137
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DEVELOPMENT OF TECHNOLOGY AND QUALITY ASSESSMENT OF DENTAL
GEL
N.M. Rizayeva
1
A. Alkorov
2
Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan
e-mail: nigoraruzikulovaphd@gmail.com
https://doi.org/10.5281/zenodo.17326011
Relevance:
Parrot and oral cavity diseases are multifactorial in nature and, as established by
modern research, are caused by microbial aggression. Therefore, dental products should primarily
have an antibacterial effect. Considering the accompanying inflammatory processes, pain, and
delayed tissue regeneration, dental preparations should be combined, possessing anti-inflammatory,
analgesic, and promoting accelerated tissue regeneration. The article is dedicated to developing the
technology of a dental gel based on modern hydrophilic bases, selecting the optimal composition, and
choosing preservatives. The article provides a classification, brief description, and possible side
effects of modern oral candidiasis medications.
Research objective:
Conduct research on selecting the composition of a metronidazole and
nystatin-containing dental gel, selecting the optimal basis for developing a gel technology for treating
periodontal diseases.
Materials and methods:
Hydrophilic gel formers readily incorporate large quantities of drugs
and contribute to their complete and uniform release, allowing for the regulation of the
biopharmaceutical and structural-mechanical properties of dental gels within the necessary range.
Hydrophilic gel-forming agents include aqueous solutions of polymers such as sodium - CMC, MC,
hydroxyethylcellulose, carbopol, sodium alginate, gelatin, and pectin. The gel-forming pH of the
above-mentioned bases lies in the neutral region, which is convenient for oral use.
Results:
A number of physicochemical indicators were identified, including the appearance,
homogeneity of the gel, thermal stability, pH value of the solution obtained by aqueous extraction,
and colloidal stability. Visual determination of the gel's appearance was carried out as follows: a gel
sample was applied to a slide with a thin layer and then assessed with the naked eye. To assess the
homogeneity of the gel, four samples weighing 0.02-0.03 g were taken. Each sample was applied to
a slide, covered with another slide, and pressed tightly to create spots about 2 cm in diameter. As a
result, the absence of particles in the stains indicates that the prepared gel meets the requirements of
the ND. Determination of the pH of the aqueous extract of the gel was carried out by the
potentiometric method using the Metler Toledo (Germany) pH meter. During the measurement
process, 5.0 grams of gel were mixed with 50 milliliters of purified water and heated in a water bath
at 50-60°C, after which they were filtered through a filter with white tape (TU 6-09-1678-86). The
data obtained during the experiment are presented in the table. Determination of colloidal stability.
Approximately 3.0-5.0 g of the gel sample was weighed and centrifuged in a CUM centrifuge at 1500
rpm for 5 minutes. Gel separation was not observed. To determine the thermal stability, 5 test tubes
were taken and filled to 2/3 and placed in a thermostat at a temperature of 40-45°C for 24 hours, then
the samples were placed in a refrigerator for 24 hours at 10-12°C. After 24 hours, they were kept at
room temperature. When viewed with the naked eye, no layering of the gel samples was observed.
Conclusions:
The obtained results show that the main advantage of the new system - a gel
absorbed in the oral mucosa - is the ease of use, the possibility of long-term action, which allows for
a course of treatment in the treatment of periodontal diseases.The quality indicators of the gel were
138
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
determined: description, homogeneity of consistency, solubility, pH of aqueous solution, colloidal
stability, and thermostability.
