No. 4 (97) (2017) Problems of biology and medicine

Статьи

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  Clinical characteristics of children with different tics The work assesses behavioral disorders in children with different tics. 181 children from 7 to 12 years old were examined. The most frequent hyperkinesias were blinking and lifting of the eyebrows, neurotic-like tics were 54.7%, in children, headache was diagnosed in 8.5%, stammering was 23.2%, in 48% signs of atten-tion deficit hyperactivity disorder, especially with Tourette's syndrome. The level of anxiety was greater in children with transient tics.

  A Kayumova, F Usmanov, S Rashidova, A Jurabekova

  52-55

  137   23

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  On the implementation of new reforms in the field of emergency medical care In Uzbekistan, including in the Samarkand region, in accordance with the Decree of the First President of the Republic dated November 10, 1998 No. 2107 "On the State Healthcare Reform Program", the Republican Center for Emergency Medical Care, its regional departments, as well as emergency medical care, have been established and there are ambulance and air ambulance services, including ambulance teams. Comprehensive measures are being taken to equip emergency medical facilities with high-tech medical equipment and specialized vehicles.

  I Khodzhaev, S Isroilova, A Bazarov, B Abdullaev

  198-201

  204   27

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  Clinical neurological features of ischemic stroke in children In this study, in neurosurgical and neurological departments, clinical and neurological features of ischemic stroke in children were studied. 50 children underwent a neurologic examination, an MRI scan and a pediatric PSOM stroke scale. Along with focal symptoms (hemiparesis), general cerebral symptoms were noted, in 23.4% convulsive syndrome. The depth of paresis was higher in school-age children, the dynamics of recovery was slow

  S Rashidova, A Jurabekova, A Kayumova, K Shmyrina

  88-92

  159   41

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  Hematoxicity and its prevention on the targeted treatment of locally advanced renal cancer The article presents the results of treatment of patients received targeted therapy with Sunitinib on me-tastasis of renal cancer to the lymph nodes. The total number of patients was 38. Male 21 (55.2%), female 17 (44.7%), ratio 1.2: 1. The average age is 50 ± 2.4 years. The complications associated with the use of angiogenesis blockers and tyrosine kinase inhibitors have been analyzed. The main undesirable side effects against the background of Sunitinib therapy, from the side of the blood indices: neutropenia, hypophosphatemia, lymphopenia, anemia, thrombocytopenia, increasing of the serum creatinine and total cholesterol. The results of treatment allow us to recommend the use of sunitinib for the treatment of patients with me-tastases in the lymph nodes of renal cancer, emphasizing the need for timely prevention of complications of this treatment

  N Rakhimov

  84-87

  80   23

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  Stage-related pharmaceutical prevention and treatment of giangivites in women in the gestation period The data of the clinical course of gingivitis in pregnant women are presented. The algorithm of the com-plex of measures for the prevention of periodontal diseases at the level of a dentist in women at different peri-ods of gestation and in the postpartum period has been developed.

  P Polevoy, S Schneider

  80-83

  191   23

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  Peculiarities of studying multifactor control of sugar diabetes 2 type The steadily growing prevalence in a combination to high frequency and weight of complications sugar diabetis and that for treatment and prevention of complications is required many efforts has resulted in development of this disease from biological in social. Till a stage there are a lot of factors the management sugar diabetis 2 such as under the standards provides ideal indemnification glycaemia and reduces the charges by treatment.

  A Narbaev, Z Juraeva, N Kurbonova, G Kuvondikov, A Davranova, S Sodikov

  78-79

  113   23

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  The role of determination of bnp with chronic heart failure diagnosis in patients with metabolic syndrome In 72 patients with metabolic syndrome, an enzyme immunoassay was performed to determine the BNP. Of these, 37 (51.4%) patients who had chronic heart failure on the background of metabolic syndrome had a higher BNP of plasma. And in 35 (48.6%) who did not have clinical and instrumental signs of chronic heart failure on the background of metabolic syndrome, 23 of them had a lower BNP. In the remaining 12 (34.3%) patients, the number of BNP was 220 + 10.5 pg / ml. This means that in this group of patients against the back-ground of MS, there is still development of chronic heart failure. To mean a determination in the blood plasma of the BNP makes it possible to diagnose chronic heart failure in the early stages

  F Nazarov, S Yarmukhamedova, M Bekmuradova

  75-77

  88   23

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  Crystallographytearfluidin patients with age-related cataract A crystallographic study of tear fluid was performed in 20 healthy and 24 patients with age-related cata-ract. Crystallization of the tear fluid of patients with age-related cataract occurs in the same way as in healthy individuals, and is characterized by the formation of continuous figures in the form of snowflakes, daisies or fern branches

  R Mukhamadiev, S Blinova, T Dekhkanov, A Yusupov, F Khamidova

  71-74

  143   44

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  The study of the state of trace elements in patients with hemophilia associated hematomesenchymal dysplasia With the purpose of studying the state of trace elements, a study was conducted in 50 patients with he-mophilia associated with hematomesenchymal dysplasia which there cured in the hemophilia center. It was established that in patients with hematomesenchymal dysplasia, there was an imbalance in the microelement status, which was characterized by reliable Mg² + deficiency - 1.6 times, Ca 2+ - 2.1 times, iron 1.2 times com-pared to the control group. The pronounced deficiency of magnesium and calcium can be explained not only by the low consumption of microelements with food products, but also by their dependence on the level of iron and potassium in the human body.

  A Mahmudova, M Mahmudova, O Sakharov, D Mahmudov, I Berger

  68-70

  70   28

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  The role of streptococcus pneumonia in the development of acute purulent middle otitis in children In the article is illustrated results of the survey 51 children (64 ears) aged 1 to 15 years with acute puru-lent middle otitis. Detected etiologic spectrum of causative agent of acute middle otitis. Among etiological de-crypted acute purulent middle otitis, 24% are caused by streptococcus pneumonia. When determining the sensi-tivity of the causative agent of acute otitis media to antibiotics revealed that S. pneimoniae retains high sensi-tivity to amoxicillin, pefloxacin, cefazolin, cefuroxime and ciprofloxacin. Slightly reduced sensitivity to azithromycin

  G Mahkamova, E Shamansurova

  64-67

  125   25

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  Application of immunomodulators in patients with conjugate cranial-brain trauma The studies were conducted in 102 hospitalized patients from 2009 to 2014 in the offices of multiple trauma, neurosurgery, and neyroreanimations Andijan branch of the Republican scientific center for emergen-cy medical assistance with a preliminary diagnosis of "brain injury". The aim of this study is a clinical study and development of algorithms for treatment of patients with concomitant traumatic brain injury to regional hospitals.

  K Kuldashev, D Narmatova, K Mamazhonov, B Isakov

  61-63

  93   13

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  Elektroencephalography in norm and with epilepsy in different age groups EEG analysis was performed in norm and with epilepsy in different age groups. As a results of the ob-servation of 168 patients with epilepsy, a prounced immaturity of the broun is determined in the group of chil-dren, which gives the risk of high epileptic activity. Epilepsy in the older age group should be considered as “invasive”, if there is an attack on the EEG, there is no change

  N Kudratov, M Umarova, A Jurabekova, N Abdullayeva

  56-60

  175   24

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  Elektroencephalography in norm and with epilepsy in different age groups EEG analysis was performed in norm and with epilepsy in different age groups. As a results of the ob-servation of 168 patients with epilepsy, a prounced immaturity of the broun is determined in the group of chil-dren, which gives the risk of high epileptic activity. Epilepsy in the older age group should be considered as “invasive”, if there is an attack on the EEG, there is no change.

  N Kudratova, M Umarova, A Jurabekova, N Abdullayeva

  56-60

  154   16

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  Molecular-genetic markers and features of the course of chronic hcv infection in Uzbekistan The aim of the study was a comparative analysis of the genotypic variants of the TNF-α and CTLA-4 genes in patients with chronic hepatitis C and liver cirrhosis and their effect on the course of the disease. The analysis of the influence of the genotypes of the TNF-α gene on the course of the disease indicates an increased risk of CVD with both moderate and highly active course of the disease in carriers of the combination of geno-types G / A + A / A. The obtained data allow us to conclude that the carriage of the allele "G" and the combina-tion of the A / G + G / G genotypes of the -49GG polymorph of the CTLA-4 gene are associated not only with a decrease in the risk of development of HCVF, but also with a lower intensity of inflammation and fibrosis in the liver and a high probability favorable course of the disease.

  S Azimova

  8-10

  119   28

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  Improvement of gernioplastic tactics in myophascial defects of the side wall This article explores the observation of the clinical results of the 54 patients treated with thoraco- abdominal surgery and urology departments on the basis of the Samarkand city medical Association in 2011-2016. Of these, 46 patients produced lumbotomies, 2 myofascial and 6 patients in laparoscopic operations. All patients were divided into two groups. The main group of patients with hernioplasty and tummy tuck, patients in the control group produced hernia repair with local tissues. And the group's attention to the comparison of the results of operations for the following parameters: various postoperative complications are rare, the reduction of recurrence in patients with postoperative rehabilitation

  D Kamilova, A Babazhanov, G Ahmedov, A Toirov, X Kurbanov

  48-51

  128   14

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  Endoscopic methods of hemostasis in bleeding from varicously expanded vienna of the esophagus The High percent of the complications survival and low sick dictate need of the improvement medical tacticians at bleedings from varicose extended vein gullets. At present for stop and preventive maintenances of the bleedings from varicose extended вен gullets (VRVP) use the facility an endockopic, medikamentoz, and surgical gemostaz. Our purpose to introduce in practical person endockopic scleroterapy and alloying at bleedings under varicose extended вен gullets. In consequence of which will is reached reduction of the re-lapse of the repeated bleeding and complications, miniinvaziveness method and mortality

  R Kadyrov, Yu Ahmedov, F Mizamov, N Kurbonov, B Normamatov

  44-47

  91   17

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  Effects of combined antihypertensive therapy on lipid and carbohydrate metabolism in patients with metabolic syndrome and hypertension The results of the study of combined antihypertensive therapy with drugs of valsartan and moxonidine on hemodynamic parameters, lipid and glycemic blood profiles in patients with metabolic syndrome and arterial hypertension are presented. A rational combination of antihypertensive drugs allowed achieving the target lev-el of blood pressure, normalizing the circadian rhythm of blood pressure, metabolic processes, in particular lipid and carbohydrate metabolism

  D Ishankulova, Sh Toshnazarov, Sh Ziyadullaev, J Ismailov

  42-43

  231   23

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  Frequency of prevalence of galitoz among patients of the stomatologic profile Indicators of questioning and organoleptic method of inspection on existence of an unpleasant smell in an oral cavity varied and differed from each other. In our researches organoleptic indicators made 86,6%, we connected a difference between these indicators use by patients various deodorizing means for an oral cavity

  T Zoyirov, M Suyunova

  36-41

  112   28

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  Optimization of treatment of intestinal failure in patients with burn injury The study included 177 patients aged 14 to 65 years who entered the state of burn shock of varying de-grees. The frequency of the development of digestive and absorption disorders depends on the severity of the thermal injury. Treatment of patients with the syndrome of intestinal insufficiency helps to reduce complica-tions and mortality in patients with heavy burns

  N Ziganshina, S Gafurova, X Azimova, R Nuralieva, X Turaev, M Ashurova

  33-35

  105   20

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  Features of the clinical course of chronic hcv infection and the factors of its prediction The purpose of this study was to evaluate the associative relationships of biochemical indices of the in-flammatory process with the virus C genotypes in patients with chronic hepatitis in representatives of the Uzbek population. The subject of the study were patients with HCV-infection and cirrhosis of the liver, as well as healthy donors, in which DNA samples were obtained. Specific features of the clinical course and association of the genotype of virus C with biochemical indices for different severity of the course of CVHC were deter-mined

  Sh Zakirkhodzhaev, S Azimova

  30-32

  113   24

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  The incidence of kidney cancer in Samarkand region. the present state of diagnostics and treatment The article retrospectively analyzed the incidence of kidney cancer in the Samarkand region in the peri-od from 2006 to 2017, and the status of diagnostics and treatment. In the structure of cancer pathology in Sa-markand region kidney cancer constitutes 2.7% and takes 12th place. We may observe increase in the inci-dence of kidney cancer over the last 7 years up to 1.8 times and a low detection of process in early stages. This study is based on the diagnostics and treatment results of 415 patients with kidney cancer. Diagnostic status until 2015 in the area did not meet the requirements of the standard. Over the past 3 years in connection with the introduction of the technique needle biopsy, percutaneous nephrostomy and appearance of ability to apply MSCT, dramatically increased the efficiency of diagnosis, and that influenced the treatment results. Radical nephrectomy performed 162 (39,0%) patients, palliative 63 (15,2%) patients. Chemo - and immunotherapy 53 (12,8%), immunotherapy 62 (14.9 %) and more modern targeted therapy 12 (2,9%) patients, 58 (14,0%) pa-tients underwent symptomatic therapy and in 5 (1,2 %) patients treatment was not conducted

  A Juraev, M Juraev

  27-29

  145   26

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  Influence of sports nutrition on physical development of children and adolescents with a high physical load Increasing training loads and the intensity of competitive activities require athletes to tremendous strain of physical and moral strength. One of the most important components of ensuring a high level of functional status of athletes of children and adolescents is a balanced adequate nutrition

  G Burkhanov, Z Mavlyanova, O Kim

  24-26

  326   43

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  Efficiency of methods of treatment of various types of isolated varicose extension of vienna lower limbs The modern development of methods of ultrasonic diagnostics assumes survey of all surface trunk venous course, an assessment of different options of a structure of veins, their valvate device throughout and allows to reveal local damage of veins directly. Conclusions. At the isolated varicosity classical and low-invasive meth- ods of treatment are used, each of which has the advantages and shortcomings. The basic principles of a sav- ings flebektomiya consist in use of tactics and methods of treatment which allow to keep BPV trunk for the shunting operations in cardiovascular surgery. The isolated varicosity is followed by local defeat of superficial venous system. In the concept of savings surgery treatment doesn't demand performance of a flebektomiya of trunks of BPV or MPV. For the safennykh and the perforantnykh of inflows method of the choice is vysoko-tochny crossing of a varicose vein in the mouth with the subsequent sklerozirovaniye or surgical removal

  A Babazhanov, D Kamilova, J Tukhtaev, A Toirov, J Alimov

  20-23

  176   27

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  Assessment of the functional state of the cardiovascular system in case of burn disease Data of retrospective analysis of 190 histories of patients with a burned howling disease given. Patients were diveded into 4 groups, depending on the severity of the burn disease. And during the shock period blood pressure slightly increased in the erectile phase and decreased in the torpid. And prognostically unfavorable cases already in the carly periods revealed persistent hypotension. Pain in the heart tachycardia, hyponetsion were noted in patients with moderate severity of the burn disease. With a mild degree of disease moderate tachycardia was observed and a sligh increase in maximum blood pressuare was observed. In patients with burns of I-II degree occupying less than 10 % of the surfaces of the body, the burn disease did not clinically appear

  M Ashurova, X Azimova, S Gafurova, N Ziganshina, O Siddikov, S Yuldashev

  17-19

  141   28

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  The use of α 1 - adrenoblocker - tamsulosin in the treatment patients with benign prostatic hyperplasia Under observation were 49 men with benign prostatic hyperplasia who underwent treatment with an α 1 - adrenoblocker-tamsulosin. The analysis of the results of the evaluation of the quality of life index in groups of patients with prostatic hyperplasia who received tamsulosin medication demonstrated a significant decrease (improvement) in the mean value of the quality of life index in the treatment of patients. In most patients, the severity of adverse reactions with tamsulosin was insignificant and did not interfere with the daily activity of the patient

  A Achilov, N Ziganshina, R Nuralieva

  14-16

  80   24

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