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METABOLIC DISORDERS IN PCOS ACCORDING TO THE NEW FIGO
2022 CLASSIFICATION OF ANOVULATION
Bhel Charvi, 402, Tashkent State Dental Institute.
Scientific Supervisor: Tojieva I.M., Senior Lecturer of the Department of
Therapeutic Disciplines No. 1
Tashkent State Dental Institute, Uzbekistan
Abstract
Anovulation is one of the major contributors to female infertility and is
frequently accompanied by notable metabolic disturbances. In 2022, the International
Federation of Gynecology and Obstetrics (FIGO) introduced an updated classification
system for anovulatory disorders, incorporating hormonal and metabolic parameters. A
special focus in this framework is placed on polycystic ovary syndrome (PCOS), a
condition marked by hyperandrogenism, insulin resistance, and dyslipidemia.
Objective:
To investigate hormonal and metabolic alterations in women with
various anovulatory conditions, emphasizing PCOS, in accordance with the updated
FIGO 2022 classification.
Materials and Methods:
The study included 4,764 reproductive-age women.
Diagnosis of PCOS was established according to the Rotterdam 2018 criteria. All
participants underwent evaluation of anthropometric data, blood pressure, lipid and
glucose metabolism, and hormone profiles. Statistical methods included ANOVA and
Mann-Whitney tests, with significance set at p<0.05.
Results:
PCOS was diagnosed in 8.73% of the participants. Women with
PCOS exhibited the highest mean div mass index (29.5±5), elevated fasting glucose
(5.23±0.97 mmol/L), and increased insulin resistance (HOMA-IR 3.06±2.8, p<0.01).
Their lipid profiles were also more atherogenic, with elevated triglycerides (1.93±1.11
mmol/L, p<0.001) and reduced HDL cholesterol (1.31±0.47 mmol/L, p<0.001).
Hormonal assessment showed elevated luteinizing hormone (13.9±9.5 mIU/mL,
p<0.001) and testosterone (1.47±1 nmol/L, p<0.01).
Conclusion:
Findings underline the
severity of metabolic disturbances in PCOS, reinforcing the importance of integrated
diagnostic and therapeutic approaches. The updated FIGO 2022 classification provides a
valuable framework for understanding anovulatory disorders and their systemic impact.
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