ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
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CHARACTERISTICS OF HIGH-PROTEIN NUTRITIONAL SUPPORT IN
CERVICAL CANCER POSTOPERATIVE PATIENTS.
Khudayberdiyeva Shohista Amirkul kizi
Basic doctoral student Samarkand State Medical University
https://doi.org/10.5281/zenodo.14575024
As for now, treatment for cervical cancer mainly consists of surgical
intervention, supplemented with radiotherapy, chemotherapy, targeted therapy,
etc. Metabolic disorders are common in patients undergoing treatment for
malignant tumors. Malnutrition and metabolic problems reduce the div's
resistance to anti-tumor therapy, increase the risk of side effects of anti-tumor
therapy, and affect quality of life. Therefore enhancing nutritional risk screening
and effective nutritional support for cervical cancer patients is of great clinical
importance.
However, the effect of nutritional support on patients during the
postoperative treatment period is currently not well studied. Therefore, in this
study, we retrospectively analyzed the clinical records of cervical cancer
patients and examined the effect of standard nutritional support therapy on
postoperative course and quality of life.
In recent years, with advances in cancer diagnosis and treatment, nutritional
indicators have come to have important value in cancer treatment. A meta-
analysis has shown that nutritional status is an important factor influencing the
prognosis of glioma patients.
Objective:
To comparatively investigate the impact of standard nutritional
support based on nutritional risk screening on the nutritional status and quality
of life of postoperative cervical cancer patients.
Materials and methods:
The clinical data of 67 patients with RSM treated
at the Samarkand branch of the Republican Specialized Center of Oncology and
Radiology between February 2021 and February 2023 were retrospectively
investigated. Routine nutritional support (control): Patients received standard
doses of enteral and parenteral nutritional support, energy requirements of 20
kcal/kg, protein requirements of 1.1 g/kg/day, and the duration of nutritional
intervention It did not exceed 5 days. Protein saturation group (main group):
Patients received standard doses of enteral and parenteral nutrition supporting
energy requirements of 30 kcal/kg and protein requirements of 1.5-2.0
g/kg/day for the duration of the nutritional intervention. was as follows. 6 days.
Primary evaluation parameters: albumin (ALB), total protein (TP), and
hemoglobin (Hb) were compared before surgery, on the morning of the next
day after surgery, and the morning of the 14th day after surgery. Secondary
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
45
endpoints: He compared readmission rates, tumor recurrence rates, and
mortality rates 6 months after discharge between the two groups.
Results:
35 (52.2%) patients with SCM who received routine nutritional support
postoperatively were included in the control group, and the remaining 32
(47.8%) patients who received protein-rich nutritional support postoperatively
were included in the main group. There were no notable differences between
the two groups in age 39.5±5.2/41.12±3.9 p=0.31 (control group/main group,
respectively), BMI (kg/m2) 20.1±1.19/21.6±1.78, p=0.388, tumor localization
p=0.874, tumor diameter p=0.235, differentiation level p=0.513, (all P > 0.05).
Before the implementation of nutritional intervention, there were no notable
variances observed in the levels of ALB, OB, and HB (allP>0.05) between the two
groups. However, following 14 days post-surgery, it was evident that the levels
of ALB, OB, and HB were notably elevated in the primary group compared to the
control group. These differences were found to be statistically significant
(P<0.05), indicating a positive impact of the intervention on the nutritional
status of the main group. The main group exhibited lower PG-SGA scores
compared to the control group at both the 60-day and 90-day post-surgery
marks, with a significant intergroup effect (F=10.081, P=0.004).
Additionally, there was a trend of decreasing PG-SGA scores in both groups over
time, as indicated by a time effect (F=74.31). 2. In the logistic regression model,
efficacy (0=good, 1=poor) was utilized as the dependent variable, while various
measures of statistical significance served as independent variables. The
analysis revealed that age emerged as an independent factor influencing the
efficacy of nutritional support in postoperative RSM patients, as detailed in
Table 3.
An examination of multiple variables influencing the effectiveness of nutritional
assistance in individuals diagnosed with glioma was conducted through
statistical analysis.
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
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Conclusion:
In conclusion, the results suggest that implementing a high-protein
nutritional intervention based on nutritional risk screening can be beneficial for
patients with RSM. This intervention can help improve their postoperative
nutritional status and quality of life, while also reducing the risk of
postoperative tumor recurrence. It is crucial to conduct nutritional risk
screening in patients with RRMS and provide them with appropriate nutritional
support. It is worth noting that elderly patients only experience an improvement
in protein balance at very high protein intakes. Due to their higher catabolism
and anabolic resistance, it is recommended to provide them with 2-2.5 g/kg
protein per day. On the other hand, younger patients do not significantly
increase protein synthesis beyond 1.5 g/kg protein intake.
Literature:
1. Bingham S.A. et al. // Lancet. — 2003. — Vol. 361. — P. 1496–1501.
2. Riboli E., Norat T. // Am. J. Clin. Nutr. — 2003. — Vol. 78, Suppl. — P. 559–
569.
3. Dem Krebs keine Chance / Red. H. Bohnenkamp, M.C. Schachl. — Frankfurt am
Main: Deutsche Krebsgesellschaft e. V., 2000. — 34 S.
4. Bozzetti F., Gavazzi C., Cozzaglio et al. Total parenteral nutrition and tumour
growth in malnourished patients with gastric cancer // Tumori. — 1999. — Vol.
85, № 3. — P. 163–166.
5. Warren S. Th e immediate causes of death in cancer // Am. J. Med. Sci. —
1932. — Vol. 184. — P. 610–615.
6. Fearon K.C., Preston T. Body composition in cancer cachexia //
Infusionstherapy. — Basel, 1990. — Vol. 17, Suppl. 3. — P. 63–66
