No. 3 (2018) Doctor’s herald

Статьи

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  The role of lipid disorders in patients with chronic diseases of kidneys Metabolic disorders in chronic kidney diseases (ChKD) can be considered as a lipid distress syndrome, which is a systemic pathological reaction of the organism that arises on the basis of violations of lipid metabolism. The detection of initial manifestations of lipid metabolism disorders in patients with ChKD allows the identification of high-risk groups with an unfavorable outcome.

  B Daminov, N Mahmudova

  6-9

  91   15

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  Analysis of causes of uterine cervical cancer on direction "patient delay" The problem of cervical cancer (cervical cancer) for many decades continues to be at the center of attention of leading foreign and domestic oncologists, as it occupies the leading position of cancers of female genitalia. Despite the existence to date of various modem diagnostic methods, the disease is detected in most cases already with neglected forms. The paper analyzes the results of an anonymous survey of 100 patients with predominantly locally advanced forms of cervical cancer to identify key barriers to early detection of cervical cancer patients, and suggests possible ways to eliminate them.

  N Zakhirova, М Tilliashaykhov, О Akhmedov, D Egamberdiev

  10-12

  116   39

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  Physical rehabilitation in the complex treatment оf lumbar spine osteochondrosis In this article, the effects of therapeutic and gymnastic exercises on patients are studied and the results of the study are presented. 46 patients with osteochondrosis of the lumbar department were examined. The patients were divided into 2 groups. The results of the study showed that the application of therapeutic physical training to patients with osteochondrosis, improves the condition of patients, improves the motor activity and the quality of life of the patient, increases efficiency, helps improve the patient's fitness.

  Yo Kamalova

  13-15

  82   33

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  Disadvantages and ways of improvement in diagnostics and surgical treatment of the diabetic foot syndrome Patients with diabetes mellitus, often, there are changes in the vessels in the form of calcification of the middle shell of arteries and arterioles (arteriolosclerosis of Menkeberg, mediacalcinosis). The determination of the x-ray stage of calcification of the arteries, gives additional information on the state of the vessels of the foot. Destructive changes in blood vessels, soft tissues and bones, conducted surgical interventions are naturally related. The study of these patterns is possible with a timely, critical study of anamnestic, diagnostic data and therapeutic measures. In this regard, to date remain relevant issues related to the development of differentiated treatment, taking into account all possible diagnostic data and improving surgical methods for treating the diabetic foot syndrome.

  E Kurbanov, S Abdullayev, А Gapparov, А Ahmedov, J Aslamov

  16-24

  123   39

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  Efficiency of laparoscopic hose rescue of the stomach and intra-cellular cylinder in reducing diseases, according with obesity The main goal of bariatric interventions is to achieve sustained weight loss in obese individuals, which reduces the risk of overall morbidity and mortality. Based on the experience of treatment of 20 obese patients, was established that 6 months after laparoscopic sleeve resection of the stomach (LSRS), which was performed by 16 patients, the body mass index (BMI) decreased from 47,7 ± 2,0 to 38,2 ± 1,4 kg/m2. The installation of intragastric balloon (IGB), carried out by 6 patients with extremely high body weight for the purpose of preoperative preparation before LSRS, helped to reduce the BMI from 71.5 ± 3.0 to 61.3 ± 1.4 kg / m2. The use of IGB and LSRS led to a positive dynamics of the conditions associated with obesity: the number of people with dyslipidemia decreased by 53%; remission ofdiabetes mellitus is achieved in 50%; normalization of blood pressure indicators - in 67%; regression of non-alcoholic fatty liver disease was achieved - in 43% of cases, depression was eliminated in 80%, and mobility disorders - in 65% of cases. IGB and LSRS allowed to improve the Cardiometabolic Disease Staging score, achieving zero cardiometa-bolic risk in 35% of patients, and in the remaining patients - transition to an easier stage.

  U Mahmudov, Sh Hashimov, Z

  25-29

  104   15

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  The risk of venous thromboembolism in patients with renal cell carcinoma With intraluminar invasion of the inferior vena cava after surgery with a fragmented a tumor thrombus The aim of this work was to determine the long-term risks of venous thromboembolism (VTE) in patients with subsequent extraction of residual tumor thrombus and the effect of residual tumor thrombus on overall survival. The first aim was to determine the risk of VTE during a 2-year follow-up period. The second aim was the determination of the overall survival within 2 years. In patients with residual tumor thrombus, the overall survival rate was lower than in patients with a fully resected tumor thrombus, or in those who did not have a tumor thrombus. Conclusions: the presence of residual tumor thrombus is an important risk factor for the development of VTE amid patients with renal cell carcinoma.

  М Tillyashaykhov, E Boyko, А Otaboev, L Koren, N Raximov, Sh Xasanov, B Aloev

  30-36

  138   20

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  Immunotoxic and endocrine-disrupting effects of pesticides on offspring in the conditions of their entry through the mother's organism The aim of the study was to identify the toxic effect of intrauterine and early postnatal exposure to pesticides on the development of the endocrine and immune system of offspring. The experiments were performed on white adult male rats, who respectively received pesticides lambda-cyhalothrin or fipronil during pregnancy and lactation. Progeny from experimental and control animals was studied on the 3rd, 7th, 14th, 21st and 30th days after birth using methods of morphology, electron microscopy, immunohistochemistry and biochemistry. It has been shown that the toxic effect of pesticide exposure during pregnancy and lactation is manifested in the form of growth retardation and formation of the thymus, lymph nodes, spleen and thyroid glands of offspring. In the mechanism of toxic effect of pesticides on the immune-endocrine system, the leading role is played by the imbalance between proliferation and apoptosis of cells, caused both by direct toxic effects of drugs, both developing hypothyroidism and oxidative stress in mother and offspring. This causes the need for early detection of hypothyroidism and oxidative stress in pregnant women and newborns, followed by their pharmacological correction.

  N Tukhtaev, N Zokirova

  37-41

  95   30

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  Features of mineral density of bone tissue with premature inefficiency of ovaries Based on the results of the study, the prevalence of low bone mineral density in patients with premature ovarian failure was determined. A complex assessment of the factors that play an important role in the reduction of BMD in patients with premature ovarian failure: the age factor and the level of sex hormones.

  F Khaidarova, S Fakhrutdinova

  42-47

  99   24

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  Influence of alcohol exploitation on the peculiarities оf the current craniocerebral injury Alcoholic intoxication leads to more severe injuries: those who suffer from alcohol intoxication. Mortality in patients with severe craniocerebral injury reaches 30%. The time of recurrence of cerebral and focal symptoms with a combination of trauma with alcohol intoxication is longer than in sober patients, on average by 28-30%.

  О Hwang, Т Zikrillaev

  48-50

  159   23

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  The peculiarities of neurologic symptomatics in the serious memeting of the enterherous etiology 41 patients with serous enteroviral meningitis were examined, the results of the analysis of clinical and neurological manifestations of enteroviral meningitis showed that it was more often characterized by an acute onset with pronounced neurologic symptoms and a good curative effect from spinal puncture as well as cases of pleocytosis of neutrophil and mixed character.

  M Ergasheva

  51-54

  68   26

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  Exenteratic of small pelvis in patients with cervical cancer Despite the existing achievements in the implementation of pelvic exenteratics (ET) in the world oncological practice, it still remains the object of considerable criticism and disputes of practicing oncologists. The main reasons for the unpopularity of this operation arc its technical complexity, high incidence of intra- and postoperative complications, problems of post-operative rehabilitation of patients. Literature data of authors of near and far abroad on this topic, historical data, examination of patients, indications and contraindications to the operation were studied, significant problems, controversial issues in this field were identified and possible further studies in this direction were indicated.

  N Zakhirova, М Tilliashaykhov, O Akhmedov

  55-59

  157   31

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  Diagnostic modern methods of women genitals anomalies Uterine malformations are congenital changes in the female genital organs, from underdevelopment to non—fusion of the Muller ducts with the formation of septa. According to some authors, abnormalities of uterine development occur in 25% of patients with disorders in the reproductive system.

  B Negmadzhanov, B Ziyatov, М Mamatkulova, V Kim, L Shukurov

  60-69

  275   110

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  Formation of artificial vagina at anomalies development of genitals Hereditary, exogenous, multifactorial factors lead to the causes of anomalies in the development of female genital organs. The occurrence of genital malformations is attributed to the critical period of intrauterine development. It is based on the absence of fusion of the caudal sections of the paramesonephral Muller ducts, deviations in the transformations of the urogenital sinus, as well as the pathological course of gonad organogenesis, which depends on the development of the primary nocturnal. These deviations account for 16% of all anomalies. Anomalies of the development of the genitals often occur during the pathological course of pregnancy in the mother at different periods of pregnancy. These are early and late gestosis, infectious diseases, intoxication, endocrine disorders in the mother's body. In addition, anomalies in the development of female genital organs can occur under the influence of harmful environmental factors, occupational harmful effects in the mother, poisoning with toxic substances. Along with anomalies of the genitals, in 40% of cases there are anomalies of the urinary system (unilateral kidney agenesis), intestines (atresia of the anus), bones (congenital scoliosis), as well as congenital heart defects.

  B Negmadzhanov, F Ostonakulova, М Mamatkulova, F Ganiev, V Kim, E Shopulatov

  70-77

  321   45

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  Modeling processes of distribution of cutaneous leishmaniasis in uzbekistan According to the World Health Organization, there are about 12 million leishmaniasis patients, about 2 million people get this disease every year. An analysis of the situation on skin leishmaniasis, as well as an assessment of the possible impact of climate change on vector carriers, is carried out by mathematical modeling using climate predictors. Modeling the spread of cutaneous leishmaniasis allows to obtain a number of data for possible approximation of the disease in the future.

  N Rabbimova, U Suvonkulov, Т Muratov, М Malikov

  78-80

  74   27

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  Risk of sudden death in athletes: electrocardiographic criteria Modern sport of high achievements requires the maximum mobilization of functional reserves and compensatory and adaptive reactions of a person, and significant physical activity can lead to pathological changes in the ECG. Discovered at the athlete Seattle criteria in the form of sinus bradycardia of more than 30 doses per minute, incomplete blockade of the right leg of the Gissa bundle, some signs of GLV, early vaginal repolarization syndrome, ectopic atrial rhythm, blockade of II st. are considered to be manifestations of adaptation to regular physical activity. Pathological changes: T wave inversion, complete blockage of the left leg of the Hyza bundle, intraventricular conduction disturbances with QRS> 140 ms duration, left atrial pathology, right ventricular hypertrophy, Wolf-Parkinson-Whitc syndrome, corrected QT >470 ms in men and > 480 ms in women, high degree of blockade, AF or atrial flutter, high grade ventricular extrasystoles require additional examination.

  О Polyanskaya

  81-84

  108   27

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  New approaches to medical rehabilitation in ischemic stroke The article describes the main approaches to the restoration of the functional state of the affected organs in ischemic stroke. The author's methods of treatment of patients after stroke with hemiparesis and significant spasticity or hypotension of muscles were proposed.

  О, Z Mavlyanova

  85-89

  103   20

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