No. 2 (2021) Journal of cardiorespiratory research

Статьи

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  ASSESSMENT OF SYSTOLIC FUNCTION AND INDICATORS OF LEFT VENTRICULAR REMODELING DEPENDING ON THE RESULTS OF REPERFUSION IN PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION The results of thrombolytic therapy, primary PCI with coronary stenting in 302 STEMI patients were studied using ECG monitoring and postoperative echocardiography follow-up according to the recommendations of the American Echocardiographic Society. The diagnosis of STEMI was based on clinical presentation and electrocardiographic criteria. To assess the effectiveness of treatment after reperfusion, using echocardiography, regional contraction of the left ventricle and violations of regional contraction in the groups were examined. Each segment was analyzed in terms of contraction function. Restoration of blood flow in coronary arteries in patients with STEMI by short-term thrombolytic therapy or percutaneous coronary intervention (PCI) stenting has shown that global LVEF, LV EDV and retain the LV regional contraction functions.

  Anis Alyavi , Sirojiddin Kenjaev , Maftuna Nazarova , Sukhrob Kenjaev , Ismatillo Kakharov, Nizom Latipov

  51-57

  98   28

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  PLATE AGGREGATION IN PATIENTS WITH MULTIVESEL CORONARY ARTERY DISESES LOSS IN THE BACKGROUND OF DIABETES MELLITUS The study included 122 patients with coronary artery disease and type 2 diabetes mellitis (69 men and 53 women) receiving treatment from 38 to 72 years of age. The average length of service in the diabetes melitis was 8.3 5.7 years. At the same time, 20 (16.4 per cent) of patients with diabetes melitus were diagnosed for the first time during the hospitalization, 24 (19.7 per cent) had a diabetes melitus duration of less than 10 years, and 78 (63.4 per cent) had a diabetes melitis history of more than 10 years. The selection and comprehensive examination of the subjects was carried out at the National Specialized Scientific and Practical Medical Centre for Cardiology.

  Nadirbek Yakubbekov

  99-103

  76   16

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  CARDIOVASCULAR CHANGES OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE COPD is one of the most common human diseases, which is primarily due to the high prevalence of smoking, environmental pollution and recurrent respiratory infectious diseases. This disease is one of the most important causes of morbidity and mortality around the world. The steady increase in the incidence rate of the population with obstructive pulmonary diseases and the severity of their clinical course with the development of complications pose challenges to modern medicine to develop new approaches to early diagnosis and increase the effectiveness of therapy for these diseases. In this regard, developing functional changes in the cardiovascular system in COPD and their timely correction seem to be an urgent problem.

  M Kholjigitova , M Safarova, F Niyazova, T Okboev, Sh Rustamova, S Juraev

  92-98

  82   25

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  RISK FACTORS AFFECTING THE COURSE OF UNSTABLE ANGINA IN YOUNG AND ELDERLY MEN WITH DYSLIPIDEMIA This article analyzes the frequency of occurrence of risk factors in unstable variants of angina pectoris among men in young and old age. All patients, depending on their age, are divided into two groups. Group 1 included 124 (54.8%) patients with NSD at a young age, the average age of which was 38.8±5.29 years. The second group included 104 (45.2%) patients with NVS in the elderly, the average age of which was 65.9±4.22 years. The main method of diagnosis was a survey of patients, ECG, echocg and analysis of the lipid spectrum. Smoking (61.1%), stress (68.3%),burdened heredity (68.3%), alcohol consumption (33.3%) and energy drinks (50%) were the most common FR in men with NS at a young age. Among elderly patients, overweight/obesity (88.5%), diabetes mellitus (19.2%), hypertension (88.5%) were the most common FR.

  Farida Khasanjanova, Eleonora Tashkenbaeva, Sarvinoz Boltakulova

  87-91

  83   16

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  RISK FACTORS AND LIFE`S QUALITY CONDITION OF CHILDREN WITH LATENT TUBERCULOUS INFECTION Background. Latent tuberculosis infection is an asymptomatic condition in which patients carry the bacteria, but do not show any sign of illness, however they are at risk of disease activation at any time in the future. Latent tuberculosis infection is often not to affect the quality of life of patients. Preventive treatment of latent tuberculosis infection can reduce the risk of activation; however, this treatment can produce such side effects as well as psychosocial challenges, which can increase stigma and psychological stress. These factors can impair the Quality of Life of patients in term of physical, mental and social well-being. Understanding of influence of latent tuberculosis infection on the physical and mental well-being of these patients is important as successful strategies to reduce the tuberculosis burden globally. Our purpose is to explore patients during diagnosis and treatment of latent tuberculosis infection, measure their quality of life. Objective. During 2019-2020 were examined 100 children 0-14 yearsold. Methods. Quality of life was defined with the help of questionnaire PedsQL version 4.0 (the Russian version), for children. Results. at children with active tuberculosis specific process has a most negative influence upon quality of life, comparatively temporary negative influence has latent tuberculous infection. Conclusions. With provision of latency currents of infecting with mycobacteria of tuberculosis, indicators of quality of life should be considered as one of defining, reflecting psychological component adaptation of child, and can be recommended to enter in program of examination and dispensary observation of children with latent tuberculous infection.

  Svetlana Khodzhaeva, Dinara Adzhablaeva

  82-86

  78   23

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  CLINICAL AND HEMODYNAMIC EFFICACY OF CHOLINE ALFOSCERATE IN ARTERIAL HYPERTENSION AND HYPERTENSIVE ENCEPHALOPATHY This article presents data on the study of the clinical and hemodynamic efficacy of choline alfoscerate in arterial hypertension and hypertensive encephalopathy in patients with high cardiovascular risk. The results of the study showed a positive trend in terms of clinical and hemodynamic parameters. This is due to the fact that, as a result of improving the transmission of nerve impulses in cholinergic neurons, the plasticity of neuronal membranes increases and the structures of the reticular formation of the brain are activated. Gliatilin, due to its neuroprotective effect, improves cerebral blood flow, enhances metabolic processes in the brain and restores brain function in patients with a high cardiovascular risk of complications, with hypertensive encephalopathy.

  G Tulaboeva, Yu Talipova, N Аbdukodirova, B Kamolov, Kh Saidov

  77-81

  105   20

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  ENERGY COVID-19 COLLAPSE: NEW DIAGNOSTIC MARKERS, TREATMENT ASPECTS An independent diagnostic criterion for assessing the prognosis in patients with COVID-19 is the dynamics of lactate levels, the overproduction of which is due to the crisis of energy-producing systems and an overload of the glycolytic pathway of energy production. The only corrector for the energy collapse caused by COVID-19 is the use of thiotriazoline, a metabolic drug with multiple pathways for lactate utilization and stimulation of oxidative phosphorylation, with powerful antioxidant properties. Such drugs as blockers of fatty acid metabolism (trimetazidine, meldonium) in this situation have no pathogenetic and biochemical substantiation.

  D Salivonchyk, E Salivonchyk

  68-76

  128   27

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  DEVELOPMENTAL IMPAIRMENT IN ADOLESCENTS AND ITS COMPLICATIONS In recent years, all over the world, the problem of impaired physical development of adolescents has acquired special medical and social significance, due to the steady increase in morbidity. The spectrum of pathology of physical development is a violation of cardiac activity, accompanied by edema of the extremities, hypothalamic obesity, pathology of the reproductive system with hormonal disorders. Particular caution is caused by impaired physical development with delayed sexual development in obese adolescents - this is a functional, temporal delay in the appearance of signs of puberty by more than two standard deviations compared to the average period.

  Nazira Karimova , Nozima Kurbanova

  64-67

  62   22

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  STRUCTURAL AND HEMADINAMICAL FEATURES OF THE HEART IN ARTERIAL HYPERTENSION IN WOMEN DURING MENOPAUSE IN RELATIONSHIP WITH PSYCHOEMOTIONAL STATUS Characteristics of the left ventricle of the heart in women, with arterial hypertension (AH) and climacteric syndrome in 30 patients and 30 women with AH without menopausal syndrome were studied, the control group consisted of 20 women without signs of cardiovascular pathology. In women with arterial hypertension and climacteric syndrome, a high level of personality and a moderate level of reactive anxiety prevailed. The presence of diastolic dysfunction in women with hypertension and climacteric syndrome was revealed.

  Gulchekhra Kadirova, Narina Raimkulova, Zebo Mamadjanova, Aziza Ikramova, Mokhitibon Ernazarova

  58-63

  72   27

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  DIET IS AN IMPORTANT FACTOR IN THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES Cardiovascular disease is the most common fatal disease of our time. Rational nutrition is an effective way of preventing these diseases, with the help of which, especially in the early stages, you can reduce the risk of cardiovascular complications. Observing the recommendations on the diet and diet, you can prevent serious complications, maintain vigor and good mood for a long time.

  Bakhrom Alyavi , Akbar Abdullayev, Dilbar Dalimova , Djamol Uzokov

  9-15

  166   32

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  COVID-19 COURSE IN PATIENTS WITH CARDIOVASCULAR DISEASES COVID-19 and cardiovascular disease are common. The co-occurrence of these diseases increases the risk of adverse consequences. Providing such patients requires physicians to know the characteristics of the viral infection, its clinic, the events that occur in combination with cardiovascular disease, as well as individual measures and collective protection. The safety of medical staff and a good prognosis for patients are among the highest values of the modern health care system.

  Barchin Togaeva , Eleonora Tashkenbaeva, Gulnora Abdieva, Dilrabo Khaidarova, Zarina Abdullayeva

  47-50

  134   30

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  EFFECT OF HAZARDOUS HABITS AND PHYSICAL ACTIVITY ON SENIOR AND SENIOR AGES In many countries around the world, there is a growing scientific interest in studying the problems of older people. Elderly and senile age is one of the most important periods of a person's life, during which morphological and functional changes occur in the body, leading to a gradual cessation of life. According to UN forecasts, by 2025 the total number of people aged 60 and over will exceed 1.1 billion. The fastest growing number of people are aged 80 and over, from 13 million in 1950 to 137 million by 2025. In this regard, the European region ranks high on the planet, with 18 of the 20 countries with the largest proportion of elderly people in the world.

  Shukhrat Teshaev, Karomat Dzhumaev, Gulchehra Razhabova

  43-46

  81   25

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  MECHANISMS OF CARDIOPROTECTIVE EFFECTS OF DESFLURANE AND SEVOFLURANE DURING REPERFUSION Myocardial conditioning is actually an important strategy in the management of ischemic reperfusion injury. The concept of postconditioning anesthetic is intriguing, its action occurs at a key moment (reperfusion, when ischemic reperfusion lesions are initiated), when activation of these cardioprotective mechanisms can overpower the mechanisms leading to ischemic reperfusion injuries. Desflurane and sevoflurane are volatile anesthetics often used during cardiac surgery. This review focuses on the efficacy of desflurane and sevoflurane administered during early reperfusion as a potential cardioprotective strategy. The mechanisms underlying the cardioprotective action of these agents and their ability to induce postconditioning have been discussed in detail, highlighting the role of reactive oxygen species generation, activation of cellular signaling pathways, and action on mitochondria. This may well be enough to revive the basis for the launch of the randomized clinical trials that are really needed to confirm that this strategy has real impact.

  Eleonora Tashkenbaeva, Zarina Nasyrova, Maksud Saidov, Mokhinabonu Yusupova, Sarvinoz Boltakulova

  39-42

  73   16

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  MECHANISMS OF FORMATION OF HEART DYSFUNCTION AND THE APPLICATION OF SAKUBUTRI/VALSARTAN IN DIABETES MELLITUS The incidence of diabetes mellitus (DM) in patients with heart failure (HF) is about 40%, regardless of the level of ejection fraction (EF) impairment. But, in addition, diabetes is considered a strong independent risk factor for the progression of heart failure with both preserved and reduced EF and is usually associated with a poor prognosis. The ability of neprilisin inhibitors to increase levels of biologically active natriuretic peptides has made them a potential therapeutic approach in the treatment of HF. The use of sacubitril/ valsartan in patients with heart failure with diabetes continues to be studied.

  Nargiza Tashkenbaeva, Raisa Trigulova, Aziza Khalikova, Shakhnoza Mukhtarova

  80   43

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  EFFECTS OF SMOKING ON CARDIOVASCULAR FUNCTION: THE ROLE OF NICOTINE AND CARBON MONOXIDE Smoking is a widespread chance thing for all factors of cardiovascular disorder. It influences the myocardium and occludes the blood supply, will increase atherosclerosis and contributes to myocardial infarction, cardiomyopathy and peripheral vascular disorder. Nicotine, carbon monoxide and different tobacco elements have direct outcomes at the endothelium, inflicting inflammation, atheroma and thrombosis. Free radicals are ample in cigarette smoke and those provoke and accentuate the inflammatory cascade, growing leukocyte infiltration and cytokine production. It is essential to reap correct records approximately smoking habit, however records amassing ought to now no longer depend on self-record that is misleading, however ought to use a few shapes of biochemical biomarker, ideally cotinine. Smokers ought to then be intensively counselled, each through in- residence skilled personnel and thru the professional smoking cessation services. It ought to be defined to sufferers in fundamental phrases approximately the deleterious outcomes of smoking on coronary heart disorder and atherosclerosis. Patients ought to be recommended to apply all reasserts of counselling and to go to the substitute treatments or different pharmaceutical aids to quit. The purpose of this article is to provide a brief evaluation of the outcomes of smoking, and especially the outcomes of nicotine and co on cardiovascular function. Nicotine deactivates cardiac autonomic function, will increase empathy hobby, increases heart rate (HR) at relaxation, while blunting HR elevation all through innovative exercise and lowering the maximum HR that may be executed. On the equal time, the smoking- generated co binds with haemoglobin and myoglobin, reduces arterial 02 blood saturation, compromises the performance of respiratory enzymes, and reasons disorder of the 02 production, transportation and transport device, specially all through exercise, notably decreasing the purposeful capability and the overall performance of the circulatory machine.

  Kumar Sachin, Eleonora Tashkenbaeva, Gulnora Abdiyeva

  26-33

  110   26

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  SIGNIFICANCE OF THE NEW ST2 BIOMARKER IN THE DEVELOPMENT OF HEART FAILURE The article provides data on the new ST2 biomarker and its predictive value in patients with heart failure. The results of large studies are described that assessed its significance in comparison with other prognostic markers.

  Guzal Mullabaeva, Davron Zhumaniyazov

  22-25

  90   102

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  FACTORS OF ARTERIAL HYPERTENSION PROGRESSION IN PATIENTS IN COMORBIDITY WITH TYPE 2 DIABETES MELLITUS Patients with diabetes and hypertension are at increased risk of macrovascular and microvascular complications. To prevent and slow the progression of these complications, it is necessary to target multiple risk factors. It has been demonstrated that optimizing the control of glycemia, lipids and blood pressure improves patient outcomes. The benefits of optimal treatment of dyslipidemia with statins may become evident within a few months in high-risk patients, while significant reductions in cardiovascular risk from hyperglycemia and hypertension control develop over several years.

  Sukhrobjon Ellamonov, Eleonora Tashkenbaeva, Gulnora Abdiyeva, Zarina Nasyrova, Nuriddin Khamidov

  16-21

  79   24

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