No. 03 (2025) Volume 05 Issue 03

This article focuses on the identification and diagnosis of neurological diseases among adolescents using computer technologies. It highlights the role of modern medical advancements in improving diagnostics and emphasizes the increasing significance of computer technologies in daily life. Additionally, the paper discusses the importance of enhancing future medical professionals’ efficiency in working with computer technologies.

The correlation between blood coagulation and viscosity plays a crucial role in understanding the dynamics of hemostasis and the risk of thromboembolic events. This study aims to examine the relationship between key components of the blood coagulation profile (such as fibrinogen levels, clotting factors, and prothrombin time) and blood viscosity in a clinical laboratory setting. A cohort of 150 patients was analyzed, with data collected on their coagulation profiles, including prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen levels, and hematocrit. Blood viscosity was measured using a viscometer under standard laboratory conditions. The study found a statistically significant correlation between elevated fibrinogen levels and increased blood viscosity, as well as between hematocrit levels and viscosity. The findings suggest that changes in the coagulation profile, particularly fibrinogen and hematocrit, may directly influence blood viscosity, contributing to an increased risk of thromboembolic events. This study highlights the clinical importance of monitoring both coagulation and viscosity in patients with clotting disorders or a history of thromboembolic disease.

It has already been demonstrated that insulin resistance (IR) is associated with the stimulation of erythroid progenitors and with increased levels of inflammation markers. Therefore, IR should also be associated with increased red blood cell (RBC) and white blood cell (WBC) count. The aim of this study is to demonstrate that IR is independently associated with altered hematological parameters in patients with metabolic syndrome. We analyzed laboratorial exams from 275 subjects. All data on hematological parameters, insulin resistance (Homeostasis Model Assessment [HOMA]) and lipid levels were included in the analysis. Demographic information included age and gender. HOMA correlated positively with RBC (r= 0.17, p< 0.001), plasma hemoglobin concentrations (r= 0.14, p< 0.001), hematocrit value (r= 0.15, p< 0.001) and WBC (r= 0.17, p< 0.01). Subjects in the upper quartile of IR had higher levels of plasma glucose, fasting insulin, triglycerides, hematocrit, hemoglobin, RBC and WBC count than those in the lower quartile. In conclusion, IR seems to be associated with alterations in several hematological parameters. These hematological alterations may be considered an indirect feature of the IR syndrome.

Background: Cardiopulmonary bypass (CPB) remains a cornerstone of modern cardiac surgery, enabling complex procedures under controlled physiological conditions. However, its use is associated with a risk of neurological complications, including ischemic and hemorrhagic stroke, cognitive impairment, and delirium. Identifying and mitigating these risks is essential to improve patient outcomes.

Objective: This study aims to assess the key preoperative, intraoperative, and postoperative risk factors contributing to the development of neurological complications in patients undergoing cardiac surgery with CPB.

Methods: A comprehensive review of recent clinical data was conducted, focusing on age-related vascular changes, preexisting comorbidities (hypertension, diabetes, atherosclerosis), duration of CPB, cerebral hypoperfusion, embolic events, and the effects of pharmacologic agents such as beta-blockers, heparin, and insulin. The neuroprotective potential of hypothermia and its adverse effects during rewarming were also analyzed.

Results: Advanced age (>70 years), prolonged CPB time (>120 minutes), hemodynamic instability, and high comorbidity index were strongly associated with neurological complications. Pharmacologic interventions showed both protective and adverse effects, depending on timing and patient-specific factors. The role of intraoperative cerebral perfusion and temperature regulation emerged as critical in reducing neurologic morbidity.

Conclusion: Neurological complications following CPB remain a significant concern in cardiac surgery. A multidisciplinary approach involving careful preoperative assessment, intraoperative monitoring, and targeted pharmacological strategies is crucial for risk reduction and improved neurological outcomes.

Constipation is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. The present study aims to evaluate the acute toxicity and efficacy of selected bioactive compounds for the treatment of constipation. Acute toxicity was assessed using standardized in vivo models to determine the safety profile of the bioactive compounds. The therapeutic efficacy was evaluated through pharmacodynamic and biochemical analyses, focusing on bowel motility, stool frequency, and intestinal microbiota modulation. Preliminary findings suggest that the tested compounds exhibit favorable safety margins and potent laxative effects, potentially offering a novel approach for constipation management. Further clinical studies are required to validate their long-term safety and effectiveness.

Early diagnosis of granulomatosis with polyangiitis (GPA) is a difficult clinical task and requires a thorough examination of the patient using modern research methods to identify pathognomonic symptoms. It is necessary to specifically search for respiratory tract damage by performing rhinoscopy, laryngoscopy, computer tomography of the paranasal sinuses, and lung scans, as the disease may be asymptomatic or have minimal clinical symptoms for a long time. Only 50% of patients are diagnosed within the first 3-6 months of disease onset, while in 7%, GPA remains undetected for 5-16 years after the first symptoms appear.

In the active period of the disease, non-specific signs are revealed in the laboratory examination: normochromic anemia, thrombocytosis, neutrophilic leukocytosis and an increase in ESR, rheumatoid factor, positivity of C-reactive protein. Clinical analysis of urine: hematuria, erythrocyte casts, proteinuria. Along with the urinary syndrome, azotemic indicators increase and the glomerular filtration rate decreases rapidly.

Neurofibromatoses (NF) are a group of hereditary diseases characterized by the development of multiple benign, and more rarely malignant, tumors in the central and peripheral nervous systems. Currently, this group includes three main conditions: type I neurofibromatosis (NF I), type II neurofibromatosis (NF II), and schwannomatosis (SWMT). Notably, neurofibromatosis, whose symptoms occur equally in both men and women, most commonly manifests in childhood, particularly during puberty.

Systemic sclerosis (SSc) is an autoimmune disease of connective tissue characterized by fibrosis of the skin and internal organs, vascular damage, and immunological changes. One of the most severe complications is renal involvement, particularly scleroderma renal crisis (SRC). Renal crisis is one of the most serious complications of SSc and often occurs in diffuse SSc. This article discusses the pathogenesis, clinical manifestations, diagnostic methods, and modern approaches to treatment of renal involvement in SSc.

In the process of searching for new effective drugs for the treatment of prostate and prostate adenoma, special attention should be paid to drugs based on natural origin. It is generally accepted that drugs obtained from natural origin are less toxic. The action of these drugs is carried out through ready-made dosage forms that are easy to use. The purpose of our work is to develop the composition and technology of an encapsulated dosage form based on Fireweed.This article presents the results of studies on the development of tablet technology based on the recommended dry extract "Prostad". An encapsulated dosage form, unlike others, does not require the mandatory introduction of excipients if the drugs have satisfactory technological properties. They can be filled into gelatin capsules, which significantly simplifies the technological process of production.

Having a complete description of the properties of the compressed substance, it is possible to scientifically approach the solution of this problem.