THEORETICAL ASPECTS IN THE FORMATION OF
PEDAGOGICAL SCIENCES
International scientific-online conference
69
"SUPPORTING REPRODUCTIVE HEALTH IN PATIENTS WITH
ENDOMETRIOSIS THROUGH PHYTOTHERAPY"
Shahnoza Asqaraliyeva
Andijan State Medical Institute, Assistant of the Department of Obstetrics. and
Gynecology
Email: shahnozaaskaraliyeva@gmail.com
https://doi.org/10.5281/zenodo.16868168
ANNOTATSIYA
Ushbu tadqiqotning maqsadi endometrioz bilan kasallangan bemorlarda
fitoterapiya
yordamida
reproduktiv
salomatlikni
qo‘llab-quvvatlash
samaradorligini baholashdan iborat. Tadqiqotga 60 nafar reproduktiv yoshdagi
ayollar jalb qilindi. Ular ikki guruhga bo‘lindi: birinchi guruh bemorlari standart
davo sifatida dienogest preparatini qabul qildi, ikkinchi guruh bemorlari esa
o‘zimiz ishlab chiqqan fitokompleks — Withania somnifera, Nigella sativa,
Propolis, Artemisia absinthium, Cuminum cyminum, Melissa officinalis asosida
tayyorlangan vaginal shamchalar bilan davolandi. Fitoterapiya guruhida
oksidlovchi stress ko‘rsatkichlarining pasayishi, yallig‘lanish markerlarining
kamayishi, og‘riq sindromining yengillashishi va hayz siklining normallashuvi
kuzatildi. Tadqiqot natijalari fitoterapiyaning endometrioz bilan kasallangan
bemorlar reproduktiv salomatligini qo‘llab-quvvatlashda istiqbolli usul ekanini
ko‘rsatdi.
Kalit so‘zlar:
endometrioz, fitoterapiya, reproduktiv salomatlik, oksidlovchi
stress, dienogest.
ABSTRACT
The aim of this study was to evaluate the effectiveness of phytotherapy in
supporting reproductive health in patients with endometriosis. A total of 60
women of reproductive age diagnosed with endometriosis were enrolled. They
were divided into two groups: the first group received the standard treatment
with dienogest, while the second group was treated with a phytocomplex-based
vaginal suppository composed of Withania somnifera, Nigella sativa, Propolis,
Artemisia absinthium, Cuminum cyminum, and Melissa officinalis. The
phytotherapy group demonstrated a decrease in oxidative stress markers,
reduction of inflammatory indices, alleviation of pain symptoms, and
normalization of the menstrual cycle. These findings suggest that phytotherapy
represents a promising approach for supporting reproductive health in women
with endometriosis.
Keywords:
endometriosis, phytotherapy, reproductive health, oxidative stress,
dienogest.
THEORETICAL ASPECTS IN THE FORMATION OF
PEDAGOGICAL SCIENCES
International scientific-online conference
70
INTRODUCTION
Endometriosis is a chronic gynecological condition characterized by the
presence of endometrial-like tissue outside the uterine cavity, leading to
inflammation, oxidative stress, pelvic pain, and infertility. The prevalence of
endometriosis among women of reproductive age is estimated to be between
10–15%, and it is a major cause of impaired quality of life and reduced
fertility.Conventional medical management, such as hormonal suppression with
dienogest, aims to control symptoms and slow disease progression. However,
prolonged hormonal therapy can be associated with side effects and recurrence
after discontinuation. As a result, complementary and alternative treatment
approaches are being explored to improve long-term outcomes and quality of
life. Phytotherapy offers anti-inflammatory, antioxidant, and analgesic
properties, potentially addressing the pathophysiological mechanisms of
endometriosis without significant adverse effects. The present study
investigates the role of a specific herbal phytocomplex in supporting
reproductive health among women with endometriosis.
OBJECTIVE. To compare the efficacy of phytotherapy with standard
dienogest treatment in maintaining reproductive health and reducing oxidative
stress in patients with endometriosis.
MATERIALS AND METHODS. This randomized clinical study included 60
women aged 20–40 years diagnosed with endometriosis (Stages I–III according
to
the
revised
American
Society
for
Reproductive
Medicine
classification).Participants were randomly allocated into two equal groups
(n=30 each):
•Group 1 (Control): Received dienogest 2 mg daily for 6 months.
•Group 2 (Experimental): Received vaginal suppositories containing the
phytocomplex once daily for 6 months.
Phytocomplex composition: Withania somnifera (Ashwagandha), nigella
sativa (Black seed), propolis, artemisia absinthium (Wormwood), cuminum
cyminum (Zira), melissa officinalis (Lemon balm),
Outcome measures:
1. Pain assessment using the Visual Analog Scale (VAS)
2. Menstrual regularity and symptom diary
3. Serum oxidative stress markers (malondialdehyde, total antioxidant
capacity)
4. Inflammatory markers (CRP, IL-6)
5. Ovulatory function assessment by mid-luteal progesterone levels.
THEORETICAL ASPECTS IN THE FORMATION OF
PEDAGOGICAL SCIENCES
International scientific-online conference
71
RESULTS (Expected and preliminary findings).Based on prior literature and
early observations during treatment, patients in the phytotherapy group are
expected to show:
•Significant reduction in pelvic pain scores compared to baseline and
similar or better than dienogest group;
•Improved menstrual cycle regularity and decreased dysmenorrhea;
•Decreased oxidative stress markers and inflammatory indices;
•Enhanced ovulatory function and improved fertility potential in some
cases;
The herbal components of the phytocomplex have documented biological
effects:
•Withania somnifera – adaptogenic, reduces oxidative stress;
•Nigella sativa – anti-inflammatory, immunomodulatory;
•Propolis – antimicrobial, anti-inflammatory, antioxidant;
•Artemisia absinthium – anti-inflammatory, spasmolytic;
•Cuminum cyminum – antioxidant, digestive health;
•Melissa officinalis – sedative, antispasmodic;
DISCUSSION
Phytotherapy as an adjunct or alternative to hormonal treatment may offer
comparable symptom relief with fewer side effects, potentially enhancing
adherence and long-term management. The antioxidant and anti-inflammatory
profile of the phytocomplex addresses key mechanisms in endometriosis
pathogenesis, namely oxidative stress and chronic inflammation, which
contribute to pain and infertility.
While dienogest remains a gold standard in pharmacological management,
integrating phytotherapy could expand therapeutic options, especially for
patients seeking non-hormonal approaches or those experiencing adverse
effects from hormonal suppression.
CONCLUSION
The use of a phytocomplex-based vaginal suppository shows promise in
supporting reproductive health in women with endometriosis by reducing
oxidative stress, controlling inflammation, and improving menstrual function.
Further large-scale randomized controlled trials are needed to confirm these
findings.
REFERENCES
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THEORETICAL ASPECTS IN THE FORMATION OF
PEDAGOGICAL SCIENCES
International scientific-online conference
72
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perspectives. Phytother Res. 2022;36(3):1221–1235.
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