No. 1 (2021) Медицина и инновации

Articles

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  Early detection of precancerous diseases of the oral mucosa Precancerous lesions of oral mucosa can be considered as diseases, which tend to maligning in various percent.Clinic picture is the same for such diseases. Pathology changes of oral mucosa are absent on early stages, but in malign process there are histological of oral carcinoma examined. Such diseases cause problems affecting social and daily life of the patient. The aim of the study was to improve the diagnosis of precancerous processes, as well as cancer of the oral mucosa, using minimally invasive examination methods. On the basis of the Department of Hospital Therapeutic Dentistry of the Tashkent State Dental Institute, in 2017- 2020, 50 patients with precancerous diseases of the oral mucosa were examined at the age of 25- 80 years. Early detection of potential precancerous processes allows avoiding interventional diagnostic methods, as well as reducing the risk of developing cancer of the oral mucosa.

  H Kamilov, A Kadyrbaeva, D Aripova

  115-117

  298   55

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  Comparative analysis of the mechanical properties of fiber reinforcement systems for adhesive splinting One o f the key stages o f complex treatment o f periodontal diseases is the immobilization o f mobile teeth. The most common designs fo r temporary immobilization are composite splint systems, which have different strength characteristics depending on the type o f fi ber weaving and chemical composition.

  M Dadabaeva, R Mirkhusanova, G Shomurodova

  87-89

  168   65

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  The use of ozonized sesame oil in the complex treatment of erosive and ulcerative forms of lichen planus of the oral mucosa Lichen planus (LP) is one of the most common and clinically manifest mucocutaneous dermatoses.According to different authors, the population frequency of LP (0.4-1.9%) varies in different regions of the world and the proportion to other dermatoses.The main problem in the study of the epidemiology of LP is the difference in the analysis of the assessment of the frequency of simultaneous lesions of the oral mucosa and skin, naturally, separately when patients refer to both dentists and dermatologists. The development of LP at the age of 30-60 is observed in 33% of cases, in 19% of cases in people from 51 to 60 years old, in 3-4% of cases in people over 70 years old.This disease is characterized by insufficient knowledge of the etiology and pathogenesis, the presence of severe forms of the disease, the possibility of malignancy, and resistance to treatment. In this regard, corticosteroids are still preferred, which can cause various complications and side effects. The use of non-drug methods of therapy, in particular, drug ozone used in the complex therapy of lichen planus is effective and safe, no complications or side effects are observed. The applied ozone therapy leads to a significant decrease in the hygiene index (OHI-S),compared with the indicators before treatment and corresponded to 87.27% (0.40 ± 0.27), which shows a decrease in the GI (OHI-S), respectively, in 7.8 times compared with the indicators before treatment (p <0.05). The PMA index in the main group by the end of the treatment period was a decrease by 82.7%, respectively (7.15 ± 2.64), which shows a decrease in the infl ammatory process by 5.77 times, respectively,compared with the indicators before treatment (p <0.05). Regression of the infl ammatory process leads to a reduction in the time of epithelialization of erosiveulcerative foci and a 2.27-fold lengthening of LP remission (p <0.05) — and reached a value o f up to 5.75 ± 0.06 months in 96.86% o f cases (31 people).

  H Kamilov, M Ibragimova, Sh Samadova

  89-93

  139   49

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  Improving the algorithm for the treatment of acute polymorphic psychotic diseases This scientific article describes the changes in immune parameters in the blood caused by acute polymorphic psychotic disorders and measures to optimize the treatment algorithm by treating them with immunomodulators.

  G Gapurova, Sh Usmanov, Sh Kurbaniyazov

  93-95

  104   46

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  Monitoring the incidence of inflammatory processes of male after tooth extraction in patients with chronic hepatitis

  As a result of numerous clinical and experimental studies, a relationship has been established between changes in the oral cavity and pathology of internal organs. In modem dentistry, interest in research on concomitant pathologies is explained by the accumulation of new arguments, the emergence of new information in the system of the whole organism [3,5]. This analysis focuses on the prevalence of hepatitis infection and its various oral manifestations,consequences and clinical course. In this regard, the monitoring of outpatient records of patients with concomitant pathology, such as hepatitis А, В, C with inflammatory processes of the oral cavity and maxillofacial area after tooth extraction for emergency indications in the clinic of surgical dentistry of the clinic of the Tashkent State Dental Institute over the past 5 years was carried out.

  O Rakhmatullaeva, K Shomurodov

  95-97

  121   34

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  Состояние метаболической системы полости рта после лечения с использованием дентальной имплантации Цель: В стоматологической практике большой ин терес для изучения представляет ротовая жидкость (РЖ). РЖ является биологической средой, которая омывает всю полость рта, взаимодействуя со слизи стымн, зубами и ортопедическими конструкциями. Ротовая жидкость оказывает влияние на все компо ненты зубочелюстной системы, с которыми контак тирует, являясь для них агрессивной средой, спо собной изменять их физико-химические показатели.

  S Safarova

  97-98

  139   31

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  Folic acid deficiency in women of fertile age The frequency o f detection o f folic acid defi ciency (DFA) in women o f fertile age (LPA) was studied. It was found that in the main group, the frequency o f detection o f folic acid defi ciency (DFC) was 30.2%, serum folic acid values were 12.09 ± 0.19 ng/ml, in the control group, 17.3% and 13.89 ± 0.11 ng/ml, the difference is signifi cant.

  M Narmetova, M Nadzhimitdinova, S. Agzamkhodzhaeva

  99-101

  133   39

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  Rationale for taking the vertical component of growth into account when diagnosing and planning treatment in patients with distal occlusion This article presents data from a clinical examination of patients with diagnosed distal bite, that have been carried out at the clinic of orthodontics and dental prosthetics of the Tashkent State Dental Institute. The diagnostic studies allowed us to substantiate the development of an integrated approach to diagnosis from the scientific point of view, taking into account the vertical growth component in patients with distal occlusion. In addition, the correlation relationships of the vertical and horizontal ratios of the jawbones which have a significant diagnostic value were studied and determined, that will allow the orthodontist to predict the probability of aggravation or self-regulation of the problem.

  Sh Rasulova, G Aripova, Z Nasimov, J Babadjanov

  101-104

  388   108

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  Зависимость распространенности кариеса зубов у детей дошкольного возраста от количества фтора в питьевой воде (на примере Ташкентской области)

  J Dinikulov, D Rakhmatullaeva, N Akhrorkhuzhaev, F Khasanov

  105-107

  112   40

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  Результаты комплексного стоматологического обсследования у студентов высших учебных заведений Проведено комплексное обсслелование стоматологческого здоровья студентческой молодежи г.Самарканда -574 студента ВУЗов Самарканда (Самаркандского Медицинского Института (СамМИ)Самаркандского Государственного Университета (СамГУ)) среди которых студентов I курса — 193 человека, II курса -175 человек, студентов III кур-са,соответственно, — 206.Выявлено распространенность кариеса зубов среди студентов ВУЗов г.Самарканда составляет 91,87±1,30%, а интенсивность кариозного процесса составила 5,31±0,14 зуба при 8,34±0,26 поверхности, выявлены признаки заболеваний тканей пародонта с интенсивностью 3,88 ± 0,06 сегмента, У 53,05±2,37% студентов зафиксировали зубочелюстные аномалии и деформации.

  L Khasanova, F Ismatov

  108-112

  140   45

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  II turdagi dentinogenez nuqsonli bolalarda qattiq tish to'qimalarining tez aşınmasının oldini olish: ikki yillik remineralizatsiya terapiyasini qo'llash natijalari To investigate the possibilities o f 2-year use of remineralizing therapy for the prevention of rapid erasability and preservation of hard tooth tissues in preschool children with type I I imperfect dentinogenesis.

  N Razakova, G Abdirimova, Z Khalmatova, M Kadyrova

  113-114

  70   20

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  Современный взгляд на этиопатогенез, диагностику лечение хронического рецидивирующего афтозного стоматита при хроническом холецистите (обзор литературы) Хронический рецидивирующий афтозный сто матит (ХРАС) является хроническим воспалнтель ным заболеванием слизистой оболочки полости рта и характеризуется появлением афт с длитель ным течением и периодическими ремиссиями и обострениями. Основное внимание отводится со путствующим заболеваниям., которые усугубляют течение ХРАС.

  H Kamilov, M Ibragimova, N Ubaydullaeva

  80-86

  412   88

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  Lymphocytic activity in chronic polyposis rhinosinusitis The purpose was to evaluate the immunohistochemical picture of various forms of polyps for antibodies to CD45 +,CD138 +, CD68 +, CD34 +. For immunohistochemical studies, paraffin blocks prepared from nasal polyps removed in 45 patients with chronic polypoid rhinosinusitis were used.The study showed the formation of difficult reversible changes in the nasal mucosa, leading to the loss of its functional activity and the creation of prerequisites for frequent relapses of chronic polypoid rhinosinusitis.

  U Vohidov, N Khaidarov, U Khasanov, H Nuriddinov

  117-122

  150   35

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  Clinical features of inflammatory periodontal diseases in patients with pemphigus Cooperative investigations into widely spreaded parodontitis and other inner deceases in these days , interferes changes in cells of paradontitis corresponding to pathogenesis of various body deceases , as well as full remission.Mouth virus is severe autoimmune illness appur appurtenant the group bubble wrap dermatosis, which its main photomorphologic cue is akontolisis.With the purpose of diagnostic, reaching and recieving the effectiveness prophylaxis of paradontisis in ill mouth viruses.There are a number of ongoing scientific investigations .The major thing of investigation is substantiating o f clinic feautures o f rnflammationing deceases parodon-tisis depending on placement o f elements o f mouth virus and the lastness o f the decease.

  N Daminova, Sh Shorasulov, H Ganieva, A Boboev

  122-124

  119   21

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  Development of oral dysbiosis in pregnant women Disclosed the relationship between body condition nonpregnant and pregnant women and microbiocenosis mouth. Found that the development and progression of oral dysbiosis is in direct proportion to the severity of periodontal: pregnant women with healthy periodontium dysbiosis occurs in 10,0 — 77,37%; with gingivitis — in 11,54-51,61%; GPLS — 8,0-13,79%; with GPST and GPTS — 100% of cases.

  N Yuldasheva, K Tadzhieva, M Safoev, Z Khabibova, M Rakhimova

  125-127

  106   37

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  Assessment of the significance of the biological value of the diet of weightlifting athletes in a hot climate The purpose o f the study was to substantiate the optimal options for the average daily intake o f food for weightlifting athletes in a hot climate based on the biological value o f food rations.

  B Tukhtarov, B Begmatov, D Karimov, M Valieva

  127-130

  152   61

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  Pathogenetic features of pathological deformity of cerebral arteries in the development of chronic cerebral ischemia The aim of this work is to study the association between patients with chronic cerebral ischemia (CCI) with pathological deformities in the internal carotid arteries and polymorphism of the ACE (angiotensin converting enzyme) ID variant, as well as to study and associate with morphological changes in the vascular wall. We have comprehensively examined 155 persons, of which the main group consisted of 105 patients with CCI. The control group of healthy individuals consisted of 50 people. An association was revealed between the D/D polymorphism of the ACE gene and the clinicalmanifestations of CCI, which was associated with degenerate morphological changes in the vascular wall.

  M Rakhmetova, M Yakubova, D Kushaeva, U Nugmanova, I Bychkov

  130-135

  95   30

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  Актуальность использования хромогенных сред — хай хром при экспресс диагностике дисбиозов полости рта в республике Узбекистан Идентификация любых бактерий с нспользованн ем метода посева на питательные<реды невозможна без выделения чистой культуры. Проблеме! получения чистой кулытры и объективной идентификации ми кроорганизмов всегда актуальна для микробиологии, микологии и вирусологии. Предпочтение отдается методам идентификации, которые выполняются за относительно короткий срок (часы) и отличают ся высокой степенью объективности и точности. Как начало пищеварительного тракта полость рта представляет собой широкий спектр микроорганиз мов число которых достигает более 700 видов [13]. Данная работа представляет результаты микроб ного пейзажа полости рта у женщин фертильного возраста с использованием хромогенных сред “Хай Хром” компании HIMEDIA для экспресс диагности ки и идентификации микроорганизлюв на первичном посеве.

  G Khaldarbekova, I Mukhamedov

  135-140

  193   41

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  Preclinical evaluation of skin irritant and skin resorptive action of ophthalmic medicinal film ≪novacel ziyo≫ The article presents the results of a study of the skin irritating and skin-resorptive action of the multifunctional film "Novacel ziyo” for the treatment of eye injuries. The experiments were carried out on 24 sexually mature male rats weighing 150-170 g. To study the effect of film solutions on the skin of 18 white rats 3 complementary methods were used: two-drop and application tests and lowering 2/3 of the tail into a test tube with a film solution. The control group consisted of 6 individuals. It has been established that the domestic film "Novacel ziyo” for the-treatment of eye injuries does not possess a toxic effect . on the skin.

  L Khegay, Z Niyazova, A Sydikov

  140-144

  118   37

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  Клинический случай болезни бехчета Болезнь Бехчета (ББ) (снн., болезнь Адаманти-адиса-Бехчета, болезнь Шелкового пути) - хрони ческое рецидивирующее полисистемное заболе вание неизвестной этнологии, в основе которого лежит системный васкулит, поражающий артерии и вены разного калибра [1,2,3,4]. Это единственный системный васкулит, при котором может развиться вторичный амилоидоз.

  B Azizov, U Nurmatov, S Agzamkhodzhaeva, Sh Ayupova

  145-147

  140   41

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  Clinical case of late diagnosis of urticaria pigmentosa The article describes the case of a patient suffering from pigmented urticaria who was repeatedly and unsuccessfully treated, but the correct diagnosis was made only at the age of 24 years. The emphasis is on simple clinical methods available for making the correct diagnosis of this disease.

  G Pagay, N Ibragimova, B Mukhamedov, N Malikova, M Allaeva

  148-150

  119   76

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  Congenital anomalies in children Revalence and risk factors Congenital malformations have been in the focus of physicians since ancient times, but despite their centuries-old history, many aspects of the etiology and pathogenesis of congenital malformations in humans have not been adequately studied even today. Congenital deficiencies of development are defined as stable morphological changes that go beyond the limits of structural variations of members or parts of organs and disrupt their fonction.Apply Ле term "sporadic the defectof birth' ’:meaningunknown cause, accidental appearance and low riskreappearance have future children. For 20-25% of anomalies more likely "multi-factor” reason - complexinteraction many small geneticdefects andrisk factorsenvironmental environment. The rest 10-13% of anomalies associated with the influence environment. Only 12-25% of anomalies have purely genetic causes.

  K Mirzarakhimova

  38-45

  154   46

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  Психические расстройства, ассоцированные коронавирусной инфекцией При коронавирусной инфекции помимо вли яния на соматику человека, имеются такие по следствия, как нарушения психической системы человека. Вирусные инфекции имеют широкую распространенность и в ряде случаев могут пора жать центральную нервную систему, вызывая раз личные психоневрологические нарушения, вклю чая когнитивные, аффективные, поведенческие и другие расстройства [3—5]. Во время пандемии COVID-19 наибольшее внимание уделяется об щим медицинским осложнениям и меньшее чис ло исследований посвящено прямому влиянию SARS-CoV-2 на психическое здоровье.

  Sh Kurbaniyazova, G Gapurova, Sh Sultanov, Sh Hamdamov, O Rakhmanov

  8-12

  319   59

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  Полость рта как входные ворота при инфекции covid-19 Во многих недавних статьях и отчетах о коро-навнрусной инфекции (COVID-19) сообщается, что эта инфекция в основном поражает верхние и нижние дыхательные пути, сердечно-со суди стую систему, иногда может вызывать наруше ния в нервной системе и желудочно-брюшной области. Но мало говорится об изменениях, про исходящих в ротовой полости. Если мы посмо трим на патогенез (COVID-19) более широко, то ротовая полость, как и органы дыхания, может быль воротами для инфекции. Первые данные 0 возможности того, что слизистая оболочка полости рта может быть воротами для инфек ций, были получены во время пандемии гриппа («испанки») [1]. Эта гипотеза позже была под тверждена при других инфекционных заболева

  N Madaminova, A Akbarov, N Ziyadullayeva

  12-14

  163   45

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  Clinical and pathogenetic aspects of Covid-19 in the Republic of Uzbekistan The article presents studies of patients with COVID-19 with a description of skin manifestations. The clinical characteristics of the skin symptom complex and its relationship with the respirator,7 and gastrointestinal syndromes of coronavirus infection have been carried out. Fibrinogen, D dimer, ferritin darajasida o'sish bilan namoyon bo'lgan hiperkoagulyatsiyaning aloqasi - o'tkir fazaliyallig'lanish belgisi va covid-19 teri namoyon bo'lgan sitokin bo'roni.

  B Azizov, G Ismailova, T Hegai, H Rustamova, S Agzamkhodzhayeva, H Magzumov, Sh Ayupova, I Salimova, O Lapasov

  14-16

  128   38

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