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NEW APPROACHES OF SUCCESSFUL IVF RATE IN WOMEN WITH
TUBAL INFERTILITY
Shodiev Botur, doctoral student of department of 2-obstetrics and gynecology of
Bukhara State Medical Institute named after Abu Ali ibn Sino
TashPMI, Scientific adviser: Professor Rasul-Zade Y.G.
These days all over the world, about 15% of married couples suffer from infertility, while
more than 55% of cases are caused by reproductive disorders. Tubal infertility (TB) is one of the
most common causes of infertility in women of reproductive age. Trace elements are essential
vitamins and minerals that are needed in small amounts as dietary components. The importance of
proper nutrition during pregnancy has already been established, affecting embryonic and intrauterine
development and, therefore, pregnancy outcomes. In addition, a number of researchers believe that
increased or decreased percentages of transport proteins in the VF and in the blood are predictors of
a negative outcome of in vitro fertilization (IVF).
The aim of the study
, is to study the significance of trace elements in women with tubo-
peritoneal infertility for predicting the effectiveness of the IVF program.
Materials and methods of research
. We studied 74 patients undergoing IVF treatment for
infertility, 26 of them with tubal factor of infertility with deficiencies of certain microelements (main
group) and 48 - with tubal factor of infertility with normal values of certain microelements
(comparison group). The examination and treatment were carried out in the clinic "Doctor D",
"Istanbul Eku Markazi" and "Ankalife" in the city of Tashkent, Uzbekistan. Depending on the
effectiveness of the IVF program, two subgroups were formed prospectively in each group. The 1st
(main) group included 26 patients with tubal factor infertility with deficiencies of certain
microelements, of which 7 (26.9%) with a positive IVF result, and in 19 (73%) women in whom
pregnancy did not occur (echographically confirmed ). The age of the surveyed women ranged from
25 to 35 years. The average age of the surveyed was 27.1 ± 2.3 years. The duration of infertility
averaged 5.6 ±1.3 years. The comparison group (group 2) included 48 patients of comparable age
(from 26 to 35 years) with tubal factor infertility (obstruction or absence of fallopian tubes). Among
them, 17 (35.4%) patients became pregnant, and 31 (64.6%) cases did not occur. After the completion
of medical and preparatory procedures, all women underwent an IVF program. Biological materials
were examined at the “Swiss Lab” clinic in the city of Tashkent. The concentration of trace elements
in blood serum and FF was studied using standard biochemical methods.
Results.
Based on our data, it was found that in the groups of women formed depending on
the result of IVF (echographically confirmed pregnancy), the frequency of pregnancy in the main
group (with tubal factor of infertility with deficiencies of certain microelements) was significantly
lower (26.9%) than in the comparison group (tube factor with normal values of trace elements) -
35.4%. In the course of studying the trace element composition of peripheral blood, zinc deficiency
was determined in 28% of women and iron deficiency in 7.14% of women. In all women, the
concentration of Copper and Folic acid did not exceed the reference values.
Conclusions.
In case of deficiency of microelements in the blood of infertile women with
tubal infertility, the reproductive outcome in ART programs decreases in all indicators. Follicular
fluid is a diagnostic indicator for tubal factor infertility. And also the concentration of copper did not
affect reproductive results. If the above results are obtained, it is advisable to consider the possibility
of delayed ovulation stimulation cycles in order to conduct a course of pregravid preparation in IVF
programs.
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References:
1.
Рузиева
,
Н
.
Х
., and
Д
.
Э
.
Назарова
. "
Изменения биофлоры гениталий у женщин
репродуктивного возраста
."
Международная научно-практическая конференция
. 2016.
2.
Рахимджанов
,
А
.
Р
., et al. "
Роль синдрома вегетативной дистонии в генезе доинсультных
форм цереброваскулярной патологии у женщин молодого возраста
."
Журн
.
неврол
.
и
психиатрии им
.
СС Корсакова
6 (1997): 19-21.
