INNOVATIVE METHOD FOR DIAGNOSTICS AND TREATMENT OF SECONDARY CHRONIC PYELONEPHRITIS IN CHILDREN

The proposed modified treatment helps prevent renal inflammation, frequent recurrence and the formation of renal failure. Objective: to evaluate the modified treatment of chronic pyelonephritis in children. Material and methods. We examined 85 children with chronic secondary non-obstructive pyelonephritis developing against the background of dysmetabolic disorders (oxalate crystalluria) at the age from 4 to 15 years. The patients were divided into 2 groups depending on the methods of therapy used. Group I included 48 children who received traditional methods of treatment. Group II - 37 patients who received modified treatment (antibiotics were administered regionally lymphotropically in combination with viferon and vitamin A). Results and discussion. The study of urine cytokines, depending on the method of chronic pyelonephritis therapy, showed that in children of group I, before discharge from the hospital, the amount of IL-1, IL-6, IL-8, IL-10 in urine remained elevated (P1> 0.1. Conclusions: In CP in children, there was an increase in pro-inflammatory (IL-1, IL-6, IL-8) and a decrease in anti-inflammatory cytokines (IL-10) in the urine.