All the main recommendations in this handbook have their own gradation, which is measured by the level of evidence and recommendations, denoted in Latin letters from A to D. Each gradation corresponds to a certain level of data evidence. This means that the recommendations were based on research data, which have varying degrees of certainty. The higher the rating of a recommendation, the higher the credibility of the studies on which it is based. Below is a scale that describes the different levels of gradation for the recommendations included in this handbook.
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