ENERGY COVID-19 COLLAPSE: NEW DIAGNOSTIC MARKERS, TREATMENT ASPECTS

An independent diagnostic criterion for assessing the prognosis in patients with COVID-19 is the dynamics of lactate levels, the overproduction of which is due to the crisis of energy-producing systems and an overload of the glycolytic pathway of energy production. The only corrector for the energy collapse caused by COVID-19 is the use of thiotriazoline, a metabolic drug with multiple pathways for lactate utilization and stimulation of oxidative phosphorylation, with powerful antioxidant properties. Such drugs as blockers of fatty acid metabolism (trimetazidine, meldonium) in this situation have no pathogenetic and biochemical substantiation.