481
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
THERAPEUTIC STRATEGIES FOR CEREBRAL ATHEROSCLEROSIS UNDER
HIGH-ALTITUDE CONDITIONS: ADAPTIVE-METABOLIC CORRECTION
Taalaibekova M. T.
Makhmudova Zh. A.
I.K.Akhunbaev Kyrgyz State Medical Academy, Bishkek city, Kyrgyz Republic
https://doi.org/10.5281/zenodo.17342808
Relevance.
Cerebral atherosclerosis under high-altitude conditions has a more severe course
due to chronic hypobaric hypoxia, which enhances mitochondrial dysfunction, lipid peroxidation, and
energy deficit in brain cells. This leads to faster progression of cognitive impairments and increases
the risk of ischemic stroke. The search for therapeutic strategies focused not only on the vascular
component but also on adaptive-metabolic support is a pressing task.
Objective of the study.
To evaluate the effectiveness of adaptive-metabolic correction in the
complex therapy of cerebral atherosclerosis under high-altitude conditions.
Materials and methods.
Clinical data were analyzed in patients with cerebral atherosclerosis
living at an altitude of 1600–2800 m above sea level. The therapeutic complex included antihypoxants
(meldonium), metabolic agents (cytoflavin, actovegin), antioxidants (vitamin E, coenzyme Q10), and
drugs improving cerebral blood flow. Cognitive status (MMSE), biochemical markers of oxidative
stress and energy metabolism (lactate/pyruvate ratio, ATP level), as well as changes in lipid profile
were evaluated.
Results.
Against the background of complex adaptive-metabolic correction, an improvement
in cognitive functions was observed (MMSE increased by 12%), a reduction in lipid peroxidation
products (MDA – by 18%), normalization of the lactate/pyruvate ratio, and an increase in ATP
content in erythrocytes by 15%. Patients showed improved microcirculation and reduced severity of
headaches and asthenic syndrome.
Conclusions.
Adaptive-metabolic correction is a promising approach in the therapy of cerebral
atherosclerosis under high-altitude conditions. The combined use of antihypoxants, metabolic and
antioxidant agents contributes to the stabilization of energy metabolism, reduction of oxidative stress,
and improvement of cognitive functions, thereby enhancing the effectiveness of treatment and quality
of life of patients.
