No. 10 (2022) Volume02 Issue10

In this article analyzes the sports performance and physical condition of female girls in the pre-competitive period of preparation for international competitions in the pre- and menstrual cycle.

This article is devoted to the problems of management in healthcare. It considers the factors of the internal environment that affect the effective management of a medical organization.

This research paper presents the isolation of norfluorocurarine alkaloids from the Vinca erecta plant, substances with different chemical structures and the study of toxicological properties in various types of animals. Experiments have shown that mice are more resistant to the effects of pyrazoline chloride and pyrazoline iodide than rats. From the conducted studies, it can be concluded that it is advisable to carry out the biological activity of the studied substances to rats that are relatively immune to the action of these substances and this will allow further use of dosages that are relatively harmless to humans in various pathologies.

Hypertension (AH) was designated by Russian scientists as the greatest non-infectious pandemic in the history of mankind [7-14]. This definition, given at the end of the 20th century, retains its significance at the beginning of the 21st century, when an increase in the upward trend in the incidence of GB was noted. Currently, in the fight against hypertension, it is important not only to reduce blood pressure, but also to prevent and treat organ complications [3,5].

Malignant ascites is frequently found in OC, with about 10% of patients suffering from recurrent OC. More than a third of ovarian cancer patients have ascites at diagnosis, and nearly all have ascites at recurrence. The presence of ascites correlates with peritoneal spread of ovarian cancer and is associated with a poor prognosis of the disease. Malignant ascites acts as a reservoir of a complex mixture of soluble factors and cellular components that provide a tumor-stimulating microenvironment for tumor cells. Ascites -derived malignant cells represent a major source of morbidity and mortality in ovarian cancer patients.  Subpopulations of these tumor cells have increased resistance to therapy and the ability to distal metastasis and recurrence. The anti-angiogenic targeted agents bevacizumab and pazopanib also showed good effects in the symptomatic treatment of malignant ascites OC, significantly prolonging the time to the next paracentesis. Thus, we conclude that further large-scale studies are needed to find out whether the reduction in ascites with these targeted drugs leads to an increase in the duration of tumor-related survival or not.