No. 1 (93) (2017) Problems of biology and medicine

Статьи

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  Analysis of options preoperative preperation and anesthesia in the treatment of thyroid diseases The results of surgical treatment, preoperative preparation and anesthesia of 72 patients operated on goiter are presented in the article. A new approach to stress-protective preoperative therapy is suggested. The efficacy of anesthesia with of ketamine and advantages of this approach in comparison with standard general anesthesia are shown.

  S Zhoniev, A Rakhimov, A Babazhanov

  60-64

  119   29

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  Rheumatoid arthritis Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the development of symmetrical arthritis of peripheral joints, leading to progressive destruction of articular structures, as well as systemic damage to internal organs. ICD-10: M05-06. Epidemiology. The prevalence of the disease is about 1%. Women get RA 3 times more often. Most often, people aged 35-45 get sick.

  N Mamasaliev, Z Mamasaliev, U Suvonkulov, M Kachkovsky

  218-220

  155   22

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  Immunologic risk factors of development otitis media with effusion in children suffering from chronic adenoiditis The study of mucosal immunity included assessment of SIgA, IL-6, IFN-y and IL-10 levels in nasal wash-es. Decrease of SIgA content and increase of the number of IFN-γ -positive samples was revealed in children from the 2nd clinical group, which allows to regard these characteristics of the mucosal immunity as the risk factors for the development of otitis media with effusion

  M Nasretdinova, N Khushvakova, A Khayitov, A Ibragimov

  94-96

  170   23

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  Changes in the indices of lipid peroxidation in the comprehensive treatment of inflammatory diseases of the eye surface with photodynamic therapy The effect of photodynamic therapy on lipid peroxidation in lacrimal fluid as a part of comprehensive treatment of inflammatory diseases of the eye surface was investigated in this study. MDA level increases in the lacrimal fluid of patients with inflammatory diseases of the eye surface as the activity of catalase decreases and imbalances in the lipid peroxidation/ antioxidant defense system occur, especially in patients with keratitis. The use of photodynamic therapy in the comprehensive treatment of patients with inflammatory diseases of the eye surface activates catalase, reduces the high amount of endogenous intoxication and stimulates reparative pro-cesses of the cornea and conjunctiva.

  K Narzikulova

  90-93

  181   25

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  Role of violations prooxidant / antioxidant balance in women with hyperplasia of endometriy A distinctive feature of hyperplastic changes of the endometrium is a significant increase in the concen- trations of lipid peroxidation products and decreased activity of antioxidant enzymes in the blood with the growth of the severity of disease

  Z Nazirova, D Asrankulova, Sh Goziev

  88-89

  77   21

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  Evaluation of treatment perforated duodenal ulcer minimally invasive of technology 162 patients with perforated gastric and duodenum ulcers treated in the Clinical Hospital since the year 2006 for the year 2016. If there is no associated complications of peptic ulcer follow as pyloric stenosis, penetration of gastric or duodenum ulcer, bleeding, the operation of choice was suture placation. During that period, completed 64 of endo-surgical interventions. 62 of them performed laparoscopyc suture placation and in 2 cases completed conversion. Percentage of laparoscopic repair of perforated gastric and duodenum ulcers has increase to 21,3% in the year 2016.

  I Mustafakulov, Z Murtazaev, S Kamolov, K Sherkulov

  86-87

  98   19

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  Endoscopic hemostasis in duodenum ulcer bleeding The results of treatment of 50 patients with bleeding from the upper sections of the gastrointestinal tract were analyzed. Methods of conservative therapy, endoscopic hemostasis and surgical treatment were used. The effectiveness of argon-clotting coagulation with continuing bleeding is shown

  I Mustafakulov, M Rustamov, U Mahramov, Z Juraeva

  84-85

  137   24

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  First experience of unilateral spinal anesthesia in patients of senior and senior age at operations in the bottom section of the abdominal cave A comparative clinical evaluation of two types of neuraxial blockade: symmetrical unilateral spinal anesthesia and spinal anesthesia during operations on the ground floor of the abdominal cavity in elder-ly patients. After obtaining informed consent were included 30 patients (17 men and 13zhenschin), which are divided into two groups of 15 people, depending on the variant carried out neuraxial blockade. Comparative evaluation of clinical neuraxial blockade was carried out on the basis of the definition of motor and sensory block. Unilateral spinal anesthesia with hyperbaric bupivacaine is an effective method of anesthesia-sided sur-gical interventions on the ground floor of the abdominal cavity and adequate postoperative analgesia positive

  M Matlubov, E Khamdamova, V Atamuradov, B Akramov

  80-83

  115   31

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  State over segmental and segmental sympathetic centers of autonomic regulation in parkinson's disease On the basis of comprehensive clinical and instrumental diagnostics of autonomic disorders by studying the skin caused by autonomic potentials revealed a syndrome of progressive autonomic failure. It proved a sig-nificant increase in the latent period and reduced amplitudes in Parkinson's disease, indicating a lesion of segmental and suprasegmental vegetative structures gemetype

  Yo Majidova, S Fahargaliyeva

  78-79

  91   22

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  Rationale for treatment of patients with echinococcosis, taking into account the functional state of the hepatobiliary system The main biochemical indicts of hepatic functions the aktivifres of alanine aminotransferase aspartate aminotransferase. Concentration of bilirubin, were studied in the sera of 72 patients with liver echinococcosis. There were detected the cytolycitic syndrome in 15, 25%, mesenchymal – inflammatory syndrome in 41,2% and cholestasis in 25,3% cases of disease. Test results medicated that ursodeoxycholic acid had hepatoprotective effect. It shoold be used in combine usage with albendazole to correct the liver function, which disturbed by action of Echinococcosis ghanulosis and albendazole

  L Kachugina, D Saidakhmedova, N Yarmukhamedova

  75-77

  86   21

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  Diagnostics of the premature break of the frozen surgery of pregnancy The study is based on a clinical and laboratory examination of 82 pregnant women with premature rup-ture of membranes at different gestational times, which were monitored and entered the obstetric ward of the maternity hospital. The slight leakage of amniotic fluid does not reduce the risk of complications, but, on the contrary, increases the danger. This is due to the fact that from the moment of violation of the integrity of the membranes before detection of this complication, a long period may elapse. It is known that the informativeness of the nitrazine test and fern phenomenon decreases as time increases from the moment of rupture of the membranes. In cases of prolonged premature rupture of membranes, these tests give no more information than a routine obstetric study.

  Sh Kasimova

  72-74

  93   17

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  Predicting the likelihood of myocarditis in patients with acute pneumonia Due to the developed criteria to determine the likelihood of myocarditis in infants with pneumonia, made possible the formation of high-risk groups for adverse outcome of pneumonia. This will increase the likelihood of the development of myocarditis in children and the effectiveness of the therapy, to reduce the incidence of morbidity of acute pneumonia and significantly reduce the number of complications, and thus mortality rate

  N Israilova

  69-71

  91   25

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  The results of the application of compressesive-distractive osteosynthesis at refract tibia diaphysis There results of osteosynthesis of tibia by Ilizarov in 540 patients are mentioned in the article. Patients were examined by dividing them into 2 groups. In 486 patients who were in the first group, it was tried to insert broken bones were at once, they were attached to the Ilizarov installation consisting of 4 rings. The part of bones that was impossible to insert at once, were inserteded gradually with the help of the installation. In 80% of patients the bones grew together in time. In 20% there was a slow fusion not fusion and false joints. In 54 patients who were in the second group, the bones were inserted at the same time with the help of IIT, and are attached to the installation of the Ilizarov. In all Patients who were in the second group but one (he had con- comitant diseases, obesity -III degree, diabetes) bones have grown together during. The reason of the fact that the bones were inserted at the same time and were strongly attached to the seam.

  S Ibragimov, X Samatov, R Mirzaev

  65-68

  114   23

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  The role of functional studies of cardiorespiratory system with funnel chest deformity The article presents its own material 66 observations of patients with funnel-like deformation of the chest. It is shown that multispiral computed tomography is the most informative method in determining the shape, severity of curvature and the degree of cardiorespiratory disorders, and also determining the choice of therapeutic tactics. Starting in 2013, patients with this congenital pathology were operated using the method of minimally invasive thoracoplasty according to D. Nuss. It is noted that the application of this method of correc-tion of funnel-shaped deformation of the chest is a method of choice and gives good functional and cosmetic results.

  A Shamsiev, J Shamsiev, Yu Turaev, A Mutalibov, M Burgutov

  9-14

  160   60

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  Efficiency of autoplazmochimiotherapy with locally advanced cancer of the mucosa of the mouth floor and tongue The article presents an evaluation of the effectiveness of intra-regional and intra-operative autoplazmohimioterapii, as a component of comprehensive cancer treatment antineoplastic the bottom of the mouth and tongue. The findings suggest that a sufficiently high efficiency, safe toxic profile and the positive dynamics of immunoregulatory proteins in intra-regional and intra-operative autoplazmohimioterapii as a component of an integrated antineoplastic treatment in patients with cancer of the mouth floor and tongue

  A Ganiev, M Khalmatova

  57-59

  84   24

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  Prognostic evaluation of the risk of chronic pathologies among tubcontacts of children in educational institutions sanatorium The method of questionnaire survey of parents to study the characteristics of regime moments and conditions of education in 1175 of children in preschool tuberculosis sanatorium profile - the main group ( 220 children) and in preschool general types - the control group (955 children). Number of children in the study group with the breastfeeding duration of 12 months or more was 1,8 times less than in the control group; the number of children in the main group 1,1 times more educated in beshik, and those children with the period of stay from 1,5 to 2 years were 1,3 times more. On average, 60% of children received the information about the elements of a healthy lifestyle in the family, 32% - in the preschool education and 8,5% - as a result of watching television, using the Internet and children's publications. Almost 70% of the duration of outdoor exercise, diurnal sleep, watch TV and play on the computer of preschool chil- dren exceded hygienic standards. The increase in the risk of chronic disease in children tubcontacts consistently influenced by factors such as the duration of the games on your computer, feeding children breast milk, watching TV, outdoor activities and education of the child in beshik

  L Basharova, S Umirova

  51-56

  228   21

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  Lifestyle preschool children are brought up in educational institutions of general and health types of tashkent city The method of questionnaire in 1175 households studied social and hygienic factors that are typical for parents and children - pupils of pre-school educational institutions and the general type of tuberculosis sanato-rium profile. Statistically reliably established that the increase in the risk of developing chronic diseases tub-contacts child consistently influenced by factors such as consumption of tobacco and alcohol by parents, the duration of feeding children breast milk (up to 9 months), consanguineous marriages between parents living child in a single-parent family, the duration of television viewing (2 or more hours a day) and play on the com-puter (more than 30 minutes a day), the social position of the father (temporarily or permanently unemployed), long walks in the fresh air (up to 1 hour per day) and the education of the child in beshik (over 2 years), the presence of professional production hazards parents (the temperature factor and contact with animals), living in a large (4 or more children) and large (7 or more people) family

  L Basharova, X Naimova

  45-50

  83   22

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  Evaluation of results reconstructive surgery on the arteries infrainguinal zone in the immediate postoperative period Operated on for chronic obliterating diseases of arteries in infrainguinal zone of 147 patients divided into 2 groups: op- erated by the method of reversed autovein (n=79) and operated by the method of using autovein in situ(n=68). In the imme-diate postoperative period thrombosis of grafts was 9.2% in group 1, 7.6% in the 2nd group. Each group performed one amputation at the hip level. Deaths cases are absent. Thus, during the femoro-distal bypasses by autovein excellent results are achieved with a method in situ, and in reversed autovein

  F Bakhritdinov, U Rasulov, B Karshiev

  41-44

  88   18

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  Comparative analysis of conditions of formation of persistent remissions in patients with opioid and cannabinoid dependence according prolonged catamnesis A comparative study of factors affecting the formation of stable remission in patients suffering from opioid and cannabinoid dependence. Studies have shown that certain differences in the characteristics of patients with opioid and cannabinoid dependence, cease taking of psychoactive substances

  F Bakhramov, L Tursunkhojaeva

  38-40

  64   22

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  Studying typoligical features of sportsmen of different specializations Properties of temperament of sportgirls. In this research took part 50 sportgirls on a calisthenics and 50.Тhe study was conducted based on a questionnaire of Eysenk. Testing method involves the identification of types of higher nervous activity: introversion - extraversion; neuroticism

  S Baratov, Z Mavlyanova, O Kim

  36-37

  170   27

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  Indicators echocardiography witch small heart anomalies in children Echocardiography results were analyzed 52 children and adolescents ages 3 to 15 years who were iden-tified by different localization and combinations of small anomalies of the heart, which are dominated by small abnormalities of the left ventricle and mitral valve. It found that clinically and functionally significant abnor-malities in children shew multiple abnormally located cords in the left ventricle in combination with cardiac arrhythmia, prolapses of the heart valves with modified wings and hemodynamically significant valve regurgi-tation.

  F Achilov, A Zhalilov

  33-35

  219   34

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  Improvement of results of furnye gangrene complex treatment with co 2 laser and photodynamic therapy using The use of CO 2 laser has allowed for the possibility of early and bloodless nekroektomy, improve wound repair, and reduces microbial contamination of purulent wounds. Method has photo coagulating and sterilizing properties effects on the tissue. Photodynamic therapy is a very effective non-invasive and gentle treatment of purulent wounds and serve as justification for the use of the method of photodynamic therapy in clinical prac-tice for the treatment of acute local inflammatory processes combined with CO 2 laser and traditional treat-ments.

  A Ataliev, A Murodov, V Shatemirov, X Kholov, X Ernazarov, N Malikov, F Bobosharipov, K Atabaev

  30-32

  166   30

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  Assessment of providing qualitative gerontological services capacity from the medical and social care heads poin of view Sociological study conducted using survey. The sample consists of the territorial departments of health heads, their deputies, heads of regional health centers and primary health care. For the data collection, a ques-tionnaire has been developed and used, which consists of 21 questions designed to assess the need and oppor-tunity for providing geriatric services (availability of facilities, human resources, diagnosis and treatment standards). Questionnaire filled out by respondents anonymously. The results of the survey showed that the ca-pacity of health institutions to provide effective gerontological care is limited, currently provided health and social care quality for the elderly is low and does not meet their needs and requirements.

  D Aniyozova

  27-29

  118   30

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  Structure of neuropsychological impairment in patients with idiopathic and symptomatic epilepsy The structure of cognitive disorders in patients with symptomatic epilepsy and idiopathic epilepsy. On the basis of the neurophysiological parameters of cognitive evoked potentials set specific disorders of higher cerebral functions in epilepsy, there were significant changes in latency and amplitude of P300, depending on the form of the disease. In the analysis of the relationship of indicators of psychometric tests and neurophysio-logical changes are revealed in all blocks of the implementation of cognitive function, more pronounced in symptomatic epilepsy.

  R Azizova

  485   33

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  Polymorphism of the dopamin receptor d 2 gene in fibrosy-cystic mastopathy in fertile age wives Genotyping of 120 women of childbearing age of Uzbek nationality, who consulted in the endocrinology department and consultative clinic of the clinic №3 Tashkent Medical Academy and in the city diagnostic cen-ter. In fibro-cystic changes in women with hyperprolactemia, the heterozygous type of polymorphism C3420T of the DRD2 gene with a mutation of the TT genotype predominates. In 75% of women there is a decrease in thyroid function.

  N Adkhamova, D Nazhmutdinova

  20-22

  106   25

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