No. 3 (96) (2017) Problems of biology and medicine

Статьи

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  Features anamnesis pregnant women reproductive losses Study the features of pregnant women with a history-governmental reproductive loss in history enable the development of proposals to improve the medical care of mother and child directed lennye to prevent re-productive losses

  M Mamadieva, G Kuzieva, Sh Mamazhonova

  62-64

  74   18

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  The right of authorship and priority in applied sciences - biology and medicine The rights of authors, inventors and innovators are protected by law [5,13,14,20]. One of the objects of legal protection is the discovery - the establishment of previously unknown objectively existing patterns, properties and phenomena of the material world, introducing fundamental changes in the level of knowledge. The state registration and legal protection provided for by the “Regulations” do not apply to discoveries of mineral deposits, as well as to geographical, archaeological, paleontological, i.e., discoveries that have the character of expeditionary finds. State registration is also not subject to discoveries in the field of social sciences [9,10]. The object of legal protection is an invention - a new technical solution of a problem with significant differences in any area of ​​the national economy, social and cultural construction or defense of the country, which gives a positive effect [10,11,17]. Rationalization proposal - a technical solution , which is new and useful for the enterprise, organization or institution to which it is submitted, and provides for a change in the design of products, production technology and applied equipment or a change in the composition of materials [19]

  S Allazov

  183-188

  137   19

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  Dynamics of cellular immunity formation in small-weight children with animal dependence on the duration of gestation Purpose. The study of cellular and humoral immunity in premature infants. Material and methods. 90 premature babies born on the gestational age of 28-37 weeks. Methods of research are immunological, statisti-cal. Results. The state of the immune system in premature infants depends directly on the gestational age. The shorter the gestation period, the more pronounced manifestations of the decrease in the links of the immune status. Conclusion. Deficiency of immunoglobulin A is due to the immaturity of the undernourished child, but also the direct effect of its action on the sub-gastric gland

  L Umarova, D Ahmedova, N Ishniyazova, X Abdurakhmanova

  102-104

  169   23

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  Surgical treatment of dysplastic instability of hip joint in children and adolescents by creating the long canopy over head of the femur Surgical treatment of congenital dislocation of the hip in the late period, especially in older children and adolescents, with high standing of the femoral head and secondary changes of elements of the hip joint, and also the muscles surrounding it is a difficult and not solved the problem. Objective: Based on the study results exist, methods of surgical interventions aimed at restoring the supporting ability of the limb in congenital dis-location of the hip in older children and adolescents, the most effective options work out operational interven-tions in this group of patients depending on the severity of hip dislocation and implement them in practical medicine. Material and Methods: The study is based on a survey and study of the results of surgical treatment of 70 patients’ older children and adolescents with unilateral congenital hip dislocation. To study the results of treatment have been used clinical, radiological and statistical methods. Results: The results of treatment were followed in the period from 1 to 6 years. Positive results were re-ceived in 82% of patients

  X Tilyakov, B Tilakov, A Tilyakov

  97-101

  115   20

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  Importance of the level of urinary acid in the clinic and pathogenesis of acute coronary syndrome 58 patients with acute coronary syndrome with asymptomatic hyperuricemia were examined. The results of the study showed that ACS is accompanied by an increase in the level of uric acid in the blood, which tends to decrease during the recovery of circulation in the ischemic myocardium, which characterizes the significant activation of the enzyme xanthine oxidase, which generates active forms of oxygen

  E Tashkenbayeva, M Atayeva, Z Nasyrovsa, F Kadyrova, D Togaev

  94-96

  140   29

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  Neurophysiological and hormonal features of adolescence epilepsy The study involved 95 teenagers with epileptic paroxysms. The study included 48 children (22 boys and 26 girls) aged between 12 and 17 years with various forms of epilepsy. All of the patients underwent clinical and instrumental methods of electroencephalography, magnetic resonance imaging and examined hormones in the blood. Survey assessment showed that epileptiform EEG changes on MRI brain structural changes identi-fied in the majority of cases. Results of the study of hormones in the blood indicate a complex interaction be-tween the endocrine and nervous systems in epilepsy in adolescents

  D Rakhmatova, S Pulatov

  89-93

  151   23

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  The results of surgical treatment of uncomplicated compression-splinter osseous fractures of lower thoracic and lumbar vertebrae Now the basic principles of surgical treatment of spinal fractures are the most quickly and effective recovery of anatomic relationship, rigid bracing of the damaged segment and early activation of the victim. 34 patients with the fractures which aren't complicated compression complete burst the lower thoracic and lumbar of vertebrae were investigated. 11 patients have a preoperative reposition of the compressed vertebra with anatomic height and corrections of a posttraumatic kyphosis of a spine column with use of the device "Pardayev-Urinbayev" (patent RF №2033775), the subsequent use by transpedicular system bracing for stabilization of vertebrae. Thus, the preoperative reposition with the Pardayev-Urinbayev device reduces duration of operation and use of TPF, reduces hemorrhages and increases showiness of operation

  S Pardaev, M Narkulov, I Zhuraev, F Gafurov

  86-88

  83   23

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  Course features of hemispheric tumors of the cerebellum The study includes data from clinical and neurological examinations of 31 patients (18 women, 13 men), whose average age was 30 years with tumors localized in 18 (58,0%) patients in left, 13 (42,0%) patients in the right hemisphere of the cerebellum. For tumors of the hemispheres of the cerebellum characteristic was the presence of general cerebral and focal symptoms. Among the cerebral symptoms were observed headache (77,4%), vomiting (67,7%) and dizziness (35,4 %), of focal disorders - dysfunction of the cranial nerves (80,0%), dominated oculomotory disorders (37,2%), indicating the progression of the compression of brain-stem.

  S Norkulov, A Chodiev, N Norkulov, X Umarov

  83-85

  61   19

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  Diagnostic of the antioxidant system in children with chronic purulent rhinosinusits Summary: In recent years the possibility of isolating groups of free radical pathologies. High sensivity of test reflecting the metabolic reaction of the membrane level in chronic sinusitis that’s explains the composition of cell membranes and obtain more information for assessing the severity of pathologic process. There were showing and treating 48children at age from 5 to 15 with an exacerbation of various forms chronic sinusitis. Applying of drug aktovegen shows not only therapeutics effect but proof his antioxidant effect which show how relapse are down after applying therapy it make possibility for recommendation necessary in complex therapy

  M Nasretdinova, F Nurmukhamedov, N Khushvakova

  79-82

  53   18

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  Optimization of conservative treatment of exudative otites media on background of allergic rhinitis in children Applying antihistamine in complex therapy exudative otitis media with an allergic rhinitis antilecotreins and topic intranasalglucocorticosteroids has show them to b reliable clinic effect which degenerated in the de-velopment of hearing decreasing symptoms and improving life style. Under our supervision there were 67 chil-dren with exudative otitis media by age from 3 to 18 year , 39 from them wereboys, and 28 were girl. Using in complex therapy with exudative otitis media with an allergic rhinitis intranasal glucocorticosteroid showing highly clinic effect, which shows reliable mucociliar transport function mucous membrane

  M Nasretdinova, O Kodirov, N Khushvakova

  76-78

  135   25

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  The analysis of surgical treatment results in patients with furnie’s gangrene Results of surgical treatment of 13 patients with scrotum gangrene (Furnie’s disease) admitted to the proctology department of the 1st SamMI Clinic are observed in the article. The early diagnostics and active management are used for radical surgical treatment of the purulent necrotic focus in combination with ne-crectomy in step-by-step maneuver. Complex system of the local treatment of the wound, purposeful and multi-ple component correction of systemic and metabolic disorders of the homeostasis are the real way to improve treatment results

  Z Murtazoev, M Rustamov, U Sherbekov, Z Saydullaev, L Rahmatova

  73-75

  99   24

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  Тhe use of the drug hemolif in the cure of iron-deficiency anemia Treatment of iron-deficiency anemia is carried out according to the etiopathogenetic condition. If possi-ble, the causes of the disease are eliminated by an etiological factor that promotes the development of anemia. Pathogenetic method of cure is the appointment of iron preparations. In this work, characteristic of the medi-cine "Hemolif" is given, which was used in 30 patients who were on cured at the Research Institute of Hema-tology and Blood transfusion with the iron-deficiency anemia diagnosis in heavy degree. The positive effect of the Hemolif action is due to the iron (III) content of the hydroxide of the sucrose complex, stimulates erythro-poiesis and leads to an increase in the hemoglobin level

  A Mahmudova, A Turabov, S Mamaradzhabov, G Davlatova

  70-72

  189   24

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  Clinical and x-ray diagnostic characteristics of the enlarged mediastinum syndrome in urgent states in children The syndrome of enlarged mediastinum is a symptom complex characterized by certain signs of diseases and conditions accompanied by an increase of the mediastinum organs. The most significant nosological units in children are carditis, cardiomyopathy, congenital heart defects, thymomegalia. Rapid determination of the nature of the disease, radiologically characterized by enlarged mediastinum, is important in urgent conditions. Timely determination of such indices as cardiothoracic, cardiothymicotorakal and vaso-cardial according to a survey X-ray diffraction can be considered an accessible method of differential diagno-sis in infants with acute conditions

  E Mamutova, X Shadieva

  65-69

  525   48

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  Epidemiological features of epilepsy according to the age and gender in rural districts of samarkand region Purpose: carry out analysis of the morbidity frequency of epilepsy and its prevalence according to the age and gender in rural districts of Samarkand region. Materials and methods: objects of research has served the territory of four rural districts of Samarkand region, which determined the incidence and prevalence of epi-lepsy. Results: Analysis of the morbidity of epilepsy in this population showed that the annual rate of total mor-bidity was higher than the indices of the previous years, designed on the basis of anamnesis. Conclusions: analysis of the prevalence of epilepsy according to the age showed a gradual increase of infestation of epilepsy in the middle age groups, with a peak in the group of 44-60 years and a gradual reduction from the sixth dec-ade

  N Abdullayev, Z Mavlyanova, O Kim

  9-13

  220   31

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  New ways in treatment of stomach malt lymphom The decisive role for the emergence of MALT ("mucosa-associated lymphoid tissue" - lymphoid tissue associated with the mucous membranes) of gastric lymphoma is the role of stimulation of anthigen of local im-munity in the presence of Helicobacter pylori infection. For retrospective study, 83 patients with MALT diag-nosis of gastric lymphoma were taken in the treatment of the Republican Cancer Research Center and Tashkent City Oncology Dispensary. The diagnosis of all patients was confirmed histologically

  M Mallaev, M Ostonova

  59-61

  64   26

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  Clinic-diagnostics factors of the forecast at the choice of immunotherapy methods at patients with ovarian and cervical cancer The purpose of the work to study of the molecular and biological markers in the ovarian and cervix can-cer as choice criteria methods such a extracorporal immunofarmakotherapy (EIFT) among the complex treat-ment. To study level of tumor markers was shown that the greatest predictive importance for treatment efficien-cy such markers as p53, VEGF and Ki-67, and level of tumor proliferative activity. The greatest effect obtained when carrying out an accompanying immunotherapy with EIFT and plasma exchange

  S Kamishov, D Pulatov, D Nishanov

  53-58

  116   30

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  Improvement of surgical treatment of acute gangrenous necrotic paraproctitis The study group is 767 patients who had been treated at the Proctology department of SamMI clinic №1 between the period from 2001 to 2016 years among which 36(4,7%) patients had necrotic form of the disease. In 731 (95.3%) aerobic etiology of damage was found. The average age of the patients was 63,1±4,9 years old. Clinical checkup, digital investigation of the rectum and rectoromanoscopy, transabdominal and transrectal ultrasound, CT and bacteriological investigation of wound’s discharges were done in all the patients. All the surgeries were performed urgently. Results of the studies showed that early diagnosis and radical operation with additional antibacterial and detox therapy led to recovery

  T Kamolov, I Mustafokulov, Sh Baisariev, U Sherbekov, M Dusiyarov

  50-52

  74   24

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  Alloplastics in postoperative ventral herbs In the Samarkand city medical association in the department of thoraco-abdominal surgery in 2013-2016, 68 patients were hospitalized for postoperative ventral hernia. Of them, alloplasty was performed in 44 patients on the anterior abdominal wall by the "onlay" method, and the remaining 24 patients underwent alloplasty of the anterior Of the abdominal wall by the method of "sublay", about large and giant hernias. Among these alloplastics, the following complications were observed using the "onlay" method: recurrence of hernias, accumulation of subcutaneous seromy. In alloplasty by the method of "s Ublay "these complications were not observed, and the postoperative rehabilitation period was reduced. The obtained results show that, according to the" sublay "method, alloplasty is considered to be the most effective method for large and giant hernias

  D Kamilov, A Babazhanov, A Toirov, G Ahmedov, A Ahmedov

  47-49

  135   38

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  Quantitative assessment risk factors of rapid development of alcoholism The comparative quantitative assessment risk factors of rapid development of alcoholism are scrutinized in the article. 140 alcoholic patients aged 25-65 years have been studied by Clinical-statistic method. Univari-ate depression analysis with the usage of Kraskola-Uolis criteria was used for comparison with medieval clinic significance, age-specific and dynamical parameters. While carrying out the research the author has revealed that early formation of alcoholic dependence is not associated with the age onset of alcohol consumption but mainly risk factors in premorbid. The results of the research showed that the dynamics alcoholism development is important to evaluate the clinical severity, the flow rate and development of optimal tactics of treatment. The presence of premorbid cofactors risk increases the development of alcoholism as quickly as 2,5 times compared to uncomplicated premorbid. In conclusion, the author draws a conclusion that quantitive dynamic develop-ment characteristics of the disease will be fairly objective criteria to predict the clinical versions and types of alcohol flow.

  Sh Imamov

  43-46

  131   19

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  Analysis of efficiency of integrated therapy of pregnancy with dysfunction placents The results of complex therapy in 65 pregnant women with placental dysfunction are analyzed. The con-trol group consisted of 30 women with a physiological pregnancy. The main group consisted of 65 pregnant women in the gestation period of 32-36 weeks, in whom placental dysfunction was diagnosed as a result of ul-trasonic screening. The inclusion of levocarnitine and L-arginine in therapy with placental dysfunction can effectively stabilize the functional state of the fetus and prolong the prolongation of pregnancy

  V Ovcharuk, A Boychuk, O Khlibovskaya

  38-42

  115   23

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  Overcoming disturbance of reproductive health of women with endometryoid kystes The condition of the ovarian reserve in endometrioid cysts of the ovaries depends to a large extent on the volume and frequency of the surgical intervention. The results of the hormonal study suggest that the most sen-sitive to intraoperative damage and an indicative marker of the ovarian reserve is the antimuller hormone in combination with the determination of the CA-125 content and the concentration of follicle-stimulating hor-mone. The results of the performed surgical intervention in a sparing amount allow us to predict the restoration of fertility after surgical treatment with the maximum preservation of healthy tissue, which allows preserving the reserve of ovaries and the reproductive health of women

  A Boychuk, O Kurilo, T Tolokova

  31-37

  81   25

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  A differentiated approach to infertility management of tubal-peritoneal genesis after an ectopic pregnancy in an anamnesis We analyzed long-term results of patency of the fallopian tubes according to metrosalpingography data in different variants of conducting an ectopic pregnancy. The data showed that in women who underwent con-servative treatment with cytostatic, the patency of the fallopian tubes was significantly better than after surgical treatment. In cases of interrupted ectopic pregnancy for which laparotomy was applied with the removal of the motor tube, infertility of tubal peritoneal genesis developed in 60 % of cases, which coincides with the opinion of many authors

  A Boychuk, V Koptyukh, Yu Yakimchuk

  27-30

  79   19

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  A study of the spectrum of anti- and proinflammatory cytokines in blood serum with family bronchial asthma The article considers the spectra of anti- and proinflammatory cytokines in blood serum at the family bronchial asthma, as well as the nature of clinical and pathogenic forms of bronchial asthma, which affect the formation of the disease. The study was conducted in 346 relatives from 49 families with bronchial asthma. It was determined in the serum of IL-6 and γ-interferon that the "Vector-Best" test was used. A study was made of the number of IL-6 and γ-interferon in the blood serum in patients with familial bronchial asthma, depending on the pathogenetic forms, stages, length of service and the degree of disease control. It was found that an in- crease in the number of IL-6 in the blood serum, a decrease in interferon-γ depending on the stage, allergic forms, an increase in the length of the disease and in patients with uncontrolled asthma are a differential diag-nostic marker.

  N Aralov, T Okboev, N Khodzhieva, G Klebleeva, P Zakiryaeva

  24-26

  126   34

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  G915c polymorphism of tgf b1 gene in type 2 dm men of uzbek population Materials and methods: 158 male patients with DM type 2 men Uzbek population have been surveyed. Results: Analysis of the research showed that the allele C gene TGFβ1 occurs much less frequently than allele G in both healthy individuals (3,2%), and in patients with type 2 DM of (8,2%). CC genotype frequency of equally high and (93,5%) in healthy patients and DM (84,8; p=0,31%). No significant differences in genotype frequency of CG in healthy subjects and 6,5% of patients with type 2 DM (13,9%). Homozygous GG genotype in healthy men was not present. Conclusion: Except for lack GG genotype among researched healthy men and patients with type 2 DM of Uzbek population no significant difference was defected neither in allele, nor in rep-resentation of genotypes G915C polymorphism gene TGFβ1

  G Akramova, Z Akbarov, F Takhirova, S Ismailov

  21-23

  96   21

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  Results and features treatment the diaphyseal fractures of both forearm bones in children Treatment of children with fractures of bones of a forearm is an urgent and complex problem. The analy-sis of treatment of the closed fractures of bones of a forearm at 118 patients is made. The patient has applied conservative treatment (a one-stage manual repozition and an immobilization with plaster steak) and expedi-tious treatment (an open repozition, an intramedullary osteosynthesis and an immobilization with plaster steak) methods. Renewal of working capacity has happened in 71,4% of cases. It has become possible thanks to a combination of terms of treatment to the rehabilitation period, and also use improved a method of expeditious treatment. The correct comparison of bone fracture, their reliable fixing, early adequate functional loading is the main principles of treatment of fractures of forearm. Studying results of clinical application of a way a one-stage manual repozition and an intramedullary osteosynthesis of fractures of bones of a forearm at children is given in article. Studied and improved ways treatment provides increase in rigidity of fixing of bone fragments, prevents deformation, promotes to successful result.

  V Akramov, A Teshaev, B Khamraev, Sh Ahmedov

  17-20

  188   24

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