ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
104
METHOD OF USING THE DRUG "ALBENDAZOLE" AS A TOPICAL
GERMICIDE FOR THE PREVENTION AND RECURRENCE OF
HEPATIC ECHINOCOCCOSIS
Radjabov Jasur Pardabayevich
Atoyeva Mokhigul Otabekovna
Usmonov Amirbek Usmonovich
Samarkand State Medical University, Republic of Uzbekistan, Samarkand
Bukhara State Medical Institute, Republic of Uzbekistan, Bukhara
https://doi.org/10.5281/zenodo.12719847
The relevance of research.
One of the most common causes of parasitic
liver invasions found in surgical practice is echinococcosis. According to WHO,
about three million people worldwide get sick with echinococcosis every year.
Uzbekistan is one of the regions endemic to echinococcosis [2, 3]. Climatic,
geographical, social and economic conditions have traditionally developed in
such a way that there are a number of zoonotic foci with varying degrees of
intensity of epizootic processes on the territory of the republic [1, 4, 5].
Materials and methods of research.
In order to circumvent the negative
aspects associated with the use of Albendazole in oral or injectable form, we
have developed a chemotherapy technique based on contact antiparasitic
treatment of liver tissue with Albendazole and oral administration of this drug in
"small" doses (5 mg / kg / day) and conducted a study of its effectiveness in
order to prevent recurrence of echinococcosis liver in patients admitted to the
multidisciplinary clinic of the Samarkand State Medical University in the period
from 2017 to 2020. The essence of the technique is that due to the tamponing of
the wound surface of the liver with Spongostan sponge treated with Albendazole
solution, a long-term local effect of the drug on the pathological focus is
achieved. In accordance with it, we impregnated a sterile sponge sponge with a
size of 7×5×1 cm with 50 ml of 0.9% saline solution with Albendazole dissolved
in it at a concentration of 10 µg/mL. Albendazole concentration of 10 µg/mL is
effective and safe for the patient, which has been proven by numerous
experiments by Erzurumlu et al. The study included patients who had:
1)
multiple cysts;
2)
cysts with daughter blisters as contents (Echinococcus Hominis);
3)
single-chamber cysts (Echinococcus Veterinorum);
4)
calcified cysts;
5)
cysts of large and medium size;
6)
cases of recurrent echinococcosis of the liver.
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
105
All the patients included in the study were divided into 2 groups: the main group
and the control group. The control group included 45 patients with
echinococcosis of the liver who took Albendazole according to the standard
regimen: 10-12 mg / kg of weight per day (no more than 800 mg per day), three
courses of 28 days with an interval between courses of 14 days. The main group
included 42 patients with echinococcosis of the liver, who, along with oral
administration of Albendazole in the postoperative period at a dose of 5 mg / kg
/ day, underwent antiparasitic contact treatment of the walls of the residual
cavity with this drug according to our method.
The results of the study.
After discharge from the hospital, patients were taken
under medical supervision with ultrasound, ELISA control and examination of
biochemical parameters of the functional state of the liver (ALT, AST) every 6
months for 1.5-2 years. According to the results of the study, a recurrence of the
disease occurred in 5 (11.1%) patients of the control group. There was no
recurrence of the disease in patients from the main group. There were also no
cases of local and general complications in patients treated according to our
method.
Conclusions.
Despite the small volume of the study performed, the use of
"small" doses of Albendazole in combination with the use of this drug as a
topical germicidal agent according to the developed methodology showed the
presence of a positive anti-relapse effect from their use.
References:
1.
Rakhmanov K. E., Davlatov S. S., Abduraxmanov D. Sh. Correction of
albendazole disease after echinococcectomy of the liver //International Journal
of Pharmaceutical Research (09752366). – 2020. – Т. 12. – №. 3.
2.
Nazyrov F. G. et al. Шляхи покращення результатів хірургічного
лікування ехінококкоза печінки //Неонатологія, хірургія та перинатальна
медицина. – 2018. – Т. 8. – №. 3 (29). – С. 39-43.
3.
Shamsiev A. M. et al. Differentiated treatment tactics in surgery of liver
echinococcosis //Experimental and Clinical Gastroenterology. – 2020. – Т. 174. –
№. 5. – С. 72-77.
4.
Shamsiev A. M. et al. Эхинококкоз печени: частота встречаемости,
патогенез, классификация, диагностика и лечение (обзор литературы)
//Клінічна та експериментальна патологія. – 2018. – Т. 17. – №. 3.
5.
Zarifovich K. B. et al. Laser photodynamic therapy as a method for treating
the residual cavity after liver echinococcectomy //Journal of biomedicine and
practice. – 2022. – Т. 7. – №. 4.
