https://www.inlibrary.uz/index.php/problems_biology <p>The scientific journal on theoretical and practical problems of biology and medicine was founded in 1996 by the Samarkand branch of the Academy of Sciences of the Republic of Uzbekistan on every 2 months.</p> Samarkand State Medical University ru-RU Journal problems of biology and medicine 2181-5674 https://www.inlibrary.uz/index.php/problems_biology/article/view/6947 20 patients a ged 15-50 years with allergic rhinitis have been studied. A complex study included collektion of allergological anamnesis, objective data, endoscopik examination of the nasal cavity, cytological examination of smears-imprints from its surface and nasopharynx. A complex treatment of allergik rhinitis wiith employment of eliminative, hyposensibilizing, immune, antimycotic, local therapy and performing operation for submucous resection of nasal septum with incision of vessels of inferior nasal conchae has been carried out. Marked favourable effect has been received in 72,6 %, insignificant effect in 23,7 % and 3,7 % of patients have not received any effect from treatment. J Khatamov X Karabaev O Kodirov N Khatamova F Nurmukhamedov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 61 64 https://www.inlibrary.uz/index.php/problems_biology/article/view/7001 Retrospective analysis of the development leprosy is conducted In article in Buhara and Navoi region. The Analysis shows that all revealled events disease leprosy in these region has migretion nature. Local population and region are not an endemic centre of the disease E Ashboev Ya Fayziev X Niyazov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 98 100 https://www.inlibrary.uz/index.php/problems_biology/article/view/7000 Анкилоз височно-нижнечелюстного сустава (ВНЧС) фиброзное или костное сращение суставных поверхностей обусловливающее частичное или полное исчезновение суставной щели. Врожденные анкилозы наблюдаются исключительно редко. Согласно имеющимся данным, до 80% анкилозов ВНЧС развиваются у детей в возрасте до 10-15 лет. Однако многие больные поступают в лечебные учреждение значительно позже. F Khamitova M Chodiev Sh Pulatov D Juraev R Shoeva Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 97 98 https://www.inlibrary.uz/index.php/problems_biology/article/view/6999 “Она ва бола” скрининг маркази республика Вазирлар Махкамасининг “Болаликдан ногиронлик олдини олиш учун хомиладорлар ва янги туғилган чақалоқларни оммавий текшириш” - “Она ва бола” скринингги тўғрисидаги қарори асосида ташкил этилган. Вилоятимизда бундай марказ 2000 йилдан бери фаолият кўрсатиб келмоқда. A Inoyatov D Ahmedova F Turaeva N Inoyatova Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 97 97 https://www.inlibrary.uz/index.php/problems_biology/article/view/6994 Врожденные пороки развития составляют одну из самых актуальных медицинских и социальных проблем в связи с их высокой частотой и тяжестью. Врожденные расщелины верхней губы и нёба (ВРГН) в структуре антенатальной патологии занимают второе место среди других врожденных уродств человека. A Inoyatov F Turaeva Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 96 96 https://www.inlibrary.uz/index.php/problems_biology/article/view/6989 Одной из актуальных проблем современной эндокринной хирургии, является проблема подхода к хирургическому лечению больных диффузно-токсическим зобом. Актуальность данной проблемы связана с множеством вопросов затрагивающих как выбор оперативного вмешательства, так и способы уменьшения послеоперационных осложнений и рецидива заболевания. T Mahmudov Z Kurbaniyazov S Davlatov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 95 95 https://www.inlibrary.uz/index.php/problems_biology/article/view/6988 Ятрогенные повреждения внепеченочных желчных протоков во время холецистэктомии происходят довольно часто, о чем свидетельствуют сообщения в различных медицинских изданиях и средние статистические данные. Z Kurbaniyazov K Rakhmanov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 90 94 https://www.inlibrary.uz/index.php/problems_biology/article/view/6986 There are study of animals change general quantity of leycocytes and its percentage correlation. Its gives a chance to control of celles as factors condition in natural resistance. Animals cells factors condition of natural resistance are depend on influence of genotype, factors of internal and external environment X Mahmudova B Bozorov Z Rajamurodov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 86 89 https://www.inlibrary.uz/index.php/problems_biology/article/view/6985 Materials 2369 of commission of experts carried out for professional legal violation by medical staff have been analysed in the article. Among revealed defects of rendering of medical aid the defects of treatment (29,34%) are of vital importance. The character of making mistakes, taking into consideration medical specialties, (surgery, therapy, obstetrics and gynecology, pediatrics et cet.) has been determined. Sh Islamov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 80 86 https://www.inlibrary.uz/index.php/problems_biology/article/view/6983 Impact of industrial environment on the parodontal tissues in workers at the oil-processing industry The Condition of paodontal tissues in 1038 workers at the Bukhara oilprocessing industry plant was studied in comparison with 978 persons in control group. It was determined a high frequency of parodontal diseases among workers of mail professions at the Bukhara plant in comparison with people in the control group. O Rajabov M Mirzaev Yu Yunusov Sh Yakubov A Ismailov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 76 79 https://www.inlibrary.uz/index.php/problems_biology/article/view/6982 Study results of clinical and forensic medical data at immortal poisonings in children were analyzed. It was revealed that computer dependence analysis poisons concentration in blood - effect" allows to get important for forensic-medical practice information on comparative toxicity of chemical compounds and death rate change depending on outcome poison level in blood of victims. D Kuldashev M Abdurakhmanova X Yakubov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 74 76 https://www.inlibrary.uz/index.php/problems_biology/article/view/6981 The new quantitative diagnostics criteria and severe degree evaluation of chemical trauma at acute poisonings were worked out. Organism's reactions (108 cases) on toxity of chlorophosus, carbophosus, phenobarbital, sodium ethaminal depending on sex, age and alcohol drink, were estimated. X Yakubov A Iskandarov M Abdurakhmanova Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 71 74 https://www.inlibrary.uz/index.php/problems_biology/article/view/6974 Инсоният пайдо бўлгандан буён ташқи муҳит билан ўзвий боғлиқлик мавжуддир. У ўзи яшайдиган муҳитга доимий равишда маълум бир таъсир курсатади, ташқи муҳит ҳам бу таъсирга нисбатан ўз муносабатини шакллантиради. U Oblokulov M Tokhtaev I Oblokulov D Kushmatova Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 68 71 https://www.inlibrary.uz/index.php/problems_biology/article/view/6960 Глобализация экономических процессов, захватившая цивилизованный мир, не прошла мимо такого отрицательного фактора развития человечества, каким является травматизм. По данным различных авторов 30-60 % от общего травматизма приходится на особо тяжелые формы травм – черепно-мозговые травмы. Щедеркин Р.И. с соавт. (2007) отмечает, что практическое выздоровление или стойкая компенсация наблюдается приблизительно у 30 % лиц, перенесших ЧМТ. Сложный патогенез травматической болезни головного мозга определяется тем, что отдаленный период ЧМТ является периодом «покоя», и представляет динамический процесс, приводящий при неблагоприятных условиях к наступлению декомпенсации состояния больных (1, 3, 5). A Jurabekova S Karaboev Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 64 68 https://www.inlibrary.uz/index.php/problems_biology/article/view/6769 The results of treatment of 177 children with septicopyemic form of acute hematogenic osteomyelitis have been presented in the article. Tactics of surgical treatment has been improved depending on the stage of pathological process by means of development and introduction into clinical practice of rational methods of drainage and sanation of the bone marrow canal of the affected bones, that made it possible to improve considerably the results of treatment. A Shamsiev D Atakulov M Burgutov Z Mahmudov S Zainiev Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 3 9 https://www.inlibrary.uz/index.php/problems_biology/article/view/6938 Под деформациями лицевого скелета понимают нарушение морфофункциональных соотношений его элементов, их эстетических пропорций. Причины возникновения деформаций различны. Часть их обусловлена аномалиями развития черепа и является одним из наиболее существенных признаков генетических заболеваний, часть отображает нарушения эндокринного ба ланса организма матери или ребёнка или формируется под влиянием тератогенных агентов в период антенатального онтогенеза [4, 9, 15, 14]. A Kubaev Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 57 61 https://www.inlibrary.uz/index.php/problems_biology/article/view/6920 Данного исследования было изучение образа жизни и досуга подростков в сельской местности, для внедрения первичной профилактики и предупреждения возникновения болезней V Turakulov N Narmukhamedova Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 54 57 https://www.inlibrary.uz/index.php/problems_biology/article/view/6908 Prospective study of the levels of TTH, Т3, Т4, blood indexes, also, treatment results at 100 women with irondeficiency anemia and endemic goiter was performed in the Maternity complex of SamMI clinics. Treatment was performed with levothyroxin, iodium and ferrum preparations. As study results has revealed the complex treatment of these conjoined conditions led to normalize not only thyroid gland dysfunctions, but also to improve pregnancy and delivery outcomes. F Mahmudov R Saidmurodov Z Yuldasheva B Toshpulatova A Rakhmonov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 52 54 https://www.inlibrary.uz/index.php/problems_biology/article/view/6899 Сохранение и повышение уровня здоровья матерей и детей – одна из важных государственных задач, решение которой позволит обеспечить воспроизводство здорового поколения. Состояние здоровья женщин и детей имеет большое социально-политическое значение и характеризует не только медицинскую помощь женщинам и детям, но и состояние системы здравоохранения и общества в целом (1, 3, 4, 8). A Jurabekova N Khamidova D Shomurodova Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 46 51 https://www.inlibrary.uz/index.php/problems_biology/article/view/6874 86 children with acute hematogenic osteomyelitis of bones of coxofemoral joint have been studied. According to the form of performed surgical interferences three clinical groups have been selected/ In the follow-up period good results have been received in 15 (57.7%) patient of the 3d group that is considerably more in comparison with the 1st group 7(33.3%) and the 2nd group 9(45%). The method of draining osteoperforations of acetabular tegmen (DOAT) made it possible to improve the outcome of the disease to decrease the number of complications twice less and exclude transfer to a chronic form. A Shamsiev Z Mahmudov D Atakulov M Burgutov S Zainiev Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 42 46 https://www.inlibrary.uz/index.php/problems_biology/article/view/6866 All the three systems turn out to belinked with one another with the help of anastomisis, which fast provides reservation and interchangeability. The number of anastomosis is greater in the wall of the right ventricle of heart. Vessels of all the system are characterized by some specific age and individual changes detectable at the electronnomicroscopic level. Unlike in Wiessens-Thebesius vessels, there are no “Fenestrae” in capillary vessels. Both Extracardiac vessels and Wiessens-Thebesius vessels have collateral, compensatory significance. The data obtained and our theory of heart blood supply can be used in the analysis of the concrete problems of cardiopathology. A Gabchenko Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 35 42 https://www.inlibrary.uz/index.php/problems_biology/article/view/6845 It was established in experiments in rats that a subchronic poisoning by a toxic metallic mix of copper, manganese, molybdenum and chrome salts induces disruption of morpho-functional state of mitochondrion membrane. It is shown, that a rate of the therapy combining enterosorption by citron pectin sorbent in a combination with a preparation Hepamal, possessing anti-oxidative properties, promotes normalization of morphology and improvement of function of liver mitochondrion. A Gutnikova I Baibekov B Saidkhanov K Mahmudov D Ashurova M Asrarov N Ergashev M Asimova Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 33 35 https://www.inlibrary.uz/index.php/problems_biology/article/view/6843 По данным ВОЗ рак мочевого пузыря (РМП) составляет около 3 % от всех злокачественных новообразований или 50-80% от всех опухолей мочевыделительной системы (Матвеев Б.П. и др., 2001). M Boltaev M Tillyashaikhov Sh Khasanov Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 27 33 https://www.inlibrary.uz/index.php/problems_biology/article/view/6840 The Purpose given work was a development to experimental model to remaining cavity liver in experiment, the most close on clinical current and morphological feature to remaining cavity after echinococus. Our experimental liver cavity consists in development of the cavities, which completely excludes presence in RLC, as expects use it, as model RLC cavities remaining after echinococus. The Experiment is organized after preliminary development of the requirements to cavities, and on which must answer the experimental model. The Experiment is organized on 25 laboratory white rat male by mass 250-270 g. The Result of the experiment has shown that using the metallic ball with talc causes formation capsules, which already on 20 day has a thickness required for framework and warns wall formed to cavities that in accuracy prototypes the remaining cavity after but final shaping OPP occurs on 25-30 day. The Proposed model to remaining cavity allows in experiment to develop the new ways of the treatment that will finally are directed on improvements result treatments patient with remaining cavity liver lengthened forms without pathology. M Khakimov J Asatullayev Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 22 26 https://www.inlibrary.uz/index.php/problems_biology/article/view/6826 Аноректальные мальформации составляют одну из наиболее многочисленных групп проктологических заболеваний детского возраста, с частотой встречаемости от 1:500 до 1:5000 живорожденных независимо от пола (Сhurchill B. et al., 1978; Ленюшкин А.И. 1990). Лечение этих пороков, при относительной несложности хирургической техники сопровождается довольно высокой частотой осложнений. M Aliyev T Narbaev A Yuldashev V Grishaev Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 19 22 https://www.inlibrary.uz/index.php/problems_biology/article/view/6809 Morphological researches are lead to 34 supervision for deeper studying a microstructure of a muscular layer of a wall ureter and its comparisons to stages of disease, prepared полутонкие cuts from a muscular layer мочеточника from a zone of obstruction and various supra stenosis the changed sites. Results of morphological researches unequivocally testified about structures the infringements underlying congenital supravesical obstruction ureter’s. Fibrosis transformation leiomyocitcs, reduction of their quantity and the deep sclerous changes occurring in a wall ureter, testified to functional inferiority of this segment. Differently, morphofunctional essence supravesical obstructions were congenital structural changes of a muscular layer ureter, that demanded performance of the same reconstructive-plastic operations - a resection is vicious the generated department ureter as much as possible within the limits of "healthy" sites with its replacement high-prade in mornhofnnctional the attitude a segment. A Yuldashev M Aliyev O Ollabergenov O Sapaev B Terebaev A Rakhmatullaev Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 14 19 https://www.inlibrary.uz/index.php/problems_biology/article/view/6807 Наше исследование основано на клинических наблюдениях над 106 больными раком прямой кишки с T3N0-2M0 стадией заболевания, которые получали комбинированное лечение в условиях РОНЦ с 2002 по 2006 гг. S Navruzov A Tulaev S Abdujabborov J Kahhorov A Khakimov E Akbarov A Galdiev Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 13 14 https://www.inlibrary.uz/index.php/problems_biology/article/view/6788 It was carried out the evaluation of some industrial poisons, agricultural and domestic insecticides, food acetic acid and drugs. It was revealed that even in similar by structural formula and pathogenesis action of chemical substances for middle mortal concentration of given poisons in man's blood are quite different. It was determined, that dependence probit-analysis '"poison concentration - effect" is very valuable method at study of quantitative interconnection side between chemical trauma's value and character of organism's response character. A Iskandarov Х Yakubov M Abdurahmonova Copyright (c) 2022 Journal problems of biology and medicine https://creativecommons.org/licenses/by/4.0 2010-05-14 2010-05-14 2 (61) 9 12