Evaluation of the effectiveness of anti-inflammatory therapy of conjunctivitis and blepharitis based on cytological analysis

Shirin Djamalova, Nodira Yangieva, Zebiniso Kuryazova, Feruza Mirbabayeva, Abdusamad Axrarov

In the complex treatment of inflammatory eye diseases, anti-inflammatory therapy takes the leading place. The use of glucocortico steroids, which have powerful anti-inflammatory and antiallergic effects, carries the risk of serious side effects. Therefore, it was quite logical to develop  and  introduce  into  ophthalmological  practice  non-steroidal  anti-inflammatory  drugs, which  are only  slightly  inferior  to  them  in  their  anti-inflammatory  activity.  On  the  basis  of  a cytological analysis of the state of the conjunctiva, to assess the effectiveness of a new domestic ophthalmic drug "0.5% benzketozone ointment" in the treatment of conjunctivitis and blepharitis of infectious etiology. Materials and methods. To assess the effectiveness of 0.5% benzketozone ophthalmic ointment (Registration certificate No. 06-07.), A study was carried out on 134 (218 eyes) patients. In the control  group,  patients  received  traditional  treatment,  in  the  main  group,  0.5%  benzketozone ointment was additionally prescribed to the traditional treatment. Cytological examination was carried out by the method of modified impression cytology. Results. The data of modified impression cytology showed that the inclusion of benzketozone ointment  in  the  traditional  treatment  significantly  reduces  the  phenomena  of  exudation  and proliferation, which at the subcellular level is manifested by a decrease in the number of basophils and eosinophils, restoration of the structure of epithelial cells and normalization of the nuclear-cytoplasmic ratio at an earlier time than in control groups, a faster decrease in the preparations of protein and tissue detritus. Conclusion. The inclusion of benzketozone eye ointment in the complex of traditional therapy increases  regenerative  activity,  improves  metabolic  processes  and  alleviates  the  symptoms  of inflammatory eye lesions

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