K Ochilov
The effect of defoliant butyphos (I), dropp (II), butylcaptacs (III), hinazopin (IV), tetra-n-butylammonium bromide (VI), etrel (VII), gemetrel (VIII), allyl-4-methylpyridinium bromide (IX), 1-aminocyclopropan-1-carbonate (ACPC) (X) at various concentrations .(1.10-5-2.10-4 M) on respiration, oxidative phosphorylation (OP) and permeability of the inner mitochondrial membrane from rat liver has been studied. It has been estab-lished that some of the compounds uncouple OP by increasing the inner mitochondrial membrane permeability for H+ (II) inhibit the respiration in V3 condition and induce less selective permeability for a number of ions (I,III). The other defoliants either induce respiration generally in metabolic states 3 and 4 (IV, VI, IX) or have no effect on the respiration and OP (V, VII, VIII, X). On the whole a good correlation between the common tox-icity of the studied preparation (LD 50 ) and their mitochondrial effect has been revealed, therefore the latter can be considered as intracellular targets involved in the realization of pesticide action
