The position of the cytokine profile and cytolysis enzymes in patients with viral hepatitis before tooth extraction

It is known that in chronic liver diseases, secondary immunodeficiency is formed, which is of great importance for the dental system and the entire body as a whole. Therefore, it becomes clear the importance of studying the state of the protective system of oral tissues in chronic viral liver pathology, which requires timely and constant correction. The aim of this study was to evaluate the activity of proinflammatory cytokines and cytolytic enzymes in patients  with  chronic  viral  hepatitis  before  tooth  extraction.  The  level  of  cytokine  IL-1  in patients  with  CVI  before  tooth  extraction  was  on  average  43.97±3.56  pg  /  ml,  whereas  in healthy people the studied indicator was on average 5.41 ± 0.42 pg / ml. The patients showed an increase in the level of IFN in the blood serum by an average of 6.2 times, the level of interleukin-18, belonging to the IL-1 family, was statistically significantly increased by 2.4 times  in  patients  with  CVI,  compared  with  the  control  group.  The  features  of  CVH  are dissociations  between  the  levels  of  proinflammatory  cytokines  IL-1,  IL-6,  IL-18  and interferon.  This  indicates  the  disintegration  of  the  inflammatory  process  occurring  in  the periodontal tissues and with the transition to a chronic course of the disease. Changes in the level of IL-1, IL-6, IL-18 and interferon in the blood serum of patients with CVI from normal parameters before tooth extraction is an indicator of the severity of the inflammatory process in the liver, as evidenced by changes in the dynamics of cytolytic enzymes.