Indicators of lipid peroxidation and their significance in pathogenetic mechanism of anaemic cardiomiopathy

To characterize the morphological and functional changes in the myocardium arising from the develop-ment of chronic iron-deficiency anemia the terms of «anemic heart» or anemic cardiomiopathy are used. For the purpose of the main pathogenetic mechanisms, in particular lipid peroxidation, 140 patients suffering from chronic anemia of varying degrees of severity and cardiomyopathy and 30 generally healthy individuals were studied. During the research it was identified that the main mechanisms stimulating the cascade of metabolic and morphofunctional changes in the heart of patient suffering from IDA are the indication of hemical hypoxia and activation of the processes of lipid peroxidation which lead to the decrease in antioxidant protection. In turn, the reduction of antioxidant protection leads to the intensification of production of pro-inflammatory cy- tokines which are involved in fibrillar collagen degradation and intensification of cardiomyocyte apoptosis, that causes cardiomiopathy