Irina Agababyan, Shuhrat Ziyadullayev, Jamshid Ismailov
Today, hypertension is considered by many authors within the framework of the manifestation of the metabolic syndrome. It has been established that in persons with hypertension in 60% of cases, various variants of MS are found. In addition, hypertension is a factor that reduces the quality of life of patients, especially those with comorbid pathology.
Adipose tissue is an endocrine organ in which a large number of biologically active substances are produced: leptin, adiponectin, insulin antagonists, angiotensinogen, angiotensin I and II, angiotensin-converting enzyme, renin, etc. Hence, antihypertensive drugs used for the treatment of patients with MS or T2DM must meet the following requirements: effectively reduce blood pressure throughout the day, not adversely affect carbohydrate, lipid, and purine metabolism, have an organoprotective effect, and reduce the risk of cardiovascular complications. In recent years, scientists around the world have again returned to forgotten statins. And they discovered, in addition to the lipid-lowering effect, which affects the level of cholesterol and low-density lipoproteins, their pleiotropic effect. The pleiotropic effect of statins is the antifibrotic action of drugs. This is especially true for rosuvastatin. Currently, scientists from China and Russia have proven their effectiveness in the outcome of severe viral pneumonia caused by Сovid-19 or SARS-Cov-2 in obese patients with diabetes mellitus who took statins before pneumonia.
