Morphologic evaluation of haemostatic agent “heprocel” effectiveness using the liver injury model

Experimental study of new polycomposition haemostatic powder was performed. 60 white male rabbits with weight 198 + 2,7 g were used. Morphologic alterations were studied at 3, 12 hours, 1, 3, 7, 14, 30 days after the operation. Results revealed the haemostatic effect of Heprocel powder. Microscopic data showed the gradual healing of the liver wound forming the thin connective tissue in injured zone. The slight inflammation developed as foreign body reaction, which reduced with implant biodegradation. Inflammation signs were manifested in the control group. The complete biodegradation of haemostatic powder Heprocel was registered on 14 – 21 days. Thus, the new haemostatic agent Heprocel might be used for parenchymal bleeding control in trauma and operation.