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MORPHOLOGICAL ASPECTS OF GROWTH OF THE PLACENTA
COVER ON THE SURFACE OF THE UTERUS MYOMETRIUM
Davronov O.T.
Independent researcher, Department of Pathological Anatomy, Samarkand State
Medical University, Samarkand, Uzbekistan
Relevance. The relevance of studying placental abruption is due to the fact that
every year pregnant women with this diagnosis suffer from massive bleeding loss, which
can lead to a long recovery period after surgery, loss of reproductive capacity during
hysterectomy, or in severe cases, death of the woman. Placental abruption is a
histopathological term for an abnormal attachment of the placenta to the uterine wall,
which means that the placenta does not completely or partially separate from the uterine
wall.
Research objective: to determine the morphological aspects of the growth of
the placental shell to the myometrial surface of the uterus.
Materials and methods: Uteruses removed from 14 women in maternity
hospitals in Samarkand due to uterine atony caused by the growth of the placenta into the
myometrium were studied at the Department of Pathological Anatomy of the
Multidisciplinary Clinic of Samarkand State Medical University. Morphological and
morphometric changes in the structures of the uterine myometrium were examined using
macroscopic, microscopic, morphometric and statistical methods. Histological sections
were stained with hematoxylin-eosin.
Results and discussion: The results of the research conducted show that, Of the
14 women, 7 had stage III pregnancy and stage III delivery, most of whom had
intrauterine infection, 4 had stage IV pregnancy and stage III delivery, no additional
diseases were identified in their anamnesis, and the remaining 3 had stage V and VI
deliveries, and their anamnesis was treated for chronic endometritis and glandular
hyperplasia of the endometrial layer of the uterus. Microscopic examination of
histological preparations prepared from the removed uterus revealed adhesion of the
placental membrane to the surface of the uterine myometrium, engorgement of
myometrial blood vessels in this area, intermuscular edema and hemorrhages. Also,
hydropic dystrophy in the cytoplasm of myocytes, karyopycosis and karyorrhexis in the
nucleus were detected. The walls of the blood vessels located in the myometrial layer
were swollen, collagen fibers were fibrillar and swollen. In the intima layer of blood
vessels, hydropic dystrophy in the cytoplasm of endotheliocytes, karyopyknosis in the
nucleus, karyorrhexis and karyolysis in the nucleus of some endotheliocytes are noted. It
is determined that sclerotic processes have developed in the wall of most blood vessels.
Chorine villi of the placenta attached to the myometrial surface are thickened, swollen,
and proliferation of fibrous tissue cells is observed. In addition, deposition of intervilli
fibrin, fibrinoid necrosis, obvious fibrosis of villi, thrombosis of small blood vessels are
determined. Fullness of placental decidual membrane and signs of weak infiltration of
erythrocytes (deciduit) are determined.
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Conclusion: Thus, the development of sclerotic changes in both placental tissue
and myometrial structures is observed during the adhesion of the placental membrane to
the myometrial surface. To prevent these conditions, it is necessary to ensure that women
of reproductive age undergo timely medical examinations.
Oydalanilgan adabiyotlar ro‘yxati
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