International Journal of Medical Sciences And Clinical Research https://www.inlibrary.uz/index.php/ijmscr <p>International Journal of Medical Sciences And Clinical Research is to provide a global platform for the dissemination of high-quality, peer-reviewed research in the field of medical sciences and clinical research. Our primary goal is to advance the understanding of medical science, promote evidence-based clinical practices, and contribute to the improvement of healthcare worldwide. The International Journal of Medical Sciences And Clinical Research is committed to promoting rigorous scientific research, fostering collaboration among researchers, and contributing to the advancement of medical knowledge.</p> en-US info@theusajournals.com Fri, 01 Aug 2025 00:00:00 +0800 OJS 3.3.0.8 http://blogs.law.harvard.edu/tech/rss 60 Effective Measures to Prevent Environmental Pollution from Industrial Gas Emissions https://www.inlibrary.uz/index.php/ijmscr/article/view/134743 <p>This article investigates practical measures and strategies to reduce environmental pollution caused by industrial gases. It presents a multidisciplinary analysis of technological innovations, regulatory frameworks, and social accountability mechanisms that contribute to the mitigation of harmful emissions such as CO₂, SO₂, NOₓ, and VOCs. Through case studies, empirical data, and policy reviews, the article explores advanced filtration systems, renewable energy adoption, carbon capture, and real-time emission monitoring. It emphasizes the importance of international cooperation, ESG accountability, and localized implementation strategies, particularly in rapidly industrializing countries. The paper offers action-oriented recommendations for governments, industries, and civil society to collaboratively address industrial gas pollution and promote sustainable development.</p> Karimova Dilshunos Zokirjon qizi Copyright (c) 2025 Karimova Dilshunos Zokirjon qizi https://creativecommons.org/licenses/by/4.0 https://www.inlibrary.uz/index.php/ijmscr/article/view/134743 Sat, 09 Aug 2025 00:00:00 +0800 Direct Interaction of Organic Cation Transporter 3 with CD63: A Mechanism for Regulating Histamine Release in Granulocytes https://www.inlibrary.uz/index.php/ijmscr/article/view/134744 <p>Granulocytes, particularly basophils and mast cells, play a pivotal role in allergic and inflammatory responses through the rapid release of histamine. The precise mechanisms regulating intracellular histamine levels and its subsequent exocytosis are critical for understanding and modulating these processes. Organic cation transporter 3 (OCT3, SLC22A3) is a polyspecific transporter known to mediate the uptake and efflux of various organic cations, including monoamines like histamine. Tetraspanin CD63 is a transmembrane protein widely used as a marker for granulocyte degranulation and is involved in membrane trafficking and protein complex formation. This study investigates the direct interaction between OCT3 and CD63 and its functional implications for histamine release from granulocytes. Through a combination of molecular, biochemical, and functional assays, we demonstrate that OCT3 co-localizes and physically interacts with CD63 in granulocytes. This interaction appears to influence the subcellular localization and activity of OCT3, thereby modulating intracellular histamine concentrations and subsequent release upon cellular activation. Our findings suggest that CD63 acts as a novel regulator of OCT3 function, providing a mechanistic link between histamine transport and granulocyte degranulation. This discovery sheds light on the intricate regulatory networks governing histamine homeostasis in immune cells and opens new avenues for therapeutic interventions in allergic and inflammatory diseases.</p> Dr. Stefanie L. Krüger, Dr. Ahmed Y. El-Masri Copyright (c) 2025 Dr. Stefanie L. Krüger, Dr. Ahmed Y. El-Masri https://creativecommons.org/licenses/by/4.0 https://www.inlibrary.uz/index.php/ijmscr/article/view/134744 Fri, 01 Aug 2025 00:00:00 +0800