No. 2 (94) (2017) Problems of biology and medicine

Статьи

• 

  Complicated course of duodenal ulcer in children of senior school age: causes, diagnostic criteria for determination Bleeding from duodenal ulcers is the most formidable complication and occupies one of the first places in the structure of mortality from duodenal ulcer. The anamnestic, clinical features and pH indices in children with duodenal ulcers were studied. 42 children of the senior school age with duodenal ulcers were examined, of them 12 had a complication in the form of ulcerous bleeding. The study makes it possible to consider the sex, age, heredity, erosive nature of gastroduodenitis, multiple ulcers, high bacterial contamination, low pH in the anthroduodenal zone as predictors of complicated course of JBD

  D Islamova, X Shadiev, I Togaev, Sh Ibatova, F Mamatkulova

  47-51

  177   23

  • Read
• 

  Climate and geographic characteristics of systemic lupus erythematosus Systemic lupus erythematosus (SLE) is one of the most severe systemic diseases of the connective tissue, more common at the age of 20-40 years, about 90% of cases are women [1;2]. Over the past decades, there has been an increase in the incidence of SLE (50-250 cases per 100 thousand population), which is due to the improvement of diagnostic methods, the identification of latent and chronic forms, and in some cases, overdiagnosis. The diagnostic criteria of the American College of Rheumatology (ACR) (1982, 1997) were developed for epidemiological studies and do not always allow one to exclude or confirm the diagnosis of SLE with absolute probability, especially in the early stages and in atypical variants of the disease [3;4] . When studying the medical records of one of the major medical institutions, J. Calyo et al. [5] found that among patients with a diagnosis of SLE, only two-thirds met the criteria for ACR, while about 10% had signs of lupus that were not sufficient to verify a reliable diagnosis, and 25% had a picture of fibromyalgia in combination with positive antinuclear antibodies (ANA), while even with long-term follow-up, no evolution of the disease into reliable SLE was noted. The question of improving the criteria for diagnosing SLE, “chameleon disease”, or “great disease simulator” has been repeatedly raised [6]. In 2012, a group of experts from Systemic Lupus International Collaborating Clinics (SLICC) presented the results of a long-term analysis of a large number of case histories (about 700 patients) with SLE and proposed modified diagnostic criteria for the diagnosis, expanded by introducing a number of dermatological , neurological signs with more accurate indicators [7;8].

  N Khamrayeva, E Toirov

  189-191

  133   27

  • Read
• 

  Endobronkhial therapy in treatment of complex therapy at patients with the thermoinhalation trauma The analysis of results of treatment of 188 victims with the severe burn injury complicated by thermoin-halation damage of airways which were divided into the main and control groups is carried out. In the main group the programmed sanatsionny fibrobronkhoskopiya from the first hours from hospitalization with a fre-quency of 2-3 times per day depending on weight of thermoinhalation defeat during the necessary period of time were applied. In control group sanatsionny bronkhoskopiya were carried out irregularly, generally on request of the attending physician. Other treatment was identical in both groups. Active application the sanatsionnykh of bronkhoskopiya allowed to reduce statistically significantly the frequency of a purulent trakheobronkhit from 38,1% in control group to 14,0% - in the main group and to reduce a lethality from 93,5% in control group to 68,4% - basically.

  Z Saidullaev, X Karabaev, I Mustafakulov, M Rustamov, K Sherkulov

  89-91

  94   15

  • Read
• 

  Results of diagnostics and surgical treatment of intrabelly bleedings The research basis included results of diagnostics and treatment of 42 patients with traumas and diseas-es of bodies of a belly cavity, for diagnostics and which treatment under indications have been used modern endovideosurgical hemostasis methods. During the spent researches it has been established that the basicmeth- ods of diagnostics of severity level of intrabelly bleedings and a choice of methods of their treatment are ultra- sonic, КТ and a videolaparoscopy. As a whole, application endovideosurgical for diagnostics and treatment of intrabelly bleedings allows to avoid technologies unjustified laparotomy, to lower death rates, to reduce quan- tity of complications, and also to reduce time of stay of patients in a hospital in comparison of medical tech- niques by means of open operative access

  S Ruziboev, K Tagaev, F Daminov, S Nazarov

  84-88

  143   22

  • Read
• 

  Informativity of magnetic-resonance tomography in diagnosis of tuberculosis spondilites and its complications 89 magnetic resonance tomograms, which were performed by 72 patients with TS, were analyzed. A spe-cific process was localized in the cervical spine in two patients, in the thoracic and thoracolumbar - in 38, in the lumbar and lumbosacral in 32 patients. Isolated lesions of one or two vertebrae were observed in four cas-es, contact destruction in 48, a combination of contact and isolated destruction at 15. Combination of MRI and X-ray methods broadens the notion of morphological changes in the spine, the stage of the tuberculous process, allows one to study the patterns of development And the dynamics of TC, the effectiveness of conservative and operative treatment

  Z Rashidov, G Yusupalieva, F Babadzhanov, A Fakhritdinova, A Davidkhodzhaeva, K Yusupalieva

  79-83

  102   26

  • Read
• 

  State of blood flow data of ultrasound angiography in tuberculosis of kidneys Ultrasonic angiography in nephrotuberculosis is a highly informative method in assessing renal blood flow. The use of ultrasonic angiography in the destructive forms of tuberculosis of the kidneys allows us to specify the tactics of management and treatment of patients

  Z Rashidov, X Kutumov, G Yusupalieva, A Manashova

  76-78

  80   15

  • Read
• 

  Endogenous intoxication and kallekrein-kinin system in pregnant women with cervicovaginal infections In pregnant women with cervicovaginal infection develops the syndrome of endogenous intoxication (EI), there is an increase of malondialdehyde (MDA), the average mass of molecules (MSM) 254, and MSM280, MDA / catalase, with a decrease of catalase and protein stability factor, reducing the performance of the kal- likrein-kinin system (KKS) - prekallikrein, kallikrein, an increase BAEE, GATA, kininase; they all depend on the state of the autonomic nervous system (ANS), the largest changes are observed in gipoadaptivе condition. The study of EI parameters and enzymes ККS can be a predictor of assessing the state and the course of preg- nancy and the severity marker of inflammation in pregnant women with cervicovaginal infection

  G Rabbimova

  72-75

  111   19

  • Read
• 

  Efficacy and safety of spinal anesthesia in operations of hernias of intervertebral discs Objective: comprehensive evaluation of the effectiveness and safety of spinal anesthesia (SA) in the rapid elimination of discogenic hernia. Material and methods: The basis of the clinical trial data are laid 65 patients with spinal disorders and spinal cord in the lumbar and sacral levels. Depending on the type of anesthesia used (CA or total intravenous anesthesia (TIA) with mechanical ventilation (MV) endotracheal way + О2), the patients were divided into two groups. Results: The research revealed that just before surgery in all patients s-BP, d-BP, m-BP, HR, SpО2 was within the normal range. These results suggest that the TIA with ventilator endotracheal way + О2 does not fully ensure the full protection of the body from operating aggression. CA isobaric with 0.5% solution of bupi- vacaine in a dose of 15 mg 20 provides anesthesia beginning 5-8 min lasts 2-3 hours. Patients were observed clinically significant disorders of respiratory function and hemodynamics. Conclusion: The described technique allows to carry out surgery safely and effectively

  S Nasriev, Sh Pardaev, B Akramov, S Mallaev

  67-71

  141   24

  • Read
• 

  The main criteria for evaluation of transient evoked otoacoustic emissions In order to develop evaluation criteria transient evoked otoacoustic emission (TEOAE), including in the age aspect, we conducted a study of the impact of ipsilateral suppression of TEOAE to change its setting. In all cases, after a series of studies there wasa decrease of the total value of the amplitude of TEOAE. The best crite-rion for assessing TEOAE is the construction a tuning curve of the ipsilateral suppression

  M Nasretdinova, A Khayits, A Holboev

  64-66

  94   21

  • Read
• 

  The use of iud in women undergoing cecareon section The study included 38 women who underwent cesarean section in a maternity complex №2 city of Samarkand was held. Women were selected for intraoperative IUD. Of the 38 women were 22 urban, 16 rural women. 13 women had higher education, 25 secondary education. In 14 women in history had one pregnancy, in 14 women 2 pregnancies, in 8 women 3 pregnancies, and the remaining 2 women 4 or more pregnancies, ie all of the women were pregnant again. In 4 women had a history of abortion 1. IUD proved to be very safe and effective method of contraception. The level of spontaneous expulsion was lower than the interval introduction. Analysis of surveillance results for patients with IUD allowed to establish a high contraceptive effectiveness of the method, the cases of pregnancy is not registered in any case.

  Z Nasirova, M Atayeva

  61-63

  77   12

  • Read
• 

  Comprehensive treatment of patients with nose papillos and primary cases The analysis of the effectiveness of complex treatment of 66 patients with papillomas of the nose and pa-ranasal sinuses was carried out. In the main group of patients, traditional therapy was supplemented by inges-tion of tyloron (Lavomax) according to the scheme and topical application of Viferon ointment. Immunological studies, as well as data of subjective evaluation, revealed high results in patients of the main group. The con-clusion is made about the possibility of using the preparation of Tyloron (Lavomax) and topically Vifeiron ointment in the complex treatment of nasal and sinus papillomas.

  U Lutfullaev, G Lutfullaev, Sh Kobilova, X Nuraddinov, D Mukhtarov

  58-60

  147   18

  • Read
• 

  Quality of life of patients and question of rehabilitation after large obstetric bleeding 73 women after massive obstetric bleeding concerning a preeclampsia of heavy degree 31 (42,4%) wom-en, a premature amotio of a normally located placenta 15 (20,5%), central and low an arrangement of a pla-centa 14 are examined (19,2%), anemia of heavy degree of 13(17,8%). Patients are divided into 2 groups: the 1st group – women of 22(30,1%), transferred organ-preserving operations with the bleeding stop purpose, the 2nd group – women, 51(69,8%) had massive bleeding with a stop by conservative methods, without laparoto-my. Use of traditional treatment-and-reabilitation measures leads to improvement of indicators of quality of life after the complicated labors at 15,4% of women. Application of conservative methods of a stop of bleeding, organ-preserving volume of surgeries allows to increase this indicator to 73,3%.

  N Karimova, Z Mardonova, F Oripova, N Fatoev, M Karomatova

  55-57

  160   19

  • Read
• 

  The cardiovascular system in children with chronic glomerulonephritis on the background of hyperuricemia and metabolic uric acid The Study was performed in 59 children aged 3 to 18 years, located in the Nephrology unit of the Samar-kand regional children's diversified medical center with a diagnosis of chronic glomerulonephritis. N in the period from 2012 to 2016. The composition of the studied children: girls 38 from 3 years to 18 years and boys 21 from 5 years to 18 years. Conducted a comprehensive study of clinical and functional state of the heart on the basis of anamnestic, clinical, laboratory and instrumental parameters in children with chronic glomerulo-nephritis. It is found that increasing the level of uric acid leads to hypertrophy of the ventricles of the heart, vegetative-vascular dystonia, arrhythmia, arterial hypertension, atherosclerosis. cardiovascular disease in children with chronic glomerulonephritis

  Z Ismoilova, A Akhmatov, B Yuldashev, Yu Akhmatova, Sh Mekhrodzheva

  52-54

  132   16

  • Read
• 

  Computer-tomographic semiology of chronic recurrent hematogenous osteomyelitis The effectiveness of using computer tomography in the complex examination of 60 patients with chronic recurrent hematogenic osteomyelitis aged from 7 to 22 years old have been analyzed in the investigation. Com- puter tomography as opposed to plan radiography allowed us more precisely determine the real sizes of de- structive process in the injured bone. In all cases computer tomography has exceeded plan radiography to de- termination of small sequesters, supporting chronic inflammation and promoting hard recurrent course of the disease. Used examination method provides the highest accuracy of detection of purulent-necrotic changes in the affected bones and increases the role of radial methods of diagnostics in developing a set of treatment measures, including the scope and tactics of surgical intervention in chronic recurrent hematogenous osteomy- elitis

  A Shamsiev, S Zainiev

  1-4

  232   21

  • Read
• 

  Comparative characteristics and diagnostic value of the taxonomic characteristics of pathogens of infectious inflammatory diseases of humans The aim was a comparative study of the variability of some taxonomic characters sown E.coli from sick women urinary tract infections. It was found that E.coli strains isolated from different habitats of the body healthy and sick women with varying frequency detected taxonomic characteristics, which are associated with the adhesiveness of the pathogen. The strains exhibit variability mainly by fermentation of mannitol, sucrose, arabinose, glucose, sodium citrate, hemolytic activity.

  D Isanova, Yu Azizov

  43-46

  142   21

  • Read
• 

  Urapedil’s efficiency in the emergency treatment of hypertensive crises complicated by acute hypertensive encephalopathy The effectiveness of the drug urapidil in the complex treatment of hypertensive crisis, complicated by acute hypertensive encephalopathy in the clinic of emergency therapy and neurology was studied. The results of the use of the drug urapidil in the complex therapy of hypertensive crisis complicated by acute hypertensive encephalopathy indicate more effective achievement of the target figures of arterial pressure, rapid and pro-nounced regression of neurological symptoms, rapid activation of consciousness and reduction of the duration of stay of patients in the hospital

  Sh Ziyadullaev, A Nasirova, M Rofeev, D Urunov

  40-42

  68   22

  • Read
• 

  Results intravenous ozone in patients with chronic cerebral ischemia Chronic cerebral ischemia (CCI) - a condition manifested by progressive multifocal disorder of brain function caused by cerebral circulatory insufficiency. The article gives a rationale for the use of intravenous ozone therapy in the complex treatment of patients with HIM at different stages of the disease, the study of the dynamics of the changes arising from the use of ozone therapy.

  J Dzhurakulov, Sh Tursunova, M Mamurova, S Khakimova

  35-39

  213   29

  • Read
• 

  Complex clinical-metabolic assessment of the status of children with obesity and arterial hypertension A total of 50 children with obesity and hypertension were examined comprehensively. It was revealed that in this category of children there is a high growth, acceleration of the rates of sexual development, a de-crease in the quality of life and a greater frequency of pathology from the side of the cardiovascular system in the form of functional disorders and increased blood pressure. Biochemical studies showed that one-third of children with abdominal obesity had a pathology of carbohydrate and lipid metabolism, which was accompa-nied by an increase in the level of uric acid in the blood

  L Garifulina, M Ashurova

  31-34

  107   24

  • Read
• 

  The clinical process prolonged neonatal jaundice in newborn with prenatal infection The article presents the analysis of clinical, laboratory and ultrasound studies of prolonged neonatal jaundice in newborn with prenatal infection proved by biochemical methods, and its clinical conditions in 60 newborn in Samarkand clinics (2014-2016). It was established that newborns with prolonged neonatal jaundice in newborn with prenatal infection are in risk group of severe infection, they require intensive care. It determinates the necessity of the infection specific prevention in newborns prolonged neonatal jaundice in newborn with prenatal infection with the help of policlinics

  N Boboeva, M Khazratkulova

  27-30

  102   26

  • Read
• 

  The role of inflammation in prolonged hyperbilirubinemii of newborns All newborns underwent standard laboratory and instrumental examination. Ultrasound examinations (brain, heart, abdominal organs), according to indications, electroencephalography was performed. In the presence of hypoxemia and mixed acidosis of newborns with respiratory distress syndrome, the use of spontaneous breathing with SDPPD improved the overall condition of newborns. This was confirmed by an improvement in the clinical and laboratory and radiographic data of each newborn. Spontaneous breathing with SDPPD is a technically simple and effective method of correction of hypoxemia in the syndrome of respiratory disorders

  N Boboeva, X Fayzullaeva

  25-26

  83   16

  • Read
• 

  Surgical tactics in cholelithiasis complications of obstructive jaundice Analysis results was performed in 116 patients with cholelithiasis complicated by mechanical jaundice who were on the treatment in the city medical association between 2014 on 2016. As a supporters of the two-stage approach to the treatment of mechanical jaundice, the first stage we carried out decompression and sani-tation biliary tract. Preference gave endoscopic retrograde intervention. Endoscopic papillosphincterotomy carried out in 68 patients (58,6%) combined with choledocholithoextraction in 39 patients (57,3%). We consid-er, that at mechanical jaundice the best is two-stage approach with the using of minimally invasive treatments. Operation of choice is endoscopic retrograde intervention with the subsequent cholecystectomy with mini ac-cess. In the impossibility of the decompression is carried out drainage of biliary with the restoration of contin-uous passage of bile in the intestines with laparotomy after stabilization of the state of the patient

  A Babazhanov, A Ahmedov, F Muminov, B Mukhiddinov

  22-24

  110   25

  • Read
• 

  Prevention of hypothyroidosis in the post-operative period in patients with multi-nose objective In order to the study of the state of thyroid remnant in the remote time after the operation at multinodu-lar colloid goiter, it was examined 82 patients at the age of 29 to 64. Revealed that in patients by multinodular colloid goiter in 6 months after the different volume of operations in thyroid remnant according to the ultra-sound revealed 3 types of volume- structural changes (stable- 48,8%, hypertrophic- 28%, hypotrophic- 23,2%)

  A Babazhanov, K Gairatov, A Toirov, A Ahmedov, E Khudoiberdiev

  19-21

  124   25

  • Read
• 

  Especially the functioning of the cardiovascular system at low heart abnormalities in children In children with small heart anomalies the most frequently detected mitral valve prolapse, anomalously located left ventricular chord, associated anomalies with the presence of mitral valve prolapse and intra-ventricular formations. Identified adverse factors influencing the occurrence of small heart anomalies, low ex-ercise tolerance, the effect of the small heart anomalies in the development of cardiac arrhythmias in the form of supraventricular and ventricular arrhythmias, supraventricular ectopic rhythm or migration of pacemaker, sinus bradycardia, atrioventricular block 1-2 degree, bundle branch block, QT interval prolongation of more than 440 ms

  F Achilov, S Khaidarova

  16-18

  143   24

  • Read
• 

  The analysis of age structure, nosologic form, associated disease patients therapeutic department of hospital emergency medicine Annotation: Presents the results of the analysis of the age structure, nosologic form, accompanying dis-eases of patients hospitalized in therapy departments Samarkand branch republican research centre of emer-gency medicine. An analysis of hospitalized patients suggests that the main place is occupied by person’s hos-pitalized elderly, and a significant place in this age is given to a chronic pathology of the cardiovascular sys-tem. Severe space also occupied by acute inflammation of the airways, possibly reflecting the immunological "trouble" in the population of older persons

  G Ahmedova, J Ismailov, M Rofeev, Sh Ziyadullaev, A Norkuziev

  131   29

  • Read
• 

  Epidemiological features of epilepsy according to the age and gender in the conditions of Samarkand city Objective: to examine the epidemiological characteristic of epilepsy, depending on age and sex in the face of Samarkand. Materials and methods: Object of research was a population of the adult population living in territory of Samarkand for January 1st, 2008 an aggregate number 55232 persons. The results of the analy-sis of the incidence of epilepsy for three years in a given population (2008-2010 years) shows that the method of monitoring population incidence rates higher than with medical history analysis. Conclusions: The preva-lence of epilepsy in the dynamics of the studied population according to age and sex was characterized by a predominance in all age groups of men.

  N Abdullayeva, Z Mavlyanova, I Sharafova

  9-12

  140   20

  • Read