Glutation system in mechanisms of cardioprotection in immobilization stress of male and female rats with high and low-resistance to hypoxic hypoxia

The effect of various modes of immobilization stress on changes in lipid peroxidation, oxidative modifi-cation of proteins, nitrogen oxide metabolite and glutathione system in high and low resistance to hypoxia (HR and LR) rats with different sexes was investigated. Periodical immobilization causes the development of oxida-tive, carbonic and nitrosative stress in the HR and LR animals, more expressed in males, in the case of a re-sistant strategy for adaptation to stress. At the same time, increases glutathione antioxidant defense in male-rats.