N Akhmedzhanova, Kh Mamatkulov, K Dilmuradova, I Akhmedzhanov
The aim of research was to determine the role of middle-sized molecules with renal partial functions in children with chronic secondary pyelonephritis (CSPN). The investigation was carried out in 2 groups of pa-tients the main group included 25 patients with the main or concomitant diagnosis of exacerbation of chronic pyelonephritis aged 4 to 14 years and a control group consisting of 30 healthy subjects. It was found that in the active phase of CSPN a suppression of renal partial functions and increased of middle-sized molecules, C-reactive protein and decreased of albumin in blood plasma. Examination 25 patients with (CSPN) showed that their blood plasma level of middle-sized molecules reflects the severity of their clinical state and corre-lates with the level of glomerular filtration and urea concentration. The diagnostic value of the method for determining middle-sized molecules, albumin in blood plasma of patients with renal diseases allows its wide use to be recommended in the clinical practice
