459
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
THE THERAPEUTIC EFFECTIVENESS IN EXPERIMENTAL GASTRIC ULCERS
ACID SODIUM SALT WITH SALLITSILAT INDUKSION GLITSERRIZIN
ANALYSIS OF MONOAMMONIY
T. B. Mustanov
Alfraganus University, Tashkent city, Republic of Uzbekistan
e-mail: mustanovtollibay@gmail.com
https://doi.org/10.5281/zenodo.17342341
Current period, gastric and o‘n two fingers of the intestine wounds (peptic ulcer disease) health
storage system important clinical and social problems one as distinguished is. The world healthyliqni
storage organization data according, this pathology of the population, 10-20 % up to that part of the
cover will. Though modern in pharmacology wide ko‘lamli medicinal drugs available are, despite
them each always also of the patient's individual needs for a complete answer you give can't. For this
reason, natural source and less nojoiz‘ya effect have that substances, the therapeutic capabilities of a
deep study topical is.
The research purpose.
Central Asian region o‘suvchi
Glycyrrhiza glabra
(licorice) from the
plant separated and taken glitserrizin acid monoammoniy of salt (glycerol) sodium sallitsilat using
generated was experimental gastric ulcers on anti the effects of evaluate.
Material and methods.
Experience white laboratory rats o‘out-check-in passengers, animals
three into groups were divided. Each of a group of 10 rats from the composed toe‘become, in them l.
m. romanov, v. l. zini a , and is koll v. e. by recommended was modifikatsiyalangan model on the
basis of gastric ulcer was called.
•
1-group – control (treatment failed),
•
2-group – metiluratsil with treated (reference drug),
•
3 and 4-groups – glycerol suitable on the basis of 50 mg/kg and 75 mg/kg, a dose ingested taken
have.
Treatment of 7 days during out did not go. The survey at the end of the animals surgical method
is taken, the stomach is cut and opened , and mucous on the floor wound area planimetry method
were assessed. Also, paul's index (healing effect) considered is.
Results and discussion.
Control group , all rats with gastric ulcers determine, in their o‘far
central surface warp 13.9 mm2 to up was. Metiluratsil methodology‘llab was in the group, wound
area 9,8 mm2 to reduced and wounded animals the number of only 15 % by is reduced. Paul the index
of this group, 43 % to up was.
Glycerin methodology‘llab was in the group while it was significantly the results recorded were.
•
50 mg/kg dose: the wound is the area of 5,6 mm2, ulcerative animals , the number of 35 % by
decreased, paul the index – 71 %.
•
75 mg/kg dose: the wound is the area of only 1.8 mm2 to up reached, wounded animals the
number of 50 % by shortrdi, paul the index while 90 % to be reached.
Glycerol content in glitserrizin acid mucous layer of protection as important biologically active
to be able to toe‘become, prostaglandin synthesis , stimulates, mucous production, production
increases and antioxidant activity shows. These factors of wound process of the lights serve will. That
is in addition to, glitseramning immunomodulyator properties of the div's total reactive that
increases, this while not only symptomatic treatment, but also in pathogenesis either‘naltirib the
complex therapy provides.
Summary
460
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
1.
Glycerin, sodium sallitsilat using they cited experimental gastric ulcers in high therapeutic
effect is possible that you will determine.
2.
75 mg/kg dosages glycerin, metiluratsil with in comparison to 3 times more effective is, the
gastric ulcer depth and the size dramatically reduce.
3.
This drug natural came out, relatively low toxicity and high efficiency, it is of clinical practice
into the introduction to the opportunities it opens.
4.
In the future glitseramning other wound in the model, results, and clinical research applied to
order according.
