Modern aspects of diagnosis and pathogenesis of acute pancreatitis

Acute pancreatitis (AP) is one of the most common and severe surgical diseases [27]. In the last decade, there has been a steady increase in the frequency of OP in the structure of surgical diseases of the abdominal organs. At the beginning of the 20th century, OP was described as a casuistry, but at present, in terms of the incidence of diseases of the abdominal organs, it is second only to acute appendicitis and acute cholecystitis [11]. Even 25 years ago, OP was 0.5-1.0% of all surgical diseases of the abdominal organs. At present, its frequency has increased by 10-15 times and, according to various authors, ranges from 4.7% to 15.6% [1]. It should be noted that in developed countries this figure exceeds 10%, while in developing countries this figure ranges from 5-8%. This is due to two reasons: an increase in the absolute number of patients and an improvement in the diagnosis of the disease [12, 31].