No. 4,1(81) (2014) Problems of biology and medicine

Статьи

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  Functional state of hepato-biliary system of patient with giardiasis. Ursosan usage at combined therapy of giardiasis Influence of Giardiasis on functional state of hepatobiliary system was studied on 61 children with Giardiasis. Efficacy of Ursosan in combine usage Giardiasis was studied. The disturbance of liver and gall bladder functions was detected in 83% cases among infected by L. intestinalis children. Test results indicated that Ursosan had hepatoprotective effect and it intensified the action of specific drugs. The efficiency percentage of combine usage of Ursosan and Metronidazol equaled to 90, 3%, Metronidazol -83, 3%

  D Saidakhmedova, U Suvonkulov, T Abdiev, L Kachugina

  68-72

  299   230

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  Innovative non-invasive ultrasound techniques in complex clinical and echographic diagnosis of chronic viral hepatitis in children Chronic hepatitis B, C, D still attract constant attention, as their main cause is acute viral hepatitis, which are among the most common infectious diseases in children. An important reason for the chronicity of the disease and its transition to a more severe stage is associated with untimely diagnosis of the pathological process.

  G Yusupalieva

  177-179

  119   22

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  Pesticides effect on exocrine pancreatic function of rats It was researched changes in exocrine pancreatic function under the impact of hexachlorocyclohexane (HCСH) on outbred white rats. The results allow concluding that decrease in secretion of amylase and lipase in the first days of the experiment due to a decrease in the intensity of their synthesis in the acinar cells. Prolonged use of HCСH in a dose 1/20 LD 50 initially causes inhibition of synthesis and secretion of pancreatic enzymes, and by the end of the study significantly increases the intensity enzyme former processes

  F Babajanova, V Askaryants, A Abdumajidov, S Sattarova, B Nigmanov

  113-117

  76   14

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  Influence of phenazepam on topography and enteral enzymes activity in growing rats with immobilization stress Experiments carried out on adult rats of "conventionally mixed" group, not been tested for aggression, as well as in growing rats of different ages showed that there is a definite pattern in the localization of the enzyme activity of the small intestine. Indicators of functional activity in adult rats of mixed and non-aggressive group are of the same type, but rats of the aggressive group have differences. Such identity is typical for rats aged 21 and 30 days. Depending on the behavioral characteristics, adult rats, as well as their progeny have more variable enzymatic activities topography. Immobilization stress differently affects the morphological and functional characteristics of the small intestine in adult rats according to their behavioral characteristics. In rats aged 21 days, born to parents of mixed, non-aggressive and aggressive group, immobilization stress causes similar disturbances in the functional state of the small intestine. Phenazepam better corrects violations in the functional state of the small intestine during immobilization stress in adult aggressive rats in comparing with individuals of mixed and non-aggressive groups. Prophylactic introduction of Phenazepam has almost no protective effects during immobilization stress in rats aged 21 days, regardless of the behavioral characteristics of their parents. Protective effect of a tranquilizer begins to emerge in young rats aged 30 days, especially those born from aggressive parents

  V Askaryants, A Abdumajidov, M Kurbanova, B Nigmanov

  109-112

  77   20

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  Index changes quality of life in patients with osteoarthritis in the elderly age after the sanatorium stage of rehabilitation In the study quality of life in elderly patients with osteoarthritis using international EuroQol questionnaire were obtained substantiated data about positive impact of spa treatment on quality of life by given group of patients compared with outpatient treatment. Multidisciplinary nature of medical rehabilitation in spa conditions, using a wide range of rehabilitation methods promotes more complex influence on an organism and allows to save remission for murch longer term.

  Т Бaкaлюк

  104-108

  111   26

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  Noninvasive lungs ventilation in pregnant women with chronic nonspecific lung diseases In recent years there has been a tendency to increase abdominal method of delivery, which is considered the optimal level of about 10% -12% of the total number of births. Abdominal delivery performed in 36 pregnant patients with chronic nonspecific pulmonary diseases (COPD), aged from 19 to 39 years. As the anesthetic technique used regional anesthesia with the use of non-invasive ventilation. The effectiveness of non-invasive lungs ventilation (NIVL) with COPD, with marked improvement in respiratory support and cardiac activity. NIVL is inexpensive and well tolerated

  Z Yusupov, B Igamberdiev, M Matlubov

  100-103

  143   28

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  Optimization of maintains of the girls with vulvitis at the diagnosed prenatal infection in puerpera at the present stage Vulvitis is inflammation of the vulva (the external genital organs). Vulvitis occupies the first place in the incidence structure of urogenital system of children. According to the facts of various researchers, from 70% to 93% of gynecological pathology of childhood age is vulvitis. Intrauterine infection of the fetus is one of the most important problems of obstetrics and perinatology. All pregnant women had carried out a comprehensive clinical and laboratory examination using molecular biological methods for the determination of infectious agents. In assessing the pathogens isolated from cervical pregnancy by PCR and ELISA. During histomorphological study of 90 women’s placentas following data were obtained: In the main group I a few more were registered inflammatory changes in the tissues of the placenta, which mainly consisted of polynuclear leukocytes and lymphocytes had a focal character in 64.4% of cases, common - in 31.1%. Thus, bacteriological and pathological research methods in pregnant at high risk of infection are important in predicting perinatal outcomes and the development of vulvitis in newborn girls

  M Shamsiev, B Negmadzhanov, M Kurbaniyazova

  97-99

  73   27

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  Research of association of polymorphism of gena urokinaza with urolithiasis development in Uzbekistan The obtained results in this study suggest that genetic variants of the gene polymorphism to be marked as urokinase 3'-UTR T / C contribute to a determination of the development of the ICD sposobstvuyuschix disorders. In particular, the residents of the Republic of Uzbekistan genetic markers of predisposition to ICD genotypes T / T and P / T. With Policy markers can be carried out identifying risk groups of the ICD. The advantage of molecular-genetic method for predicting the ICD using genetic markers is that a predisposition to the disease may be established in the absence of any clinical or biochemical manifestations, t. E. At a very early preclinical stage of pathology, which will contribute to a focused preventive measures and improve the quality of life of these patients. Found an association between the presence of genotype T / T and C / T gene of urokinase and urolithiasis, consider it appropriate to include the definition of a gene of urokinase in a comprehensive program of prevention ICD in Uzbekistan

  A Shamsiev, Sh Yusupov, B Adylov, D Dalimova, Sh Turdikulova, D Islamova, L Khakimova

  93-96

  179   22

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  Clinical course and defined flora of sinusitis in children with type 1 diabetes Sinusitis are common disease of childhood and observed in all age groups, starting with the first months of life. The study was performed in order to determine the features of the clinical course of sinusitis and the nature of the microflora in children suffering from diabetes mellitus (DM). The study involved 54 children. Defined microflora of the nasal cavity of children and their clinical course. In patients with DM purulent sinusitis is characterized by long, sluggish flow, involvement of other sinuses, the development of complications

  N Khushvakova, N Istamova

  89-92

  85   18

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  The use of continuous glucose monitoring daily in clinical practice In the pathogenesis of type 1 diabetes the leading role played by the development of an absolute deficiency of insulin due to autoimmune destruction of beta cells of the pancreas. The only way to treat pathogenic SD-1 is insulin replacement therapy, which aims - maintaining compensation of carbohydrate metabolism throughout the life of the patient. In connection with the above, of great interest are the new modern tools: automatic system for continuously monitoring blood glucose or insulin pumps. The study included 31 patients with type 1 diabetes. Were studied in detail hyperglycemic and hypoglycemic fluctuations. Thus, as a result of research, the use of insulin pump therapy in patients with type 1 diabetes provides less variability of blood glucose levels, as compared with the regime of multiple injections of insulin

  D Khamrayeva, H Khamraev, P Khamrakulova, O Muminov

  86-88

  122   18

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  Age, sex characteristics and condition inherited premorbide systemic lupus erythematosus 54 patients (23 in the first therapeutic clinic Sammy, I group and 31 in Berlin, clinic of rheumatology and immunology, Сharité, group II, Germany) were studied age, sexual characteristics and condition of hereditary premorbid systemic lupus erythematosus (SLE). Often hurt women of childbearing age in both groups, the numerical ratio of women and men was 9:1. The average age of patients of german nationality less than men and the average age of the patients uzbek statistically almost does not differ from that seen in men. In the Samarkand region, the disease developed at a young age and often proceeded with high activity. In patients of german nationality SLE begins at a later age, often has a subacute or chronic course. Among relatives on the maternal line often found rheumatism, arthritis and heart disease, which in many cases have a poor prognosis

  N Khamrayeva, G Mardanova, D Toirov

  82-85

  129   22

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  Clinical and laboratory features of interstitial nephritis in children with dismetabolism purines The purpose of the study. Explore the clinical and laboratory features of the flow of interstitial nephritis in children that developed on the background of hyperuricemia and hyperuricosuria. Materials and methods. Examined 82 patients with an established diagnosis of interstitial nephritis dysmetabolic genesis background urikozurii more uric acid 1mg to 1ml of urine. Metabolic status of the patients was evaluated by a special program, which included a genealogical analysis, screening tests and quantitative biochemical studies. As the main biochemical marker to determine the level uricemia (> 320mkmol / l) and urikozurii. Results. Comparative analysis has shown that the difficulties can be overcome diagnosis by careful comparison of medical history, clinical and laboratory data and timely diagnosis urikozuric genesis nephropathy. Found that when dismetabolic interstitial nephritis unlike glomerulonephritis in the disease onset is no extra renal symptoms, does not suffer from glomerular filtration, azoth-excretory renal function. The diagnosis is confirmed by the presence of the characteristic spectrum of extra renal disease in the pedigree, the presence of hyperuricemia (> 0,310mmol / l) and urikozurii (> 1.0 mg uric acid 1ml urine). The most informative of the disease is the debut at an early age, the absence of extra renal symptoms in the presence of isolated bladder syndrome.

  N Turaeva, B Yuldashev, G Ishkabulova, G Gapparova, N Goyibova

  77-81

  171   29

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  Selection of the optimal surgical treatment for acute cholecystitis From 2013 to 2014 we have analyzed the treatment of 121 patients aged 19 to 88 years with various forms of acute cholecystitis. Only 13 (10.7%) were hospitalized within 6 hours from the start of the disease. In 53 (43.8%) patients had disease duration was 6 - 24 hours, and 55 (45.5%) patients were admitted to the surgical ward after 24 hours from the time of acute holetsistita.V 9 (7.4%) cases of acute cholecystitis was complicated by obstructive jaundice, which persists with the use of minimally invasive (PTHC 2 (22.2%), ERCP+ERS + 7 (77.8%) of instrumental methods in the beginning of treatment.Of these 18 (14.9) patients treated without surgery. 103 (85.1%) patients were operated on at different times from admission to the surgical ward. The main type of operation was - cholecystectomy. Analyzing the technical aspects of the operations, it should be noted that the use of minimally invasive surgical procedures in a number of cases have been associated with certain technical difficulties. In acute catarrhal and phlegmonous cholecystitis without evidence of perivesical process more efficient laparoscopic cholecystectomy. When phlegmonous cholecystitis with moderate perivesicular process and gangrenous cholecystitis operations choice where these are cholecystectomy through intramuscular mini access to the right upper quadrant in the case of technical difficulties identified during surgery, it is justified by the expansion of wounds. When performing open surgery for acute cholecystitis is the most rational right sides intermuscular access

  O Teshaev, E Zhabborov, A Kholdorov, Z Abdullaev

  73-76

  119   24

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  Results of introduction system of the rating estimation of efficiency medical staff rural medical points on example family nurse Research was spent in 96 rural medical points from 5 areas of republic. A research basis results of approbations of system to a rating estimation on 684 family nurse. Approbations passed in 2014 since April on October months. At a comparative estimation of results to a rating estimation have shown quantity family nurse with high points more than 85 % in October in comparison with April have increased 16 to 67 and with low points below 55 % have decreased from 31 to 15 nurses. The developed system to an activity estimation motivated family nurse of rural medical points to type higher balls has served as the factor of better performance of the functional duties

  R Asimov

  8-13

  136   26

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  Results of treatment of postoperative and recurrent hernias of the forward belly wall The Results of treatment of 85 patients with postoperative and recurrent hernia of anterior abdominal wall have been analized in the article.The Patients underwent autoplastic and alloplastic («onlay» and «sublay»technique) operations.Investigations showed that employment of alloplastic metods of anterior abdominal wall plasty makes it possible to increase efficacy of surgical treatment of postoperative and recurrent hernia of anterior abdominal wall,to decrease the number of recurrencies,to improve qualitative features of postoperative period course

  S Ruziboev, G Tagaev, N Allaberdiev, H Samiev

  64-67

  95   23

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  Assessment of influence of dialipon on the course of diabetic neuropathy at patients with sugar diabetes 2 types Aim of exploration: study about effect application of drug comprehensive therapy diabeticpolineropaty with way impact hemodynamic and functional condition nervous system. Exploration take in 54 sick people suffering from diabetic polineropaty in 2 group: in first group sick people get drug intravenously during 10 days, after that they pass tableted form; in second group patients take only traditional cure (angoprorector, resorption, vitamin therapy). Exploration revealed positive influence to the drug demonstration demolition neorapathy.Begin the second week of treatment, sick people mark reduction debility and sick people`s organism lower showings sensivitity and vegetative disorder. Take the tablet of prolong reach effect, at abolition of the drug therapy effect saved during 2-3 months. Thereby influence diabetic neropaty with using the neoprorector along the propose circuitry show substantial effect current method of treatment.

  A Narbaev, S Khaidarov, Yo Normatov

  61-63

  116   23

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  Assessment of volume and functional indicators of the myocardium at patients after stenting of coronary arteries It was found that after stenting for 1-2 hours a reduction in the volume-functional indicators, increased ejection fraction improves segmental contractility of the left ventricle in patients with coronary artery disease. Stable angina FC III as with PICS and without PICS. Reducing the volume-functional parameters after stenting, has a positive effect on the subsequent remodeling of the left ventricle. In both groups of patients surveyed noted the change in myocardial contractility as normakineza or improved kinetics in patients with coronary artery disease stable angina FC III without PICS these indicators were more pronounced

  D Muhammadiev, S Shukurjanova, K Zakirov

  56-60

  106   23

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  Clinical and biochemical characteristics of congenital hypothyroidism in children The study involved 48 patients with congenital hypothyroidism, aged 3 months up to 16 years, on the basis of Samarkand Regional Screening Center of mother and child. In a study of children used the entire set of methods (Apgar score, percentiles table, thyroid status, physical performance, neuropsychological development, the state of the cardiovascular system). The study found that among children with congenital hypothyroidism diagnosed during the neonatal screening, rarer delayed physical and psychomotor development, functional disorders of cardiac activity and the formation of disabling variations in health status, due to early diagnosis and the start of replacement therapy

  V Kim, X Xamraev, N Babaeva

  53-55

  83   33

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  New appaches to mass dehelmintisation of children from enterobiasis The research work was focused on study of efficiency of two methods mass dehelmintisation from enterobiasis by Albendasole. The first method (89 children): Albendasole was prescribed for two courses 2 day each, with interval two weeks, in a single dose 10 mg/kg/day. In the second method (112 children) Albendasole was prescribed in a single dose of 400 mg for one day; it was repeated 21 days later. The percentage of children infected E.vermicularis decreased from 52.8% to 3.3% in the first group; and from 70.53% to 3.5% in the second group.

  L Kachugina, T Vakhobov, D Saidakhmedova, G Rustamova

  50-52

  107   25

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  Comparative analysis of laparascopic and celiotomy technology at treatment of girls with ovarian cysts Ovarian cysts are not true tumors, they formed due accumulation of the liquid in the cavity. Usually ovarian tumors in children meets more in adolescence (10-14 years). Among the causes of the picture of «acute abdomen» in children, according to pediatric surgeons, torsion ovarian formations is about 15%. The use of modern laparoscopic technologies will allow to avoid postoperative complications and to preserve the reproductive potential of future women

  A Kasimova, B Negmadzhanov, G Rabbimova

  47-49

  74   22

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  Cardio-renal relationship with kidney disease in children The aim of this work is to study the role of heart failure in the fatal outcome of patients with symptoms of chronic renal failure in predialysis stage. Materials and methods. We have retrospectively studied 52 patients with CKD in predialysis stage with chronic renal failure and 15 children who died in the predialysis stage with symptoms of chronic renal failure at the age of 2 to 14 years. GFR was determined by the Schwartz formula (Schwartz) .Otsenivali clinical, laboratory and echocardiographic parameters. Stage of chronic kidney disease was determined according to the criteria of KDIGO. Results. Analysis of causes that led to the development of chronic renal failure revealed 40 cases of chronic glomerulonephritis, 6 cases of hereditary and congenital diseases of the urinary system. Left ventricular hypertrophy (LVH), an extension of the left ventricle revealed third of patients at an early stage of CKD, glomerular filtration rate (<60 ml / min / 1.73 m2) .The most unfavorable in terms of remodeling proved LVH with anemiey. This combination noted in 36.1% of patients with stage I CKD, 71.4% with Conclusion. High lights the shortcomings of holding renocardioprotektory therapy, the observed cases, and early correction of renal anemia

  N Goyibova, G Ishkabulova, Б Yuldashev, A Akhmatov, N Turaeva

  38-46

  161   33

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  Features conservative treatment of patients with injury craniofacial The purpose of the study. Analysis of the structure and to determine the clinical course of acute phase patients with combined injuries of the head and face. Materials and methods. The analysis of medical records of 112 patients with combined injuries of the head and maxillofacial region, who were hospitalized in the department of traumatology, neurosurgery and maxillofacial surgery 2 - Tashkent Medical Academy Hospital in the period 2008 - 2012. The results of the study. In patients with associated trauma psycho-emotional changes occur that affect the neurophysiological state of the central nervous system. The study deserved special attention to determine the degree of adjustment of patients. Research findings show that despite some progress made in this complex area of surgery, requires modernization of methods of diagnosis and treatment, as well as the continuation of scientific - practical research combined craniofacial injuries

  Sh Boymuradov

  32-37

  103   20

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  Methods preinduction and induction of labor Purpose: To describe the main methods of obstetrics. Material and Methods: The search results in scientific journals CIS used sites www.medline.ru, www.pubmed.com, www.google.co.uz and others. Results: during the search revealed publications, which are the results of the use of different methods of preinduction and induction of labor process, their positive and negative qualities. Conclusions: All methods of induction of labor carried out only with the consent of the patient and under the control of sonography. The most common medical methods, mainly prostaglandins. Of mechanical methods in studies of induction preference is given to the balloon catheter, kelp and synthetic analogs in the absence of contraindications

  F Atakhodjaeva, X Alimova

  27-31

  192   31

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  Relaparotomies programmed in the treatment of advanced peritonitis In article advantages and lacks of a traditional way of treatment of a sharp widespread peritonitis and programmed relaparotomy are compared. Researches have shown, that programmed relaparotomy is an effective method in the prevention of development of purulent complications of a belly cavity and by that, promotes decrease летальности from 26,6% to 12,4%

  U Abdullaev, K Tagaev, B Abdullaev

  21-26

  93   40

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  Clinical features of pneumonia in the newborn, being in contact with ard in anamnesis ARD is of great specific gravity among the causes of pneumonia in children. But the most frequent are adenoviral and respiratory-cynticial infections. Addition of microbe infection following ARD makes the clinical picture of various types of pneumonia similar , associated with different respiratory agents but at the same time some differences are established. Anamnesis and clinical manifestations of pneumonia were studied in 116 newborn being in contact with ARVI and admitted to the hospital of them 44 patients were admitted from maternity hospital (a group for comparison) , 72 newborn from their home. The analysis of the structure according to groups showed that most of patients were admitted in april and September and what is more they were admitted from their home, i.e. they were in contact with ARVI and their number was larger (62%). Clarification of peculiarities indicates to predominance of obstructive syndrome of pneumonia in the newborn admitted in spring and intestinal symptomatics in autumn. The analysis of clinical picture according to seasons indicates to predominance of RC infection in spring and adenoviral infection in autumn period that coordinates with conclusions of epidemiological service

  M Abdullayev, F Yakhshilikova

  17-20

  101   17

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