No. 2 (2021) Journal of Biomedicine and Practice

The materials of rendering aid to 78 patients with fractures of the scaphoid bone in different periods after the injury were analyzed. The patients underwent treatment in the Republican Specialized Scientific and Practical Medical Center of Traumatology and Orthopedics in the department "Hand and foot surgery" 2019-2021. In the process of diagnosis, 14 patients were diagnosed between the years 2019-2021 , with modern methods of clinical examination, early diagnostic weight loss and primary medical treatment, and in suspected cases, CSCT and MRT examinations have clarified the diagnosis.

The article presents the results of our own research on the study of the period of postnatal adaptation in newborns with a vitamin D deficiency. It was revealed that early postnatal adaptation in most newborns with vitamin D deficiency occurs with disorders manifested by the pathological course of neonatal jaundice, maladjustment of the cardiovascular system, significant loss of the initial body weight and its long recovery

As a result of the study, it was revealed that patients with severe uncontrolled course of bronchial asthma received combination therapy with the drug "Foster 100/6" 1 inhalation 2 times a day for 12 weeks, daytime symptoms disappeared, the need for using short-acting bronchodilators per day decreased, and asymptomatic days increased.

Сurrently comorbidity is relevant in the outcome of many diseases. In particular,we are talking about IHD,unstable angina and anemia of varying severity. In 30 patients with coronary artery disease in combination with anemia, 3 valence iron was changed, the drug Sufer (Yuria-Pharm Ukraine) at a dose of 5.0 ml iv for 5 days against the background of standard therapy.In examined patients,that an increase in hemoglobin levels contributes to the normalization of the vibros fraction reduce or disappear angina attacks,increased exercise tolerance

The author shows the clinical and statistical study of the impact of various risk factors (age, sex, bad habits, dietary treatment, occupational hazard) for the development of pathology gepatopankreatoduodenalnoy system, the gravity of the current.

The age is common risk factor for cardiovascular diseases (CVD). One of the main risk factors for ageing is biologic age of vessels or vessel ageing. Main mechanisms of vessel ageing are oxidative stress, chronic inflammation, endothelial disfunction, apoptosis of endothelial cells, demage of endothelial EPCs progenitory cells functions, replication ageing of endothelial cells, disregulation of circadian system, arterial stiffness. Understanding of the mechanisms that lead to ageing pathophyziological changes in vessels is important and necessary of for novel methods of patogenetic treatment

Systemic lupus erythematosus is a chronic disease with multiple defects of immune regulation. The prevalence of systemic lupus erythematosus varies from 12.5 to 40 per 100000 populations, with predominance among women of reproductive age. Nervous system impairment in systemic lupus erythematosus occurs in 25 to 83% of cases of SLE and is associated with vasculopathy, thrombosis and hemorrhages, and direct damage to brain tissues with antibodies. The article presents a summary of clinical observation

The presented literature review highlights the problems of fluid therapy at the present stage of development. A brief classification and history of the development of infusion therapy are given. The advantages and disadvantages of various groups of infusion drugs are highlighted. Special attention is paid to infusion preparations with the ability to eliminate damage to the lipid component of biomembranes, of which the most valuable are those with antioxidant membrane stabilizing and antihypoxant properties. The drugs developed at the Republican Specialized Scientific and Practical Medical Center for Hematology (RSNPMCH) of the Ministry of Health of the Republic of Uzbekistan are described. In conclusion, the prospects for further development in the development of new generation infusion preparations are given.

Among rheumatic diseases reactive arthritis occupies one of the leading places in terms of prevalence and it is one of the most common chronic inflammatory joint diseases. When the process is chronic, destructive processes in the joints develop up to ankylosing. This article presents the results of studies on the features of the clinical course of reactive arthritis of post-enterocolitic and urogenital forms. The study was carried out in 120 patients with an established diagnosis of reactive arthritis.

A total of 241 lactating women with varying degrees of severity of iron deficiency anemia were examined. In breast milk, there is a decrease in the content of food ingredients (proteins, fats, carbohydrates) and calories, depending on the age of the mothers, the parity of childbirth, the lactation period and the severity of the pathology.
In sick women with grade III anemia in all groups, there is a significant drop in the content of all food ingredients and caloric value of breast milk, which leads to a significant deficit in the consumption of nutrients and energy by their children, which can serve as the basis for the development of nutritional deficiency states. Among nursing mothers with degree I anemia, there is a category of women who have a decrease in proteins, fats, carbohydrates and its caloric value in the composition of GM. In women with II degree of anemia in the composition of GM, there is a significant decrease in the content of food ingredients and calories. The latter are even more visible in groups of women aged 30 years and older, parity of 3 or more births and a lactation period of more than 6 months. The energy cost of GM is supported by carbohydrates

This article presents an actual problem of our century-the causes and mechanisms of flatfoot development, as well as our experience and methods of its correction. Republican Specialized Scientific and Practical-Medical. Center of Traumatology and Orthopedics in the department of "Hand and foot surgery" a research was carried out in the patient treated with 29 flatfoot diagnoses from 2019 to 2021. In this patients were used methods of CT, radiography, podometry, MRI and clinical examination. The average age of the patients is from 10 to 22 years (12±4) 12 female 17 male, mainly adolescent patients

In children’s tuberculosis inpatient departments of the PMCforPhandP and the Tashkent city tuberculosis hospital, 272 children and adolescents with various forms of tuberculosis were examined. Among children with various forms of tuberculosis, 28(10,3%) patients were diagnosed with complicated forms and 244 (89,7%)-uncomplicated forms of tuberculosis. When studying the risk factors for the disease, it was revealed that there were 225 (87,7%) children vaccinated with BCG, of which 58 (25,8%) children (76,8%), of whom anemia was found in 35 (12,9%) patients. In the structure of clinical forms in childrenand adolescents with tuberculosis, tuberculosis of the intrathoracic lymph nodes (57,0%) and primary tuberculosis complex (11,0%) predominate. Most of the children hada positivity to tuberculin (77,5±2,5%) and to the test for Diaskintest (69,5±2,7%).

The state of biochemical markers of inflammation in 337 patients with destructive tuberculosis with different genetic backgrounds was studied. It was found that in the indicators of inflammation – sialic acids, haptoglobin, seromucoids in patients with destructive pulmonary tuberculosis with different genetic backgrounds, there is a significant difference between individuals with different reactivity. The most profound and long-lasting changes in the activity indicators of acute-phase proteins are characteristic of patients with an unfavorable and relatively unfavorable genetic background

The results of the application of photodynamic sanitation of the abdominal cavity with the use of the photosensitizer methylene blue at a concentration of 0.05% with widespread peritonitis in the experiment are presented. It was found that when using the "FDU-1" device with a wavelength of 640 ± 20 nm as a source of LED radiation, the following parameters are required: exposure time 3-5 minutes for each irradiation area, output radiation power in continuous mode 100 mW / cm2, energy density from 25 to 35 J / cm2. The use of the developed method of sanitation of the abdominal cavity in experimental animals made it possible to reduce postoperative mortality from 25% to 7.5%.

21 patients with a severe course of COVID-19 were under observation. The study was carried out in a specialized hospital for the treatment of patients with coronavirus infection. A more detailed analysis of the ECG was carried out: the duration of the corrected QT interval, the variance of the QT interval, the Tp-Te interval and the Tp-Te/QT ratio were determined. Prolonged repolarization rates are a poor predictor of a dangerous COVID-19 outcome.

The article presents the results of the study, including both the epidemiological aspects of the disease and the factor analysis of the main causes of unsatisfactory treatment results, according to the largest institution specialized in COVID-19 – the Republican Specialized Multidisciplinary Infectious Diseases Hospital (Zangiata No. 1) – from the opening of the medical center on July 09, 2020 to December 31, 2020.

Any epidemic and pandemic that is a great stress or emergency leads to disruptions in the psycho-neurological system and human behavior. Psycho-emotional excitement in patients with severe Covid-19 dramatically reduces the effectiveness of non-invasive ventilation. Purpose of the study: to assess the efficacy, safety and impact on the quality of life of patients with dexmedetomidine and propofol against the background of a decrease in need for oxygen. The study included 21 patients with severe and extremely severe Covid-19. In the first group of patients with fear of death, a combination of drugs propofol + sibazone + fentanyl was used. In the second group, dexmedetomidine and promedol. Conclusions: in patients with a severe course of coronavirus infection, dexmedetomidine is more effective in reducing psycho neurological arousal and improving cognitive functions, which leads to an effective supply of oxygen and to their faster recovery.

As a result, the study found that allergic diseases in children with hereditary burden, and the clinical manifestations of allergies in children do not always coincide with the allergic disease in the mother. Children born to mothers with bronchial asthma and pollinosis have hypersensitization, polysensitization, meteorological stability, and a frequent combination of the underlying disease with other allergic reactions.

Identification of the clinical and neurological features of various forms of sleep disorders in children. The article includes data from the literature analysis on the aspects of insomnia and parosomnia in children, which are important for doctors, and the study of this problem in pediatric neurology remains an open question

Patients with COVID-19 show certain dental symptoms that can help doctors identify suspicious cases. These include oral ulcers, bladder-bladder lesions, erythematous patches, and acute mumps. The actual prevalence of dental pathology in patients with COVID-19 is underestimated, mainly due to the lack of documentation on the examination of the oral cavity in this group of patients, and the dental manifestations of this disease are not adequately covered due to the novelty of the pathology, the isolation of patients and the presence of other manifestations of COVID -19. If COVID-19 is suspected, a thorough oral examination should be performed, as oral manifestations may be the first symptoms of COVID-19. Therefore, dentists should be familiar with all the potential manifestations of COVID-19.

This article presents the results on the species composition of the genus Lactobacillus of the vaginal tract in women of fertile age. Having data on changes in this microorganism in different states of the body, it became interesting to study pregnant women in the first trimester with a normal course of pregnancy and women after an abortion on day 5. The results showed a significant difference in the species composition of lactobacilli in these two studied groups

The aim of the study was to assess the level and depth of various types of anesthesia by studying the BIS-index in intraocular operations in children.
The data of the study of the dynamics of the BIS-index and, accordingly, the depth of sedation indicated the effectiveness of the anesthesia options used, including the use of inhaled anesthetics sevoflurane and isoflurane in the anesthetic support of intraocular operations. The following combinations were used to provide anesthetic protection in 46 children with intraocular surgery: fentanyl with sevoflurane (group 1), fentanyl with isoflurane (group 2). At the stage of basic anesthesia in patients of group 1, the BIS index was in the range of 45,8-57,4, in group 2, the BISindex was in the range of 37,61- 53,6.
All the proposed options of anesthesia provide a sufficient level of sedation of patients during intraocular operations and can be used in practice. Thus, conducting anesthesia using BIS-monitoring allows you to reduce the doses of drugs used, reduce the amount of excessively deep and superficial anesthesia, and reduce the time of recovery of consciousness after the end of the operation

The possibilities of endoscopic surgical correction of colon pathologies in children have been studied. The features of endoscopic surgery for congenital pathologies of the colon in children are assessed. The review analyzes the effectiveness of endosurgical correction of congenital colon pathologies in children. The characteristic complications after endosurgical correction of colon pathologies are analyzed in detail. The use of the endoscopic technique in patients with colon pathologies allows minimizing postoperative complications

In spite of the fact that the first operation for funneled deformation of a thorax is executed more than 100 years ago, the problem of treatment of this disease cannot be considered finally solved. Points the fact that for correction of FDCh more than hundred ways and modifications of surgery are used to it.

Overview of literature on problems of nervous manifestations of HIV-infection is presented. Issues of pathogenesis, classification, diagnostics of nervous system affection are reflected. Characteristics of illness proceeding in children are considered.