Contracture remodelling of lower limbs sceletal muscles among rats of before reproductive and reproductive age under conditions of experimental hyperuricemia

In the experiment with white rats of before reproductive and reproductive age there were studied the features of lower limbs skeletal muscles remodeling under conditions of experimental hyperuricemia. It was defined that contracture remodeling during all terms of experiment had one-way and progressive character, which we associate with ischemia as the result of structural blood vessels reorganization due to the effect of uric acid. The contracture and cytolysis remodeling of skeletal muscles in conditions of hyperuricemia among animals of before reproductive age can be observed mainly in femoral-popliteal segment as hypertrophic thickening of intima and media, while among animals of reproductive age can be mostly seen in shin group of muscles where hypertrophic type of remodeling combines with inflammation and sclerotic changes - that can be considered the basis of sclerotic alternations in arteries