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THE INTERCONNECTION BETWEEN THE MICROBIOME AND
BRAIN HEALTH: A NEW NEUROMEDICAL DIRECTION
Eshmamatov AZ SаMSMU 1st Medical Faculty , 104th group student
Samarkand state medicine university pathological anatomy department associate professor
Amanova G.O., Uzbekistan
Relevance .
Latest in years human organism not only systematic , maybe ecosystemic
approach based on is being studied . Especially the intestines microbiota organism other
important systems , including central nerve system with complicated , two one-sided in touch
that increasingly wider is being studied . Modern research intestine microorganisms by
working removable metabolites , e.g. serotonin, GABA, dopamine , short chained fatty acids
and neuroactive substances , brain to the activity straight away or indirectly impact to show
This is showing . such as depression , Alzheimer's , Parkinson's neurological and spiritual
diseases pathogenesis microbiome participation showing gives . Gut–brain arrow through to
the surface coming molecular mechanisms understanding modern in neuromedicine new the
period starting is giving . This because of this topic not only theoretically , maybe practical
extremely current is considered and it is modern medicine many areas ( gastroenterology ,
neurology , psychiatry , microbiology) and nutraceuticals ) directly involved.
Research objective :
To study in depth the effects of the gut microbiota on the
functioning of the central nervous system through neuroactive substances, immune
mechanisms, and neural signaling pathways. In particular:
To determine how metabolites produced by intestinal microorganisms (shortchain fatty
acids, tryptophan derivatives, serotonin, GABA, dopamine, etc.) affect brain cells;
Dysbiosis in cases to the surface coming inflammation and oxidative stress reactions
neuron to the function the impact assessment ;
The microbiome neurodegenerative and spiritual with diseases ( e.g. , depression ,
Alzheimer's , Parkinson's) dependence explanatory molecular and cellular mechanisms to
explain ;
This dependency based on neuromedical prevention and therapy new methods
justification
Materials and methods.
Scientific literature and modern articles analysis ( PubMed ,
ScienceDirect , Google Scholar databases) based on );
Microbiome of the composition
metagenomic analysis ;
Blood and feces in samples neuroactive metabolites ( e.g. SCFA,
tryptophan) derivatives ) to determine ;
Brain tissue neurohistological and
immunohistochemical research .
Results and discussion ;.
According to the results of the analysis of scientific studies
,
changes in the intestinal microbiota (dysbiosis) lead to a 1.5–2-fold increase in inflammatory
factors in the central nervous system. GABA production issuer bacteria decrease with related
without test in groups depressive symptoms in 60% of cases 70–80% of serotonin is found in
the gut synthesis confirmed , this and intestine health and emotional situation between directly
dependency the existence Alzheimer 's disease and Parkinson's disease played patients
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intestine in the microbiota Firmicutes / Bacteroidetes ratio 1.7 equal difference what did
Probiotic and prebiotics with the microbiome restoration through psychological 35–45%
improvement in symptoms record is being done .
Neurodegeneration take incoming oxidative stress level dysbiosis in cases approximately
2.3 equal high to be is observed .
Conclusion .
Intestine microbiota and central nerve system between mutual dependency
human health for solution doer from factors is one of them . Research this shows that the
microbiome in the content changes — dysbiosis cases — central nerve in the system
neuroinflammation , oxidative stress, neurotransmitters deficiency , neurons apoptosis take
arrival possible . Exactly this mechanisms depression , Alzheimer's and Parkinson's disease in
development main place It also controls the microbiome . to restore aimed at approaches ( e.g.
, probiotics , prebiotics , diet) therapy ) of patients psychological and cognitive status in
improvement promising direction become is going on . So doing , gut-brain arrow based on
diseases pathogenesis deep understanding in neuromedicine new the period starting gives and
healthy microbiome — healthy mind concept scientific justification opportunity creates.
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