising owing chemical and electrochemical interactions with environment what has caned to financial waste amounting by millions of sums1. The material for mordent technologies - alloys on the base of iron in great degree undergo to corrosion under action of air’s oxygen, moisture and exide’s of sulfur, nitrogen and other chemically- active compounds.
During years of Independence in Republic the great attention has been devoted to development of scientifically investigation in field of chemical industry production of new type of productions and their realization and at this some results by satisfaction of local market in import substituted chemical products. From this paint of view for protection of metal equipment working in water systems, in nets of water-supplying, oil-pressuring and oil chemical industries and also energetically installations problem is arised by using of new inhibitors obtained in the base of organic and oligomeric compounds and grate degree prolonging time of its explutations.
Carrying out of purpose investigation by increasing of quality of metals and their effective using is important un all world at this special attention is devoted to following tasks: using of water-soluble oligomeric and polymeric inhibitors fighting with salt-deposits, determination of optimal conditions as of inhibition of metals corrosion, synthesis of water-soluble inhibitors on the base of nitrogen and phosphorous- containing compounds effectively protecting black and non-ferrous metals from corrosion in deferent mediums, investigation of mechanisms of their action, determination of different physic-chemical particulates. Investigation by protection properties abovementioned inhibitors in results of their adsorption interaction with surface of metallic equipment at different temperatures and studying of mechanisms of their action are at presence time are actual tasks.
This dissertation work is oriented on realization of decision of president of Republic Uzbekistan PP-1442 from 15 december 2010 year year «About priorities of development of industry of Republic Uzbekistan in 2011-2015 years» and also decisions of Cabinet Ministers of Republic Uzbekistan from 09.12.1992 year «About protection of environment of Republic Uzbekistan», from 27.05.2013 year «About program of additions by protections of environment of Republic Uzbekistan on 2013-2017 years».
Aim of investigation. Construction inhibitors of oligomerical type which are a new class of compounds of effective inhibitoral protection metals from corrosion investigation and physic-chemical regulatory of different mediums by watersoluble oligomer inhibitors.
Scientific novelty of dissertational research is concluded in following:
for the first time nitrogen, phosphorous and sulfur containing adducts of thiourea, urea melamine and oligomerical type on the base of phosphorus acid have been synthesized;
mechanisms interactions and protections of metals by oligomer inhibitors;
determination of optimal conditions of influence of concentration, temperature on corrosion current velocity of corrosion, degree of protection, coefficient of breaking, and also using of inhibitors for high effective protection;
degree of filling of electrodes and constants of adsorption equilibrium of metals corrosion by different nitrogen containing, organic compounds and also by adducts on the base phosphorous acid and oligomer inhibitors have been determined by electrochemical and gravimetrical methods;
it was shown that synthesized oligomers have formed protective lowers on the steel surface which in great degree have distinguished by composition and structure from initial samples in different mediums.
CONCLUSIONS
The following conclusions on doctoral dissertation «Synthesis and physicchemical properties of oligomeric inhibitors of corrosion on the base of N, P, S containing compounds» are represented:
1. Number of nitrogen and phosphorous -containing adducts on the base of phosphates of thiourea, urea, melamine andhexamethylendiamine and also inhibitors of oligomeric type on thebase of nitrogen containing organic compounds and phosphoric acid have been synthesized. Molecular dynamical and quantum chemical characteristics of synthesized compounds were determined, mechanism of inhibition by oligomeric compounds was established and general regularities inheriting to such inhibitors were determined what mill promoted to elaboration of new approaches of purposeful synthesis of inhibitors.
2. It was shown that such oligomeric compounds as phosphate of dimethilourea (OIK.M-8) have displayed effect of inner molecular synergism owing to presence of different functional groups and mechanism of their adsorption is differed by fact of formation of more compact layers of inhibitors on the surf are of metal and correspondely increasing their inhibition effect.
3. By using kinetics and thermodynamically investigation it was shown that adsorption properties of inhibitors of oligomeric and low-molecular type have different about what high values of filling degree of electrode surface and constants of adsorption equilibrium are witnessed. Constant of equilibrium in 4 time is higher it’s value of low-molecular inhibitors.
4. Systematical studying of two component inhibitors on the base of dihydrophosphate of potassium was carried out and it was found that addition of second component has increased their inhibitional action, from obtained results conclusion have been mode about passible mechanism of their protective action which has included formation of thin layers of complex composition preventing appearance of ulcerous corrosion.
5. Effectively of inhibitor dimetilolmelamin in aggressive mediums with increasing temperature has increased before achieving definite temperature after which it didn’t changed what has indicated on chemo-sorption mechanisms of action of this inhibitor forming strong protective layers on the surface of protective metal.
6. Phosphates dimethilolurea and dimethilolmelamine in mediums with different values of pH have formed on the steal surface protective layers which differed by composition and structure from initial samples, it was determined that their compounds were acted as anionical inhibitors with braking of anodic process.
7. Oligomeric inhibitors of OIKM-8 and OIK.M-9 and composition on their base have demonstratedthe highest effectively and they were tested Becabod metallurgical combination, AJ «Navoiyazot», ООО «Elektr uskuna sozlash» and «Suvoqova» of PKP and also UDP «Fergana» NPZ.

The actuality and claiming of the theme of dissertation. Currently in the world selecting medical components from plants and getting a new medical components on their basis is 50-60%. Gossypol obtained from cotton can also be attributed to such medical drugs which efficiency of interferon inductors was shown at some viral diseases (ARVI, influenza, herpes virus infection, hepatitis and others).
Since the acquisition of independence of our republic large-scale activities on the creation of scientific research at a high level on the development of the creation of medicines on the basis of local raw materials and the supplying with quality drugs a pharmacy national market have been carried out and appropriate results have been achieved. It can be highlighted the drugs (mcgocin, ragocin, kagocel, gozalidon and etc.) obtained from gossypol derived from local raw materials against viral diseases.
Nowadays synthesizing new components of gossypol, identifying its biologic activity and creating drugs against diseases of immunity arc considered as the urgent tasks in the world. Moreover, preventing infectious pathology on the base of gossypol and synthesizing amino-compounds of alkaloids for producing drugs on carrying out research for producing therapeutic drugs, creating effective machinery in synthesizing herbal matters, identifying the construction, products and features of synthesized compounds with the help of modem physic-chemistry methods, decreased the poisonous effect with the help of modifying the gossypol with other various substances intensifying the activity against fungi and identifying the activity of gossypol products against dangerous swellings and others arc considered as the urgent tasks.
The research of this dissertation in a sense is devoted to fulfilling the tasks which were outlined in the decree of President of Uzbekistan Republic № 416 from 14.07.2006 «Objectives on supporting the manufacturers producing local medicine and medical equipment», and the decree № 1442 from 15.12.2010 «Prime ways on the development of manufacture of Uzbekistan Republic during 2011-2015 years», and in other documents concerning to this field.
The aim of research work is purposeful modification of gossypol molecules and its structural analogies, investigation of biological activity and determination of physic-chemical properties of synthesized compounds.
Scientific novelty of the research work is as follows:
formation of free radicals in cotton has been investigated and also more then 100 new azomcthinc derivatives of gossypol, 2-oxybcnzaldchyde, 2-oxynaphtaldchydc and pyrridoxalc and also compounds containing hydrazine like pharmakophiric group (derivatives of ephedrine, salsolinc, carbazol and diphcnylaminc) have been synthesized;
anti-virus activity of new derivatives of gossypol against virus stomatite (VVS) was shown and at this height antivirus active for thrcptophanc compounds was determined and also compounds possessing by high biological activity again bacterium's - E.coli, St.aureus, X.malvasearum, B.subtilis and some others has been determined;
supramolecular and metal- complexes (on the base of salts containing ions of metals Cu2+, Ni2+) of Schiff bases of gossypol have been obtained. On the base of investigation of UV-, IR-, PMR- and mass-spectrums of obtained compounds their structure was confirmed;
diaminogossypol was synthesized by two methods; on its base were obtained Schiff bases with aldehydes of different nature; with using of gaunt-chemical calculations, their molecular-dynamical constants and electronical structure were determined;
it proved greater intcrfcron-inducing activity of supramolecular complexes mcgosin and tagosin with MASGA relatively gossypol, mcgosin and tagosin;
HPLC method was developed to identify, and quantify the separation of content and mcgosin MASGA in mcgafcrone defined supramolecular complex composition and the degree mcgafcron crystallinity substances.
CONCLUSION
On the basis of conducted research for his doctoral thesis on «Synthesis, structure and biological activity of novel derivatives of gossypol» presented the following conclusions:
1. The studies synthesized new azomethine derivatives of gossypol, 2-hydroxybcnzaldehyde, 2-oksinaftaldcgida and pyridoxal, diaminogossipol and on its basis a new Schiff base, this will in the long term for drugs based on local raw materials.
2. Revealed that the composition of cotton, in various conditions free radicals arc formed, it is proved that the formation of free radicals occurs at temperatures above 30°C due to the decomposition of dissolved O2 in lipid complexes, in the future it will serve to improve the development of new drugs have representatives have fungicidal properties the importance of agriculture.
3. A systematic analysis of activity against bacteria and fungi (E.soli, St.aurcus, V.dahliae, F.ohusrorum, R.solani, X.malvascarum, S.cerevisiae, C.scotti, C. albicans and B. subtilis ) synthesized compounds, the results obtained will hereinafter important when developing new drugs having antibiotic properties.
4. Installed Activity supramolecular complexes mcgosin and tagosin with MASGA to peritoneal fluids number of macrophage cells, it gives the opportunity to create products with higher interferon inducers based mcgafcron.
5. Biological activity of some derivatives gossypol PASS calculated by the program, and the data obtained showed identical results with the experimental methods of performing various pre calculation using computer programs subsequently result in savings of expensive reagents.
6. With the help of special programs of computer package designed power growth dynamics of the formation of the synthesized complexes with the growing number of GA molecules, low probability of consolidation of clusters, it is predicted that, in real systems the number of GA associates can make n = 2-4.
7. The crystal structure was studied clathrates gossypols Schiff bases with o-toluidinc and p-xylidine, it was found that the reaction of 1,4-dioxanc with Schiff bases molecules occurs by hydrogen bonds, these data allow to obtain different clathrates using various solvents.
8. For the first time developed a method of identifying and separating mcgosinc and MASGA in mcgafcronc by HPLC. Quantitative data processed by statistical methods. The data in the future will serve to study the quantitative composition of supramolecular drugs.

Topicality and demand of the subject of dissertation. Today, the materials obtained on the basis of agricultural and industrial wastes are widely used in manufacturing processes of the chemical industry, for cleaning and remediation of waste and surface water.
In our Republic put into operation new industrial enterprises using modern technologies, carried out modernization of the production of a number of new products for various industries. These enterprises are widely used adsorption materials for water treatment and purification of waste water from toxicants.
Heavy metals (HM), radionuclides, phenolic substances are priority pollutants to the aquatic environment and their monitoring is an important eco-analytical task. Currently, there are a large number of physical, chemical and physico-chemical analysis techniques to determine ultrasmall amounts of HM in aqueous media, however, they do not always provide the required sensitivity of the assay at the level of the LPC and below.
The importance of the global problem of environmental pollution with heavy metals, radionuclides, phenolic substances requires dedicated research on their monitoring, with a focus on the following issues: get cheap sorbents based on natural and synthetic materials for the realization of sorption technologies; creation of materials based on bio-sorptional microorganisms of different taxonomic groups are able to accumulate heavy metals, radionuclides and other ecotoxicants; creation of novel sorbents which can replace the expensive synthetic and natural sorption materials; obtaining new sorption materials based on agricultural, food waste and pharmaceutical waste using living organisms; to evaluate the potential of bio-sorptional brewing yeast Saccharomyces towards heavy metal ions; set sorption analytical properties biosorbents based on yeast cell walls; obtaining new biosorbents from waste brewing plants for extraction and concentration of heavy metals, toxins, radionuclides and for analytical purposes.
This dissertation work is oriented on the realization of resolutions of President of Republic of Uzbekistan PP-1071 From March 11, 2009 and the decision №142 of the Cabinet of Ministers from May 27, 2013 «About Program by Protection of Environment of the Republic of Uzbekistan during 2013-2017 years» and also provided by other normative documents.
Aim of work. To prove of ability of using biomass of walls cells of yeast Saccharomyces cereviriae and biosorbents on its basis for concentrating low levels of HM ions, radionuclides and other toxicants natural environment and to develop a method stripping-voltammetry determination of the group of HM at the level of the LPC and below using their pre-concentrating from the aqueous solutions of these sorbents
Scientifically novelty of investigation is consist in following :
the first time demonstrated the possibility of using the WCY Saccharomyces cerevisiae as a sorbent for concentrating the HM group, radionuclides and toxins for analytical purposes;
developed a method of inversion-voltammetric determination HM ions in aqueous media at concentrations at or below the LPC using a pre-concentrating biosorption;
the first time experimental lined with the contribution of the functional analytical groups of biopolymers of the cell walls of yeast in a specific and nonspecific binding of HM ions;
is proposed salvation - house mechanism of ion exchange in a heterogeneous system «biosorbent-solution» that allows you to select reagents for quantitative desorption and regeneration biosorbents;
the first time was show that the relative electronegativity of the metal ioncomplexing agent can be a criterion of priority sorption capacity of the sorbent.
CONCLUSIONS
On the basis of research on this doctoral dissertation on the topic «Sorption concentration and determination of toxicants using biosorbents based on cell walls of brewers yeast» the following conclusions are presented:
1. For the first time the possibility of application of the cell walls of yeast Saccharomyces cerevisiae as biosorbents for the concentrating of heavy metals, radionuclides, organic compounds for subsequent determination is shown. We have developed a process for preparing new bio-sorptional material, and their study with using physical and physic-chemical methods. It established its basic functional-analytical group (FAG) and their contribution to the concentration of HM ions.
2. With the use of cinetic and thermodynamic studies it was found that the sorption concentrating of HM ions is carried out in mixed arrangements of specific binding, ion exchange and physical sorption with a predominance of the latter.
3. Sorption analytical capabilitiy of yeast cell walls (WCY) S. cerevisiae with respect to individual ions Cd (II), Pb (II), Си (II), U (VI) and phenol. Has been shown an explanation for the influence of pH on metal ions biosorption metalposition proton exchange location and shape of metal ion in solution.
4. Displaying the mutual influence of ions on the completeness and selectivity in concentrating multi-ion systems, reflected in the decrease in the total sorption capacity biosorbent, it is found that the best adsorption capacity ions in inherited to Pb (II) in the case of mono-, di- and tri-ionic systems. The explanation of this phenomenon from the point of the Lewis-Pearson theory of the nature of the specific binding of «hard» and «soft» complexing ions with appropriate ligands -FAG. Was given it is noted that the relative electronegativity ions may be an indicator of their relative sorption capacity.
5. In order to improve sorption analytical and expluatation characteristics of biosorbents it was studied the possibility of chemical modification. It is shown that the native biomass treatment by polyvinylpyrrolidone solution greatly enhances sorption capacity of the sorbents. To improve performance solid biosorbents were immobilizatied in Ca-alginate gel. Sorption HM ions by such sorbents in static and dynamic conditions was invertigated. The technology and Variants of using of magnetical sorption smart materials based on the joint inclusion in Ca-alginate gel biomass WCY and synthesized magnetite was elaborated.
6. For the first time is shown possibility of using inversion-voltammetric method in the study of bio-sorptional processes. It has been developed computerized voltammetric complex and electrochemical sensor allowing to carried out measurements in the «drop». Technology for manufacturing mercury-film graphite electrodes and the criteria for assessing their suitability in the determination of trace content of HM was elaborated.
7. The method of inversion - voltammetric determination of low contents of ions cadmium, lead and copper in waste-, surface- and drinking waters with advanced bio-sorptional concentrating was developed. This method allows to determine the concentration of the specified HM at LPC and below with mean square error not more than 0,2 • 10’4.
8. The method of group determination of ions of cadmium, lead and copper by inversion-voltammetric method using pre-concentrating bio-sorption were tested and implemented in laboratory practice «West Labs» SPC «Geology of precious metals and uranium» NMMC. The technology of production of biosorbents based CWY was implemented in the «Pulsar - Group Brewery» Ltd.

The urgency and relevance of the theme of dissertation. According to the report of the World Health Organization (WHO), hypertensive disorders in pregnant women should be considered the main among the most common major diseases, which occur in 4-8% of pregnant women. “The importance of this major international health problem is defined by severely impaired health and even death of the mother (in some countries up to 40%), high level of infant and perinatal morbidity and mortality, as well as a number of obstetric complications observed in pregnant women with gestational hypertension. Along with this, the complications observed during pregnancy, which takes the 2nd-3rd place in the maternal mortality, stress the importance of this issue. Perinatal morbidity in children bom to mothers who have had complications of gestational hypertension (pre-eclampsia) ranges from 463.0 to 780.0 %, and deaths from 10.0 to 30.0 %.”’
In our country, during the years of independence, close attention was paid to strengthening the healthcare system, especially, protection of maternity and childhood, and tremendous results were achieved. At the same time, the results achieved in the prevention of prenatal complications in pregnant women with gestational hypertension should be particularly emphasized.
In the world, close attention is also being paid to the development of effective treatment methods and improvement of the prevention of prenatal complications in pregnant women with gestational hypertension. Besides, there is a need to improve the choice of optimal tactics of controlling the pregnancy and childbirth, prevention of perinatal and obstetric risks, reduction of complications of the maternity process and isolation of the group of women with disorders of vital functions of fetus, moreover, pathogenic, clinical, prognostic methodical approaches defining the quantitative determination of autoimmune antibodies, vascular endothelial growth factor and placental growth factor (PGF) in women with gestational hypertension. It is necessary to emphasize that “the study of the features of influence of the corrector of endothelial dysfunction and angiogenesis - L-argininc in the course of preventive therapy on the indicators characterizing the status of dysfunction of endothelial angiogenesis, autoimmune processes, the incidence of complications in pregnant women at risk of gestational hypertension and the development of the algorithm of prediction and prevention activities for pregnant women at risk of development of gestational hypertension requires modem solutions to this problem”2. The above underlines the relevance of the topic of the dissertation.
This dissertation research to a certain extent will serve to fulfil the tasks set out in the Decree No. PD-1096 of the President of the Republic of Uzbekistan “On additional measures for the protection of the health of mother and child, formation of healthy generation” of April 13, 2009, the State program “Strengthening the reproductive health of the population of Uzbekistan, protection of the health of mothers, children and adolescents in 2014-2018” approved by the Decree No. PD-2221 of the President of the Republic of Uzbekistan of August 1, 2014 and other regulatory and legal documents relating to this activity.
The aim of the research is determining the prognostic significance of the levels of autoimmune antibodies and angiogenesis in prenatal complications in pregnant women with gestational hypertension and improving their preventive measures.
Scientific novelty of the research was concluded in the following:
On the basis of the indicators of angiogenesis and endothelial function a method for predicting the gestational hypertension was developed in the early term of pregnancy.
It was proven that low content of angiogenesis indicators and imbalance of autoimmune processes in the 1st trimester of pregnancy arc the risks of HIP development after 20 weeks of gestation.
For the first time the formation of endothelial dysfunction at the prcclinical stage of gestational hypertension was shown and prognostic criteria were developed.
For the first time the influence of the periodic LPA on the emerging prcclinical stage of gestational hypertension, endothelial dysfunction was proven.
CONCLUSION
On basis of the research conducted on the theme of the doctoral dissertation “Prognosis and prophylaxis of prenatal complications in pregnant women with gestational hypertension” we provided the following conclusions:
1. As a result of the survey, early preclinical revelation of the signs of gestational hypertension in pregnant women, we found that in 17.7% of the pregnant women there was the possibility of HIP development (risk group), of them in 44.6% HIP developed.
2. In the blood scrum of the pregnant women, we detected a reliable decrease in AAB level versus dsDNA to 30.5%, Tnn-0.01 - to 9.5% and Trm-0.15 -to 6.9% in the 2nd trimester of pregnancy in relation to the 1st trimester. The indicators of AAB amount to Kim-0.5-300, Kis-0.7-120 and HMMP insignificantly increased and reliably did not differ between the trimesters of pregnancy. This indicates that autoimmune processes involve all the studied antigens, but the intensity of changes in antigens differs from each other.
3. We revealed the direct dependence of high level of DAP on the degree of the increase of LPA, CEC, cytokines IL-IB and TNFa, which indicates their importance in HIP pathogenesis.
4. We proposed the method of HIP prognosis including the indicators of endothelial dysfunction, embryonic angiogenesis and autoimmune response, and then made a calculation of the index of resistance of vascular endothelium and embryonic angiogenesis (IR.VEEA) with the help of discriminant functions. The calculation was performed according to the formula: IRVEEA (P)=EZ:(ZX ZW);
5. The amount of NO in the range from 31.6 to 55.3 mkmol/1, the activity of eNOS - from 10.8 to 5.5 mkmol/min/1 and iNOS - from 0.37 to 1.1 mkmol/min/1, the concentration of ONO‘2=0.3-O.71 mkmol/1, ET-1 - 28.8-29.7 pg/ml, VEGF -228.7-271.3 pg/ml and PGF - 228.3-186.3 pg/1 should be considered to be critical in relation to the possibility of development of complications and unfavourable outcomes of HIP.
6. Maximal endothelial protective effect of L-arginine and the decrease of DAP level in the pregnant women with HIP were revealed in the groups with low and moderately low level of NO and activity of eNOS, expression of iNOS, ONO2‘, ET-1 and CEC, unlike the group of the women with high expression of NO in blood. The prescription of L-arginine to the pregnant women with HIP led to the reduction of the frequency of PE development of mild and severe degrees to 2.1 and 6.2 times, FGRS to 3.7 times, FPF and preterm deliveries to 3.0 and 7.5 times respectively.
7. The worked out algorithm of prognosis and management of pregnant women of the risk group of gestational hypertension development allows a general practitioner to reveal and assess timely the development of vascular changes induced by pregnancy.

The urgency and relevance of the theme of dissertation. According to the United Nations Office on Drugs and Crime1, the number of drug addicts is increasing year by year. In particular, if in 2006-2007 the number of drug addicts was 200 million, in 2013-2014, the number reached 246 million people. Annually alcoholism and its consequences cause death of approximately 2, 5 million people. Also, in some cases strong forms of it may cause such negative consequences as working capacity loss, conflicts with people around, and committing crimes. Therefore, nowadays the issue of deviant behavior is a serious social problem worldwide.
Since obtaining independence, Republic of Uzbekistan has achieved positive changes in the organization of up-to-date drug abuse services such as effective examination of patients with alcoholism and drug addiction, consultation, diagnosis and medical and social rehabilitation in the framework of large scale reforms.
Currently the whole world is paying special attention to exploration of interrelation of formation and development of alcoholism and opiate addiction with negative influence of deviant behavior in premorbid, effective ways of treatment and prevention measures. Due to this theoretical foundation of personal biological peculiar properties of patients with alcoholism and drug addiction, defining the importance of social-psychological factors of deviant behavior and deviant personality formation, comparative classification of clinical-dynamic features of pathological attraction and ncurovisual state of the brain of patients with alcoholism and opiate addiction with and without deviant behavior.
The dissertation research particularly addresses the tasks outlined in the government program “The year of a healthy child” signed by the President of the Republic of Uzbekistan, № PP-2133 on 19th of February in 2014 year, the decree of the President of the Republic of Uzbekistan "On efforts of further deepening the reform of the Healthcare system", № PP-1652, 28th of November 201 land the decree of the State commission of the Republic of Uzbekistan of the controlling of drugs “The program of complex methods against the drug violation and criminal turnover in 2011-2015 years”, No: 11/11 since 8th of August, 2011.
The aim of research work is examining clinical-psychopathological features of alcoholism and opium addiction in patients with deviant behavior in premorbid with consideration of personal-biological, social-psychological factors and improving trcatmcnt-and-rchabilitation and preventive measures.
The scientific novelty of the research work is as follows:
interference of existence of perinatal pathology in the anamnesis, prevailing of emotionally unstable and impulsive personality types, hereditary drug abuse inclination and mental illnesses major role in the formation of deviant behavior in patients with premorbid alcoholism and opiate addiction have been proved;
high progressive progress of addiction in patients with alcoholism and drug addiction with deviant behavior in premorbid, which in turn is associated with factors such as early onset of drug abuse, the rapid formation of dependence, severe course of abstinent syndrome;
it was established that at most of alcoholics and drug addicts with deviant behavior in a premorbid the reference high-progreduated course of dependence explained by the early beginning of the use drugs, high speed of formation and the heavy course of an abstinence syndrome.
the prevalence of behavioral and affective components of the pathological craving in patients with deviant behavior in premorbid has been justified;
morphological and structural changes in the brain, which vary from slight signs of an atrophy to expansion of subcortical space and furrows of bark of frontal lobes, as a result of high gradient progress of dependence in patients with deviant behavior have been identified;
the necessity of introducing cognitive-behavioral therapy to improve the social adaptation of patients with alcoholism and drug addiction with deviant behavior in premorbid has been pathogcnetically justified.
CONCLUSION
On the basis of the research on a doctoral thesis on “Role of the apoptosis factors for realization ofprotectivc-barricr function of the stomach mucosa and the intestine at the salmonella infection and chronic hepatitis” provided the following conclusions:
1. The particularity of deviant behavior in the premorbid of alcohol and opioid dependence is the prevalence of aggressive and delinquent behaviors, and what is more in the premorbid of alcohol dependent patients occurs more aggressive behavior and in opioid dependent patients more delinquent behavior. Both forms of behavior is characteristic mainly for explosive and unstable type of persons, whereas suicidal deviant behavior for hystcroid type personalities.
2. Among patients with alcohol and opioid dependence with deviant behavior in premorbide prevails psychopathic personality or accentual personalities with explosive and unstable types. Among patients without deviant behavior in the premorbid personality prevails psychasthenic and conformal type.
3. The formation of deviant behavior in patients with alcohol and opioid dependence have been developed due to the social and psychological factors including, to be brought up in incomplete families or families with low cultural level and material prosperity, upbringing defects likcless caring for children, cruelty and violence, getting involved with antisocial or criminal groups.
4. Clinical features ofalcohol and opioid dependence with deviant behavior in premorbide is early onset of psycho-active drug abuse, high progress of formation of abstinentsyndrome, the severity of abstinence, a highly progressive course of the disease with the rapid development of personality degradation and negative medical and social consequences.
5. In the same duration of the disease in patients with the presence of deviant behavior in the premorbid is morphostructural changes of the brain, ranging from minor atrophicstillto the expanding of subcortical space and sulci of the cortex of the frontal lobes, in patients without deviant behavior in premorbide - only the expansion of perivascular spaces, and problems with blood circulation in the veins.
6. Improving the treatment and rehabilitation measures of persons with deviant behavior in premorbide requires cognitive-behavioral psychotherapy methods for correcting deviations of personality and behavior.
7. When the developing of preventive measures for persons with deviant behavior must be considered the personality traits, social and psychological factors and clinical-dynamic features of the main disease with the definition of the form and direction of the work of performer.

The urgency and relevance of the theme of the dissertation. The role of indirect taxes is of great importance in economy of the world countries. In particular, in the countries of Europe, China and Japan receipts from indirect taxes in the government budget account for 30%-60% of the main receipts. Therefore, in these countries special attention is paid to the issue of enhancing of accounting of indirect taxes.
During independent development of the Republic of Uzbekistan a particular attention has been concentrated on conducting financial accounting on the basis of the international standard models. If the necessity of accounting of taxes, in particular indirect taxes, occurred with the development of the law “On Accounting”(1996), then enhancement of forms of tax accounting in the form of separate accounting and determination of transfer by the tax authority, introduction in the tax legislation of a concept of tax accounting, control of tax accounting by auditors and tax authorities promote complete development and improvement of this system.
Nowadays in the world, especially in national economic entities, the researches on improving of the accounting, analysis and audit of indirect taxes arc of a particular importance. In this field the attention is paid to the solution of the following important scientific tasks: critical studying of reflection in initial accounting documentation of indirect taxes in economic entities, generalization of data in primary accounting documentation and formulation of the tax accounting, studying of the database and analytical data on indirect taxes, ensuring transparency of data of financial accounting during the carrying out the analysis of indirect taxes, development of scientific recommendations aimed at improving the methods of carrying out tax reports, as in case of financial records audit.
This doctoral research, to a certain extent, conduced the execution of the tasks determined by the Law of the Republic of Uzbekistan «On audit activity» (2000) and the Decree of the President of the Republic of Uzbekistan №UP- 4720 «On measures to implement modem methods of management in joint-stock companies” dated from April 24, 2015, in the Resolution of the Prcsidctnt of the Republic of Uzbekistan PP-2520 “On measures of improving the system of purchasing potatoes, fruit and vegetables and melon production and their use” as well as the Decree of the President of the Republic of Uzbekistan UP - 4848 “On additional measures of ensuring of a rapid development of the business activity, comprehensive ensuring of private property protection and high-quality improvement of the entrepreneurial environment” dated from October 5, 2016.
The aim of the research is to develop scientific-methodological and practical recommendations aimed at improving the methodology of accounting, analysis and audit of indirect taxes.
Scientific novelty of the research work is the follow ing:
proposals to enter in the tax legislation the structure and the list of additional documents which can be a basis for return of the excessive amount of the value added taxes which resulted from the support of the zero degree of the rate for the rendered international shipping services;
ffers on approval of the export of products, use of a zero rate with value added taxes have been developed, amendments have been made in the taxation basis and results of change have been reflected in accounting;
the order of accounting of the advantage of the transition on the voluntary basis on a voluntary basis to the value added tax has been developed;
improving of accounting of indirect taxes, reflection in documentation of communication of processes in accounts has been offered;
the system of collection of information and calculating sources in the organization of the analysis of indirect taxes and their use while carrying out analysis has been created;
the technique of carrying out audit of indirect taxes on the basis of documents of an automated system has been developed;
recommendations on the order of carrying out audit about write-off of shortage and the property detected during audit of indirect taxes have been proved.
CONCLUSION
In the dissertation as a result of the conducted research the following conclusions have been developed:
1. In case of purchase of the equipment by the foreign citizen, the technology and other assets made in Uzbekistan, the use of privileges in the system of export on indirect taxes and application of the proposal on reflection in initial accounting documents of these privileges increases export volume of retail items of producers (according to the experience of Japan).
In case of purchase of the property, intangible assets reflection of the indirect taxes paid to supply agents as a tax in the budget, and also considering in the corresponding long-term and current advance accounts, in a production process of products to write off, it will lead to lowering of product cost (experience of the Russian Federation).
2. With the aim of accounting of long-term indirect taxes, transfer of the property in financial rent, accounting of account 7410 - “By types of the accounts considering debts on receipts in the budget” in the chart of accounts, the correct organization of accounting of a tax, determination of a taxation basis create possibilities of reflection in a generalized view of data in the tax reporting.
3. As a result of application of the zero rate on the value added taxes excessively paid tax amount, having opened account 4420 - “The value added tax, excessively paid to the budget” based on account 4400 and to reflect it in the debit part prevents the confusion connected with the budget, increases efficiency of control in accounting.
4. The proposal on introduction in the main additional documents which arc the basis, application of the zero rate on international carriages of passengers, baggage, freights and mails led to simplification of calculations of taxpayers, as a result of application of the zero rate the order of return of the excessive amount became simpler that resulted in efficiency of an annual figure which averaged 2,2 billion UZS.
5. Determination of the efficiency of transition to the value added tax on the voluntary basis, the proposal on application from the small enterprises operating separate accounts on different types of activities serve in types of activity of the value added tax to the correct forecasting of tax deductions of small businesses.
6. The offer on implementation of the zero rates in relation to the fixed assets purchased by small businesses of the industrial sphere, farms and their reflection in financial accounting raises possibilities of purchasing of the modern equipment and lowers product cost.
7. The proposal on accounting of indirect taxes in the analysis of taxes and determination of the tax burden, from the point of view of recognition of expenses in accounting, provides the correct distribution of tax expenses.
8. Having proved the need of reduction in general system of the accounts which arc a data source for financial and tax reporting, having cancelled accounts 6240, 6250, 6990, 7240, 7250, proposals of accounting of the current tax debt in the accounts 7410-90 ensures improvement of providing the information and accounting analysis of indirect taxes, reliability and transparency of the data.
9. Proposals of improved versions of the invoice, the register of the invoices which arc the main source of the data on indirect taxes, and also paid cheques in case of trade through corporate plastic cards provide the effective organization of audit of indirect taxes, use of accounting documents at the same time as the register of accounting and saving time.
10. The proposal on entering into the tax legislation of the issue of indirect taxation of shortage of the property determined during the inventory count, providing certainty and reliability of an audit opinion, prevents payment of penalties and fees.

The actuality and claiming of the theme of dissertation. In the whole world the problems of the pollution as well as the issues of the environmental security of the population and territories arc taking on and increasingly growing urgency. According to the data of the World Health Organization, app. 24% of illnesses and 23% of fatal cases on the planet arc caused by the harmful environmental factors that might have been prevented. «In the present world negative exogenous conditions steal more than 13 mln human lives yearly and arc the immediate causes of every third illness among the children under five».5
Upon gaining the independence, a great attention in our country is focused on socio-cconomical and environmental issues including the modernization of public health system. In particular, the Government of the Republic of Uzbekistan has adopted a number of decrees and regulations to improve the quality of life and the health characteristics of the population that, in their turn, shall provide a significant growth of the living standards and amend the nosogcographical situation in the country.
Presently, all over the world, geographical distinctions in the structures of sickness rates and life intervals on the global, regional and local scales are determined by the territorial changeability of harmful natural and socio-cconomical factors and their impact on human health. The nowadays orientation of the ‘environment-health’ vector is governed not only by natural conditions but also by environmental factors as well as by the need for the revelation of the causc-and-cffect relations between the environment and the sickness rate of the population, compilation of maps to reflect medico-geographical situation in the world and in certain territories, elaboration of medico-geographical forecasts for countries and their regions and, in the long run, taking into account the spatial differentiation of the morbidity in the perfection of the health system. All these circumstances determine the topicality of the present dissertation research.
The present dissertation research, within certain limits, is to solve the tasks anticipated in the Decree № ПП-2487 of the President of the Republic of Uzbekistan as of february 9, 2016 «On the State Program «The Year of the Healthy Mother and Child», in the Decree № ПП-2221 of the President of the Republic of Uzbekistan as of august 1, 2014 «On the State Program for the Further Strengthening of the Reproductive Health, and Mothers’, Children’s and Juveniles’ Health Protection for the period of the Years of 2014-2018», in the Decision of the Cabinet of Ministers of the Republic of Uzbekistan № 142 as of may 27, 2013 «The Action Program of the Environment Protection in the Republic of Uzbekistan in 2013-2017» as well as other legal documents adopted in the sphere.
The aim of research work is to develop scientific practical recommendations for the steady development of the region and for the improvement of human health in the Republic of Karakalpakstan.
Scientific novelty of the research work is as follows:
determined the spatial differentiation and the geographical peculiarities of the human morbidity in the Republic of Karakalpakstan;
revealed the correlation links between the illnesses and harmful environment factors in the Republic of Karakalpakstan in the context of the medico-geographical zones;
discovered local and zonal regularities of the influence of certain natural and environment factors on the illness rate;
developed a series of nosogcographical maps to reflect the mcdico-geographical situation in the region;
determined fundamental geographical peculiarities of the improvement of human health and the provision of the steady social development of the Republic of Karakalpakstan.
CONCLUSION
Taking into account the main results and conclusions of the study can make the following scientific-practical suggestions and recommendations:
1. It is necessary to conclude a new agreement for the protection and sharing of transboundary water resources of the river. Amu Darya, in accordance with the UN Convention, the implementation of the previously reached agreements of Central Asian states for the assurance of water passes into the Aral Sea and the Aral Sea region, as well as the adoption of a coordinated solution to the problem of construction of the Rogun hydropower station in Tajikistan.
2. Establishment of environmental monitoring of the environment on the part of government, academic and nongovernmental organizations; improving the integration of environmental protection and health sectors in solving environmental problems and public health.
3. Implementation of a new environmental policy and sustainable development, gradual implementation of rural employment problems, the regulation of migration processes, reducing the outflow of population from Muynak, Takhtakupyr, Kungrad and other areas of Takhiatash through the creation of new jobs, support private sector investment, construction joint socially significant enterprises, etc.
4. Keeping monitoring of nosoecological situation, further improvement of the forecast development with the development of timely practical advice. Comprehensive analysis of the environmental situation in the context of individual areas, evaluation of interventions, environmental culture and consciousness of the population.
5. Provision of sanitary-epidemiological prosperity by strengthening preventive measures. Providing the population of cities, district centers and rural localities of RK with tap water (tap water bring security to the average level in Uzbekistan) and the improvement of its quality, the creation and expansion of sewerage networks in cities and towns, improving the health of environmental infrastructure of medico-geographical areas.
6. In the Northern medico-geographical area it is advisable to carry out a periodic watering, so-called "sanitary water releases" of water along the river Amu-Darya to increase the amount of drinking and irrigation water, combat desertification and soil salinity, filling drying lakes, improve landscape and biotic environment. Ultimately, these measures will contribute to the improvement of mcdical-gcographical situation and the life conditions for the population, reduce the incidence of child and infant mortality.
7. In Central and Southern medical-geographical areas it is necessary to develop a network of municipal and departmental water supply systems, to reconstruct and repair the head of centralized sewage treatment plant water supply systems in order to bring water quality up to state standards and to achieve water supply to the population, excluding the hourly water supply.
8. In the Southern medical-geographical area, a population for drinking and household purposes widely uses water tube wells, it is advisable to improve the system of hand pumps, to develop a network of local items for cleaning and selling purified drinking water for the population.
9. Retrofitting modem diagnostic medical equipment (eg, appliances such as doplergraf), in particular, oncological clinic in Nukus. Fitting Oncology Center in the capital of RK with advanced radiotherapy equipment, improvement of the nosogcografical situation in Muynak, Chimbay, Takhtakupir, Karauzyak areas. Fitting Republican General Hospital with hemodialysis unit.
10. For specializing in livestock administrative regions, rates of some populations of parasitic diseases (such as brucellosis) higher than in the RK. This shows that we must also focus more on monitoring the epidemiological situation in the region.
11. Development and adjustment of forecasts of population health as an integral part of the concept and strategy of socio-economic development of the RK, cartographic support for the implementation of the project of scientific -research works.
12. Further development of research in the field nosoecology as directions, emerging at the intersection of geo-ecology and nosogeography. This is of paramount importance and implementation of comprehensive large-scale monographic research works on individual nosogcographical habitats, homes and centers of the most common forms of disease of population.
13. The expert 6 interviews revealed that in Karakalpakstan, in the future it is expected to remain high in comparison with the national average of general and primary morbidity of the population, the incidence of respiratory diseases, tuberculosis, diseases of the digestive system, circulatory system diseases, as well as the preservation of infant and maternal mortality.

The urgency and relevance of the theme of dissertation. Today around the worldbroad application of cold in food, chemical the industries, etc. allows to provide to medicine, pharmaceutics rhythm of production, it is more rational to use fixed assets, to keep quality of foodstuff, drugs, etc. In recent years, according to the International institute of cold, about a third of world production falls to the share of perishable goods. The general losses of all food in the world make ~25%, fruit and vegetables ~35%, perishable goods because of a lack of refrigerating capacities ~20%.In this regard construction new and reconstruction of the operating refrigerators arc inseparably linked with technical progress in area of production, application of artificial coldandisone of important tasks.
For years of independence special attention is paid on production of refrigeration and climatic units of different function. Essential results on increase in productivity and efficiency of the compressors entering them and the hcatexchange equipment arc achicved.lt is possible to note especially reduction of power losses in devices.
Todayimprovement of schemes of the produced installations, conservation by use of the ozone-safe and not creating greenhouse effect coolants arc one of important tasks.Carrying out purposeful research works, in particular, development of safe mixes of coolants, effective hcatexchange devices, programs of calculation of refrigerating cycles and selection of componentsis one of importanttasks.
This dissertation research to some extent serves performance of the tasks provided by the Resolution of the President of the Republic of Uzbekistan of April 7, 2011 No. PP-107 "About measures for development and strengthening of material and technical resources of storage of fruit and vegetable products for 201 l-2015"and also in other standard and legal documents accepted in this sphere.
The aim of research work is development of scientific and methodical bases of process of boiling of multicomponent mix of coolants on a surface with cross and ring flutes and of the hcatexchange device from pipes with cross and ring turbulizers.
Scientific novelty of the research work:
the heat exchange model at vesiculate boiling of hydrocarbonic coolants and their ncazcotropny mix R290/R600a/R600 on pipes with cross and ring turbulizers is created;
on the basis of the carricd-out tests skilled data on refrigerating capacity, energy expenses in the one-stage and cascade refrigerators equipped with the effective condenser, the evaporator and the condenser evaporator arc obtained;
dependence of refrigerating capacity, the spent power on a type of coolant, the place of application of effective pipes is revealed (in the condenser, the evaporator and the condenser evaporator);
semi-empirieal models of a thermolysis when cooling, heating, boiling, condensation arc offered;
on the basis of the analysis efficiency of hcatexchange devices with the pipes having ring flutes outside and smoothly outlined diaphragms inside is shown.
Application of knurled pipes in the evaporator thermodynamic is favorable, the efficiency of the condenser with cross ring turbulizers made of pipes 1,06 + 1,25 in an interval;
on the basis of the analysis efficiency of vapor-compression refrigerators with the hcatexchange devices manufactured of pipes, having ring flutes and ledges is shown. The best mashines on power characteristics with pipes No. 3 in the condenser and with pipes No. 4 in the evaporator have, respectively, efficiency and 0,59 at To. Application of knurled pipes in the condenser evaporator practically docs not influence efficiency of the refrigerator;
the criterion for assessment of power efficiency of hcatexchange devices is offered;
the technique of the eksergetichcsky analysis of the one-cascade vaporcompression refrigerator is developed. The technique is based on the sequence of the analysis of one-stage machinarics.
CONCLUSION
The main results of dissertation operation arc as follows:
1. The technique of processing of experimental results of the cascade refrigerator with the intensified hcatexchange pipes is developed.
2. Changes arc entered into a method of calculation of density of a thermal stream at vesiculate boiling taking into account parameters of surfaces with ring flutes.
3. Fall of temperature of condensation in the top branch when using all options of pipes with ring diaphragms and flutes as hcatexchange surfaces in the condenser is revealed.
4. The non zeotrop mix R290/R600a/R600 offered as the alternative agent to ozonoaktivny R12 has almost identical power indicators with R12.
5. Arc defined efficiency on refrigerators with condensers from effective pipes. Application of a pipe No. 2 in the condenser lowers efficiency of the mashine, and pipes No. 4 - does not influence on. The best surface of heat exchange is the surface from pipes No. 3.
6. Under equal conditions the refrigerating coefficient of the cascade mashine on pure propane is more, than on mix. With growth of temperature of boiling £ raises. The mashine with d! D- 0,945 pipes in the evaporator is most effective.
7. The criterion for evaluation of efficiency of hcatexchange devices is offered. The criterion of efficiency is based on a concept of an exergy. It is convenient to them to use for definition of the best options of the hcatexchange surfaces operating and selection thermodynamic of the naivygodny designed devices. The technique of the ekscrgctichcsky analysis of the one-cascade vapor-compression refrigerator is developed. The technique is based on the sequence of the analysis of one-stage mashincs.
8. Operation of the cascade refrigerator by means of the developed technique in the range it is analysed by 213 < To < 233 A?. r)e kritcry of efficiency served. The best mashines on power characteristics with pipes No. 3 in the condenser and with pipes No. 4 in the evaporator have, respectively, efficiency/^, =0,60 and 0,59 at To =213. Application of knurled pipes in the condenser evaporator practically docs not influence efficiency of the refrigerator. The maximum efficiency of the machine is reached at TO<213A’. In all cases atTo, exceeding 213 K, sharp reduction of efficiency is observed. Power characteristics of compressor and condenser knot of the refrigerator with the device equipped with effective pipes arc calculated. The size of losses of energy is reduced by 5190,5 kW ■ h/year at the 7000th hour of work in a year.

The relevance and demanding of the dissertation the theme. Today in the world the significance of pumping stations in the energy sector, land reclamation, pumping of petroleum products, as well as housing and communal services is continuously increasing. In these industries to ensure reliability, continuity, high energy efficiency and flexibility of pumping stations work, as well as performance under transient conditions is actual. In order to achieve all of the above mentioned parameters the certain progress has been made in other countries of the world where modem pumping equipment is constantly updated and improved. "In this regard, the use of a popular high-tech specialized basic and auxiliary power equipment of pumping stations, prolonging the life of the pipeline system by 1.5-2 times is necessary"1.
In the Republic of Uzbekistan, the large-scale activities on the effective organization of measures for the creation of energy-saving techniques and the control system of pumping stations operating modes arc carried out. In this regard, the notable progress has been made in developing effective methods, techniques and devices to reduce the influence of electromechanical and hydro-mcchanical transients on power equipment and pipelines of pumping stations. On the basis of controlled electric drive, the block diagrams and pumping units’ control algorithms are developed, frequency variable systems "asynchronous motor - pump" are designed, a combined management structure of asynchronous motor in turbo-machines are developed.
In the world, the questions of reliability and uninterrupted operation of pumping stations during transient conditions, the creation of new techniques and technologies of protection of the power equipment and pipelines of pumping stations against sudden transients are becoming particularly important. In this area, the implementation of targeted research in developing the control methods of the steady and transient modes of pumping stations operation, creation of the main power equipment and pipelines protection devices against water hammer, creating technical solutions and improving the reliability of the auxiliary power equipment for the removal of drainage and wastewater are the priority problems.
This dissertation research to a certain degree performs the tasks provided in the Law of the Republic of Uzbekistan "On the Rational Use of Energy" (1997), the Decree of the President of the Republic of Uzbekistan № PD-2343 on May 5, 2015 " On the program to reduce energy consumption measures, the introduction of energy saving technologies in the fields of economy and social sphere for 2015-2019", decree of the Cabinet of Ministers № 499 dated November 16, 1999 "On Measures for the Implementation of the Law of the Republic of Uzbekistan "On the safety of hydraulic structures" as well as in other regulatory documents adopted 
The aim of the research is the creation of algorithms, methods, techniques and devices to reduce the negative influence of unsteady modes and sudden transients on the main and auxiliary power equipment and pipelines of pumping and hydroelectric stations.
Scientific novelty of the research consists in the following:
the algorithm of phased solving of electromechanical and hydro-mechanical transients at pumping stations, taking into account the duration of power equipment operation is developed;
the generalized mathematical model and software complex for calculation of "pipeline - pump - electric motor - electric grid" system elements, which allows to explore the power system transient processes during pumping stations transient modes are developed;
the new method of protecting of pumping stations pipelines against water hammer using the bypass device is substantiated;
the device of proportional control of the pump butterfly valve to improve the reliability of the pumping stations power equipment work is designed;
the method of simultaneous pumping of drainage and sewage water with different suction height by means of jet pump with the system of regulation is developed;
the regulated system of simultaneous removal of filtration, drainage and sewage water from buildings and adjacent territories of pumping and hydroelectric stations by means of jet pump to protect against flooding is developed.
CONCLUSION
On the basis of research on the doctoral dissertation on the theme: "Algorithms and methods of regulation of the pumping stations operating modes” the following conclusions arc presented:
1. Conducted systematic analysis of operation modes of pump stations showed that one of the main causes of accidents at the pumping stations is simultaneous electromechanical and hydro-mechanical transients, complicated by water hammer. In connection with this phenomenon the problem of development of methods and devices of the protection of the pumping stations main power equipment and pipelines against water hammer is becoming important.
2. A model of the system "pipeline - pump - electric motor - electric network", which allows investigating the power system transient modes at various emergency and operating conditions is developed: at changing the voltage on the buses, emergency shutdown of the synchronous motors, accidents associated with the pumps or pipelines, and so on. When an intermittent decrease in power of synchronous motor by 15% (0.85Pmot) unit stability is preserved, and the electromagnetic processes decay quickly and hydro-mechanical processes continue about 140s. By reducing power by 30% (0.7Pmot) unit enters the long-tern fluctuations. Power reduction by 50% leads to the violation of the motor stability and to the break of its synchronism.
3. Software system capable to calculate water hammer on pumping stations with piping diameters up to 4.2 meters is recommended, ft may greatly influence the selection of the main and auxiliary power equipment, the design and parameters of water conveyance structures. Certificates of official registration of programs for electronic computers number DGU 03124 and number DGU 03644 are taken out.
4. The use of bypass device at the pressure pipelines for reduction the amount of pressure increase at water hammer is recommended. When using the bypass device water hammer in pressure pipelines is considerably softer. When the pressure in one of the pipelines increases water escapes into the adjacent pipelines or when pressure decrease it causes water flow from adjacent pipelines. This reduces water hammer by an average of 40%, the pressure reduction duration reduces by more than 1.5 times.
5. The proportional device of butterfly valve control for the protection of the pumping stations against water hammer is recommended. The utility model Patent number FAP 01119 is taken out. Change of butterfly valve closing speed is occurring smoothly and proportionally to flow velocity in the pipeline. Technical characteristics of the programmable logic controller is programmed in such a way that when the liquid direct velocity changes in the pressure pipe to the reverse, i.e. at the moment of zero liquid velocity, fixed by a digital velocity sensor, butterfly valve is fully closed which eliminates the possibility of water hammer in the main equipment and pipelines during emergency electricity shut down at the pumping or hydroelectric station.
6. The method of simultaneous pumping of filtration, drainage and sewage water from buildings and adjacent territories of pumping and hydroelectric stations is recommended. It meets the requirements of reliability and safety of operation at the increase of water flow associated with duration of stations and pressure pipelines exploitation.
7. The result of calculating of parameters of the suction flows from the building and the adjacent territory of the pumping station became the algorithm of regulation of hydraulic float system. Analysis of the dependences showed that the maximum suction flow rate out of the pumping station territory is attained in the area of overlap of butterfly valve regulating float device at an angle of about 40°-45°.
8. The system of the simultaneous removal of the filtration, drainage and sewage water from buildings and adjacent territories of pumping and hydroelectric stations is designed and recommended. The utility model Patent number FAP 00592 is taken out. The device is designed to work in steady-state conditions and during emergency flooding.
9. The results of the dissertation arc implemented into practice at a number of pumping and hydroelectric stations. Performed complex experimental studies confirmed the adequacy of the developed methods and mathematical models. Maximum discrepancy between the theoretical and experimental values does not exceed 6%, which indicates the accuracy of the studies. Proven cost-effectiveness of the implementation of the results of the research is about 200 mln. sums per year.

The relevance and demanding of the subject of the thesis. Today, in the world practice, in the sphere of ensuring the stable operation of electric power systems (EPS), pride of place goes to the creation of high-performance control systems of power generation and consumption processes, involving intelligent technologies. One of the most crucial tasks of rapidly developing modem EPS is ensuring its steady-state stability based on real-time operational data processing and analysis. In this area, the leading countries of the world focus on the improvement of control systems to ensure the stability of electric power systems, taking into account fluctuations of mode parameters. «Expenses for the creation of intelligent electric systems, including Smart Grid, arc as follows: USA - 7.1 trillion, China -7.3 trillion, Japan - 0.8 trillion US dollars. The use of the Smart Grid system in 2020 will allow the USA to save about 1.8 trillion US dollars»1.
Large-scale activities on the effective organization of power generation and improvement of the EPS stability arc held in the Republic of Uzbekistan. A number of research works arc carried out in this area, including high-performance reequipment of the steam-gas and gas-turbine technology, providing electricity generation, the development of effective control system of technological objects and improvement of methods and algorithms of research of control systems.
The world's attention is paid to the development of more advanced methods for determining the stability of electric systems, in particular, matrix methods and algorithms that allow to more deeply explore the modal properties of electric power systems, taking into account modem control devices. The implementation of targeted research is a priority in this field, while researches arc more relevant in the following areas: the development of matrix methods and algorithms for determining the stability of the electric power system based on automatic generator field regulators; the development of simplified criteria for determining the limit mode for the stability of complex EPS; the development of a model of synthesis of automatic field regulators on the basis of the system inclusion technology. Ongoing researches in the above-mentioned areas show the relevance of the subject of this thesis.
This thesis research is designed, to a certain extent, to perform the tasks stipulated in the Decree of the President of the Republic of Uzbekistan ПП-2343 dated 5 May 2015ycar “On the Program of measures to reduce energy consumption, to implement energy saving technologies in the fields of economy and social sphere for 2015-2019 yy.”, in the Decree of Cabinet of Ministers of the Republic of Uzbekistan No.238 dated 13 August 2015 year “On approval of the regulation relating to the republican commission on energy efficiency and development of the renewable energy resources”, as well as other legal documents adopted in this area.
The objective of the research is to develop matrix methods and algorithms of analysis of steady-state stability of complex EPS, to develop simplified methods of estimation of steady-state stability limit and synthesis of controller models based on the systems’ embedding approach.
Scientific innovativeness of the dissertation study consists in the following:
on the basis of Lyapunov’s function in the quadratic form, the simplified criterion of steady-state stability of the electric power system was obtained, which consisted in positivity of the first major minor of the quadratic-form matrix (<7n > 0), ensuring necessary and sufficient conditions of the EPS stability;
the combined use of the method of Lyapunov’s function in the quadratic form and node voltage equations was developed, which allowed for reducing studies of steady-state stability of a complex electric power system to the circuitry of a simple electric power system, or the “generator-bus” system;
a promatrix of the complex unregulated and regulated electric power system was developed on the basis of the system’s embedding method, which allowed for the study of dynamic properties of EPS;
the algorithm of pole transfer from the spectrum of the matrix of own dynamics of the electric power system was developed, which ensured stability and damping of fluctuations of the operation condition parameters at small oscillations in electric power systems;
mathematical model of the class of regulators of the complex electric system was constructed on the basis of the system’s embedding method, which ensured stability and damping of fluctuations of the operation condition parameters at small oscillations in EPS.
CONCLUSION
The theoretical and computational-experimental studies of steady-state stability of complex electric systems, carried out on the basis of the developed matrix methods and algorithms, using Lyapunov’s functions in the quadratic form and system’s embedding method, allow for the following conclusions.
1. Lyapunov’s functions in the quadratic form arc recommended as the effective method for studying the linear dynamic systems, including the electric power system described with the help of linear zed differential equations.
2. Adequacy of conditions of the steady-state stability loss of the electric power system, obtained on the basis of positivity of major minors of the quadratic-form matrix of the Lyapunov’s function in the quadratic from, to the same conditions provided by Hurwitz criteria, was proven.
3. Obtained theoretical and computational results allow one to investigate the stability of EPS “in the small” by means of analysis of the positivity condition of the first major minor of the Lyapunov’s function in the quadratic formq11; > Oand consider it to be the practical (simplified) criterion of steady-state stability of EPS, providing for both its necessary and sufficient conditions.
4. The combined use of Lyapunov’s functions in the quadratic form and nodal equations allows one to reveal the generator (station), operating in the complex EPS, which is coming to the limit in terms of steady-state stability. The mathematical condition of this proposition is dqnj /dFl -» max, i.e. the maximum of the derivative of the first major minor of the quadratic-form matrix by the regulated parameter for the j-th generator. It is evident that in this case, the study of the steady-state stability limit of the complex EPS turns into the study of the “generator-bus” circuit.
5. On the basis of the systems embedding method, promatrices of the unregulated and regulated complex EPS arc developed, which provide a full description of all kinds of characteristics of transitional processes, including the possibility of studying dynamic properties of electric power systems at small oscillations of their operation condition parameters.
6. The model is proposed, in which the regulator of the complex electric power system has been synthesized on the basis of the systems embedding theory to describe analytically the class of regulators ensuring stability and damping of oscillations of the studied EPS.
7. The conducted computational-experimental studies aimed at analysis of steady-state stability of complex EPS on the basis of the systems embedding method have shown the qualitative match of the obtained results with the results, checked in the course of practical running of electric power systems on the basis of Classical Methods that confirms the adequacy of the models developed to the already existing ones.
8. The mathematical model of the electric power system, resolved relative to deviations of absolute angles of synchronous generators, is developed, which can be used autonomously for the study of small oscillations of complex EPS. This model of small oscillations must be used together with node voltage equations, determining voltage modules of nodes and their arguments, representing absolute angles relative to the balancing node.

The urgency and relevance of the topic of the dissertation. The experience of the advanced countries of the world illustrates that the sphere of rendering services is one of major factors of the national economy development. In many civilized countries the share of the services sector in the GDP fluctuates within 70-75%. Moreover, the main part of the population engaged in the economy is involved in this sphere, so this indicator in the USA accounts for 80% and in Japan amounts to over 70%. A significant part of services, in particular, of 99% of household services arc rendered by small businesses. In turn, up to 90% of expenses of small enterprises are financed by the loans and investments of commercial banks (in large corporations this indicator accounts for about 30%)37.
In Uzbekistan the services sector is considered as one of necessary conditions of ensuring a sustainable development of economy. «In 2015 the services sector has provided more than a half of the gain of the GDP (Gross Domestic Product) that illustrates how high is the role and impact of this branch on our economy»38.
Raising the share of loans of commercial banks, including increase of their share in the total volume of loans allocated by commercial banks to economic entities and population for developing services sector; raising a stable level of the cash flow at subjects of services sector; reduction of risks related to lending of services sector; raising efficiency of the use of commercial banks’ loans by the subjects of the services sector; improving the methodological bases of lending to services sector present an urgent scientific and practical significance for further development of the services sector in the international practice.
This doctoral research, to a certain extent, conduced the execution of the tasks determined by the Decrees of the President of the Republic of Uzbekistan №UP-1754 «On the program of developing a services sector in the Republic of Uzbekistan for 2012-2016» dated from May 10, 2012 and №UP- 4725 «On measures to ensure a reliable protection of the private ownership, small business and private entrepreneurship, removal of barriers to their accelerated development» dated by May 15, 2015 as well as other legal documents regulating this type of activity.
The purpose of the research is to develop proposals and practical recommendations aimed at raising efficiency of lending of services sector in the Republic of Karakalpakstan.
Scientific novelty of the research is the following:
efficiency of the accounting of the accrued interest charged by credit institutions for providing leasing services to the rendering services sphere at the price of the object of leasing and fair distribution of interest income by all the discount period, and covering of the share of interest income of leasing services of banks at the expense of the standard profit of the lessee has been proved;
the offer on application of lending and factoring forms by opening of credit lines in the activity of commercial banks has been proved; on raising the volumes of unsecured loans (without collateral) allocated to the sphere of rendering services by uniting in separate group of subjects of the services sector having a stable cash flow;
expediency of raising the volume of loans extended to the subjects specializing in rendering outreach types of service to replenish working capital and financing of their investment expenditures by their uniting in limited liability companies or in the form of share fund by acceptance of the liquid assets belonging to them as a deposit has been justified;
proceeding from specifics of the social and economic development of the Republic of Karakalpakstan, the proposal on covering interest rates (with the account that the refinancing rate of the Central bank is basic) the loans issued by commercial banks to the subjects of the services sector which arc carrying out their activity in northern regions due to direct financing of these banks by the state has been proved.
CONCLUSION
1. Loan efficiency, while determining profitability and social significance of loans extended by banks with the aim of satisfying material and spiritual necessities of the members of the society also means necessary condition of the timely and full repayment of the loan.
2. Development and implementation of the normative bases and measure of the gradual development of subjects of the services sector depending on the directions of their activities and taking into account regional conditions in the territory of the Republic of Karakalpakstan will enable to achieve a qualitative improvement in the services sector.
3. In the Republic of Karakalpakstan, on the one hand, there is the tendency of the growth of number of subjects of the services sector and a number of employees working in them, and on the other hand, urgent problems, such as sluggish activity of thee subjects rendering to the population individual household services, the insufficient level of development of the services sector in tailoring and repair of clothes, repairing of household appliances have been revealed.
4. On the basis of the analysis of the received results of a research it is possible to speak about feasibility of inclusion of the superimposed percent levied for provision of leasing services by credit institutions to the sphere of rendering services for the purpose of enhancement of leasing practice in leasing project cost as a trade margin and uniform distribution of interest incomes on all accounting period, and coverings of a share of an interest income of leasing services of banks by standard profit of the lessee.
The lessee, after he receives the object of leasing, after certain time reaches stable (normal) profitability level, and after that he can get the standard income. If he is demanded to pay interest payments from first months of the leasing contract, there can be a threat to the financial condition of the lessee who didn't reach the sufficient level of profitability.
5. With the aim of ensuring reimbursement in the framework of the leasing agreement, a lessor must require from a lessee an additional collateral.
6. In the activity of commercial banks it is necessary to adjust application of forms of lending and factoring by opening of credit lines, and also to increase amounts of unsecured confidential (without collateral) loans allocated to the sphere of rendering services by uniting in a separate group of subjects of the services sector with a stable cashflow.
Currently our republic hasn’t developed the practice of selection of clients in a separate group of subjects of the services sector with stable cashflow and their lending by credit lines without collateral, and by factoring, which hinders the increase of volumes of loans extended to this field. Moreover, registration of loan collateral is associated with an increase of expenses of the borrower associated with the loan. In addition, there can arise contradictions in harmonizing the margin of cost between the collateral and the loan (the ratio of the volume of the loan and the collateral value).
7. It is recommended to take into account the volume of loans extended to the subjects specializing in rendering outreach types of service to replenish working capital and financing of their investment expenditures by their uniting in limited liability companies or in the form of share fund by acceptance of the liquid assets belonging to them as a collateral.
Legal entities established in the form of limited liability companies for pledging its property for the purpose of getting loans from commercial banks, in accordance with the requirements of the Law of the Republic of Uzbekistan «On companies with limited and additional liability» must submit the original of the decision of the competent authority or its notarized copy to the bank.
After getting a loan, the issue of its distribution between the members of the limited liability company is solved by the relevant competent authority.
The result of the practical implementation of this proposal, first, the costs of commercial banks associated with lending to small businesses to provide services arc reduced; second, small businesses to provide services that do not have sufficient collateral, can also have access to loans of commercial banks; third, banks will be able to assess the solvency of the society with limited responsibilities as a separate legal entity and to formulate its credit history.
8. It is necessary to make changes and amendments to the legislation regulating the enforcement of obligations in the loan relations, and to introduce specific ways of lending of subjects of the sphere of rendering services and performance of obligations.
In accordance with Article 259 of the Civil Code of the Republic of Uzbekistan, execution of an obligation may be ensured by forfeit, pledge, retention of the debtor’s property, surety, guarantee, deposit and other ways provided by the law or contract. In practice, however, in credit relations arc mainly used only pledge, surety of third parties and forfeit. When working with such forms of collateral, bank employees make some mistakes andfaults, whereby while turning the execution of the obligation to the collateral object and receiving the ownership of the debtor’s property from the lending bank, many problems can arise.
9. With the aim of raising efficiency of lending to the services sector it is necessary to introduce the norms for the non-performing loans, resource deductions and cost of loans.
10. Basing on the specifics of the socio-economic development of the Republic of Karakalpakstan it is necessary to accept the proposal for the coverage of interest rates (with the account that the refinancing rate of the Central Bank is a basic rate) loans extended by commercial banks to the subjects of the services sector carrying out their activities in the northern regions, through direct funding of these banks due to the funds of the state budget placed in the authorized capital of these banks.
This proposal is based on the system of the state financial support to the lending practices of banks.
The result of the practical implementation of this proposal, firstly, the level of using loans of commercial banks by the entities of the sphere of rendering of services will increase; second, the interest of commercial banks in lending services will also rise as the level of credit risk will reduce for banks. That is, the difference between market rate loans and a reduced rate will be charged to the branch of the commercial bank by its Head office the expense of the state budget.
11. There is a strong correlation and regression connection between the indicators of the services sector development and the volumes and efficiency of loans.
The increase of the annual interest rate of loans extended to the services sector, by average one percentage point will result in raising profitability of the loans extended by banks by average 0,80%. The increase of the volume of loans, extended by banks by average one percentage point will lead to the decrease of these loans’ profitability by average 1,80%;
Coefficient R2, demonstrating the sizes of ratios of the obtained results arc equal to 0,8. This justifies the presence of the strong economic dependence between these economic indicators in this model.

The urgency and relevance of the theme of the dissertation. In the world, in particular, the requirement for natural fiber grows in cotton fiber. Now in more, than in 25 countries of the world preliminary processing of cotton fiber is issued and made. Now one of actual problems of the cotton industry is improvement of technological machines taking into account modem requirements, working out of working bodies and transfers of technological machines on scientific basis and their introductions in the industry. «In this branch in the USA, China, India, Brazil and other states arc reached certain successes, is paid special attention production efficiency in the cotton industry and to improvement of technological machines and equipment with view of maintenance of competitiveness of production»1.
Wide actions for perfection of technological processes in the cotton industry and to creation of highly effective units and machines arc carried out. In this area number of research works, including working out of automatic control systems of operating modes of technological machines of the cotton industry and production quality assurance, creation new geared mechanisms of working bodies for the purpose of high efficiency maintenance, substantiation of their technological parameters and movement modes have been spent.
In world practice special value has perfection of technics cotton-industry by creation of the new transfers influencing quality indicators of cotton fiber. Therefore one of the important problems is completion of target research works, including, scientific searches in following directions: working out of new effective designs of belt and chain transfers with the variable transfer relation, substantiation of laws of the movement accelerating necessary technological processes and working out for this purpose optimum geared of mechanisms, working out of effective designs of the working bodies, allowing increase of productivity and reception of cotton quality fiber.
In certain degree the present dissertational research is directed on the decision of the problems planned in the decree of the president of Republic of Uzbekistan No. ПФ-4761 dated October 27, 2015 «About creation of holding company Uzpaxtasanoatcksport», in the decision of the Cabinctof Republic of Uzbekistan No. 70 dated April 3, 2007 «Modernization and reconstruction of the enterprises of cotton industry in 2007-2011» and corresponding in is standard-legal documents.
The aim of the researchcrcation of new effective schemes of working bodies geared mechanisms of technological machines of the cotton industry, working out of the parameters providing rcccptionof high-quality cotton fiber.
Scientific novelty of dissertational research is concluded in following:
The workingbody and cylinder wire-typing machines arc improved, the device of clearing of dust of working body of baking powder is created;
The new schemes of design providingnecessarylawsof movement of working body of baking powderarc created;
The new schemes of design providingnecessarylawsof movement of working bodies of technological machines of the cotton industryarc created;
Methods of the kinematic analysis of new schemes of transfers arc developed;
New methods tension definition in conformity arc developed by the developcdschcmcsof belt drives;
Laws of movement of working bodies of units taking into account the recommended new schemes of transfer as part of technological machines of the cotton industry arc received;
The experimental method dcfineslaws of movement and loading of working bodies, the substantiation of rationalparametersof the technological processes providing quality of fiber also is executed.
CONCLUSION
Results spent scientific investigated on thesis for doctor's degree theme «Creation of rational schemes the basic technological machines of the cotton industry and methods of calculation of parameters» consists of the following:
1. New effective schemes geared mechanisms of technological machines (a clap separator, drying cylinder, the unit of clearing of clap of small and large rubbish and Linter machines) arc developed and recommended the cotton industry. New effective constructive schemes of separate working bodies of separator of clap, the unit for clearing of clap of large and small rubbish and lintcring machines arc created.
2. The new design of belt drive with the effective variable transfer relation, having compound with an clastic element an eccentric tension roller for application in transfer mechanisms of technological machines is recommended.
3. The analytical method of calculation of tension in transfers with vertical and horizontal consumer extensible and not extensible belts is recommended. The expressions showing communication of tension of belt from parameters of transfer arc received. On the basis of their analysis it is possible to ascertain the following: an increase to an extensibility of material of belt leads to pressure reduction; facilitates uniform distribution of tension between belt branches; the belt friction is characterized by the form of cross-section section of belt and vector of jet pressure force in the conditions of contact; laws of movement of pulleys from tension roller belt transmission, relations of diameters the guiding and conducted pulleys arc defined.
4. For technological machines of the cotton industry the kinematic analysis belt transfers with the variable transfer relation is executed by an analytical method and expressions for angular speed the guiding pulley arc defined. Angular speed, angular acceleration of conducted pulley of belt drive with PPO, laws of change of the transfer relation depending on eccentricity and radius of tension roller arc defined. Schedules of amplitudes of angular speed of conducted pulley of transfer depending on eccentricity arc constructed and radius of tension roller, laws of reduction of fluctuations of angular speed and transfer the relation with increase in radius of tension roller arc defined; the mathematical expressions arc defined, allowing to find preliminary tension and factor of sliding of belt of belt drive with PPO drive.
5. Settlement schemes arc developed for systems (drying the unit, clap regenerator, saw gin, fiber-extracting, Lintcr machine), having an advanced drive of technological machines of the cotton industry, also arc received the mathematical models expressing laws of movement of working bodies. Laws of movement, angular speed and rotating moment arc received at loading of rotor of the electric motor on the basis of the numerical decision of the equations.
6. Settlement schemes arc made and mathematical models improved geared mechanisms of regenerator of clap, dusty gin, fiber-extracting, Linter machines taking into account the mechanical characteristic of the electric motor, belt drives with PPO and resistance of clap arc received.
7. Laws of change of fluctuation of angular speeds of rotating weights depending on the inertia moments stake roller cylinders arc defined. For cleaner from small rubbish the most comprehensible values arc recommended:
J, = (0,02 - 0,026)Hmc2; J2=(0,32-0,35)Hmc2; J3 =(0,27-0,30)Hwc2
8. For maintenance of corresponding factors of non-uniformity of angular speed the elastic factor of belt drives (350-450) Nanometers/is glad is recommended.
9. As result of application of offered transfer mechanisms for technological machines of the cotton industry the following data of tests is obtained:
- in the dryer to the machine under the recommended scheme of drive under the relation there is: fiber-extracting is increased by 1,2%; the cleaning effect has raised on the average on 4,1 ... 4,5%; fiber waste on the average on 0,45 has decreased 0,5%;
- in the advanced separator device under the relation of separator SS-15A the damaged seeds and parts of fibrous seeds decreased almost two times, allocation small and large rubbish has increased by 2,3%;
- in drive of cleaning section from small rubbish establishing belt drive for everyone stake roller cylinder separately at use of corresponding eccentric tension rollers in relation to the existing scheme efficiency of clearing increased by 5,1%, the sum of waste and defects of fiber have decreased for 0,23%, mechanical damage of seeds has decreased on 0,1%;
- at application of recommended chain transfers, brush platens, design of gridirons rather variant increase of cleaning effect on 16,34% is reached, damagcability of seeds has decreased on 1,46%, the quantity of free fibers on clap has decreased in 2 times. The drive resource has increased almost two times.
- in the saw gin with chain transfer and facilitated sawing the cylinder in relation to the existing machine the quantity of the damaged seeds has decreased for 0,03%, combined defects of fibers have decreased on 0,08%. part of seeds with fiber has decreased on 0,02% if productivity has increased in an hour of 18 kg the fiber exit in an hour has raised on 1,18%;
- by results of tests of the unit with recommended for fiber cleaner 1VPU facilitated sawing the cylinder and having chain transfer with compound asterisk in relation to the existing machine in the recommended variant the sum of waste and defects have decreased for 0,215 %, including small waste on 0,008%, large waste on 0,195%, the damaged seeds on 0,0105%;
- as result of application of the recommended belt drive with PPO in drive agitator lintcring machines concerning existing lintcring machines 5LP decreased omission of seeds for 1,9%, mechanical damage of seeds on 0,7%, waste as part of down and mass quantity of the whole seeds on 0,5%. In relation to down productivity has increased to 4,3 kg / hour, the down exit has raised on 0,4%. The general annual economic efficiency improvements drives has made 124 mln 914 thousand sum.

The topicality and significance of the subject of dissertation. At the present time the cocoon and silk products occupy an important position in the world market. Every year harvested an average of 640 thousand tons cocoons and among countries growing cocoons was worked 130 thousand tons of raw silk in 20151. In view of the international market demand, special importance is the production of high-quality competitive product made of natural silk. As a result, on the quality of raw silk material for the production of textile products arc placed high demands. Therefore, the most urgent problems of today is to increase the rate of cultivation of cocoons, production of raw silk, fabrics, knitted fabrics and other products, improvements in technology and methods of production of the product. In the field of production and conversion of silk certain success, including, in China, India, Brazil, Japan, Uzbekistan, Koreas and other countries, implementation of technologies of increase in efficiency of reeling of cocoons and production of raw silk providing product competitiveness and remaining one of the major tasks is achieved.
In days of independence in the country special attention was paid to effective development of silkworm breeding, and also production of raw silk and silk products with high qualitative indexes and competitiveness. In this aspect notable results, including, enhancement of the equipment and the production technology and conversion of silk, receipt of high-quality production from local raw materials, expansion assortments of silk products arc achieved.
In world practice, special attention is paid to the creation of new breeds and hybrids of cocoons, improving primary processing technology and producing high quality raw silk. In this connection, an important task is based on a single unwinding, development of modeling unwinding cocoons dynamics create a theoretical basis to justify the technological parameters of high-quality raw silk, yam: torsion as a raw material for the production of knitted fabrics, surgical and «Silk Lycra», as well as cotton-silk yam. Completed research projects related to the above listed tasks confirm the relevance of the theme of this thesis.
This dissertation research is to a certain extent the tasks provided for the Resolution of the President of the Republic of Uzbekistan N PP-512 of November 15, 2006 «On measures to further reform the silk industry of the Republic» and the PP-1442 of 15 December 2010, «Priorities of industrial development of the Republic of Uzbekistan in 2011-2015», as well as the Cabinet of Ministers dated August 2, 2012 №234 «On additional measures to increase the volume of production of non-food products in 2012-2015». Innovative technologies for processing of local raw materials domestically, as well as other regulatory legal instruments adopted in this area.
The aim of the research. On the basis of improving the technology of new local unwinding of cocoons hybrids, producing high-quality raw silk to provide methods and develop a wide range of silk products.
Scientific novelty of dissertational research is concluded in following:
a process for preparing a mixed bi-componcnt yam;
a method of preparation of twisted silk yams for knitwear;
a process for preparing a combined yam "Lycra Silk";
defined patterns of influence and shape parameters of the reel, the properties of the shell cocoon unwinding on the technology development of raw silk of high quality;
develop parameters of modem hybrids cocoons allow to produce high quality raw silk, meeting the requirements of world-class standard "A".
developed a shortened two transition process for producing surgical eye improved quality yams.
CONCLUSION
On the basis of the survey on his doctoral dissertation on the theme "Improving the technology of new unwinding of cocoons and obtaining high quality raw silk local hybrids" arc presented the following conclusions:
1. Justify and obtain analytical expressions taking into account plots dynamic tension of inertia and movement on semiimmersed cocoons axis.
2. Movement periods immersed cocoon modeled and tested in the four phases of the movement and found that when a static cocoon is at the bottom of the tub and unwinding pops up and unwound in semisubmerged condition.
3. On the basis of theoretical and experimental studies have established that:
• The abrupt change in the speed of unwinding hex reel leads to tension force variations and creates conditions for breakage cocoon thread and deterioration of quality indicators of raw silk;
• it is advisable to proceed with the reel round shape.
4. By a single unwinding found that:
- The interception zone cocoon thread tension is increased by several times (3 to 0.2 cN), which in turn leads to yam breakage and negatively affects the quality of the product; cocoons evenly rounded spherical unwound almost without break; necessary to achieve breeders breeding breeds and hybrids producing cocoons rounded shape.
5. On the basis of a research of properties of covers and the cocoon’s threads, and also dynamics of reeling of local new hybrids of cocoons of a improvement technology reeling parameters for production of raw silk meeting the requirements of the international standard of a class "A" arc also set.
6. A process chain, cut into two processes than the current, to produce ocular surgical improved quality of threads: the limits of deviation from the linear density of 25-40% decreased, and the relative breaking load increased by more than 20% compared with the control.
7. The technology of production of bi-componcnt yam "Silk Lycra"on the way to the novelty of the patent №1AP04441.
8. The technology of production of cotton-silk yam with improved physical and mechanical properties by 20-40% compared with pure cotton (patent №IAP04347)

The topicality and significance of the subject of dissertation. In the world of cotton cleaning industry creating of cleaning system of seed cotton from foreign matters based on the alternative technological processes takes up the leading role. In connection with that in the USA, Australia, China, India, Uzbekistan and other countries a special attention is fixed consideration given to rising of the efficncy of production in cotton cleaning branch and provision of competitiveness of fiber. Due to using of alternative technology machinery and primary ginning of seed cotton natural properties of fiber the certain progress in reduce production costs was achieved1.
In the Republic of Uzbekistan a large scale measures in creating of technological processes and high effective machinery in cotton ginning industry have been realized. In this connection with a number of researches, in particular, in creating of controlling system of multiplex cleaning of seed cotton dust, innovative development of technological processes, technology of cleaning from small and large foreign matters with the help of hot air and feeding system in cleaners have been stated.
In the world, in creating of alternative technologies of seed cotton cleaning, machinery and application of the achievements of science to production is given fixed consideration. In this connection with the aimless scientific researches in the directions of including the creating of variable automatic system of cleaning technology of seed cotton from dust, the new methods and directions of cleaning technology, high productive, alternative technology of equipment, technological flow lines, combination of drying and cleaning of seed cotton have been realized. Conducting researchs on the above scientific areas e world confirms the actuality of the dissertation’s theme.
This dissertation research is to the certain extent focused on the tasks for the implementation of measures provided by Presidential Decree of the Republic of Uzbekistan dated October 27, 2015, №PP 4761 «About the formation of holding company of Uzpakhtasanoat» and the Decree of the Cabinet of the Ministers of the Republic of Uzbekistan dated April 3, 2007 №70 «About the program of modernization and reconstruction of cotton cleaning industry for the period of 2007-2011 years», as well as legal documents adopted in this area definite degree serves for caring out the problems
The aim of the research is the development of the effective technology of seed cotton cleaning from small and large foreign matters, the new resources saving of working parts of cleaners and also the creation of a mass line production on the base of cleaner with the successive technology.
Scientific novelty of dissertational research is concluded in following:
a cleaner of seed cotton from foreign matters with the successive technology was developed;
a drum with the long splits for seed cotton cleaning from foreign matters was developed and determined its technological parameters;
a removal drum that taking off from the surface of saw drum, the directing drum, the fixing device were developed;
technological indicators of less worn-out of the working parts of a new cleaner were determined;
an effective mass line for cleaning seed cotton from small and large foreign matters was created.
CONCLUSION
On the basis of the survey of this doctoral dissertation on the topic « Creating the effective technology for the cleaning process of seed cotton and construction of rational working parts of the cleaners» the following conclusion arc presented:
1. It has been determined entering despite the arrangement of two rows of seed cotton cleaning UHK. aggregates for lack of seed cotton cleaning because of entering in many cotton gins on a share of fiber according to high class has in sufficient volume. Entering gins of seed cotton with the obstruction above rate of indicators, a quality of seed has been reduced by one class and the more,manufactures, processing 3000 tons of seed cotton will receive the profit more than 500mln sum.
2. It has been determined, one of the main reason that seed cotton arc not cleaned by the required degree due to violation of technical processes of cleaning, imperfection of working parts of seed cotton cleaners from large foreign matters, breakage of saws gin drums, worn-out of brushes of the removal drums and grid brushes.
3. Thc opportunity of improving the efficiency of cleaning by means of changing distribution of removal and cleaning drums having achieved the maximum length of arc cleaning in existing cleaners of seed cotton from large foreign matters at the distance between two fire-bars 60-80mm is achieved by the highest efficiency of cleaning.
4. The rubber strip drum and directing metal drum were developed and inculcated in production.
5. The fixing device for holding the seed cotton on the surface of saw gin drum was developed.
6. The drum with long splits for catching the foreign matters was created and inculcated in production.
7. The saw cylinder of seed cotton with successive technology of cleaning with the less worn-out working parts was created. The researches of the new cleaner showed its total cleaning effect which made 65% and 85% by large foreign matters, the quantity of seed cotton in wastes as in regenerates RH, mechanical damage of seed and a number of frequent fiber in seed cotton cleaning remains in limits of rates. Practical tests of cleaner with the successive technology showed the efficiency of its work with the productivity of lOtons per hour on the first classes and 7 tons per hour on the low classes of seed cotton with the high obstruction and humidity.
8. The mass line cleaning on the base of saw gin cleaner with the successive technology cleaning and the drum with the long splits was developed. Practical tests of the mass line showed that its cleaning effect made 80-90%
9. The jointly using of metal strip drum, fixing device and the drum with the long splits to the passage of the fiber to higher class and inculcation in production the new mass line due to reducing productive principle expenses give a total economic effect 324,2 mln sum.

The topicality and significance of the subject of dissertation.In the world market demand for natural production, including cotton the fiber, increases. According to the international advisory committee on a cotton (ICAC) «the leading countries on delivery to a foreign market of a cotton fibre arc China, the USA, India, Pakistan, Brazil and Uzbekistan». In a season 2016-2017, concerning previous, manufacture cotton a fiber on 5,1 % (22,48 million ton), and demand for 1,7 % (24,09 million ton) is predietted increases' . Cotton-raw processing is carried out on process equipment’s, basically, made in the USA, China and Uzbekistan. One of the important problems for stability of volume of cultivation of a cotton crop and increase of compc-titiveness of raw materials in the world market is the further improvement of quality a fiber. In this direction research works for creation of new generation technologically reliable and highly effective equipment a cotton-raw preprocessing arc conducted.
In Republic Uzbekistan wide actions for working out highly effective technics and technologies for a preprocessing of the cotton-raw, providing improvements consumer properties of their production arc carried out. Here the great value has the technics and technology introduction, providing preservations quality and quantity of a prepared cotton-raw and developed cotton production in cotton cleaning the enterprises, giving possibilities decrease in the expense of raw materials and electric energy.
In world practice the special attention is given to questions of working out of new samples of technics and the technologies of drying positively influencing technological processes of processing and quality indicators of a cotton-raw. Here the major a problem is carrying out target scientific research in directions of creation of scientific bases of law change heat physic indicators of a cotton and its components, a substantiation of uniformity and speed of drying of a fiber and seeds in non-stationary process warmly and mass exchange, fibers providing release with a competitive quality indicator. Research works performed on the set forth above directions confirm an urgency of a theme of dissertational work.
The given dissertational research in certain degree serves performance of the problems provided by the Decision of the President of Republic Uzbekistan №PO-4761 from October, 27th, 2015 «About formation of holding company Uzpaxta-sanoatexport» and the Decision of the Cabinet of Republic Uzbekistan №70 from April, 3rd, 2007 «About the program of modernization and reconstruction of the enterprises cotton cleaning to the industry for 2007-2011», and also in other is standard-legal documents accepted in given sphere.
The aim of the researchis creation high-cfficicncycotton drying installations and technologies on the basis of an intensification warmly-mass exchange processes.
Scientific novelty of dissertational research is concluded in following:
the new technology and high-cfficicncy drying drum with an advanced design of internal devices arc developed;
the method of calculation of changes of heat conductivity and thermal capacity of a cotton-raw, fiber, the downy and bared seeds depending on humidity, volume density and drying temperature is developed;
the mode of drying providing uniform drying of a cotton fiber and seeds on the basis of various laws of distribution of warmth in weight of a fiber and a kernel of seeds, humidity in space and on time is developed;
the method of calculation of the effective (resulted) heat conductivity of a damp cotton-raw, on the basis of the theory of distribution of heat in the porous environments considering multi components environments is developed;
changes of volume of a kernel and peel of seeds, formations of air space between them during drying and degree of influence on them of initial humidity of a cotton-raw arc revealed;
possibility of an effective utilization of length of drying drum in the course of drying on the basis of laws of defining changes of temperature of air, cotton-raw and humidity components is created.
On the basis of results of the made researches on creation high-cfficicncy drying installations and technologies on the basis of process intensification arc warmly-mass exchange presented following conclusions:
1. It is revealed necessity of carrying out of researches on defined thermo physic properties of components of a cotton-raw, on research of possibility of operating technology and techniques of drying on maintenance of increase of intensity and uniformity of drying with optimization heat moisture conditions of air and parameters of drying installations.
2. On the basis of spent research on establishments of dependence of heat conductivity of a cotton-raw and its components from humidity, cotton-raw density, and also air temperature it is defined the following:
It is established laws of change of heat conductivity of a cotton-raw, a fiber and seeds from their humidity, density and air temperatures. It is thus defined, that heat conductivity of a cotton-raw is more than heat conductivity of a fiber, with growth of humidity and temperatures of drying the difference size between them increases;
It was observed, that at humidity of the downy and bared seeds to 7 % of temperature of drying on their heat conductivity does not influence, with the further growth of humidity the heat conductivity factor slowly raises and further fast growth in the form of the curves having nonlinear character is swept up.
It is defined, that at identical humidity, heat conductivity of the bared seeds depending on degree falling is more than volume density and temperature of drying 1,2-2,2 times, than heat conductivity of downy seeds.
3. It is developed a technique and the scheme of processing of experimental data by definition of a thermal capacity of a cotton-raw and its components.
It is offered to dependence of a thermal capacity for a quantitative estimation of influence of temperature and density on a thermal capacity of a cotton-raw, a fiber, downy and bared seeds. It is established increases of a thermal capacity of a cotton-raw and its components with humidity growth, and with temperature growth, not to linear laws.
4. On the basis of the theory of distribution of heat in multi-component environments the method of calculation is developed for definition of change of effective heat conductivity of a damp cotton-raw, possibility at sufficient level is as a result created to conduct numerical calculations differential the equations heat mass exchange at cotton-raw drying.
The method of calculation is developed for definition of change of effective heat conductivity of a damp cotton-raw on the basis of the theory of distribution of heat in multi-component environments.
5. Laws warmly and mass exchange processes in a fiber and seeds, spatial and time distribution of heat and a moisture in fibrous weight and a kernel arc received, is as a result defined, that a difference of fields of temperature and humidity on length of a fiber is insignificant and in short time they is leveled, and temperature of heating of kernels of seeds low, at identical modes average time of drying of a fiber and seeds the various.
6. It is established, that because of complexity, multi component , distinctions thermo physic characteristics of components of the cotton-raw, put into practice convective the way of drying does not eliminate a difference in heating temperature in cotton-raw components, docs not provide uniform moisture selection from components that presses additional conditions thermo moisture for processing for achievement of necessary technological humidity of a fiber.
7. Quantitative estimations of change of volume of a peel and a kernel of a seed in the course of drying arc made. For the first time it is made qualitative and quantitative estimations of influence of the air space formed between an internal surface of a peel and an external surface of a kernel on efficiency of drying.
8. Achievement of an intensification of process of heat exchange by increase in a surface of contact of external surfaces of the cotton-raw which is in a blockage and on blades, and rise in temperature of heating of internal devices of a drum is experimentally established. It is shown increase achievements moisture selection dryers on 64,2 % (per.), thanking heating rise in temperature a drum to 70°.
9. It is defined optimum frequency of rotation of a drum on the basis of the received mathematical model moisture selection, arc thus provided uniform distribution of a cotton-raw in cross-section section of a drum at the expense of use of a useless zone for cotton-raw drying.
Economic benefit of introduction of an advanced dryer at the expense of increase moisture selection and decrease in a mass fraction of defects and weed impurity of a fiber makes 17400 sum counting on 1 ton of the dried up cotton-raw.

The urgency and relevance of the theme of dissertation. An estimated food and agriculture organization of the UN in 2050 year to satisfy the demand for food the annual global production of agricultural crops and animal production must increase by 60% compared with the level of 2006 year6. In the world every year because of the damage generated losses of grain products by 30%, root vegetables, fruits and vegetables by 40-50%, oilseeds, meat and dairy products by 20% and fish by 35%7.
In the years of independence of special attention is paid to the cultivation and efficient development of the industry, processing agricultural products. As a result of conducted in this area of program activities, including to ensure the quality of processing of products of agriculture and forestry, tangible results have been achieved in the production of import-substituting and export-oriented food and pharmaceutical products. In 2015 year the country is grown 200,3 tonnes of tubers of Jerusalem artichoke and 199,2 tons of rose hips8. One of the most widespread methods of processing of these products assumed to be their drying.
Today important objective of global scale is the development of equipment and technology for the processing of products of agriculture and forestry, including the Jerusalem artichoke and rose hips, special attention is paid to improvement methods of processing of raw materials through the application of new technologies, taking into account the results of scientific research in this area focused on the preservation of biologically active substances in the finished product. It is necessary to substantiate the appropriate scientific decisions and recommendations aimed at improving the methods of drying and the development of technology for obtaining high-quality products, including the necessary: to develop equipment and technology of processing of Jerusalem artichoke and rosehip with the preservation of biologically active substances in the composition of the final products, to develop a mathematical model of the distribution of trace elements in the drying process, to explore and formalize the process of heat transfer, taking into account the changes of heat in infrared (IR) heating and nonlinear heat transfer phenomena, as well as examine the activity of heat during drying of the product to develop a vacuum drying apparatus with infrared heating and mill to produce a powder of the dried product. Actuality of and relevance of the theme of the dissertation is confirmed by the implementation of scientific research in this direction.
This dissertation research is to a certain extent perform tasks provided for the Resolution of the President of the Republic of Uzbekistan PP-1047 of 26 January 2009 year «Concerning Additional Measures for increase food production and saturation of the domestic market» and PP-1633 of 31 October 2011 year «On measures to further improve the management of the organization and development of the food industry of the republic in 2012-2015», as well as other legal and regulatory documents adopted in this area.
The aim of research work it is to improve the technology for the processing Jerusalem artichoke tubers and rosehips using a vacuum dryer with infrared heating, providing increased energy efficiency and technology of equipment and preservation of biologically active substances.
Scientific novelty of the research work is as following:
determined the kinetics of Jerusalem artichoke tubers drying process and rosehips in a vacuum-drying equipment with infrared heating;
substantiated model of the motion of moisture in capillary pores and the distribution of microelements in the products of the process by controlling the drying process in the preparation of high-quality products;
determined the transfer of heat and moisture in the internal layers of the material in the low-vacuum conditions with infrared heating and revealed the specific features of the nonlinear propagation of heat in terms of discrete modes of the drying process;
substantiated comparative analysis of processing methods sorption isotherms and desorption appropriateness of the choice of the method of orthogonal regression equation in the form Posnova;
developed a mill construction with a cooling system to produce a powder of sugar-containing products;
determined by the vacuum pressure and the optimal drying temperature in the vacuum system with infrared heat to dry the tubers Jerusalem artichoke and rosehips with preservation of bioactive substances.
On the basis of the research on a doctoral thesis on «Development of technologies for the processing of the tubers of Jerusalem artichoke and rose hips with preservation of biologically active substances» provided the following conclusions:
1. As a result of the analysis of the modern state theory and practice of drying and heating activation of Jerusalem artichoke tubers and rose hips encountered trends their further development and improvement, which made it possible to put forward innovative ideas. As one of the most effective methods of drying the tuber of Jerusalem artichoke and rose hips products acts dehydration in vacuo with an infrared heating.
2. Developed and implemented a mathematical model of movement of moisture in the capillary pores studied materials showed the need to address the internal redistribution dissolved substances, and also confirms the regularity dynamics of the drying process under the given initial conditions with attendant phenomena sorption and desorption in the internal structures of the capillary channel walls. Proposed non-linear functional connections between the pressure inside the capillary, hydrodynamic movement speed, temperature, and density of the investigated material.
3. Proposed parametric identification of the correlation coefficients of a mathematical model and carried out analysis of the experimental statistical data.
4. The dependence of the irradiation power of the distance between the object and dewatered emitters and defined between emitters and methods of providing a uniform distribution of infrared radiation in the volume of dewatered products by means-reflector elements corresponding configuration in a vacuum drying installation with infrared heating.
5. Proposed sorption and desorption characteristics of tubers of Jerusalem artichoke: shows a capillary specific surface constituting 18,38 m2/g and the total pore volume for artichoke in the conditions vacuum infrared drying is 0,440 cm3/g. For the rose hips characteristic sorption and desorption: confirmed the specific surface area of the capillaries of 12,30 m2/g and the total volume of pores amounts to 0,390 cm3/g.
6. According to research of thermotechnical and sorption properties of the dried product identified: allowable temperature, drying time and construction vacuum drying equipment with infrared radiation. The method of calculation of industrial vacuum drying equipment with infrared emitter based on the results of experimental studies in a laboratory equipment.
7. It is shown that for the process of infrared drying fruit is necessary to optimize the amount of power input, so that the fruits quickly dehydrated. The optimum thickness of the product layer constituting about 2-2,5 mm, the optimal wavelength 3 mm, and the production time of dehydration amounts to allowable value, and temperatures do not exceed fruits 65-70 °C, while vacuum amounts to -0,8 atm.
8. As a result of an experimental research the influence of vibration on the technological process of drying found that dehydration efficiency increases to 4-5% in the conditions continuous heating - at a certain frequency and amplitude. It is shown that the composition of preservation inulin shredded pulp from Jerusalem artichoke tubers in a process of vacuum drying amounts to infrared to 45,4 mg%, and the slices of tubers of Jerusalem artichoke to 38,75 mg%, and thus the safety of ascorbic acid in the fruit pulp under vacuum rosehip infrared-drying up to 0,77 mg%. As part of the same fraction of the seeds rose hips contains ascorbic acid at a vacuum infrared drying up to 4,0 mg%. 
9. A result of researches established that using the method of vacuum drying with an infrared heating and the reflector at a temperature no higher than 60-70 °C allows save electric energy by 10-12%, and a full structure of vitamins and other biologically active substances (inulin and ascorbic acid) in the final product is 80-90%. 
10. Modernized technological line for producing a powder of Jerusalem artichoke with a vacuum drying installation with infrared heating and hammer mill. Developed and implemented an aerodynamic separator for fractionation (pulp, seeds, fluff) crushed rose hips. On the basis of these results is recommended for implementation in the industry to develop technological regulation for the production of powder from the tubers of Jerusalem artichoke varieties «Muzhiza» and the rose hips.
11. Developments and the recommendations of the thesis in the technology for processing of Jerusalem artichoke tubers and fruits rose hips at preservation of biologically active substances introduced into the State Joint Stock Concern «Uzfarmsanoat» and the entities of the system of the Ministry of agriculture and water management (Reference the State Joint Stock Concern «Uzfarmsanoat»from 30.11.2015 year MD-06/1868 and Ministry of agriculture and water management from 10.09.2015 year 06/14-893). A result of applying the vacuum drying technology with infrared radiation productivity increased by 1,2 the average annual overall economic efficiency was 233 million sum.

The urgency and relevance of the theme of dissertation. Today in the world practice of the the natural sciences the development of methods of efficiency of the reaction-diffusion processes control system, study of nonlinear mathematical models is considered one of the most urgent tasks. According to the Elsevier information base the scientific works of scientists around the world devoted to the study of nonlinear reaction-diffusion equation, as the Cauchy problem and boundary-value problems to this equation and their practical applications.
In the Republic of Uzbekistan conducted extensive works on the effective organization of events dedicated to the development of automated systems for the computer visualization of diffusion processes, mathematical modeling of diffusion processes described by nonlinear equations with double nonlinearity in a heterogeneous environment. At the same time, carried out a series of research projects dedicated to the improvement of research methods and visualization of non-linear process, the creation of automated production systems, which play an important role in the study of mathematical models of nonlinear processes.
Currently, in the world a number of fundamental problems require mathematical modeling of nonlinear processes, the improvement of the methods and visualization tools, and applying to the practice of obtaining important results of the reaction-diffusion problems with double nonlinearity. At present, the study of equations with double non-linearity and practical application, conducting targeted research on the following areas is considered one of the most important tasks: the development of imaging methods in the study of nonlinear models; creating software systems that help the study of nonlinear processes; creating technology of computational experiment, monitoring the evolution over time of the process, the establishment of a computerized system of determining the properties of which depend on the parameters of the dynamics of change. Research carried out on the above areas of research, indicate the relevance of the topic of this thesis.
Research of this thesis, to a certain extent, serve to implement the objectives of all legal acts on this activity, the decree of the President on March 21, 2012 № PP-1730 «On measures for further implementation and development of modem information and communication technologies», dated December 15, 2010 № PP-1442 «On the priorities of industrial development of Uzbekistan in 2011-2015», Resolution of the Cabinet of Ministers dated February 1, 2012 № 24 «On measures to create conditions for further development of computerization and information and communication field of technology», as well as other legal documents adopted in this area.
The aim of research work is consists of mathematical modeling of reaction-diffusion, heat conductivity, luquids and gas distribution, filtration processes described degenerate parabolic equations and systems of equations with double nonlinearity with the influence of the source and absorption.
Scientific novelty of the research work is as follows:
the properties of finite speed of distribution of the disturbance and spatial localization, proof of the asymptotic behavior of blow-up solutions of reactiondiffusion systems with double nonlinearity and with variable density have been studied;
global solvability of the Cauchy problem for a model reaction-diffusion equation with double non-linearity to the source or absorption have been proven;
the estimates of the solution, and the front and for the class of systems of equations with double nonlinearity parabolic, asymptotic expressions of generalized solutions with compact support for degenerate nonlinear self-similar equations and systems have been produced;
the solution of type Zcldovich-Barcnblatt to the mutual diffusion system with double nonlinearity with a source and convective transfer have been found, the properties of finite speed of distribution of disturbations and spatial localization arc shown and an algorithm for determining the value of the critical exponent have been developed;
on based of the properties studied nonlinear mathematical models, have been built an iterative process that converges quickly;
nonlinear problem for a system or a degenerate parabolic equation with double non-linearity, take into account external factors and properties of the medium (variable density, medium conductivity, convective transfer, etc.) has numerically solved.
CONCLUSION
On the topic of the doctoral thesis «Mathematical modeling of reactiondiffusion systems with double nonlinearity» presented the following conclusions:
1. In solving problems of nonlinear models of reaction-diffusion, filtering, heat conductivity, as in homogeneous and in heterogeneous environments, based on the theoretical study by the self-analysis and the comparison principle, the analysis of the use of computational algorithms and software complexes isolated original properties and defined the further development of research.
2. The proposed methods arc used to study the properties of FSPD and localization solutions of nonlinear reaction-diffusion model with double nonlinearity for variable density environments by constraction solutions of type Zeldovich-Barcnblatt.
3. It is shown that the property FSPD and localization arc shown in moving nonlinear medium whose velocity depends on time.
4. For non-linear reaction-diffusion model in absorbing media or source found occurrence of localized wave structure.
5. Established property FSPD and spatial localization of a mathematical model of reaction-diffusion systems with double nonlinearity and with variable density.
6. It has been shown that there is a blow up property for the solutions of a system of self-rcaction-diffusion equations with double nonlinearity.
7. Built asymptotic behavior of generalized solutions with compact support and vanishing at infinity of solutions of self-similar equations or systems with double nonlinearity.
8. It is proved the global solvability of such problems for reaction-diffusion systems with double nonlinearity with the source or absorption.
9. At the critical exponent for the preparation of reaction-diffusion systems with double nonlinearity with the source or absorption and convective transfer use a universal algorithm.
10. A solution of type Zeldovich-Barcnblatt for nonlinear systems with cross property FSPD and spatial localization solutions.
11. The developed programs allows you to carry out computer simulations to study on the basis of the qualitative properties of nonlinear mathematical models of reaction-diffusion systems.
12. The developed computational schemes, algorithms and programm for solving a system of parabolic equations with double nonlinearity provide high performance in the study of the theory and process of numerical solution of such problems.

The urgency and relevance of the theme of dissertation. Gold is mined in 72 countries, among which Uzbekistan occupies the 9th place with 103 production capacity tonnes/ycar. Gold mining in the world in 2015 increased by 0.33% and amounted to 2678 tons. Global stocks of deposits to easily extract and a high initial content of gold is now almost depleted and the development involved the extraction of difficult and complex orc processing. Therefore, to date, the current world market is experiencing a clear shortage of minerals.
High gold prices have created favorable conditions for the expansion of the mineral resource base and involvement in the testing of complex treatment of refractory gold sulfide-ore. The main reason for gold strength associated with fine particulate association with ferric sulfide gold (gold particle size is from tens to less than one micron) and therefore it is not dissolved by cyanidation conventional technology, even when grinding without the use of ultra-thin preparatory operations prior to cyanidation. Thin association of fine gold with iron sulphides in the ore and the presence of significant amounts of carbonaceous substances may occur simultaneously (especially persistent ore), which is particularly complicates processing technology.
In this regard, increasing the efficiency of processing of persistent and highly refractory gold ores through the development of technological and technical solutions aimed at maximum opening auriferous sulfides, and the combined technology of their processing, providing additional recovery of gold is an actual scientific problem facing modem gold mining industry and has great economic importance.
This thesis research is oriented on realization of the decree of the President of the Republic Uzbekistan PD-1442, December 15, 2010 «Priority on development of industry of the Republic Uzbekistan in 2011-2015», as well as in other legal documents adopted in this area.
The aim of the research work is the development of technological and technical solutions aimed at maximum opening gold sulphides, and development of combined processing technology, providing additional recovery of gold.
Scientific novelty of the research work lies in the following:
Based on the study of behavior of gold in the process of washing bio oxidation product, it was first established presence of gold in the sink counter current decantation in colloidal form and the dependence of their behavior on the pH of the medium. That case developed bio oxide technology of enrichment by reducing the irretrievable loss of gold (50%) during washing biological pulp;
The cause of the deterioration in clarifying thickeners CCD, which was the salt hydrolysis of Fe+3;
(Variation with pH by washing) in the liquid phase slurry to form a colloidal solution of ferric arsenate and oxysulfatc, leading to an increase in viscosity of the liquid phase of the slurry and decreasing the deposition rate of biooxidation product slurry fraction;
study foaming mechanism during biooxidation detected gold enrichment process (6-8 times compared with the flotation concentrate) by fractionating fine and colloidal gold by flotation factors parts carbonaceous slurry in the reactors;
investigated the kinetics of cyanide thiocyanates during biooxidation product and its participation in competitive adsorption with a cyanide complex of gold and the dynamics thiocyanates content changes depending on the concentration of sodium cyanide and time (10-12 hours), after which the change of its content does not depend on the length process. It is also found that the rate of cyanide leaching of gold is higher than the rate of thiocyanates;
based on the study of the behavior of ion exchange resin in the process of sorption cyanidation products bio-oxidation reduction set sorbent properties after successive cycles of «saturation - regeneration» by poisoning his thiocyanates, which leads to a dynamic increase in the gold content in the liquid tails sorption and reduction of its extraction;
based on the results of theoretical and experimental studies on the state of thermo-chemical processes occurring in the process of bio-oxidation product of oxidizing roasting, set the temperature which determines the role of the quality of the resulting calcine - at a temperature of 570-600°C the degree of extraction of gold is higher than at 650-743°C. This is because at 650-743°C results in the formation of fast films preventing cyanidation of gold.
CONCLUSION
On the basis of the research on a doctoral thesis on «Scientific and technical efficiency principles for refining of refractory and highly refractory of auriferous ores» provided the following conclusions:
1. According to the study, gold properties in the process of washing, the bio oxidation product is first established the presence of gold in the sink of counter current decantation in colloidal form. The dependence of behavior on the pH of the medium on which developed bio oxide enrichment technology by reducing the irretrievable loss of gold (50%) in biological pulp during washing.
2. The reason of deterioration of clarification countercurrent decantation thickeners with salts of Fe+3 hydrolysis (with a change in pH by washing) in the liquid phase slurry with the formation of colloidal solution of ferric arsenate and oxy sulfate, which led to an increase in viscosity of the liquid phase of the pulp and reducing the deposition rate sludge of bio-oxidation cake fractions has been found out.
3. A study of the mechanism of foaming has been observed during the bio oxidation, the process of gold enrichment (6-8 times compared with the flotation concentrate) by fractionating fine and colloidal gold by flotation factors parts carbonaceous slurry reactors has been noticed. A method for processing the foam product, based on the sorption cyanidation gold at higher concentrations of sodium cyanide, which is the most effective compared to defoaming process in reactors.
4. The kinetics of formation of thiocyanates in the process of bio-oxidation cyanidation of products and its participation in the competitive adsorption of gold from the cyanide complex have been studied. Theoretically and experimentally substantiated set content change of thiocyanates cyanidation process depending on the concentration of sodium cyanide and time have been proven. Time for complete formation of thiocyanates is not dependent on the concentration of sodium cyanide, and is 10-12 hours, after which no change in its content depends on the process time. It is also found that the rate of cyanide leaching of gold is higher than the rate of formation thiocyanates.
5. On the basis of studying the behavior of ion exchange of resin in the process of sorption cyanidation of bio-oxidation product is installed after the reduction of the sorbent properties of cycles «saturation - regeneration» by poisoning his thiocyanates, which leads to a dynamic increase in the gold content in the liquid tails sorption.
6. Research has shown the influence of the concentration of thiocyanates saturation of different gold sorbent (resin, coal). In terms of direct cyanide leaching bio-oxidation products concentration of thiocyanates is up to 5 g/1, which is the main reason for the low saturation gold sorbents. Also found that one of the universal ways biological pulp conditioning is oxidative roasting, prevents the formation of thiocyanates cyanidation.
7. On the basis of theoretical and experimental research of thermochemical processes occurring under oxidative firing bio-oxidation product, set temperature determining role in the quality of the cinder. It was determined that at a temperature of 570-600°C extraction of gold higher than 650-743 ° C. This is explained by the fact that at 650-743°C results in the formation of fast films preventing cyanidation gold.
8. Developed and industrialized the combined technology of refractory and highly refractory gold orcs and concentrates containing carbonaceous material, using oxidizing roasting. At the initial stage of oxidation of flotation concentrate bio-oxidation is carried out under the scheme: opened sulfide gold, a significant part of the arsenic dissolved, transferred to the solid state in the form of insoluble scorodite (FeAsO4). Then bio-oxidation product with a low content of arsenic is exposed to oxidizing roasting, in which the carbonaceous gold opened, oxidized remaining sulfide sulfur, destroyed products of metabolism of microorganisms, oxidizing roasting product is directed to sorption cyanidation of gold from pyrite cinders.
9. In introducing the combined technologies of processing and highly resistant refractory gold ores and concentrates, with the use of bio-oxidation product of oxidizing roasting is established that the firing of the product of the charge and Daugyztau and Kokpatas orc deposits in the ratio of 60:40 at a temperature of 600°C for 2 hours and subsequent sorption cyanidation cinder enhances extraction of gold from 73.3 to 82.5%, decrease in consumption of sodium cyanide 2.5 times, reduction Thiocyanate concentration in the liquid pulp phase from 5000 mg/1 to 16.
10. The industrial precious metals recovery technology by improving the technology of sorption cyanidation leaching bacterial product on the basis of circuit testing have been developed and acquired which provide input for the design and subsequent transfer node sorption cyanidation of bio-oxidation product in the scheme of «carbon in pulp».
11. In experimental-industrial conditions of the off-balance sulphide orc gold extraction technology in Kokpatas by heap leaching with continuous bacterial extraction in the order of 50% (versus 25.7% in direct cyanidation) have been developed and tested.
12. The existing scheme and combined technology of processing of refractory and highly refractory gold ores arc introduced at HMP-3 of the State Enterprise «Navoi Mining and Metallurgical Combine» have been developed and improved. As a result of significantly increase of through extraction and annual gold production while maintaining the existing volume of orc processing, reduced the cost of the manufactured product and get the actual total economic impact of 222.2 billion sums per year (prices of 2016).

The urgency and relevance of the theme of dissertation. Nowadays «...mountain systems occupy the fourth part of the land of the world, their nature has many peculiar features that distinguish mountains from plains and various complexes of landscapes from the tropics to the artic zone»1. Uniqueness of mountain ecosystems defines features of soil formation and nature of use of the foothill and mountain soils. From this point of research of genesis, evolution and fertility of soils of vertical zones is one of the major theoretical challenges. From the depth and longitude of its solution depends understanding of patterns of geographical distribution of soils, development processes of geochemical landscapes, knowledge and use of the natural resources as a whole.
In the Republic climate change of modem mountain and foothill soils provide as a integral inducator, in this regard, the foothill and mountain soil of Fegana valley with arid and humid climate, soil-ecological regime act as example of their response to natural and human-induced changes of a regional nature. Consequently, an evaluation of the effects of hydrothermal and other soil forming factors, soil properties in elementary and geochemical landscapes, in different expositions, moreover fertility assessment, conservation and its improvement arc undoubted relevance.
In the world of the research of soil properties, including content and migration of a row of macro- and microelements arc an important link in knowledge of genesis and evolution of mountain and foothill soils. Issues of migration of chemical elements in geochemical landscapes of soil vertical zones, both natural and anthropogenic conditions arc insufficiently researched. In general, analysis of genesis of accumulation and differentiation of macro- and microelements, their connections in geochemical barriers with the position of soil-geochemical barriers appear to be quite a challenge for soil science at present.
The problems of mountain soils without taking into account their regional and local characteristics cannot be resolved. Theoretical section of modern soil science in this regard would certainly require extensions, in addition, ecological-genetic, agrophysical and chemical as well as biogeochemical properties of foothill and mountain soils of Fergana valley studies were insufficient. Research on the factors influence the genesis and formation of soils and geochemical landscapes of mountain areas, as well as the behavior of micro elements, especially low studied, non-studied (Rb, Cs, Cr, U, Sc, La, Hf, Sb, Ce, Sm, Tb, Yb, Lu, Th) elements in the elementary systems, the type of genetic horizons of soil-rock-soil-plants arc practically non-studied. In addition, humus state, background content of macro-and microelements, soil-geochemical provinces not developed that make up the relevance of the topic of the thesis.
The dissertation to some extent may contribute to solve problems defined in the law «On Earth» the Republic of Uzbekistan, decree of the Cabinet of Ministers of the Republic of Uzbekistan from August 23, 2016 №273 «On approval of the environmental monitoring program in the Republic of Uzbekistan for 2016-2020» and the on May 27, 2013 №142 «On the program of environmental action of the Republic of Uzbekistan for 2013-2017», as well as other legal documents adopted in this area.
Purpose of the study is the complex characteristic of mountain and foothill soils with use of morphogenetic, landscape-geochemical methods of a research, influence of ckological-gcnctic properties of migration, accumulation and differentiation of chemical elements in a chain «maternal breed-soil-plant», and also to reveal fertility.
Scientific novelty of the research is in the following:
first proven processes of soil formation Foothill and mountain soils of Fergana Valley under the influence of precipitation, terrain, irrigation waters and other acquired modem ecological-genetic and soil-geochemical properties;
it is defined morphological, biogeochemical, physical and chemical, chemical properties and geochemical barriers in the brown mountain-forest, mountain-brown soils created on different conditions and breeds;
the pcdochcmical and background structure of Rb, Cs, Cr, U, Sc, La, Hf, Sb, Ce, Sm, Tb, Yb, Lu, Th in soils and the soil formation breeds is defined;
it is proved that a humus condition of mountain and foothill soils, and also processes of hymification and a mineralization, humus type fulvatc-humatc where the ratio of CGA:CFA varies within 1-2 are revealed;
new bilateral pcdochcmical barriers, baric, magnesium, molybdenum and other provinces on the basis of which genetic, geochemical, ecologic-genetic conditions and properties of soils and the soil formation of breeds arc defined are allocated;
within vertical zonality hydrothermal indicators of the North and South of the valley, in particular average annual temperature are raised on 1,85°C from which process of an aridization under the influence of which in genesis and properties of soils of elementary landscapes there arc important changes results.
CONCLUSIONS
1. Researches of soil formation factors in mountains shows their unequal significance in comparison with plains. It is shown that the leading role in mountain soil formation process belongs to a relief and climate, which influence in mountains created variety of soil-geochemical landscapes, connected with geochemical flows of elements.
2. Distinction in soils, maternal breeds and content of separate elements arc connected with ancient deposits, so in the north of the territory of Nanay and above, rocks have upper Permian and lower the Neogen-Mioccne content consisting of a limy-slate and glauconitic complex, and in the south within Yordon and Khaydarkan have lower Silurian and lower carbonic, Devonian content which consists also limy-dolomite thickness.
In the conditions of foothill and mountain soils of the Fergana valley is allocated light-gray meadow-steppe, gray mountain-forest , mountain-brown, carbonate and sierozems formed generally on skeletal eluvial , proluvial and also on the loess and loess type loams which in the soil-ecological relation sharply differ. The morphology of northern soils is more stretched than southern.
3. Due to growth of an aridization, that is growth of annual average temperatures in general goes slow, but notable changes in climate towards growth of annual average in the north and in the south of the region which inevitably smoothly lead to change of borders of distribution of soils in a vertical, this process goes in the south of the region quicker.
4. By comparison of a general content of organic substances of the conditional-irrigated and irrigated soils it is established that mountain-brown, dark and typical sierozems in case of irrigation in the first years lose humus, the washed soils arc enriched with them. However these changes owing to hydrogeological, gcomorphological conditions do not lead to complete equalization of these soils. In this plan the leading role is played by climate, a relief and an anthropogenesis factor.
On the example of the foothills and mountains of the Fergana valley very difficult and various on soil formation factors, which influence the processes of soil formation and differentiation of landscapes and the soil horizons also geochemical and biogeochemical interconnected and interdependent mechanisms of an evolution and distribution of soils are established.
5. In landscape-geochemical conditions with mountain soils and a sierozcmic belt on the way of migration macro - and microelements the system of various radial the pcdogcochcmical barriers is created: vaporizing, carbonate bilateral, carbonate-gypsum bilateral, oxygen, gley.
6. With increase in degree of calcareousness of the soil, receipt, respectively a coefficient of biological absorption of plants of a row macro - and microelements decreases. This process from dark sierozems to light sierozems amplifies, as a result of watering smoothes out a little.
The relation of content of СаСОз in soil thickness and soil formation breed constitutes 1,25. Accumulation of carbonate in a soil profile happened mainly not in case of evaporation of ground waters which depth reaches more than 10m, and cannot take part in forming of a soil profile, but with the participation of a soil biota and vegetation. Thus, accumulative functions of the studied soils of sicrozcmic and mountain zone are shown in the relation not only organic carbon and carbon of carbonates.
7. The irrigated sierozems of the valley on content of gross molybdenum belong to geochemical provinces of enrichment where it contains in sierozems 2,2-4,7 CC. Depending on a provision of the upper bound of the carbonate horizon migration of molybdenum on a profile of soils either is complicated or does not happen. This provision protects the living being from negative influence of molybdenum.
8. Content of the elements Fe, Ba, Sc, Cr, Rb, Sb, Cs, Hf, La, Ce, Sm, Tb, Yb, Lu, Th, U can serve as a background for soils of a mountain and foothill, such as the brown mountain-forest, mountain-brown, carbonate, irrigated sierozems. The clement background at the same time can serve in these soils for clarification of a row the pcdogcochcmical and genetic characteristics and creation of soil-gcochcmical monitoring, placement of crops for the purpose of receipt of environmentally friendly food. 
9. Accumulation of boron (CC=6-8), zinc (CC=l,6-2,8), molybdenum (CC=l,0-l,9), manganese (CC=1-1,7), copper (CC=1,4-1,5) is characteristic of landscapes of a sicrozemic zone with sierozems and they belong the province of enrichment. The greatest nature of communication of the soil with soil formation breeds was peculiar to zinc, and the greatest coefficient of local migration - to boron, the others took the following places: Mn>Cu>Mo>Zn.
High communication between a cotton, the soil and breeds arc found for molybdenum (Ax =0,4), other microelements took the following places among: B>Cu>Zn>Mn, which Ax lower than 0,4.
For zones with sierozcmic soils were characteristic superfluous and raised zincum - molybdenum geochemical province and the excess copper geochemical province is characteristic of the subordinated geochemical landscapes.
10. Soils of the considered geochemical landscapes differed among themselves in the content of gold. Its content was more in soils and the soil formation breeds of the right coast. The highest content of gold is revealed in the loess and the loess type loams and in the humic horizons (arable and sub arable) of sierozems. His maximum contents have been revealed in accumulative landscapes.
Big variability of content of gold, arsenic, molybdenum, cadmium, lanthanum and samarium was characteristic for sierozems of the region.
11. Many mineral salts of potassium arc readily soluble, however owing to bigger a biophility it migrates more weakly than sodium. Potassium as it has been specified, owing to the bigger ionic size it is quickly taken by clays and by that provides a low migratory capability in soils and breeds. On chemical properties potassium almost analog of sodium in the biosphere its geochemistry is closer to magnesium and barium.
12. Rather high concentration of arsenic (but below CC) was characteristic for the humic and gley horizons. Nature of communication in arable soils between content of a humus and arsenic has been expressed poorly. Arsenic in soils and the soil formation breeds of the left coast was 25% more, than in soils and the soil formation breeds of the right coast that is obvious, can form the basis for allocation of the soil-geochemical arsenical province in the south of the Fergana valley.
The biogeochemical method allows, to reveal features of accumulating of mercury, arsenic, antimony and others in plants and to determine extent of biological accumulating taking into account the existing geochemical background and fertility level. Biogeochemical provinces, especially mcrcury-antimony-arscnic, shall be used carefully in agricultural production.
Provinces with excessive content of strontium were characteristic of the south of the valley, but they were not as dangerous as zones of an urovsky illness. It is connected with the high content of calcium in all landscapes of the Fergana valley.
13. A chemical composition of the plants which arc grown up in different ecological conditions (the province of enrichment and control - nonenriched), almost on all elements differed for benefit of the plants which arc grown up in an enrichment zone.
In mercury, arsenical, antimonies biogeochemical provinces it is not necessary to cultivate com, potatoes, tomatoes and some other types of the cultures possessing high coefficients of biological absorption.
14. The research and design-survey organizations, committee on nature conservation, graduates and researchers of higher educational institutions when carrying out monitoring researches can use results of the elemental compositions (Fe, Ba, Sc, Cr, Rb, Sb, Cs, Hf, La, Ce, Sm, Tb, Yb, Lu, Th, U) as a background for mountain and foothill soils of the Fergana valley. Besides, results of the elemental analysis and geochemical provinces arc recommended to be used when reading special courses to students and undergraduates of the biological-soil and ecological, agricultural directions.
15. For management of water and agriculture it is recommended to carry out placement of crops taking into account boric and other geochemical province where big crops arc yielded by sugar beet, sorghum and other cultures.
Use of results on the content of humus and nutrient elements, water-soluble salts in these soils is recommended to regional land registry offices in creating soil bonitet maps.

INTRODUCTION (abstract of doctoral dissertation)
The necessity and need of the dissertation’s theme. At present, there arc observing different natural extreme conditions in the World, particularly such as drought, soil salinity, global warming and various diseases which causing a certain obstacles at cultivation to get a high and qualitative yield of crops. Development of upland cotton varieties tolerant to the different environmental extremes and elaboration their yield cultivation ways arc actual task in cotton production to overcome the current problems.
There arc implimcnting wide range of measures in the republic on getting high cotton yield having qualitative fibers responding to the International market demands through the development of new cotton varieties tolerant to drought, salinity, hot dry wind, various diseases and pests, adapted to the different soil-climatic, geographical and land reclamation conditions of the republic and their optimal dislocation. In the sphere of cotton breeding, there arc increasing a demand for varieties development using a new modem ways with a stable hereditary traits, micronairc indicators which respond to the textile industry requirements.
Worldwide scale cotton breeding practice arc giving a particular attention for realization of scientific-researches targeting to develop of new high yielding cotton varieties belonging to Gossypium hirsutum L. species having a high qualitative fiber, tolerant such different extreme factors as: water deficiency, soil salinity, various fungal and bacterial diseases pathogens and elaborate of qualitative seed preparation technologies. At cotton initial breeding materials selection tolerant to the different environmental extreme conditions there arc playing great importances of new varieties and lines development using of y-rays at dry seeds of the new cotton varieties, biochemical methods of Marker assisted selection (MAS), synthetic and other ways of traditional breeding. It is an actual task development of cotton breeding materials tolerant to the different environmental extreme factors using the mutagenesis, MAS biochemical methods and other hybridization methods, revealing their advantages by some economically valuable traits concerning to the standard cultivars, testing a developed varieties and lines at the different specific natural extreme conditions, and revealing law of correlation and regression interactions between some morpho-biological traits. The present dissertation researches serve in a certain manner to implement of tasks envisaged by the adopted Laws of Uzbekistan «About selection achievements» on 29.08.2002, «About seed production» on 30.08.1996 and by the Resolution of President of the Republic of Uzbekistan № 2484 of 01.02.2016 «About cotton varieties placing and rawcotton volume production forecasting for 2016» and other legislative documents, related to this sphere.
The purpose of the study arc development of G. hirsutum L. cotton breeding initial materials using the different doses of gamma rays induement at the dry cotton seeds, MAS’ biochemical method, synthetic and other traditional selection methods and their testing for tolerance under the different extreme conditions.
Scientific novelty of the research arc as follows;
for the first time, dry seeds of cotton varieties’ of C-9082, Turan, Bukhara-102 and Jarkurgan of G. hirsutum L. species’ induced by the different doses of r -rays of 60Co and afterwards there have been selected such cotton mutant varieties having a valuable economic traits as; CP-2530, CP-2531, CP-2532;
in cotton mutant lines’ drought tolerance definition, there have been used various irrigation regimes and created artificially hard water deficiency, experiments carried out under the deep groundwater level, eroded and densely typical serozem conditions;
created new both the medium and long stale mutant lines have been tested for the both Verticillium and Fusarium fungal and Xanthomonas bacterial pathogens under the artificially («Phytotron-greenhouse» complex) and naturally infected by Verticillium pathogen conditions;«yield» formation of L-712 line (C-6570) had been determined depending on plant density in Kashkadarya region under the such complex extreme factors as; natural hot atmospheric temperature, low level of relative humidity, densely and low humus content bald like soil conditions;
since 2013, tolerant to soil salinity and water deficiency «С-9085» variety of G. hirsutum species inscribed to the list of perspective varieties by Karakalpakstan Republic and since 2016, the «Namangan-102» cultivar inscribed to the State Register by Kashkadarya region;
«yield» formation of the different lines of G. hirsutum L. species’ have been investigated and under the complex extreme factors both the low level of some nutrients contents and severe salinity soil conditions of Karakalpakstan Republic, selected adapted ones;
correlation and regression interactions of valuable economic traits of both the new cotton varieties and lines have been justified;
CONCLUSIONS
1. There have been justified the advisibility using a gamma rays, MAS biochemical method, synthetic selection and other hybridization methods in developing G. hirsutum species’ initial breeding materials resistant to extreme factors.
2. For development mutant forms of C-9082 variety with the aim to increase cotton boll weight and fiber outturn it is advisable to use 5-15 kR doses of t- rays irradiation on dry cotton seeds.
3. The following MT-7 and MT-118 lines of G.hirsutum species and MT-100 and MT-165 lines of G.barbadense species arc recommended involving in cotton breeding and genetic researches as an initial tolerant accessions to the Xanthomonas campestris pv. malvacearum pathogens.
4. There have been determined the resistance of MT-70 and MT-7 lines of G.hirsutum species for Rhizoctonia solani disease, as well as determined the resistance of МТ-80, MT-60 lines of G.hirsutum species and MT-165 line of G.barbadense species for T. basicola pathogens.
5. There have been selected the resistance for pathogens afterwards the investigation under the artificially infected and field conditions of the following MT-118, MT-90 and MT-80 lines of G.hirsutum species for V. dahlia Kleb and the resistance of MT-144 line of G.barbadense for F. oxysporum Schl. f. sp. vasinfectum and identified the possibility their using as the primary breeding sources in applied breeding and genetic researches.
6. There have been identified the such lines in accordance with the requirements of International market as MT-10, MT-118, MT-7 and MT-90 of G. hirsutum species by micronaire index - 4,1-4,4 and by fiber length uniformity index - 84,5-85,1 % (MT-7 MT-10, MT-118 and MT-36) and the following MT-134 and MT-144 lines of G. barbadense species by both the micronaire index-3,9-4,1 and strength-40,4-40,6 gf/tex and possibility their use as a valuable material in applied breeding and genetic researches.
7. It was identified a early maturity of such accessions as MT-7 104 days, CP-2532 variety and МТ-71, MT-27 lines 106-107 days of G. hirsutum species and possibility their using as a primary valuable breeding sources in development of early mature varieties.
8. There have been established the following correlation links between the traits of selected on base of investigations varieties and lines; among the hS\ and total boll number - r = -0.11, the hS\ and weight of cotton boll - r = -0.01, the hS\ and weight of 1000 seeds r = -0.04. These data showing, that correlations between the traits tend to zero, that means between the learnt traits present the weak interrelations. As well as taken following correlations justified among the hS\ and plant productivity r = -0.20, the hS\ and fiber outturn r = -0.34, hS\ and fiber staple length-r=-0.1.
9. There arc taken following positive correlation coefficients among such traits of selected varieties and lines as the weight of boll’ rawcotton and plant productivity r = + 0.42, the weight of cotton boll and fiber outturn had a weak positive correlations r = + 0.14, the weight of boll’ rawcotton and staple length r = + 0.14, the weight of boll’ rawcotton and weight of 1000 seeds also weak positive correlation r = + 0.24.
10. There were identified a high yield capacity of MT-7 line for 0,05-0,07 t ha’1 and MAS-1 line for 0,2 t ha’1 comparatively to standard cultivars under the Surkhandarya region’s such natural extreme conditions as hot temperatures, low level of relative humidity of air, storm and hot dry wind (garmsel).
11. Based on the high yield capacity both the Namangan-102 and CP-2530 cotton varieties and МТ-85, MT-62 and MAS-1 lines of G. hirsutum species under the medium saline in the beginning and severe saline in the end of cotton growth period soil conditions of Karakalpakstan Republic, it is advisable their using these accessions in breeding researches.
12. It is recommended to use irrigation regime 70-70-60 % by the LWHC and mineral fertilizers norms N-240, P-160, K-120 kg/ha for harvesting high rawcotton yield and qualitative seed of C-6524 cultivar under the eroded and medium impacted typical serozem conditions of Tashkent region, in such cases sccdcotton should be harvested up to the Г' place of 8,b sympodial branch.
13. The following cotton varieties arc recommended for evaluation in ACVTSC Ground control, which developed by the both the MAS biochemical method MAS-1, MAS-2 lines and mutagenesis CP-2531, CP-2532.
14. The following high yielding, tolerant to diseases and water shortages such cotton varieties as CP-2530, C-6570 and Shodlok-11 and CP-2531of G. hirsutum species, which past the ACVTSC Ground control evaluation arc recommended to broad production areas testing.
15. It is need inscribing to the State Register by the Republic of Karakalpakstan and enlargement of cultivated areas tolerant to soil salinity and water shortages of perspective cotton variety C-9085 of G. hirsutum species. It is recommended for enlargement of cultivated areas, the State Registered by Kashkadarya region tolerant to water shortages, high cotton yield and qualitative fiber, upland cotton cultivar Namangan-102

The urgency and relevance of the theme of the dissertation. Present time Global environmental change creates complicated situations all over the world. One of them is biodamages of anthropogenic landscapes by birds. For example, «currently horticultural sector of Australia has 300 billion dollars of the USA damage, African countries grain and grapes production loose approximately 87.3 billion. Dollars, every year it takes part about 4000 accidents between birds and aircrafts»1. In this regards the determination of birds caused damages, its prevention and working out the methods of its control are very important task.
After getting independence in our country it is payed solid attention to the modernization of economic sector, specially to the main branch of agroindustrial sector such as agricultural production. The were some achievements on the basis of effective methods of prevention of biodamages caused by birds and development of safe means of protection, including protection of the agricultural yield from various biodamages, as biodamage caused by birds and also in this regard the improvement of the development of harmless recourses, improve the results of their efficiency.
Currently, the increase of the area of anthropogenic landscapes and dependence of birds from these landscapes caused to increase of several problems of biodamages in different sectors of agriculture, economy and aviation transport. In this regards, in the conditions of anthropogenic landscapes, the scope of damage caused by birds in grain production, horticulture, viticulture, as well as honey bee production and their ecological technological nature, prototype and analog quantities determination, development of the ways to reduce of damage, as well as regulation of birds behavior near airports to limit accidence between birds and aviation transport by application of ecological technological systems and its modernization is very significant problem. Implementation of the results of investigation for modernization of ecological technological methods for prevention birds caused damages can be explained as following: determination of ecological causes of attraction of birds to the important production sectors (agriculture, aviation, industry, power lines etc) by application of single and differential approach; determination of the nature of highest culmination points of birds acoustic and repellent signaling systems; synthesis of acoustic repellent imitators and development of mechanisms of inter-specific effects; approval of complexes of biotechnological systems to prevent birds caused damages; development and implementation into practice of preventive ecological and technological methods on the basis of behavior and sensory organs features of birds.
The research of this dissertation in a certain degree serves to the solution of tasks stipulated in the decree № PF-3709 of January 9, 2006 «Programs for economic modernization in horticulture and grape production» of the President of the Republic of Uzbekistan, and the decree № PF-2460 of December 29, 2015 of the President of the Republic Uzbekistan «Programs for modernization and development of agriculture» and the decree №294 of October 24, 2014 «On measures for further development of civil aviation and strengthening the material-technical base of the National Airline «Uzbekistan havo Yullari» and also in other legal documents adopted in this area.
The aims of the research is an investigation of birds caused biodamages and modernization of ecological technological methods of their prevention.
Scientific novelty of the research are in the follows:
it was determined the level and dynamics of biodamage caused by birds at the croplands and in the territories of aeroports;
populations of Sturnidae and biological importance of acoustic signals in the interspecies acoustic communicative relationship as well as phylogenetic origin of acoustic repellent signals were determined;
on the basis of bioacoustic investigation it was first time described an alarm repellent signals of common bee-eater (Merops apiaster L.) and blue-cheeked bee eater (Merops superciliosus L.) the highest part - existence of alarming signals was identified and application of this signals in honey bee farms was scientifically proved;
it was first time investigated interspecific influence of an alarm signals of my-lady's-belt to other species of birds;
dangerous migration of birds alongside of territories of aeroports and eco-technological methods of forecast of situation were developped;
first time in the Uzbekistan condition, it was created an acoustic-reppelent complex of birds on the basis of birds sensors features.
CONCLUSIONS
On the basis of the conducted research on doctoral dissertation on the theme «The biodamages, caused by birds in Uzbekistan and improvement of eco-technological methods of their prevention» the following conclusions were presented:
1. It was proved that the nature of biological damages caused by birds to different sectors of economy is linked with ecologic pliability, ethology, migration, and sinanthropy as well.
2. It was assessed the biological damage caused by birds to different croplands which were as followings: grape yards 17-19%, horticulture 31-86%, wheat 7,6-8,3%, rice 2,1-3,4%, sorgum 33-42%, breeding plots, seed testing plots 45-100%. All it depends from seasonal birds’ life.
3. About 30 species of birds are nesting in the airports and nearby areas. These causes to accidents with aircrafts which has a seasonal shape, where spring and autumn were higher which can be explained by migration, nesting and other factors.
4. Altruistic behavior of birds provided a stable population structure, and imprinting was linked directly with biological damages caused by birds.
5. The alarm signal of Indian starling and other predator birds with interspecific effect to birds, spectral-time sound closeness, principal similarity, simplicity of modular frequency, mechanisms of signal origination can be explained by simple signal initiation.
6. Rapid analyses of spectral timely structure of acoustic repellent signals shows that acoustic repellent signals of sparrows have common phylogenetic root and allows to determine an imitone.
7. It was in first time determined of the higher culmination point-alarm signal of bee-eater and with using this signals it was possible to protect a honey bee from biological damage.
8. In principal object it is necessary to apply biotechnological systems together with ecological approach and by imitation real-dangerous situation to enhance efficiency of application of repellent system.
9. It was developed special methodology to prevent biodamages caused by birds and complex installation «Optical repellent installation» and «Optical acoustic repellent complex» strategy to limit harmful effect of birds were recommended.
10. In case of combined use of «Optic repellent installation» and «Optical acoustic repellent complex» there were possible to reduce a damage up to 80% in airports, civil buildings 90-95%, power line system 100%, horticulture and viticulture 80%, honey bee form 70% and grain croplands 60% higher efficiency.