№ 3 (79) (2014) Биология ва тиббиёт муаммолари

Статьи

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  Эпидемиологические особенности течения риккетсиозной инфекции по Самаркандской области Инфекционные болезни, возбудители которых циркулируют в природе, остаются сложной проблемой, несмотря на все усилия по борьбе с ними. Нарастающая в последние десятилетия тенденция сосредоточения очагов природных инфекций на территориях, освоенных или осваиваемых человеком, заставляет искать закономерности их формирования и устойчивого функционирования.

  Н Ярмухамедова, Н Раббимова

  186-187

  102   18

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  Клинико-гемодинамические параметры при бруцеллезном миокардите Целью исследования явилось изучение ситолической и диастолической функций сердца у больных бруцеллезом.

  С Ярмухамедова

  187

  50   14

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  Screening for toxocariasis of patients with allergic diseases Toxocariasis is a disease of humans caused by larvae (immature worms) of either the dog roundworm (Toxocara canis) or the cat roundworm (Toxocara cati). Toxocariasis is often called visceral larva migrans. This zoonotic, helminthic infection is a major cause of blindness and may provoke rheumatic, neurologic or asthmatic symptoms. Humans normally become infected by ingestion of embryonated eggs from contaminated sources (soil, fresh or unwashed vegetables).

  М Ахмедова, М Ибрагимов, Ж Анваров

  188

  124   15

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  The corelations between immunogram parameters in the patients with chronic viral hepatitis c The wide prevalence of hepatitis С virus among the population, prediction to chronic process, frequent development of the liver cirrhosis and hepatocellular carcinoma as well as variability of immune responses make the problem of chronic hepatitis C one of the most important aspects in the area not only in the hepatology but also in the whole field of the internal medicine.

  У Набиева, Т Агзамова

  188-189

  105   13

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  Immunogenetic factors in adults and children with chronic viral hepatitis c infection in uzbek population Hepatitis C leads to severe liver damages and one of the indications to liver transplantation (according to WHO ~3% of worldwide population is infected by HCV infection.) The current standard of therapy of chronic hepatitis C (CHC) is pegylated interferon-α (PEG-IFNα) in combined with ribavirin (RBV). The treatment achieves a sustained viral clearance in only approximately 50% of patients. Recent whole genome association studies revealed that single nucleotide polymorphisms (SNPs) around IL-28B have been associated with response to the standard therapy and could predict treatment responses at approximately 80%. According to 4 independent GWAS approaches have revealed the significant SNPs associated with response to PEG-IFNα/RBV therapy for CHC. These significant SNPs were found around IL-28B were rs12979860 and rs8099917 they showed the statistical significance in each study (M. Mizokami at al., 2011).

  E Назаров

  189

  73   10

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