Analysis of the associotion of the rs1045642 polymorphism of the mdr1 gene with the development of myeloprolifertive diseases

Early diagnosis of Myeloproliferative diseases (MPD) is one of the serious problems of oncohematological practice. MPD efers to multifactorial diseases, the development of which is influenced by both environmental factors and genetic predisposition. The study studied the association of the carriage of the genotype for the polymorphic marker encoding glycoprotein-P and the development of MPD. The homozygous T / T genotype of the rs1045642 polymorphism of the MDR1 gene is a significant determinant of the increased risk of developing MPD in Uzbekistan (P<0.05). Conclusion. Genotype association the rs1045642 polymorphism of the MDR1 gene is associated with the risk of developing MPD.