The efficacy of substitutive surfactant therapy for correction of oxidative stress manifestations in lung tissue after experimental thermal injury in dynamic

Complex structural and metabolic changes in lung tissue after burn injury occur as a result of free radical processes activation under decrease of antioxidant protection enzymes activity and increase of endotoxemia. The correction of thermal trauma by surfactant reduces free radical processes and increases antioxidant enzymes activity in the blood and lung tissue of experimental animals and restores prooxidant-antioxidant balance that consequently causes the decrease of endogenous intoxication intensity