All articles - Autoabstract

Subject of the inquiry: 148 patients with degenerative dystrophic diseases of the hip joint, of them 103 with osteoarthritis and 45 with avascular necrosis of the femoral head.
Aim of the inquiry: improvement of the diagnosis of degenerative-dystrophic diseases of the hip using possibilities of ultrasonography and magnetic resonance imaging.
Methods of research: X-ray, ultrasonography and magnetic resonance imaging.
The results achieved and their novelty: For the first time, the role of ultrasonog-aphy and magnetic resonance imaging in osteoarthritis and avascular necrosis of the hip was established in comparison with conventional X-ray. The result have shown that sensitivity of ultrasonography in osteoarthritis was low (57.7%) in the detection of femoral head deformation. In avascular necrosis of the hip detection of femoral head deformation was revealed better - 89.7%, which can be explained by differences in the mechanism and localization of deformation in these diseases. Ultrasonography was quite sensitive to changes of the joint capsule both in osteoarthritis and avascular necrosis, the sensitivity 86.0% and 84.6% respectively. MRI was superior to X-ray in the assessment of space orientation of the joint surfaces, necrosis zone, synovitis, subchondral cysts, structural changes and joint effusion. X-ray was more preferable for the detection of ostephytosis, subchondral sclerosis and changes of the joint space in osteoarthritis.
Practical value: of the work consisted in the concretization of sonographic and MRI signs of degenerative dystrophic diseases of the hip joint and in the suggested algorithm of using radiological methods for establishing the nature of hip joint pathology.
Degree of inculcate: the results of research were introduced in the Radiology Department of First Tashkent Medical Institute and the Department of Large Joint Pathology Department of the Traumatology and Orthopedy Research Institute.
Sphere of usage: radiology, traumatology and orthopedy, rheumatology.

Objects of research: 92 immature rats with term of 30-40 days. 108 patients with asiderotic an anemia: men - 13 (12%), women - 95 (88%); middle age - 39,9 years. The control group was made by 17 healthy persons.
The purpose of work: Increase of efficiency of treatment of patients asiderotic [iron-deficiency] anemia by an induction of synthesis and a metabolism a theme in a liver.
Methods of research: clinical, biochemical, morphological, tool.
The received results and their novelty: Activization of the initial stages of synthesis is established on models alimentary asiderotic [iron-deficiency] anemia in mitochondrial and microsomal-cytosol fractions of a liver a theme, on a background to inhibit its final stage. Correction of a level malonic dialdehyde and activity of enzymes superoxide dismutase (SOD) and catalase (CAT) is revealed as a result of application of a combination of preparations maltofcr and neosclcn in mitochondrial and microsomal-cytosol fractions of a liver of experimental animals. For the first time we analyse parameters of ions of tri valent, bivalent iron both dif-feritin in mitochondrial and microsomal-cytosol fractions of a liver of experimental animals. The morphological picture of a liver at alimentary iron deficiency is submitted an anemia and correction of the revealed infringements by preparations maltofcr and ncosclcn. For the first time on the big clinico-expcrimcntal material efficiency of application of a combination of preparations maltofer and neoselen is shown.
The practical importance: Application of a combination of preparations maltofer and neoselen on a clinico-experimental material restores activity of enzymes of synthesis and disintegration a theme in hepatocyte’s, improves ferroki-nctic, hematologic parameters and promotes improvement of a functional condition of a liver. The received positive results in clinical researches have found acknowledgement (confirmation) on an experimental material that allows to recommend the given circuit of treatment железодефицитной to an anemia in clinical and outpatient conditions.
Degree of introduction and economic efficiency: Results of research are introduced into practice гематологического, therapeutic branches, and as for doctors of an initial link.
Scope: hematology, therapy.

Subject of the inquiry: diets for nutrition in the families and kindergardens, biological active addition to the food, animals, children.
Aim of the inquiry: elaboration of effective methods of rationalization of diet for nutrition of studying-cducational institutions with usage of biological active additions for food.
Methods of inquiry: hygienic, medical- biological, toxicological, biochemical, chemical and statistical.
The results achieved and their novelty: According to the results of hygienic and toxicological explorations of biological active addition “ Biovit” was selected as the most successful, which made compensation of the deficit of vitamin C, A, B6, В 12; folium acid, calcium, magnesium; irreplaceable aminoacids in daily diet of children, who attends kindergardens. It was estimated the increase of biological value of nutritional diet, increase of nitrogen’s balance, secretion of nitrogen, assimilation of the protein and improvement of biochemical index of nitrogenical components of the urine and sufficiency in vitamin C among children. The methodological approach was established to the basis of using biological active additions and estimation their effect in kindergardens.
Practical value: The results of research, which was appvouba by Sanitary rules and norms Republik of Uzbekistan, 2 methodical recommendations, method of avaluation of nutrition’s condition was elaborated and approved for practical health care according to research works;
Degree of embed and economic effectivity: the introduction on the Republic level has public cultural, general prophylactic, social and ecological hygienic role in the safety of the health of population.
Sphere of usage: in prophylactic medicine and hygienic practice, in study of medical Universities.

Objects of research: 1st group (control) - 8 dogs, which apply traditional intensive therapy at craniocereberal trauma without hypothermia. 2 st group - 8 dogs, which apply drug treatment with external craniocerebral hypothermia. 3 st group -8 dogs, which apply drug treatment with perfusion method of hypothermia. At 286 patients with heavy craniocerebral trauma, efficiency hyperventilation on a background of various methods CCH is investigated depending on type of infringement of a cerebral blood flow.
Purpose: to optimize results of protection and reanimation of a brain at a severe craniocereberal trauma by perfection of a method craniocerebral hypothermia and the differentiated choice of a mode of artificial ventilation easy.
Methods: the cerebral blood flow parameters estimated by transcranial Dop-plcrography datas. Also was definite saturation of arterial (SataO2) and venous (SaI. vjO2) blood oxygen, cerebral blood flow (arteriovenous difference O2), a level of lactate in peripheral blood and in liquor, parameters of intensity.
Results and novelty: by complex study was proved that perfusion method of the craniocerebral hypothermia is an effective and adequate method of protection of a brain caused by hypoxia and secondary damages at severe craniocerebral trauma. It is established, that at carrying out perfusion CCH the important factor of protection of a brain from hypoxia and secondary damages to which the death of animals at severe craniocerebral trauma, is preservation on a limit of physiological norm of functioning erythrocytes owing to adaptable decrease in processes the lipid peroxidation, preservation at high enough level of activity of enzymes antioxidant system, reactions peroxide hemolysis erythrocytes and which can serve as criteria of an estimation of the forecast of efficiency of spent treatment, an outcome of disease.
Practical value: it is developed and pathogenetic efficiency of a perfusion method of the CCH is proved at severe craniocerebral trauma. The algorithm of differential use hyperventilation at patients with severe craniocerebral trauma is developed depending on type of cerebral blood supply disturbance and a degree of development intracranial hypertension.
Inclusion of a method perfusion method of the CCH increase efficiency of protection of a brain from hypoxia and secondary damages reduces frequency of lethal outcomes at severe craniocerebral trauma.
Introduction and economic efficiency: results of research are introduced in practice of the Republican science centre of neurosurgery Health Ministry of the Republic of Uzbekistan and department of anesthesiology and resuscitation of 2-clinic of the Tashkent medical academy.
Field of application: resuscitation and neurosurgery.

To study the anti-inflammatory and some other pharmaco- logical properties, toxicity of the new thiocarbamate and thiourea derivatives (codes UB-421 and BIK-15, respectively), selected after the scrinning reseaches among the compounds of this group and to ground the possibility of their using in clinic

Object of research: formation process of elements of graphic literacy at children of the senior and preparatory groups of children's preschool institutions.
The purpose of work: to develop pedagogical system to the doctrine of elements of graphic literacy of senior and preparatory groups pupils.
Methods of research: the theoretical analysis, individual, group oral and written conversations, questioning, experiment, innovative and interactive methods, the mathematic -statistical analysis.
Novelty of research: the problem formation of elements of graphic literacy at children of the senior preschool age is first developed in a scientific way by proceeding and opening features of Uzbekistan. The theoretical and practical basis, pedagogical system and system of problems tasks included into it is developed; scientifically proved technique of elements formation of graphic literacy at children of the senior preschool age is developed.
Network of introduction and economic efficiency: the point of research and pedagogical system developed on ins basis, methodical recommendations and workbooks’ will help teachers and chiefs of graphic activity courses in formation of graphic literacy elements at children.
The practical importance: an essence research and on the basis of it’s the developed pedagogical system, methodical recommendations and the grant will help teachers and heads of a circle on graphic activity in formation at children of elements of graphic activity. Ideas stated in dissertational work is possible to use in teaching lessons of graphic activity in pedagogical High schools and colleges. Proceeding from conclusions the developed methodical recommendations will help to organize and increase the efficiency of lessons of graphic activity.
Scope: conclusions and the basic ideas of the dissertation can be used at faculties of preschool education of High schools, professional colleges whey teaching «Pedagogics of preschool age", at the organization of lessons heat are included into the in that are included into the group of graphic activity in children's preschool institutions.

Subject of the inquiry: diets for nutrition in the families and kindergardens, biological active addition to the food, animals, children.
Aim of the inquiry: elaboration of effective methods of rationalization of diet for nutrition of studying-educational institutions with usage of biological active additions for food.
Methods of inquiry: hygienic, medical- biological, toxicological, biochemical, chemical and statistical.
The results achieved and their novelty: According to the results of hygienic and toxicological explorations of biological active addition “ Biovit” was selected as the most successful, which made compensation of the deficit of vitamin C, A, B6, B12; folium acid, calcium, magnesium; irreplaceable aminoacids in daily diet of children, who attends kindergardens. It was estimated the increase of biological value of nutritional diet, increase of nitrogen’s balance, secretion of nitrogen, assimilation of the protein and improvement of biochemical index of nitrogenical components of the urine and sufficiency in vitamin C among children. The methodological approach was established to the basis of using biological active additions and estimation their effect in kindergardens.
Practical value: The results of research, which was appvouba by Sanitary rules and norms Republik of Uzbekistan, 2 methodical recommendations, method of avaluation of nutrition’s condition was elaborated and approved for practical health care according to research works;
Degree of embed and economic effectivity: the introduction on the Republic level has public cultural, general prophylactic, social and ecological hygienic role in the safety of the health of population.
Sphere of usage: in prophylactic medicine and hygienic practice, in study of medical Universities.

The problem of preventive maintenance of wound infection remains by an actual problem of modern surgery. In emergency surgery this parameter achieves up to 48.7%.
Per the last years in medicine with success the surgeries of liver, thoracic surgery, and so on are used electrolysis water solutions (EWS) sodium hypochlorite, in particular in purulent surgery. However, the expediency of application EWS sodium hypochlorite for preventive maintenance of wood infection is not enough investigated.
The author with the purpose of decrease of weight and frequency of wound complications has developed methods the express train - processing of surgical suture EWS sodium hypochlorite in modes 0.2%-10 minutes and 0.01%-60 minutes. Has studied the modification of mechanical strength of various kinds of surgical suture for want to processing in the developed modes.
The morphological researches reasonable a mode sanation of soft fabrics of operational wound in a mode 0.2 % - 5 minutes. The outcomes of comparative morphological study of slices of skin fabrics of experimental animals sutured by silk treated by conventional method and after processing EWS sodium hypochlorite have shown, that of differences in healing of wounds and response of enclosing fabrics it is not marked.
For warning of bacterial contamination the method of a guard of the operational wound is developed which consists in suturing of peritoneum to the skin on all stretch of operational wound and between them the gauze napkin moistened 0.2 % EWS sodium hypochlorite is kept. In an extremity of operation the 5-minute processing 0.2 % EWS sodium hypochlorite the ambassador suturing of each stratum of the operational wound is conducted.
The clinical material includes the inspection and operating treatment 831 patients, of them 502 have made of control groups and 329 patients were included in main group. The comparative analysis of outcomes has shown high efficiency of the developed complex of preventive maintenance, which promoted decrease of frequency of wound complications from 14.8 % up to 5.1%.

The results of surgical treatment of 126 patients with acute obstructive calculous cholecystitis were analyzed. Depending on the nature of performed operations all patients were divided into 2 groups: control group - 50 patients who underwent traditional cholecystectomy and main group - 76 patients who underwent LCE.
In the main group in case of impossibility to identify the elements of the gallbladder neck the author developed an original technique of LCE performance, which was performed in 37 patients, that allowed to perform even technically difficult operations by laparoscopic way, reducing the percentage of conversions to a minimum.
The author developed a technique of gallbladder and its bed sanation with 0.4% EVR of sodium hypochlorite and ozonized solutions, which allowed to prevent contamination of the abdominal cavity with infected gallbladder contents, and sanation of its bed and subhepatic space with ozonized solution, spread of the pathological process into the abdominal cavity.
The author developed the tactics of management and surgical treatment of patients with acute obturation cholecystitis, which allowed to improve the results of treatment of this category of patients and reduce the frequency of postoperative complications and lethality.
Based on the analysis of clinical results, indications and contraindications for laparoscopic interventions on the gallbladder in acute cholecystitis were developed.
The developed method of LCE, sanation of the gallbladder cavity and its bed by the proposed antiseptics, application of the developed tactics of treatment of patients with acute obturation cholecystitis allowed to reduce the treatment time from 18.2 + 5.6 to 6.1 + 1.9 days, to reduce the incidence of postoperative complications from 26% to 1.3%.

Purpose of reseach: to optimize outcomes of therapy of the patients SD, purulent - septic complicated of lower extremities (PSCLE), by monitoring, duly revealing of character disturbans of function of the liver and purposeful correction them in complex therapy of the specified pathological condition.
Methods of research: clinical-biochemical researches, ECG, ultrasonic research of the liver, ultrasonic dopplerography, percutaneus definition a pressure (voltage) of oxygen, angiography, radionuclide researches, psichometric tests.
The results achieved and their novelty: the carried researches have shown, that the liver is not one of the basic organs - targets at SD (at the expense of features it blood circulation), at decompenciation SD, complicated PSCLE, there is an essential infringement liver blood circulation in system lever artery, to the subsequent disturbance of its numerous functions. The inclusion in complex therapy hepatoprotectory, antioxygents and preparations blocking ALT activity is pathogenic proved and promotes optimization of outcomes such of complication SD, as PSCLE.
Practical significance: the elaborated and offered complex therapy of the patients provides of optimization of outcomes, is an effective method of treatment and preventive maintenance of complications.
Degree of introduction and economic efficiency: the results of research have been introduced into practice of branches intensive therapy and reanimation 2-clinic TMA and Republican Centre of Purulent Surgery and Surgical Complication of Sugar Diabetes
Area of application: reanimation and intensive therapy, surgery.

Is analyzed the experience of treatment 257 patients with cholcdocholithiasis, complicated mechanical jaundice. All patients were divided into 2 groups: control (72 patients); basic (185 patients).
In control were carried out one-stage of open operative intervention at height jaundice. In the basic group the treatment was multi-stage. Were applied retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic cholangiography. At the first stage were carried out dosage decompression of biliary system, liquidation mechanical jaundice, restoration of the vital functions organisms on the developed technique.
The basic group was shared into 2 subgroups. In 1- (151 patients) were used ERCP. In 2 - (34 patients) - were used percutaneous transhepatic cholangiography or their combination with ERCP.
The application of an original technique has allowed in 2 times to raise efficiency of treatment cholangitis and has enabled to lower frequency of development inflammation of changes in bilious ducts in 3 times.
The developed original way has allowed to define further tactics of conducting the patients choledocholithiasis. The efficiency ERCP thus has raised up to 82,7 %.
The developed ways and algorithm treatment - diagnostic measures have allowed to lower frequency of complications at treatment of the patients choledocholithiasis, complicated mechanical jaundice. At application ERCP they managed to be reduced in 9 times, and percutaneous transhepatic cholangiography - in 4 times.

Subject of the inquiry: rabbits, visceral-ischemic shock, metabolism, mitochondria, suktsinasol, suktsivil.
Aim of the inquiry: to study effect of new hemocorrectors such as suktsinasol and suktsivil on the basic pathogenetic mechanisms of visceral-ischemic shock.
Methods of inquiry: physiological, biochemical, biophysical, statistical.
The results achieved and their novelty: A complete evaluation of indices in hemodynamics is given in VIS including AAB and toxemia, functional changes in liver, indices of carbohydrate-phosphoric metabolism. A number of research methods have been studied which gave the opportunity to have a distinct understanding about metabolic status of the organism. Efficiency of a new polyfunctional hemocorrection - suktsinasol on hemodynamic and metabolic indices of VIS have been studied for the first time. The effect of a new polyfunctional hemocorrector Suktsivil on the hemodynamical and metabolic indices of VIS have been studied. A comparative analysis of effective blood substitutes during infusion for VIS in experiment has been carried out.
Practical value: We have determined hypothesis about disorder of energetic metabolism in liver cells in VIS. We have proved efficiency of using new complex blood substitutes sulktsinasol and suktsivil as supply of rich energetic compounds (sulktsinasol) and corrector of electronic and transport function of mitochondria in liver in emergency complicated by hypoxia and toxemia.
Degree of embed and economical efficiency: Obtained results concerning effective new substitutes suktsinasol and sukrsivil for VIS can be recommended for combined treatment of VIS in medicine new blood substitutes can restore hemodynamics, acid-alkaline balance, metabolism, reduce toxemia.
Sphere of usage: medicine.

Subject of the inquiry: 298 patients with finn deformations of the larynx and trachea
Aim of the inquiry: early rehabilitation of patients with firm deformations of the larynx and trachea path optimization and creating clinical and pathogenic methods of complex treatment.
Methods of the inquiry: clinical examination, special examination: LOR-examination, endoscopy of air ways, X-ray, CT, MRI of larynx, trachea and bronchus, bacterial examination of larynx and trachea wounds; morphological examination, biochemical methods of examination: lipid peroxidation, antioxidant enzymes, activity of hepatic monooxygenase system (MOS); biophysical methods of examination: исследование electric damage of erythrocytes’ membrane (EDEM), blood viscosity (BV) and blood shift velocity (BSV); cytological examination.
The results achieved and their novelty: In patients with firm deformations of the larynx and trachea, firstly basing on complex investigation clinical and structural-functional parameters revealed pathomorphological changes in neck tissues as chronic inflammation with productive component. Despite, revealed disrupt balance of process lipid peroxidation and antioxidant system, hydroxylic function of liver, decrease of electoral penetrability of erythrocytes’ membrane and aggravate of hemorheology. With this, level of expression of changes depends on clinic form and load disease, correlate with stage of wound healing and after restore of functions of the larynx and trachea gradually becoming normal. Presented classification of the firm deformations of the larynx and trachea, permitting complexly counting etiologic factor and morphological variant of the damage of laryngotracheal tract. In scheme of the pathogenic complex conservative therapy before and after reconstructive operations included medicine, influencing on Hemodynamic, with ability membranotrope action, systemic enzymotherapy, immunostimulators, and correction of the tissue metabolism by laser. Created private and modified methods of reconstructive laryngotracheoplasty in case of cicatricle stenosis of glottic and subglottic parts, bilateral paralyses of the larynx, cicatricle deformations of pharyngolarynx, combination deformations and defects of the larynx and trachea, permitting single stage restore laryngotracheal ways.
Practical value: The investigation of pathogenic mechanism of developing of the firm deformations of the larynx and trachea on data of changes of main functional and metabolic processes will permit not only activating and improving of pathogenic therapy, and forecasting variant of development and course of postoperative period after reconstructive operations.
Use of proposed methods of complex conservative and surgical treatment of the firm deformations of the larynx and trachea allowed to provide whole volume of restoring means in more short time and with less quantity of stage operations, preoperative preparing till 3 days, hospital stay till 14-20 days, surgical operations in 1.9 time.
Degree of embed and economical effectivity: The results of investigation intruded in treatment practice of the First and Second Tashkent Medical Institutes, LOR-clinics of Samarqand territorial children hospital, territorial hospital of Karshi. Materials of the investigation using in study process of LOR - cathedra First Tashkent Medical Institutes during lectures and practice tutorials with students, magistracies, and clinic ordinators. Determined main economic effect in use of proposed complex therapy in connection with reduce of term of treatment and hospital stay (on an average 10 days) and taking off or decreased disability on 67% patients.
Sphere of usage: otorhinolaryngology, surgery, reanimation

Subjects of the inquiry: 103 patients with rheumatoid arthritis, 20 healthy individuals.
Aim of the inquiry: To study therapeutic effect of low frequency physical factors on the cytokines and the processes of lipid peroxidation and to confirm scientifically the efficacy of their use based on the their effect on the clinical laboratory findings.
Methods of investigation: Clinical and laboratory investigations, immunological analyses of the blood scrum cytokine levels and synovial fluid, biochemical examinations of the lipid peroxidation and antioxidant system indicators, phospholipase-A2 activity, nonspecific phosphatases and free oxyprolinc in the blood serum of patients.
The results achieved and their novelty: There was studied clinical efficacy of ultraphonophoresis with benzketozon during treatment and rehabilitation of the patients with rheumatoid arthritis. It was proved that disbalance between inflammatory and anti-inflammatory cytokines as well as lipid peroxidation activation activity in the erythrocyte membranes and blood scrum destabilized cellular membrane structures, increase in phospholipase-A2 activity and, consequently, stimulating prostaglandines, inflammation mediators, synthesis. There was shown that complex therapy with inclusion of low frequency physical factors, particularly ultraphonophoresis with benzketozon, gave marked positive effect normalizing interrelation ship between inflammatory and anti-inflammatory cytokines reducing activity of phospholipase-A2, lipid peroxidation products and rising the levels of antioxidant system indicators.
Practical value: There has been shown rationality of inclusion of the physical-pharmacological method ultraphonophoresis with benzketozon into clinical practice. The differential indicators developed for application of low-frequency physical methods of therapy for rehabilitation of the patients with rheumatoid arthritis allow prolongation of the remission, improvement of the patients life quality.
Degree of embed and economic effectivity: The practical recommendation and guidelines have been applied in the clinical practice of the out-patient special course of arthrological treatment in the Republican Rhcumatological Center, Clinical Hospital N 1, Central Hospital of Zangiota district of Tashkent province. Sphere of usage: Rheumatology, physiotherapy.

Object of the research: the process of teaching physics
The aim of the research: The periodical law of physics and the proof of the physical education according ot the law.
Methods of the research: To analyze literature regarding the research; to observe teaching process, conversation with the teacher and a pupil, to observe professional expricnce of school teachers, to prepare questionnaires, to conduct, to work out and analyse statistically the pedagogical experiment.
Scientific novelty of the research: Considering the periodic education law as a separate subject, the periods of physical education were methodically characterised, the diffcrcnciation was analyzed, the practical outcome of physical pcriodisation was reflected and the technology of governing physical education periodically at secondary schools and learning teaching materials were thoroughly established.
Practical importance of the research: the periodic technology of teaching physics which is the result of the research - can be widely used in teaching physics at secondary schools; in creation of teaching material; in working out new forms of independent and distance learning and in teachers’ training system. It can also be used in teaching other subjects at secondary schools and in other stages of education.
Efficiency and the implementation of the project: More than 30 articles, brochures and a monography were published on this dissertation. The results of the research were discussed and analyzed in the scientific conferences in foreign and local teachers and professors conferences and meetings at Bukhara State University and in another educational establishments. (Bukhara - 2000, 2001,
2002, 2003; Karshi city - 2003, 2004; Guliston city 2002, 2005; Samarkand -
2003, 2004, Tashkent city 2003, 2005; Termez city 2003, 2004; Namangan city 2005, Ferghana city 2002, 2004). The efficiency of the research at secondary schools has reached 20.8% at average.
The degree of implementation: The results of the research can be used in teaching physics at secondary schools, in teachers training system, in the creation of text-books and other teaching materials and in condiction research works connected to this matter.

Subject of the inquiry: the problem of a computerization of teaching the Bases of informatics and computer engineering techniques (BICET) in the system of secondary education.
Aim of the inquiry: to create effective means of pedagogical programmes (PPM) on BICET, aimed at computerization of teaching and to work out the methods of using it.
Methods of inquiry: studying and analysing the literature on the topic of the investigation; observing the teaching process; talks with teachers and schoolchildren; generalizing school teacher’s experience; internet forum; pedagogical experiment.
Novelty and theoretical importance of research: the concept of computer education of secondary education was worked out; the structure of process of computerizing teaching was analysed; the principles of computer education were worked out and means of computer education of teaching were systematized the ways of modelling the teacher’s and schoolchildem’s activities in the PPM, the process of accomplishing all types of exercises with the help of computer; the mechanism of working out the PPM of the BICET.
Practical value: PPM worked out by us were effectively used in BICET; the concept, principles and means of computer education of teaching may be used while computerization of other subjects, improving teachers’ training, compiling textbooks and educational supplies of computerization; the ideas in the thesis may serve as a theoretical basis to computerize all stages of education.
Degree of embed and economical effectivity: 80 works of the author concerning the theme of the dissertation were published, including monograph, textbooks and teaching supplies; the content of the investigation was discussed at a number of conferences.
Sphere of usage: while computerization of all stages of education; while compiling syllabi, textbooks and teaching supplies.

Purpose of the study: to evaluate the results of complex therapy including retrobulbar catheterization and magnetic stimulation of the optic nerve in patients with ChASN of different genesis by studying clinical and functional features of the eye in this case.
Methods. 105 patients (155 eyes) with the diagnosis: partial optic nerve atrophy of different genesis (PAN) received conventional treatment, treatment with the method of retrobulbar catheterization, as well as with the method of retrobulbar catheterization in combination with MS for 10 days. The dynamics of OD indicators, visual field, electrophysiological studies, ophthalmoscopy and ultrasound Dopplerography were investigated.
Results. The analysis of the obtained data indicates that the effectiveness of the proposed methods of treatment depends on the degree of MN destruction, so the treatment is more effective in the 11th degree of ChASN. However, in the group of patients treated by the combined method the efficiency is equally high both at II and III degrees of ChASN.
According to the data of visual acuity dynamics in patients with II stage of Chasnosis in the course of treatment it follows that if in the group of patients treated by the traditional method the effect was observed only in 64,3% of cases, in the group of patients treated by the method of retrobulbar catheterization the efficiency was observed in 89,3%.
The dynamics of the ocular fundus state under the proposed methods of treatment due to the short period of observation (2-3 weeks) underwent the following changes: dilation of CAC vessels, reduction of capillary tortuosity, reduction of retinal edema, as well as the appearance of foveal and macular reflexes distinctness. The data of ultrasound Dopplerography indicate a significant improvement of hemodynamic parameters in the CAC in patients with ChASN of different genesis in early terms after treatment. Improvement of systolic pressure indices was noted. In each case of the examined patients the improvement of hemodynamic resistance index Ri towards normalization was revealed. Accordingly, there was a significant increase in diastolic pressure, indicating the strengthening of elastic-elastic properties of vessels under the influence of treatment.
In our opinion, the improvement of hemodynamic parameters after the course of the proposed method of treatment is associated with an increase in the volume of the microcirculatory channel in the area of direct influence on MN by retrobulbar catheterization and MS.

Research object: 126 patients: 66 of them suffered from congenital malformation development of car, 36 suffered from squarrosc auricles, 24 suffered form traumatic injury of auricles.
Purpose of research: Improvement of Reconstructive-Plastic Operations Methods at Congenital Malformation Development of Ear and at Traumatic Injury of Auricle.
Research methods: Roentgenography of mammillary processes; computer tomogram; acumctry; audiometry; anthropometric examinations; genetic examinations; examination of psycho-emotional conditions.
Received results and their novelty: A new method of plastic of external acoustic meatus has been developed and implemented into clinic practice with the help of two skin flap on feeder legs, which provides full restoration of its lining and this method eliminates postoperative complications (An acknowledgment of receipt IAP 2003 1011 has been received). Methods of Auricle correction during its squarrosc has been modified, and these methods form relief structure and eliminate wearing of fixed bandages. Methods of restoration of helix and lobule of auricle have been developed. These methods arc used to restore isolated and combined posttraumatic defects, and these methods allow to obtain satisfactory anatomic-aesthetic results (An acknowledgment of receipt IAP 2003 1010 has been received).
Practical significance of works: The developed methods of plastic operation of external acoustic meatus and of auricle provide stable clinical effect, improve cpithclization conditions and prevent from occurring of cicatricial obliterations, and provide good anatomic-functional effect, which is of high aesthetic significance.
Degree of implementation: The results arc implemented at otorhinolaryngologic clinic of Second Tashkent State Medical Institute.
Field of application: Otorhinolaryngology.

The preventive wound infection remains by an actual problem of modem surgery, that is connected to high frequency aftcropcration wound of complications, which reaches up to 48.7 % in emergency surgery.
Per the last years the increasing application find electrolysis of water solutions sodium hypochlorite, which arc successfully used of purulent surgery, for want of treatment peritonitis, cavities formations of a liver and other.
However, this antiseptics about today was not applied in prophylaxys wound infection.
The author for the first time uses electrolysis of water solutions sodium hypochlorite in preventive wound infection and offers a method aftcropcration of processing of hands of the surgeon in a regime 0.4%-5 minutes, methods intraopcration the express train -processing of surgical gloves in regimes 0.4%-3 minutes and 0.6%-2 minutes, methods intraopcration the express train - processing of surgical tools in regimes 0.3 % during 7 minutes, 0.4 % during 5 minutes, 0.6 % during 3 minutes and processing in a regime 0.05 % during 45 minutes.
For estimation of clinical efficiency of the developed complex intraopcration of preventive wound infection the author develops clinical mark scales on distribution of operations to groups of risk of development wound infection, mark scale of estimation of a condition postopcration wound and scale of estimation of outcomes of healing of wounds.
The clinical material includes an inspection and treatment 643 patients. From them control group included 453 patients and in the basis group included 190 patients. The developed complex intraopcrctation of preventive wound infection has shown high efficiency. Use of the developed complex of preventive wound infection has allowed to reduce frequency wound of complications from 15.3 % up to 8.9%.

Subjects of research: 815 patients with the various forms acute pancreatitis, 235 patients with primary erronous diagnosis of acute pancreatitis.
The purpose of research: improve the treatment results of the patients with acute pancreatitis by upgrading existing and developing new diagnostic methods in the treatment complex.
Methods of research: clinical, biochemical investigation.
The results achieved and their novelty. On the basis of the analysis of occurance frequency of various clinical symptoms, diagnostics system of the acute pancreatitis is offered, the criteria of the laboratory and ultrasonic diagnostics for given disease arc advanced, for a quantitative estimation of severity of a condition of the patients the ball scale is offered; the complex conservative therapy is advanced, the technique of realization of long intraarterial catheter therapy is optimized, the optimum indications to realization of retrograd and pcrcutanc endobiliar interventions in treatment of acute biliar pancreatitis arc determined, drainage and sanation of omental bag for open operative interventons is offered, the technique of treatment of the patients in postoperative period is advanced and the algorithm of medical measures is offered at acute pancreatitis.
The developed diagnostic and treatment complex has allowed to reduce frequency of diagnostic errors from 28,4% to 16,8%, to increase efficiency of conservative therapy from 89,8% up to 95,3%, long intraarterial catheter therapy -from 72,0% up to 82,8%, to reduce mortality from 7,4% to 3,4%.
The practical importance. The offered clinical system for diagnostics and the advanced criteria of laboratory diagnostics promote to increase reliability of diagnostics, the systematized ultrasonic criteria allows verify the form of acute pancreatitis. The offered scale of definition of severity of the acute pancreatitis allows quantitatively characterize a condition of the patients, dynamical changes of pathological process and efficiency of used of a complex of medical measures. The advanced complex conservative therapy, technique of realization long intraarterial catheter therapy, definition of the indications to performance retrograd and pcrcutanc endobiliar interventions, advanced draining method and sanation of omentum bag at pancrcanccrosis, combined treatment in postoperative period allow to improve results of treatment of the given category of the patients.
Degree of introduction and economic efficiency: the received results arc introduced into practical activity of surgical branches of second clinics TMA.
Area of application: emergency and abdominal surgery.

Subjects of the research: 1066 patients with peritonitis.
Purpose of the research: improvement of the results of treatment of the patients with peritonitis by determination of the prognostic significance of clinical-metabolic parameters in the estimation of severity of patients condition, flow and outcome of the disease.
Methods used in the research: clinical, microbiological, biochemical methods of investigation, mathematical statistics and mathematical modeling.
Results obtained and their novelty
1. The prognostic significance of clinical-anamnestic, microbiological, laboratorial- instrumental and metabolic data has been determined on the basis of the correlational interrelation between metabolic parameters and bacterial contamination in patients with peritonitis
2. When the actions of NIDE (UIDI) RC and GI are studied in clinical conditions it is shown, that their combined application during the operation and postoperative periods considerably decreases the culture growth in peritoneal exudates and improves metabolic parameters.
3. On the basis of the method of mathematical modeling, programs arc proposed to estimate the severity of patient s condition and predictability of flow, the outcome of disease in the patients with peritonitis.
Practical significance
1. The special features of the disturbance of metabolic parameters dependent on the bacterial contamination have been established, which makes it possible to reveal the patients with high risk of development of complications.
2. It is proven that the application of the infra-R emitters in combination with the traditional treatment in patients peritonitis contributes to more favorable flow of the disease and to reduction of postoperative complications and lethality.
3. Two programs have been created with the methods of mathematical modeling which allow: 1) To estimate severity of the patients condition on the basis of clinical-anamnestic, laboratorial- instrumental, metabolic and microbiological data;
2) To predict the complications of the disease; 3) To predict the healing of the postoperative wound; 4) To identify the indications for NIDE (UIDI) applications.
Level of induction: method of application of narrow-spectrum infrared distant emitters in peritonitis is used in surgical department of the Clinical Hospital of Emergencies and Casualties, Г' Municipal Clinic Hospital and in Central Military Clinical Hospital named after P.F. Borovskiy.
Region application: Surgery.

Objects of inquiry: 107 women with rheumatoid arthritis in climacteric period.
Aim of inquiry: studying clinical-immunologic and roentgenologic indices in females with rheumatoid arthritis in connection with climacteric periods and perfecting therapeutic approaches.
Methods of inquiry: clinical studies, assessment of pain syndrom under visual analogous scale (VAS), determination of pro-inflammatory cytokins in blood scrum, roentgendensitometry, determination of body mass index, gravity of climacteric syndrom under modified menopausal index, determination of osteosyndrom by Ritchie and Lee test.
Results achieved and their novelty: for the first time in RA women in climacteric an interrelation between clinical laboratory RA manifestations and an expression of reproductivity disorders has been revealed. An interplay between acute phase indices, rheumatoid arthritis and Lee test and grade of severity of climatcric period has been established. An intcraggravating effect of RA and climacteric syndrom was approved. Predictive valuable factors in RA women in climacteric were determined. Osteoporosis in females with RA was began earlier before climacteric, it lasted more pronounced with lowering mineral density of bones. An advancing lowering of mineral density of bones in RA began in climacteric was shown. Dependance between a level of pro-inflammatory cytokins and duration of disease has been revealed, and less expressed regression of IL-ip indices in women with preserved menstrual function. Recommendations for strategy of RA treatment in women in climacteric taking into consideration features of a course of disease were worked out.
Practical value: rocngcnometry in females with RA, determination of TNF-a, IL-ip cytokins, modified menopausal index by Kuppermann contributed to diagnosis and prediction, management of an adequate therapy. Using of plasmapheresis and climadinon in complex therapy of rheumatoid arthritis reduced manifestations of disease and climacteric syndrom.
An implementation degree and economic efficacy: results of studies were implemented into activities of the Republican Arthrology Center, Specialized Qualified Ambulance Treatment, departments of Rheumatology, Cardiorhcumatology, 1st clinic of the Tashkent Medical Academy, in teaching process on a department of Faculty & Hospital Therapy, Oriental Medicine and Internal Diseases of the medico-preventive faculty.
A field of application: Internal Diseases, Rheumatology

Steady growth of frequency of defeat stops at a diabetes causes a urgency of a problem. Death rate from complications of a diabetes takes the third place among the direct reasons of death, therefore this problem gets social value.
By the author it is analyzed results of inspection and treatment of 1895 patients which were divided into 4 groups. Control (first) group compose 125 patients; 728 patients with “diabetic foot” which received treatment in hospital formed 2 group; 723 patients by whom economical amputations foots and exarticulation fingers compose 3 group; 319 patients by whom complex treatment was included in long intraarterial catheter therapy formed 4 group.
The analysis of unsatisfactory results of control group has allowed the author to reveal, that a principal cause of progressing is purulent - necrotic defeats stops at a diabetes arc tendon-sinews formations. In view of anatomic features sparing operative interventions arc offered at various localizations of defeat stops which essence consist at a distance interested tendon-sinews environments of fingers stop in view of the developed factor proximo-distal a gradient microbic impurities.
The system of the integrated medical aid by the ill diabetes, consisting of 3 parts with concrete functional duties and including experts of a various structure (diabctologists, surgeons, cardiologists, chiropodists et al.) is developed and introduced.
The technique of realization long intraarterial catheter therapies is advanced at generalization purulently-nccrotic process. She consists in constant drop introduction of 50 % of daily volume and 3-4 times per day strcamly 50 % of daily volume of an antibiotic. The basic components were the preparations improving rcological properties of blood, antibiotics of a wide spectrum of action, spazmolitics. The volume daily solution did not exceed 1-1,4 litres. Thus duration catheter therapies have made 7-10 days.
Application of the developed ways of surgical treatment of a diabetic gangrene of the lower extremities at various localizations of defeat has allowed to reduce frequency of high amputations from 40,8 up to 8,4% and to lower mortality from 12,0 to 3,0%. In the remote period of supervision till 5 years frequency of preservation of basic function of the lower extremities has increased from 38,4 up to 75,2%. It has allowed to improve quality of life due to what mortality in terms till 5th years has decreased from 72,2 up to 24,5%.
Complex treatment of a diabetic gangrene of the lower extremities with use of the advanced technique of realization long intraarterial catheter therapies has allowed to raise in the nearest terms of supervision safety of basic function of the lower extremities from 59,2 up to 78,0%. Lethal outcomes thus has decreased from 12,0 up to 3,2%. In the remote term of supervision (5 years) the number of patients with safe basic function of the lower extremities has increased from 38,4 up to 54,5%. The survival rate of patients thus has increased from 28,8 up to 48,2%.

Subject of the inquiry: 120 patients with inflammatory diseases of the maxillary sinuses (177 affected sinuses).
Aim of the inquiry: improve the diagnosis of inflammatory diseases of maxillary sinus diseases using B-modc ultrasonography
Methods of research: Ultrasonogrpahy, X-ray, magnetic resonance imaging.
The results achieved and their novelty: Based on the results of investigation of 120 patients with inflammatory diseases of the maxillary sinuses (177 affected sinuses) the following was found: in acute sinusitis (irrespective of the form) ultrasonography had quite low specificity - 50.0+6.7%. However the sensitivity of the method in catarrhal and purulent forms of acute sinusitis came to 75.0+11.6% and 93.0+3.9% respectively. In all the forms of chronic sinusitis the parameters indicated good informativeness of B-modc ultrasonography: hyperplastic - sensitivity 82.0+5.2%, specificity 95.0+3.0%; purulent - sensitivity 88.0+6.8%, specificity 79.0+8.5%; cysts and polyps - sensitivity 87.0+5.0%, specificity 93.0+3.8%. The research demonstrated possibilities of ultrasonography in the diagnosis of inflammatory diseases of the maxillary sinuses. Diagnostic value of B-modc ultrasonograhy was shown in different forms of maxillary sinusitis. Practically convenient interpretation technique of maxillary sonograms and protocol of examination were developed. Sonographic criteria were defined for differential diagnosis of different inflammatory diseases of the maxillary sinuses as well as the role of B-modc ultrasonography in the algorhithm of radiological investigation of the maxillary sinuses.
Practical value: improvement of maxillary sinusitis, decrease of patient’s exposure to radiation (unjustified use of X-ray in the absence of pathology), avoiding of invasive methods (diagnostic puncture in case of mucosal hyperplasia of cysts) Degree of inculcate: The results of the investigation were introduced in the Otorhynolaryngology and Radiology departments of the 1-st Tashkent Medical Institute Sphere of usage: radiology, otorhynolaryngology.

The treatment of obliterative diseases of the lower limb vessels remains a significant challenge in modern vascular surgery. The high frequency of postoperative complications, high mortality, and progression of atherosclerotic processes after reconstructive interventions on the vessels of the lower limbs have led to a search for pathogenetically justified ways and means of preventing complications of reconstructive surgeries.
The author employed hypolipidemic agents, namely glyrofam and colestid, to develop a conservative prophylaxis regimen for postoperative complications of obliterating atherosclerosis. The regimen was based on the study of platelet aggregation activity indices and lipid metabolism state. It consisted of a course of treatment with hypolipidemic drugs, administered in 1-month cycles with a 3-month periodicity.
The clinical material comprises the examination and treatment of 138 patients. The control group included 61 patients. The main group comprised 77 patients, 39 of whom took colestid and 38 patients used glyrofam.
The study of long-term outcomes demonstrated a reduction in the incidence of postoperative thrombosis from 8.1% to 1.3% and a decrease in mortality from 13% to 2.6% in patients undergoing hypolipidemic therapy.
These findings suggest that hypolipidemic drugs that affect lipid metabolism may prevent the progression of atherosclerotic processes and that drugs that affect the rheological properties of blood may reduce the incidence of postoperative thrombosis.