Volume 03 Issue 02-2023
44
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
02
P
AGES
:
44-49
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
ABSTRACT
The article presents data on the study of the immediate outcomes of unstable angina in women and men with
metabolic syndrome. The study was conducted for 2021-2022 on the basis of the Department of Internal Diseases of
the Pediatric Faculty of SamSMU. The study included 20 patients with coronary artery disease and metabolic
syndrome. Clinical examinations were carried out according to the standard scheme, the metabolic syndrome was
studied by analyzing the lipid and glycemic spectrum. In the course of the study, it was determined that women prevail
in terms of gender distribution, as well as the metabolic syndrome aggravates the course of unstable angina pectoris
and often leads to complications.
KEYWORDS
Cardiovascular disease (CVD), coronary heart disease (CHD), unstable angina (UA), metabolic syndrome (MS), arterial
hypertension (AH), myocardial infarction.
INTRODUCTION
Research Article
IMMEDIATE OUTCOMES OF UNSTABLE ANGINA IN METABOLIC
SYNDROME
Submission Date:
February 18, 2023,
Accepted Date:
February 23, 2023,
Published Date:
February 28, 2023
Crossref doi:
https://doi.org/10.37547/ijmscr/Volume03Issue02-09
Shahzoda Isokova Kuychi Kizi
Master Of The Department Of Internal Diseases Of The Faculty Of Pediatrics Samarkand State Medical
University, Uzbekistan
Zarrina Bakhtiyarovna Babamuradova
Phd, Associate Professor Of The Department Of Internal Diseases, Faculty Of Pediatrics Of Samarkand State
Medical University, Uzbekistan
Journal
Website:
https://theusajournals.
com/index.php/ijmscr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
Volume 03 Issue 02-2023
45
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
02
P
AGES
:
44-49
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
Cardiovascular disease (CVD) is the leading cause of
disability and death worldwide. So, at present, in the
structure of mortality of the population, 57% are
diseases of the cardiovascular system, of which 49.3%
are coronary heart disease (CHD). The study of
coronary artery disease, and in particular unstable
angina (UA), its complications and the effectiveness of
treatment dictates the need to study risk factors. It is
known that metabolic disorders such as excess div
weight, dyslipidemia and impaired glucose metabolism
accelerate atherogenesis. All these disorders are
components of the metabolic syndrome (MS). The
question of the effect of MS on the cardiovascular
system has been studied in sufficient detail in the
literature, but the effect of the syndrome on the results
of angioplasty procedures and long-term prognosis of
NS requires further study.
Over the past 20 years, a large number of studies have
been conducted that have confirmed the existence of
close
relationships
between
obesity,
arterial
hypertension (AH), hyperlipidemia, impaired glucose
tolerance and cardiovascular diseases. The term
"metabolic syndrome" encompasses a group of risk
factors associated with coronary heart disease and/or
diabetes. According to a number of authors, patients
with MS have an increased risk of major cardiovascular
events: stroke, acute myocardial infarction, and
sudden death. Patients with metabolic syndrome are
characterized by more massive lesions of the coronary
arteries, a more severe course of coronary artery
disease, and a decrease in the quality of life.
Separately, it should be noted the widespread
prevalence of MS (according to some authors, more
than 20% of the world's population). However, despite
the active study of MS, the available literature,
including publications of the leading cardiological and
endocrinological associations, lacks clinical guidelines
for the management of these patients. The practical
importance of these unresolved issues has led to
further study of these issues.
Purpose of the study:
To study the immediate
outcomes of unstable angina in women and men with
metabolic syndrome.
MATERIALS AND METHODS
The study was conducted for 2021-2022 on the basis of
the Department of Internal Diseases of the Pediatric
Faculty of SamSMU. The study included 20 patients
with coronary artery disease and metabolic syndrome.
Clinical examinations were carried out according to the
standard scheme, including clarification of complaints,
history taking, assessment of the state of internal
organs and systems, stress echocardiography, ECG.
The state of the metabolic syndrome was studied by
analyzing the lipid and glycemic spectrum.
The data obtained during the study were subjected to
statistical processing using the Microsoft Office Excel-
2012 software package on a Pentium-IV personal
computer, including the use of built-in statistical
processing functions. The arithmetic average value
(M), standard deviation, standard error of the average
(m), relative values (frequency, %), statistics of the
measurements obtained when comparing the average
values of the studied indicator significance was
determined by calculating the probability of error (P) in
testing the normality of the distribution (according to
the kurtosis) with Student's test (t).
RESULTS AND DISCUSSION
The patients were between 30 and 70 years old. The
mean age was 49.8±3.1 years. The duration of angina
was from 1 to 10 years. 15% had a confirmed myocardial
infarction in history. Among the surveyed, men
accounted for 35% (7), women - 65%.
Volume 03 Issue 02-2023
46
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
02
P
AGES
:
44-49
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
Despite
the
fact
that
patients
received
recommendations for lifestyle changes (diet and
regular exercise), anthropometric parameters did not
change during antihypertensive therapy. Initially, the
average weight of patients was 79.5±4.2 kg, after
treatment this figure was 78.3±3.4 kg. Similar data
were obtained for BMI (before the study - 33.2±1.4
kg/m2, after - 32.3±1.14 kg/m2) and waist circumference
(before the study - 104±2 cm, after - 104±3 cm).
Hyperglycemia was detected at admission, low levels
of high-density lipoproteins, elevated levels of C-
reactive protein. Initially, patients with lipid
metabolism
disorders
had
the
following
characteristics: mild hypercholesterolemia (5-6.5
mmol/l) in 45%; moderate hypercholesterolemia (6.5-8
mmol / l) - in 30%; mild hypertriglyceridemia (1.7-2.3
mmol/l) in 35%; moderate hypertriglyceridemia (2.3-4.5
mmol/l)
-
in
45%.
Severe
degree
of
hypercholesterolemia and hypertriglyceridemia was
only in 15%.
During the treatment, when observing patients for 6
months, violations were noted both in therapeutic
tactics and in the behavior of the patients' lifestyle
after a month. When studying the immediate
outcomes, a negative dynamics of the disease was
revealed, 15% of patients had a myocardial infarction,
40% of the symptoms of coronary artery disease
progressed, the frequency of arrhythmias increased by
30%. If we compare these indicators with patients
without metabolic syndrome, it can be seen that the
metabolic syndrome leads to a worsening of the
course of the disease and the frequency of
complications is higher than in patients without the
metabolic syndrome.
Patients with metabolic disorders require more careful
monitoring, both during hospitalization and after
discharge from the hospital. Identified laboratory
parameters, such as hyperglycemia on admission, low
levels of high-density lipoprotein, elevated C-reactive
protein, may be predictors of life-threatening cardiac
arrhythmias. Interpretation of these indicators will
help plan the stages of stay in various departments of
the hospital, including when risk factors are identified
for longer treatment in intensive care units.
CONCLUSIONS
In the course of the study, it was determined that
women prevail in terms of gender distribution, as well
as the metabolic syndrome aggravates the course of
unstable angina pectoris and often leads to
complications.
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